NAMPT
抑制剂选择性比较
NAMPT产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S2799 |
Daporinad (FK866, APO866)Daporinad (FK866, APO866)有效抑制烟酰胺磷酸核糖转移酶(NMPRTase; Nampt),Daporinad (FK866, APO866) 可引发自噬,无细胞试验中IC50为0.09 nM。Phase 1/2。 |
![]() ![]() Effect of metabolic inhibitors on SRC-1 protein levels. A549 cells grown in glucose-containing medium were treated with NAM or FK866 at the indicated concentration.
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S7316 |
STF-118804STF-118804是高特异性NAMPT抑制剂。 |
![]() ![]() RSV-induced SIRT1 expression is PARP1-dependent in PC12 cells. a, PC12 cells were pretreated with STF-118804 (100 nM) for 1 h prior to treatment with RSV (20 lM) for another 2 h, followed bytreatment with or without of Ab25–35 (30 lM) for an additional 24 h. SIRT1 expression was determined by western blot analysis. b, The bar graph shows the quantification of endogenous SIRT1. c, Cells were treated with various concentrations (1, 5, 10, and 20 lM) of RSV for 24 h. PARP1 expression was detected by western blot analysis.
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S6629 |
GNE-617GNE-617是强效NAMPT抑制剂,IC50为5 nM。 |
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S8444 |
KPT 9274 ( ATG-019)KPT 9274 ( ATG-019) 是一种具有口服活性的小分子化合物,是非竞争性的PAK4和NAMPT双重抑制剂。在cell-free的酶活实验中,对NAMPT的IC50值约为120 nM。 |
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S9706New |
OT-82OT-82 是一种新型烟酰胺磷酸核糖基转移酶 (NAMPT)抑制剂,在非HP癌细胞中的平均IC50为13.03 nM,在HP癌细胞中的平均IC50为 2.89 nM。 |
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S8117 |
GMX1778 (CHS828)GMX1778 (CHS828)是一种有效的特异性nicotinamide phosphoribosyltransferase (NAMPT)抑制剂,IC50 和 Kd分别为 < 25 nM 和120 nM。GMX1778 可诱导具有凋亡特征的细胞程序性死亡。Phase 1。 |
![]() ![]() (d) Representative images of haematoxylin and eosin staining from young colons treated with or without specific Nampt inhibitor GMX1778. Bar=100 μm. (e) Colonic NAD+/NADH ratio was analysed in young mice treated with or without Nampt inhibitor GMX1778 (n=5). *P<0.05. (f) Daily faecal number of young mice treated with or without specific Nampt inhibitor GMX1778 (n=6). **P<0.01.
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S7968 |
P7C3P7C3是一种有效的促神经生长性和神经保护性化学药品,靶向作用于NAMPT酶。 |
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S8980 |
SBI-797812SBI-797812 是一种 NAMPT 的激活剂,其在结构上与活性位点导向的NAMPT抑制剂相似,可阻止这些抑制剂与 NAMPT 结合。SBI-797812 可将NAMPT转变一种“超级催化剂”能更高效地生成NMN。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S2799 |
Daporinad (FK866, APO866)Daporinad (FK866, APO866)有效抑制烟酰胺磷酸核糖转移酶(NMPRTase; Nampt),Daporinad (FK866, APO866) 可引发自噬,无细胞试验中IC50为0.09 nM。Phase 1/2。 |
![]() ![]() Effect of metabolic inhibitors on SRC-1 protein levels. A549 cells grown in glucose-containing medium were treated with NAM or FK866 at the indicated concentration.
|
|
S7316 |
STF-118804STF-118804是高特异性NAMPT抑制剂。 |
![]() ![]() RSV-induced SIRT1 expression is PARP1-dependent in PC12 cells. a, PC12 cells were pretreated with STF-118804 (100 nM) for 1 h prior to treatment with RSV (20 lM) for another 2 h, followed bytreatment with or without of Ab25–35 (30 lM) for an additional 24 h. SIRT1 expression was determined by western blot analysis. b, The bar graph shows the quantification of endogenous SIRT1. c, Cells were treated with various concentrations (1, 5, 10, and 20 lM) of RSV for 24 h. PARP1 expression was detected by western blot analysis.
|
|
S6629 |
GNE-617GNE-617是强效NAMPT抑制剂,IC50为5 nM。 |
||
S8444 |
KPT 9274 ( ATG-019)KPT 9274 ( ATG-019) 是一种具有口服活性的小分子化合物,是非竞争性的PAK4和NAMPT双重抑制剂。在cell-free的酶活实验中,对NAMPT的IC50值约为120 nM。 |
||
S9706New |
OT-82OT-82 是一种新型烟酰胺磷酸核糖基转移酶 (NAMPT)抑制剂,在非HP癌细胞中的平均IC50为13.03 nM,在HP癌细胞中的平均IC50为 2.89 nM。 |
||
S8117 |
GMX1778 (CHS828)GMX1778 (CHS828)是一种有效的特异性nicotinamide phosphoribosyltransferase (NAMPT)抑制剂,IC50 和 Kd分别为 < 25 nM 和120 nM。GMX1778 可诱导具有凋亡特征的细胞程序性死亡。Phase 1。 |
![]() ![]() (d) Representative images of haematoxylin and eosin staining from young colons treated with or without specific Nampt inhibitor GMX1778. Bar=100 μm. (e) Colonic NAD+/NADH ratio was analysed in young mice treated with or without Nampt inhibitor GMX1778 (n=5). *P<0.05. (f) Daily faecal number of young mice treated with or without specific Nampt inhibitor GMX1778 (n=6). **P<0.01.
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目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S7968 |
P7C3P7C3是一种有效的促神经生长性和神经保护性化学药品,靶向作用于NAMPT酶。 |
||
S8980 |
SBI-797812SBI-797812 是一种 NAMPT 的激活剂,其在结构上与活性位点导向的NAMPT抑制剂相似,可阻止这些抑制剂与 NAMPT 结合。SBI-797812 可将NAMPT转变一种“超级催化剂”能更高效地生成NMN。 |