NLRP3

抑制剂选择性比较

NLRP3产品

所有产品 NLRP3抑制剂(9) NLRP3激活剂(1)

目录号	产品描述	文献引用	实验数据
S3939	4'-Methoxyresveratrol 4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
S3290^New	Procyanidin B2 Procyanidin B2 (PCB2) 是一种存在于常见食品中的天然类黄酮，具有抗炎、抗氧化和抗癌活性。Procyanidin B2 可激活 PPARγ 并诱导小鼠巨噬细胞M2极化。Procyanidin B2 可显著抑制百草枯在大鼠模型中肺组织中 NLRP3 炎性小体的活化。
S8559	INF39 INF39是NLRP3的无毒性的、不可逆的抑制剂，通过与NLRP3不可逆地直接相互作用以及部分抑制LPS驱动的促炎性基因表达，阻止NLRP3的激活。	Cell Biol Int, 2020, 10.1002/cbin.11429 Mediators Inflamm, 2019, 2019:1082497 Biomed Res Int, 2018, 2018:1294951	Yupingfeng San reduced the expression of NLRP3 Inflammasome in LPS-stimulated U937 cells. Cells were pre-treated with PMA for 48 h and then incubated with LPS for 2 h. Subsequently, cells were stimulated with YPFS. INF39 was used as the positive control. After 48 h, cells were collected. (A–C) The mRNA levels of NLRP3, ASC and Caspase-1 were detected by real time-PCR. (D–I) The protein levels of NLRP3, ASC and Caspase-1 were detected by western blotting, and the ratio of NLRP3/GAPDH, ASC/GAPDH and Caspase-1/GAPDH were shown. ∗P < 0.05, ∗∗P < 0.01, compared with model group.
S8907^New	Dapansutrile (OLT1177) Dapansutrile (OLT1177)是一种新型的、选择性的NLRP3 inflammasome抑制剂。
S5774	CY-09 CY-09是一种特异的NLRP3 inflammasome的抑制剂，直接靶向NLRP3。它对5种主要的cytochrome P450酶的IC50值分别为18.9, 8.18, >50, >50 和 26.0 µM。	Transl Stroke Res, 2020, 10.1007/s12975-020-00840-x J Neuroinflammation, 2020, 17(1):330 Biosci Rep, 2020, BSR20200730
S8930^New	MCC950 MCC950 is a potent and selective inhibitor of NLRP3 with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.	Cell Death Dis, 2020, 11(10):901 J Inflamm (Lond), 2020, 17:22 J Dent Res, 2020, 22034520933533
S7809	MCC950 Sodium (CP-456773 Sodium) MCC950 Sodium (CP-456773 Sodium) 是一种有效的、选择性NLRP3抑制剂，在骨髓来源的巨噬细胞中IC50为7.5 nM。对AIM2, NLRC4或NLRP1炎症体没有作用。	Gastroenterology, 2020, 158(1):253-269 Cell Rep, 2020, 31;30(13):4370-4385e7 Arterioscler Thromb Vasc Biol, 2020, 40(3):751-765	A-C, Expression of caspase 1 and its active form caspase 1-p20, as demonstrated in representative Western blots (top) and the relative expression levels (B and C) in each group.
S3871	Muscone Muscone 是一种增香成分，一种有机化合物，是麝香气味的主要来源，也是一种有效的消炎剂。Muscone 可显著地下调LPDM诱导的炎症细胞因子水平，并抑制BMDM中 NF-κB 和 NLRP3 炎性小体的活化。Muscone 还可以显著地降低炎性细胞因子inflammatory cytokines (IL-1β, TNF-α, IL-6) 的水平。	J Pharm Pharmacol, 2019, 71(11):1706-1713
S3680	NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome Inhibitor I是合成格列本脲的中间底物，它是NLRP3 inflammasome的抑制剂。	Biomed Pharmacother, 2020, 125:109925 J Cell Mol Med, 2019, 23(11):7360-7371 Exp Cell Res, 2019, 10.1016/j.yexcr.2019.111779
S6653^New	Nigericin sodium salt Nigericin钠盐是从Streptomyces hygroscopicus衍生的抗生素，通过充当H⁺，K⁺和Pb²⁺的离子载体起作用。Nigericin可以激活NLRP3炎性体以诱导促炎和免疫刺激过程。

目录号	产品描述	文献引用	实验数据
S3939	4'-Methoxyresveratrol 4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
S3290^New	Procyanidin B2 Procyanidin B2 (PCB2) 是一种存在于常见食品中的天然类黄酮，具有抗炎、抗氧化和抗癌活性。Procyanidin B2 可激活 PPARγ 并诱导小鼠巨噬细胞M2极化。Procyanidin B2 可显著抑制百草枯在大鼠模型中肺组织中 NLRP3 炎性小体的活化。
S8559	INF39 INF39是NLRP3的无毒性的、不可逆的抑制剂，通过与NLRP3不可逆地直接相互作用以及部分抑制LPS驱动的促炎性基因表达，阻止NLRP3的激活。	Cell Biol Int,2020, 10.1002/cbin.11429 Mediators Inflamm,2019, 2019:1082497 Biomed Res Int,2018, 2018:1294951	Yupingfeng San reduced the expression of NLRP3 Inflammasome in LPS-stimulated U937 cells. Cells were pre-treated with PMA for 48 h and then incubated with LPS for 2 h. Subsequently, cells were stimulated with YPFS. INF39 was used as the positive control. After 48 h, cells were collected. (A–C) The mRNA levels of NLRP3, ASC and Caspase-1 were detected by real time-PCR. (D–I) The protein levels of NLRP3, ASC and Caspase-1 were detected by western blotting, and the ratio of NLRP3/GAPDH, ASC/GAPDH and Caspase-1/GAPDH were shown. ∗P < 0.05, ∗∗P < 0.01, compared with model group.
S8907^New	Dapansutrile (OLT1177) Dapansutrile (OLT1177)是一种新型的、选择性的NLRP3 inflammasome抑制剂。
S5774	CY-09 CY-09是一种特异的NLRP3 inflammasome的抑制剂，直接靶向NLRP3。它对5种主要的cytochrome P450酶的IC50值分别为18.9, 8.18, >50, >50 和 26.0 µM。	Transl Stroke Res,2020, 10.1007/s12975-020-00840-x J Neuroinflammation,2020, 17(1):330 Biosci Rep,2020, BSR20200730
S8930^New	MCC950 MCC950 is a potent and selective inhibitor of NLRP3 with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.	Cell Death Dis,2020, 11(10):901 J Inflamm (Lond),2020, 17:22 J Dent Res,2020, 22034520933533
S7809	MCC950 Sodium (CP-456773 Sodium) MCC950 Sodium (CP-456773 Sodium) 是一种有效的、选择性NLRP3抑制剂，在骨髓来源的巨噬细胞中IC50为7.5 nM。对AIM2, NLRC4或NLRP1炎症体没有作用。	Gastroenterology,2020, 158(1):253-269 Cell Rep,2020, 31;30(13):4370-4385e7 Arterioscler Thromb Vasc Biol,2020, 40(3):751-765	A-C, Expression of caspase 1 and its active form caspase 1-p20, as demonstrated in representative Western blots (top) and the relative expression levels (B and C) in each group.
S3871	Muscone Muscone 是一种增香成分，一种有机化合物，是麝香气味的主要来源，也是一种有效的消炎剂。Muscone 可显著地下调LPDM诱导的炎症细胞因子水平，并抑制BMDM中 NF-κB 和 NLRP3 炎性小体的活化。Muscone 还可以显著地降低炎性细胞因子inflammatory cytokines (IL-1β, TNF-α, IL-6) 的水平。	J Pharm Pharmacol,2019, 71(11):1706-1713
S3680	NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome Inhibitor I是合成格列本脲的中间底物，它是NLRP3 inflammasome的抑制剂。	Biomed Pharmacother,2020, 125:109925 J Cell Mol Med,2019, 23(11):7360-7371 Exp Cell Res,2019, 10.1016/j.yexcr.2019.111779

目录号

产品描述

文献引用

实验数据

S6653^New

Nigericin sodium salt

Nigericin钠盐是从Streptomyces hygroscopicus衍生的抗生素，通过充当H⁺，K⁺和Pb²⁺的离子载体起作用。Nigericin可以激活NLRP3炎性体以诱导促炎和免疫刺激过程。