LC3

LC3产品

目录号	产品描述	文献引用	实验数据
S7683	PIK-III PIK-III (VPS34-IN2), 一种选择性VPS34酶活性的抑制剂，抑制细胞自噬以及LC3的重新脂化，稳定自噬底物。其对VPS34和 PI(3)Kδ的IC50值分别为0.018 μM和1.2 μM。	Nature, 2020, 10.1038/s41586-020-03056-z Cell, 2020, S0092-8674(20)31394-5 Nat Commun, 2020, 17;11(1):1416	LC3 and DAPI immunofluorescence staining were performed to detect autophagy in VSC4.1 cells treated with 25 mM HD alone, 25 mM HD + 5 μM PIK-III, 5 μM PIK-III and 0.1% DMSO alone (control group). Scale bar: 20 μm
S0778	LC3-mHTT-IN-AN1 LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.

目录号	产品描述	文献引用	实验数据
S7683	PIK-III PIK-III (VPS34-IN2), 一种选择性VPS34酶活性的抑制剂，抑制细胞自噬以及LC3的重新脂化，稳定自噬底物。其对VPS34和 PI(3)Kδ的IC50值分别为0.018 μM和1.2 μM。	Nature,2020, 10.1038/s41586-020-03056-z Cell,2020, S0092-8674(20)31394-5 Nat Commun,2020, 17;11(1):1416	LC3 and DAPI immunofluorescence staining were performed to detect autophagy in VSC4.1 cells treated with 25 mM HD alone, 25 mM HD + 5 μM PIK-III, 5 μM PIK-III and 0.1% DMSO alone (control group). Scale bar: 20 μm

目录号	产品描述	文献引用	实验数据
S0778	LC3-mHTT-IN-AN1 LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.