NAMPT
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S7316 | STF-118804 | <1 mg/mL | 61 mg/mL | <1 mg/mL |
| S8444 | KPT-9274 | <1 mg/mL | 100 mg/mL | 100 mg/mL |
| S8117 | GMX1778 (CHS828) | <1 mg/mL | 74 mg/mL | <1 mg/mL |
| S7968 | P7C3 | <1 mg/mL | 95 mg/mL | 20 mg/mL |
- NAMPT抑制剂（4）
- 新NAMPT产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7316 |
STF-118804STF-118804是高特异性NAMPT抑制剂。 |
RSV-induced SIRT1 expression is PARP1-dependent in PC12 cells. a, PC12 cells were pretreated with STF-118804 (100 nM) for 1 h prior to treatment with RSV (20 lM) for another 2 h, followed by
treatment with or without of Ab25–35 (30 lM) for an additional 24 h. SIRT1 expression was determined by western blot analysis. b, The bar graph shows the quantification of endogenous SIRT1. c, Cells were treated with various concentrations (1, 5, 10, and 20 lM) of RSV for 24 h. PARP1 expression was detected by western blot analysis.
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| S8444New |
KPT-9274KPT-9274是一种具有口服活性的小分子化合物，是非竞争性的PAK4和NAMPT双重抑制剂。在cell-free的酶活实验中，对NAMPT的IC50值约为120 nM。 |
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| S8117 |
GMX1778 (CHS828)GMX1778 (CHS828)是一种有效的特异性nicotinamide phosphoribosyltransferase (NAMPT)抑制剂，IC50 和 Kd分别为 < 25 nM 和120 nM。Phase 1。 |
(d) Representative images of haematoxylin and eosin staining from young colons treated with or without specific Nampt inhibitor GMX1778. Bar=100 μm. (e) Colonic NAD+/NADH ratio was analysed in young mice treated with or without Nampt inhibitor GMX1778 (n=5). *P<0.05. (f) Daily faecal number of young mice treated with or without specific Nampt inhibitor GMX1778 (n=6). **P<0.01.
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| S7968 |
P7C3P7C3是一种有效的促神经生长性和神经保护性化学药品，靶向作用于NAMPT酶。 |
