Neprilysin
抑制剂选择性比较
Neprilysin产品
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S3388New |
SacubitrilatSacubitrilat (Sac, LBQ-657) 是一种 neprilysin (NEP) 的活性抑制剂。 |
||
| S7678 |
Sacubitril/valsartan (LCZ696)Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan)，由valsartan和sacubitril以1：1的摩尔比组成，是一个口服生物有效，双重作用的angiotensin receptor-neprilysin inhibitor (ARNi)，用于治疗高血压和心脏衰竭。Phase 3。 |
Histological analysis staining of three groups. (a) Representative H&E-staining micrographs displaying transverse myocardial section (original magnification ×200). (b) Masson staining of three groups (original magnification ×200). Collagen content (%) of heart tissues were presented as fibrosis (***P < 0.001, n = 7 per group). (c) Cardiac section of three group mice hearts stained with WGA (original magnification ×400) (*P < 0.05, n = 7 per group). (d) The expression of Drp1 significantly increased in DOX group (***P < 0.001, n = 7 per group) and it decreased in DOX + LCZ696 group (**P < 0.01, n = 7 per group).
|
|
| S4426New |
Sacubitril hemicalcium saltSacubitril (AHU-377) hemicalcium salt 是心力衰竭药物LCZ696的组成部分，一种有效的 neprilysin (neutral endopeptidase, NEP) 抑制剂。 |
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S3388New |
SacubitrilatSacubitrilat (Sac, LBQ-657) 是一种 neprilysin (NEP) 的活性抑制剂。 |
||
| S7678 |
Sacubitril/valsartan (LCZ696)Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan)，由valsartan和sacubitril以1：1的摩尔比组成，是一个口服生物有效，双重作用的angiotensin receptor-neprilysin inhibitor (ARNi)，用于治疗高血压和心脏衰竭。Phase 3。 |
Histological analysis staining of three groups. (a) Representative H&E-staining micrographs displaying transverse myocardial section (original magnification ×200). (b) Masson staining of three groups (original magnification ×200). Collagen content (%) of heart tissues were presented as fibrosis (***P < 0.001, n = 7 per group). (c) Cardiac section of three group mice hearts stained with WGA (original magnification ×400) (*P < 0.05, n = 7 per group). (d) The expression of Drp1 significantly increased in DOX group (***P < 0.001, n = 7 per group) and it decreased in DOX + LCZ696 group (**P < 0.01, n = 7 per group).
|
|
| S4426New |
Sacubitril hemicalcium saltSacubitril (AHU-377) hemicalcium salt 是心力衰竭药物LCZ696的组成部分，一种有效的 neprilysin (neutral endopeptidase, NEP) 抑制剂。 |
沪公网安备 31011502012800号