NLRP3

抑制剂选择性比较

NLRP3产品

所有产品(10) NLRP3抑制剂(9) NLRP3激活剂(1)

目录号	产品描述	文献引用	实验数据
S3939	4'-Methoxyresveratrol 4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
S3290^New	Procyanidin B2 Procyanidin B2 (PCB2) 是一种存在于常见食品中的天然类黄酮，具有抗炎、抗氧化和抗癌活性。Procyanidin B2 可激活 PPARγ 并诱导小鼠巨噬细胞M2极化。Procyanidin B2 可显著抑制百草枯在大鼠模型中肺组织中 NLRP3 炎性小体的活化。
S8559	INF39 INF39是NLRP3的无毒性的、不可逆的抑制剂，通过与NLRP3不可逆地直接相互作用以及部分抑制LPS驱动的促炎性基因表达，阻止NLRP3的激活。	Int Immunopharmacol, 2021, 92:107358 Cell Biol Int, 2020, 10.1002/cbin.11429 Mediators Inflamm, 2019, 2019:1082497	Yupingfeng San reduced the expression of NLRP3 Inflammasome in LPS-stimulated U937 cells. Cells were pre-treated with PMA for 48 h and then incubated with LPS for 2 h. Subsequently, cells were stimulated with YPFS. INF39 was used as the positive control. After 48 h, cells were collected. (A–C) The mRNA levels of NLRP3, ASC and Caspase-1 were detected by real time-PCR. (D–I) The protein levels of NLRP3, ASC and Caspase-1 were detected by western blotting, and the ratio of NLRP3/GAPDH, ASC/GAPDH and Caspase-1/GAPDH were shown. ∗P < 0.05, ∗∗P < 0.01, compared with model group.
S8907	Dapansutrile Dapansutrile 是一种新型的、选择性的NLRP3 inflammasome抑制剂。
S5774	CY-09 CY-09是一种特异的NLRP3 inflammasome的抑制剂，直接靶向NLRP3。它对5种主要的cytochrome P450酶的IC50值分别为18.9, 8.18, >50, >50 和 26.0 µM。	Biochem Biophys Res Commun, 2021, 553:119-125 Transl Stroke Res, 2020, 10.1007/s12975-020-00840-x Front Immunol, 2020, 11:619096
S8930^New	MCC950 MCC950 is a potent and selective inhibitor of NLRP3 with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.	J Exp Med, 2021, 218(9)e20202637 EMBO Rep, 2021, e50743 Metabolism, 2021, 118:154748
S7809	MCC950 Sodium (CP-456773 Sodium) MCC950 Sodium (CP-456773 Sodium, CRID3 sodium salt)是一种有效的、选择性NLRP3抑制剂，在骨髓来源的巨噬细胞中IC50为7.5 nM。对AIM2, NLRC4或NLRP1炎症体没有作用。	Nat Commun, 2021, 12(1):3964 Nat Commun, 2021, 12(1):4664 EMBO Rep, 2021, e50743	A-C, Expression of caspase 1 and its active form caspase 1-p20, as demonstrated in representative Western blots (top) and the relative expression levels (B and C) in each group.
S3871	Muscone Muscone (3-Methylcyclopentadecanone, Methylexaltone)是一种增香成分，一种有机化合物，是麝香气味的主要来源，也是一种有效的消炎剂。Muscone 可显著地下调LPDM诱导的炎症细胞因子水平，并抑制BMDM中 NF-κB 和 NLRP3 炎性小体的活化。Muscone 还可以显著地降低炎性细胞因子inflammatory cytokines (IL-1β, TNF-α, IL-6) 的水平。	J Pharm Pharmacol, 2019, 71(11):1706-1713
S3680	NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome Inhibitor I是合成格列本脲的中间底物，它是NLRP3 inflammasome的抑制剂。	Front Pharmacol, 2021, 12:627557 Nutrients, 2021, 13(3)856 Phytother Res, 2021, 10.1002/ptr.7191
S6653	Nigericin (NSC 292567) sodium salt Nigericin (NSC 292567) sodium salt是从Streptomyces hygroscopicus衍生的抗生素，通过充当H⁺，K⁺和Pb²⁺的离子载体起作用。Nigericin可以激活NLRP3炎性体以诱导促炎和免疫刺激过程。

目录号	产品描述	文献引用	实验数据
S3939	4'-Methoxyresveratrol 4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
S3290^New	Procyanidin B2 Procyanidin B2 (PCB2) 是一种存在于常见食品中的天然类黄酮，具有抗炎、抗氧化和抗癌活性。Procyanidin B2 可激活 PPARγ 并诱导小鼠巨噬细胞M2极化。Procyanidin B2 可显著抑制百草枯在大鼠模型中肺组织中 NLRP3 炎性小体的活化。
S8559	INF39 INF39是NLRP3的无毒性的、不可逆的抑制剂，通过与NLRP3不可逆地直接相互作用以及部分抑制LPS驱动的促炎性基因表达，阻止NLRP3的激活。	Int Immunopharmacol,2021, 92:107358 Cell Biol Int,2020, 10.1002/cbin.11429 Mediators Inflamm,2019, 2019:1082497	Yupingfeng San reduced the expression of NLRP3 Inflammasome in LPS-stimulated U937 cells. Cells were pre-treated with PMA for 48 h and then incubated with LPS for 2 h. Subsequently, cells were stimulated with YPFS. INF39 was used as the positive control. After 48 h, cells were collected. (A–C) The mRNA levels of NLRP3, ASC and Caspase-1 were detected by real time-PCR. (D–I) The protein levels of NLRP3, ASC and Caspase-1 were detected by western blotting, and the ratio of NLRP3/GAPDH, ASC/GAPDH and Caspase-1/GAPDH were shown. ∗P < 0.05, ∗∗P < 0.01, compared with model group.
S8907	Dapansutrile Dapansutrile 是一种新型的、选择性的NLRP3 inflammasome抑制剂。
S5774	CY-09 CY-09是一种特异的NLRP3 inflammasome的抑制剂，直接靶向NLRP3。它对5种主要的cytochrome P450酶的IC50值分别为18.9, 8.18, >50, >50 和 26.0 µM。	Biochem Biophys Res Commun,2021, 553:119-125 Transl Stroke Res,2020, 10.1007/s12975-020-00840-x Front Immunol,2020, 11:619096
S8930^New	MCC950 MCC950 is a potent and selective inhibitor of NLRP3 with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.	J Exp Med,2021, 218(9)e20202637 EMBO Rep,2021, e50743 Metabolism,2021, 118:154748
S7809	MCC950 Sodium (CP-456773 Sodium) MCC950 Sodium (CP-456773 Sodium, CRID3 sodium salt)是一种有效的、选择性NLRP3抑制剂，在骨髓来源的巨噬细胞中IC50为7.5 nM。对AIM2, NLRC4或NLRP1炎症体没有作用。	Nat Commun,2021, 12(1):3964 Nat Commun,2021, 12(1):4664 EMBO Rep,2021, e50743	A-C, Expression of caspase 1 and its active form caspase 1-p20, as demonstrated in representative Western blots (top) and the relative expression levels (B and C) in each group.
S3871	Muscone Muscone (3-Methylcyclopentadecanone, Methylexaltone)是一种增香成分，一种有机化合物，是麝香气味的主要来源，也是一种有效的消炎剂。Muscone 可显著地下调LPDM诱导的炎症细胞因子水平，并抑制BMDM中 NF-κB 和 NLRP3 炎性小体的活化。Muscone 还可以显著地降低炎性细胞因子inflammatory cytokines (IL-1β, TNF-α, IL-6) 的水平。	J Pharm Pharmacol,2019, 71(11):1706-1713
S3680	NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome Inhibitor I是合成格列本脲的中间底物，它是NLRP3 inflammasome的抑制剂。	Front Pharmacol,2021, 12:627557 Nutrients,2021, 13(3)856 Phytother Res,2021, 10.1002/ptr.7191

目录号

产品描述

文献引用

实验数据

S6653

Nigericin (NSC 292567) sodium salt

Nigericin (NSC 292567) sodium salt是从Streptomyces hygroscopicus衍生的抗生素，通过充当H⁺，K⁺和Pb²⁺的离子载体起作用。Nigericin可以激活NLRP3炎性体以诱导促炎和免疫刺激过程。