NAMPT

抑制剂选择性比较

NAMPT产品

所有产品 NAMPT抑制剂(5) NAMPT激活剂(2)

目录号	产品描述	文献引用	实验数据
S2799	Daporinad (FK866, APO866) Daporinad (FK866, APO866)有效抑制烟酰胺磷酸核糖转移酶(NMPRTase; Nampt)，Daporinad (FK866, APO866) 可引发自噬，无细胞试验中IC50为0.09 nM。Phase 1/2。	Cell Metab, 2020, 31(3):564-579 Mol Ther Nucleic Acids, 2020, 1;20:801-811 Front Cell Dev Biol, 2020, 17;8:191	Effect of metabolic inhibitors on SRC-1 protein levels. A549 cells grown in glucose-containing medium were treated with NAM or FK866 at the indicated concentration.
S7316	STF-118804 STF-118804是高特异性NAMPT抑制剂。	Cell Metab, 2020, 31(3):564-579 Neurochem Res, 2016, 41(9):2367-79	RSV-induced SIRT1 expression is PARP1-dependent in PC12 cells. a, PC12 cells were pretreated with STF-118804 (100 nM) for 1 h prior to treatment with RSV (20 lM) for another 2 h, followed by treatment with or without of Ab25–35 (30 lM) for an additional 24 h. SIRT1 expression was determined by western blot analysis. b, The bar graph shows the quantification of endogenous SIRT1. c, Cells were treated with various concentrations (1, 5, 10, and 20 lM) of RSV for 24 h. PARP1 expression was detected by western blot analysis.
S6629^New	GNE-617 GNE-617是强效NAMPT抑制剂，IC50为5 nM。
S8444	KPT 9274( ATG-019) KPT-9274是一种具有口服活性的小分子化合物，是非竞争性的PAK4和NAMPT双重抑制剂。在cell-free的酶活实验中，对NAMPT的IC50值约为120 nM。
S8117	GMX1778 (CHS828) GMX1778 (CHS828)是一种有效的特异性nicotinamide phosphoribosyltransferase (NAMPT)抑制剂，IC50 和 K_d分别为 < 25 nM 和120 nM。Phase 1。	Cancer Res, 2020, 80(4):890-900 Acta Physiol (Oxf), 2020, 10.1111/apha.13439 Signal Transduct Target Ther, 2017, 2:17017	(d) Representative images of haematoxylin and eosin staining from young colons treated with or without specific Nampt inhibitor GMX1778. Bar=100 μm. (e) Colonic NAD+/NADH ratio was analysed in young mice treated with or without Nampt inhibitor GMX1778 (n=5). P<0.05. (f) Daily faecal number of young mice treated with or without specific Nampt inhibitor GMX1778 (n=6). *P<0.01.
S7968	P7C3 P7C3是一种有效的促神经生长性和神经保护性化学药品，靶向作用于NAMPT酶。
S8980^New	SBI-797812 SBI-797812 是一种 NAMPT 的激活剂，其在结构上与活性位点导向的NAMPT抑制剂相似，可阻止这些抑制剂与 NAMPT 结合。SBI-797812 可将NAMPT转变一种“超级催化剂”能更高效地生成NMN。

目录号	产品描述	文献引用	实验数据
S2799	Daporinad (FK866, APO866) Daporinad (FK866, APO866)有效抑制烟酰胺磷酸核糖转移酶(NMPRTase; Nampt)，Daporinad (FK866, APO866) 可引发自噬，无细胞试验中IC50为0.09 nM。Phase 1/2。	Cell Metab,2020, 31(3):564-579 Mol Ther Nucleic Acids,2020, 1;20:801-811 Front Cell Dev Biol,2020, 17;8:191	Effect of metabolic inhibitors on SRC-1 protein levels. A549 cells grown in glucose-containing medium were treated with NAM or FK866 at the indicated concentration.
S7316	STF-118804 STF-118804是高特异性NAMPT抑制剂。	Cell Metab,2020, 31(3):564-579 Neurochem Res,2016, 41(9):2367-79	RSV-induced SIRT1 expression is PARP1-dependent in PC12 cells. a, PC12 cells were pretreated with STF-118804 (100 nM) for 1 h prior to treatment with RSV (20 lM) for another 2 h, followed by treatment with or without of Ab25–35 (30 lM) for an additional 24 h. SIRT1 expression was determined by western blot analysis. b, The bar graph shows the quantification of endogenous SIRT1. c, Cells were treated with various concentrations (1, 5, 10, and 20 lM) of RSV for 24 h. PARP1 expression was detected by western blot analysis.
S6629^New	GNE-617 GNE-617是强效NAMPT抑制剂，IC50为5 nM。
S8444	KPT 9274( ATG-019) KPT-9274是一种具有口服活性的小分子化合物，是非竞争性的PAK4和NAMPT双重抑制剂。在cell-free的酶活实验中，对NAMPT的IC50值约为120 nM。
S8117	GMX1778 (CHS828) GMX1778 (CHS828)是一种有效的特异性nicotinamide phosphoribosyltransferase (NAMPT)抑制剂，IC50 和 K_d分别为 < 25 nM 和120 nM。Phase 1。	Cancer Res,2020, 80(4):890-900 Acta Physiol (Oxf),2020, 10.1111/apha.13439 Signal Transduct Target Ther,2017, 2:17017	(d) Representative images of haematoxylin and eosin staining from young colons treated with or without specific Nampt inhibitor GMX1778. Bar=100 μm. (e) Colonic NAD+/NADH ratio was analysed in young mice treated with or without Nampt inhibitor GMX1778 (n=5). P<0.05. (f) Daily faecal number of young mice treated with or without specific Nampt inhibitor GMX1778 (n=6). *P<0.01.

目录号

产品描述

文献引用

实验数据

S7968

P7C3

P7C3是一种有效的促神经生长性和神经保护性化学药品，靶向作用于NAMPT酶。

S8980^New

SBI-797812

SBI-797812 是一种 NAMPT 的激活剂，其在结构上与活性位点导向的NAMPT抑制剂相似，可阻止这些抑制剂与 NAMPT 结合。SBI-797812 可将NAMPT转变一种“超级催化剂”能更高效地生成NMN。