Neuraminidase
抑制剂选择性比较
Neuraminidase产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S2597 |
Oseltamivir PhosphateOseltamivir Phosphate 是一种有效的和选择性的,甲型流感和乙型流感病毒复制必需的神经氨酸酶的抑制剂,用于治疗流行性感冒。 |
![]() ![]() Nystatin, filipin III, and oseltamivir inhibit the labeling of trophozoites by CTXB and GM1 antibodies. (A) Trophozoites were treated with nystatin (27 μM), filipin III (7.6 μM), and oseltamivir (20 μM) for 30 min before labeling with Alexa Fluor-conjugated CTXB antibody (images a to d) and GM1 antibody (images a′ to d′). Myriocin (27 μM), a sphingolipid inhibitor, was used as a negative control (images e and e′). N, nucleus; PM, plasma membrane; F, flagella; VD, ventral disc. Bars, 5 μm. (B and C) Changes in intensity of control and inhibitor-treated trophozoites. For intensity measurements, cells were randomly selected from 10 to 15 fields from 3 to 5 separate experiments. Approximately 50 cells were considered for each condition and were analyzed using Zeiss Zen 2009 confocal software. One-way ANOVAs were performed to evaluate differences (means ± SDs) between the treatment and control groups. Mean intensities from 3 to 5 separate experiments are shown in panels B and C. Statistical significance was calculated using a one-way ANOVA test, followed by the Tukey (B) and Holm-Šídák (C) methods. *, P < 0.05; **, P < 0.01; ***, P < 0.001; NS, not significant. |
|
S2716 |
Peramivir TrihydratePeramivir Trihydrate (BCX-1812, RWJ-270201, S-021812)是抗感染剂Peramivir的三水合物,这是一种过渡状态模拟和一个强有力的流感病毒神经氨酸酶特异抑制剂,IC50中位数为0.09 nM。 |
![]() ![]() Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of peramivir (C) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice. |
|
S3007 |
ZanamivirZanamivir (GG167) 是神经氨酸酶抑制剂,用于治疗A型流感病毒和B型流感病毒引起的流感的治疗。 |
![]() ![]() Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of oseltamivir zanamivir (B) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice. |
|
S0946New |
TheaflavinTheaflavin is a suitable natural inhibitor of influenza A (H1N1) neuraminidase. |
||
S0861New |
Laninamivir OctanoateLaninamivir octanoate (CS-8958, R-118958, Inavir, LANI) 是 Laninamivir (R-125489)的前药,一种长效的神经氨酸酶 neuraminidase (NA) 的抑制剂,具有优异的抗流感病毒的活性。 |
||
S2838 |
Compound Y-1Compound Y-1 (Neuraminidase-IN-1, Y-1) is a neuraminidase inhibitor with IC50 of 0.21 μM. Compound Y-1 (Neuraminidase-IN-1, Y-1) has excellent activity against H1N1 influenza virus and good inhibitory effect on the A/WSN/33 H1N1 virus strains. |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S2597 |
Oseltamivir PhosphateOseltamivir Phosphate 是一种有效的和选择性的,甲型流感和乙型流感病毒复制必需的神经氨酸酶的抑制剂,用于治疗流行性感冒。 |
![]() ![]() Nystatin, filipin III, and oseltamivir inhibit the labeling of trophozoites by CTXB and GM1 antibodies. (A) Trophozoites were treated with nystatin (27 μM), filipin III (7.6 μM), and oseltamivir (20 μM) for 30 min before labeling with Alexa Fluor-conjugated CTXB antibody (images a to d) and GM1 antibody (images a′ to d′). Myriocin (27 μM), a sphingolipid inhibitor, was used as a negative control (images e and e′). N, nucleus; PM, plasma membrane; F, flagella; VD, ventral disc. Bars, 5 μm. (B and C) Changes in intensity of control and inhibitor-treated trophozoites. For intensity measurements, cells were randomly selected from 10 to 15 fields from 3 to 5 separate experiments. Approximately 50 cells were considered for each condition and were analyzed using Zeiss Zen 2009 confocal software. One-way ANOVAs were performed to evaluate differences (means ± SDs) between the treatment and control groups. Mean intensities from 3 to 5 separate experiments are shown in panels B and C. Statistical significance was calculated using a one-way ANOVA test, followed by the Tukey (B) and Holm-Šídák (C) methods. *, P < 0.05; **, P < 0.01; ***, P < 0.001; NS, not significant. |
|
S2716 |
Peramivir TrihydratePeramivir Trihydrate (BCX-1812, RWJ-270201, S-021812)是抗感染剂Peramivir的三水合物,这是一种过渡状态模拟和一个强有力的流感病毒神经氨酸酶特异抑制剂,IC50中位数为0.09 nM。 |
![]() ![]() Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of peramivir (C) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice. |
|
S3007 |
ZanamivirZanamivir (GG167) 是神经氨酸酶抑制剂,用于治疗A型流感病毒和B型流感病毒引起的流感的治疗。 |
![]() ![]() Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of oseltamivir zanamivir (B) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice. |
|
S0946New |
TheaflavinTheaflavin is a suitable natural inhibitor of influenza A (H1N1) neuraminidase. |
||
S0861New |
Laninamivir OctanoateLaninamivir octanoate (CS-8958, R-118958, Inavir, LANI) 是 Laninamivir (R-125489)的前药,一种长效的神经氨酸酶 neuraminidase (NA) 的抑制剂,具有优异的抗流感病毒的活性。 |
||
S2838 |
Compound Y-1Compound Y-1 (Neuraminidase-IN-1, Y-1) is a neuraminidase inhibitor with IC50 of 0.21 μM. Compound Y-1 (Neuraminidase-IN-1, Y-1) has excellent activity against H1N1 influenza virus and good inhibitory effect on the A/WSN/33 H1N1 virus strains. |