Ganciclovir (BW 759)

For research use only. Not for use in humans.

目录号:S1878 别名: RS-21592, 2'-Nor-2'-deoxyguanosine 中文名称:更昔洛韦

Ganciclovir (BW 759) Chemical Structure

CAS No. 82410-32-0

Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine)是一种抗病毒药,作用于猫科动物1型疱疹病毒,无细胞试验中IC50为5.2 μM。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 732.15 现货
RMB 565.06 现货
RMB 2212.74 现货
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客户使用Selleck生产的Ganciclovir (BW 759)发表文献9篇:

客户使用该产品的1个实验数据:

  • Effect of ganciclovir on viral DNA accumulation (A,B) and induction of TGF-β1 production after human cytomegalovirus infection in human trabecular meshwork cells (C). Cells were harvested at 5 day post-infection at a high multiplicity of infection (MOI 1) under the treatment with different concentrations of ganciclovir (GAN). Treatment with 10 μmol of ganciclovir significantly decreased the viral DNA accumulation (p < 0.001) (A,B). However, treatment with ganciclovir did not affect the TGF-β production using a TGF-β1 luciferase bioassay. Results are expressed as the mean +/− standard deviation of three different experiments.

    Sci Rep, 2017, 7: 43349. Ganciclovir (BW 759) purchased from Selleck.

产品安全说明书

CMV抑制剂选择性比较

生物活性

产品描述 Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine)是一种抗病毒药,作用于猫科动物1型疱疹病毒,无细胞试验中IC50为5.2 μM。
体外研究

Ganciclovir由3种主要细胞酶代谢成三磷酸形式:(1)诱导的巨细胞病毒感染的细胞的脱氧鸟苷激酶; (2)鸟苷酸激酶;和(3)磷酸甘油酸激酶。[1] 在与HSV-TK表达细胞共同培养的大部分旁观者细胞中, Ganciclovir足以诱导细胞死亡。[2] Ganciclovir显著减少转化的细胞中DNA合成,而Ganciclovir对在非转化细胞的DNA合成的影响不大。Ganciclovir表现出浓度依赖性降低成熟的DNA中的伸长率。[3] 在HSVtk所转导的B16F10黑色素瘤细胞中,Ganciclovir诱导细胞周期阻滞,而不是直接的化学效应。[4]Ganciclovir轻度抑制DNA合成。Ganciclovir处理的细胞积聚在早S期并保持直到细胞死亡,这表明Ganciclovir掺入DNA模板中对细胞毒性很重要。[5]Ganciclovir诱导的凋亡是由于药物插入DNA导致复制依赖性的DNA双链断裂的形成,并在稍后的阶段产生S和G2 / M期阻滞。Ganciclovir激起的DNA不稳定性可能是Bcl-2的水平和caspase-9/-3活化水平降低的原因。[6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
E6SM cell lines NHXBfINHfW6ldHnvckBie3OjeR?= M1yxXmVn\mWldHn2[UBkd26lZX70doF1cW:wIILldZVqemWmIITvJIlvcGmkaYSgTIVzeGW|IIPpcZBt\XhidnnyeZMuOiBqSGPWMVIqKGmwZIXj[YQh[3m2b4DheIhq[2m2eTDifUA2OCViaX6gSVZUVSClZXzsJIxqdmW|LDDFR|UxRTFwMjDuUS=> NIrCTFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUS5OVU5Pid-MUG0PVU2QDZ:L3G+
OST TK- cells NG\MNZZEgXSxdH;4bYNqfHliYYPzZZk> NWfGd3F{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hV1OWIGTLMUBk\WyuczDlfJBz\XO|aX7nJGhUXjFiVFusJGlEPTB;MD6wNFE6|ryPLh?= NEDxUog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE2QCd-MUexPFEyPTh:L3G+
HEL NIPYVo9CdnSrdnnyZYwh[XO|YYm= MXnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKEdiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6NCCPSVO9NE4xODZ2zszNMi=> MmfHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4N{K0OFUoRjF5NkeyOFQ2RC:jPh?=
HEL NVyzbFBESW62aY\pdoFtKGG|c3H5 Mnz6RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDygSWM2OD1yLkCx{txONg>? NWHQ[ZVuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyN|I5OjhpPkKxNlMzQDJ6PD;hQi=>
HEL M3fNR2FvfGm4aYLhcEBie3OjeR?= M2rOTmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXi1{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXytbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTygSWM2OD1yLkCx{txONg>? MlPTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5OUWyN|goRjJ|N{m1NlM5RC:jPh?=
HEL Ml\0RY51cX[rcnHsJIF{e2G7 NYXZU4c4SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYLUGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtNWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJktKEWFNUC9NE4xOc7:TT6= M3\pXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{m1NlM5Lz5{M{e5OVI{QDxxYU6=
HEL M3fWW2FvfGm4aYLhcEBie3OjeR?= NV22NWJxOyCmYYnz NFrZRYdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHHmeIVzKDNiZHH5d{BjgSCvaXPyc5Nkd3CrYzDt[ZRpd2RuIFXDOVA:OC5yMd88UU4> NYjKNG5VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyPFY6PTJpPkOwNlg3QTV{PD;hQi=>
HEL MULBcpRqfmm{YXygZZN{[Xl? MlrzN{Bl[Xm| MWjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czCyJJN1emGrbjDHJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhOyCmYYnzJIJ6KG2rY4Lvd4NweGmlIH3leIhw\CxiRVO1NF0xNjBzzszNMi=> M4XoWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMki2PVUzLz5|MEK4Olk2OjxxYU6=
HEL MonkRY51cX[rcnHsJIF{e2G7 MVjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCxiRVO1NF0xNjBzM988UU4> M2KzbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEm5NFk4Lz5{M{C5PVA6PzxxYU6=
HEL NXm1T2o5SW62aY\pdoFtKGG|c3H5 M1TXZmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;MD6wNVXPxE1w M2P3SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEm5NFk4Lz5{M{C5PVA6PzxxYU6=
OST TK- cells MXfDfZRwfG:6aXPpeJkh[XO|YYm= NUiy[Xc2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hV1OWIGTLMUBk\WyuczDlfJBz\XO|aX7nJGhUXjFiVFugbY4heHKnc3XuZ4Uhd2ZiMj61JJVOKDFvW{[tLJRzcXCqZX75cI1mfGixeImpbIV5gWyfdHj5cYlv\SxiSVO1NF0xNjBzON88UU4> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG1PEc,OTdzOEGxOVg9N2F-
HEL Mlf3RY51cX[rcnHsJIF{e2G7 MW\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YyKEuRUzDpckBJTUxiY3XscJMtKEWFNUC9NE4xOToQvF2u NH\FTVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE3Oid-MUexPFEyPjJ:L3G+
HEL M1vP[2FvfGm4aYLhcEBie3OjeR?= Mn;4NkB1dyB|IHThfZM> NYq3d2ZySW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHCuYYH1[UBnd3KvYYTpc44hdWWjc4Xy[YQh[W[2ZYKgNkB1dyB|IHThfZMheG:|dDDpcoZm[3Srb36sJGVEPTB;MD6wNVnPxE1w NHzxbFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW1NFc{PCd-Mkm1OVA4OzR:L3G+
HEL MXPBcpRqfmm{YXygZZN{[Xl? NGnQS25CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{BqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicILveIVkfGmxbjDh[4FqdnO2II\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLkCy{txONg>? M1PFcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkixNlI2Lz5zOUK4NVIzPTxxYU6=
HEL MX;BcpRqfmm{YXygZZN{[Xl? MkDKOEBl[Xm| M1LydWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZYZ1\XJiNDDkZZl{NCCHQ{WwQVAvODMQvF2u M4DQXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEW5PFc3Lz5{MkS1PVg4PjxxYU6=
HEL NFnmPIlCdnSrdnnyZYwh[XO|YYm= NIDpbYpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;MD6wNu69VS5? MnvWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEGzOFQoRjJ4MECxN|Q1RC:jPh?=
HEL NUDqe4c3SW62aY\pdoFtKGG|c3H5 M16wU2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF0xNjB{zszNMi=> NUXs[lF6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PFAzPTFpPkK5PFgxOjVzPD;hQi=>
HEL MY\BcpRqfmm{YXygZZN{[Xl? M1fEfWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9NE4xOs7:TT6= Mom5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl6OECyOVEoRjJ7OEiwNlUyRC:jPh?=
Vero MWPBcpRqfmm{YXygZZN{[Xl? NHPkXWU4OiCqcoO= M2\Ue2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXi1zIHnu[oVkfGWmIHnuJGFnemmlYX6g[5Jm\W5ibX;ub4V6KF[ncn:gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCJRmCg[ZhxemW|c3nvckBi\nSncjC3NkBpenNiYomgS2ZRNWKjc3XkJIZtfW:{ZYPj[Y5k\SCvaXPyc5Nkd3CrYzDhcoFtgXOrczygSWM2OD1yLkCyOe69VS5? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTVyM{S3Okc,OzF3MEO0O|Y9N2F-
HEL MUTBcpRqfmm{YXygZZN{[Xl? MYTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czCyJGchcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h[WejaX7zeEB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9NE4xOjgQvF2u M3O4UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNU[1OVE3Lz5{MUW2OVUyPjxxYU6=
HEL NFHqZpdCdnSrdnnyZYwh[XO|YYm= MV3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[nlidnnyZYwhS1CHIHHzd4F6NCCHQ{WwQVAvODJ5zszNMi=> MoWxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NUiyNlIoRjJ{OEW4NlIzRC:jPh?=
HEL MoP3RY51cX[rcnHsJIF{e2G7 NXqyZlVOSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCkeTD2bZJidCCFUFWgZZN{[XluIFXDOVA:OC5yMkpOwG0v NUHScZJSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OVgzOjJpPkKyPFU5OjJ{PD;hQi=>
HEL NXHYOmdFSW62aY\pdoFtKGG|c3H5 NGfrWHgzKHSxIEOg[IF6ew>? MknuRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYN6[2yxdnnyMZNmdnOrdHn2[UBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdJJwfGWldHnvckBnem:vII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgNkB1dyB|IHThfZMh[nliTWTUJIF{e2G7LDDFR|UxRTBwMEROwG0v NXfwd3E6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwN|Q4OTFpPkKwNFM1PzFzPD;hQi=>
HEL M{O3bmFvfGm4aYLhcEBie3OjeR?= MXKyJJRwKDNiZHH5dy=> MlTSRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5Rm[3Srb36g[pJwdSC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IEKgeI8hOyCmYYnzJIJ6KE2WVDDhd5NigSxiRVO1NF0xNjB|zszNMi=> M1nOXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEO0O|EyLz5{MECzOFcyOTxxYU6=
HEL MYTBcpRqfmm{YXygZZN{[Xl? NGT1eXMzKHSxIEOg[IF6ew>? M4f2RWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicILveIVkfGmxbjDmdo9uKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZYZ1\XJiMjD0c{A{KGSjeYOgZpkhVVSWIHHzd4F6NCCHQ{WwQVAvODQQvF2u Ml:0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByM{S3NVEoRjJyMEO0O|EyRC:jPh?=
HEL MWTBcpRqfmm{YXygZZN{[Xl? MUO0JIRigXN? MVrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFQh\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB|zszNMi=> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ7Nkm2N{c,OjF4OU[5OlM9N2F-
HEL NIjuVmxCdnSrdnnyZYwh[XO|YYm= M1z0XmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFEhU0:VIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCycn;0[YN1cW:wIHHnZYlve3RidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTBwMEROwG0v M{[y[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNU[1OVE3Lz5{MUW2OVUyPjxxYU6=
HEL NVrxV4NpSW62aY\pdoFtKGG|c3H5 MVS0JIRigXN? NVfreYUzSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNvMjDHJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhPCCmYYnzJIJ6KG2rY4Lvd4NweGmlIHHuZYx6e2m|LDDFR|UxRTBwMEROwG0v MlzmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4OU[5OlMoRjJzNkm2PVY{RC:jPh?=
HEL MV;BcpRqfmm{YXygZZN{[Xl? MVq0JIRigXN? MmqzRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliYX\0[ZIhPCCmYYnzMEBGSzVyPUCuNFPPxE1w NU\kRok6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OVk5PzZpPkKyOFU6QDd4PD;hQi=>
HEL NEXvdodCdnSrdnnyZYwh[XO|YYm= M2rabWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{NTJiRzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJktKEWFNUC9NE4xO87:TT6= M2XnelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEGxNFk{Lz5{M{ixNVA6OzxxYU6=
HEL M1vuWWFvfGm4aYLhcEBie3OjeR?= NIKzSFhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2ey1zIFvPV{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OC5yM988UU4> M4TzZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEGxNFk{Lz5{M{ixNVA6OzxxYU6=
HEL NGjSSYtCdnSrdnnyZYwh[XO|YYm= Mm\KRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF0xNjB|zszNMi=> M{TxR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MECxN|Q1Lz5{NkCwNVM1PDxxYU6=
HEL M2L6R2FvfGm4aYLhcEBie3OjeR?= MmfWRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|IIDsZZF2\SCob4LtZZRqd25uIFXDOVA:OC5yM988UU4> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ|OUO2PEc,Ojd4M{mzOlg9N2F-
HELF MlW2RY51cX[rcnHsJIF{e2G7 NEmz[llCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDo[ZJx\XO4aYL1d{AyKEuRUzDzeJJicW5iaX7m[YN1\WRiaX6gTGVNTiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OC5yM988UU4> M1mxbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm4OFgyLz5|MEC5PFQ5OTxxYU6=
HELF NFPGPHdCdnSrdnnyZYwh[XO|YYm= MkTtRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgNkBIKHO2cnHpckBqdm[nY4Tl[EBqdiCKRVzGJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME2wMlA{|ryPLh?= MmjWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOUi0PFEoRjNyMEm4OFgyRC:jPh?=
HEL MWjBcpRqfmm{YXygZZN{[Xl? MmnLRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCxiRVO1NF0xNjB|zszNMi=> M3jUd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEK5PVE{Lz5{OEiyPVkyOzxxYU6=
HEL M{KyZmFvfGm4aYLhcEBie3OjeR?= NGDRempCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDygSWM2OD1yLkCz{txONg>? NX3nRWJ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVcyODJpPkK4O|U4OTB{PD;hQi=>
HEL M4C1Z2FvfGm4aYLhcEBie3OjeR?= Ml3qRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCrbjDISWwh[2WubIOsJGVEPTB;MD6wN|LPxE1w NHHBXYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE3Oid-MUexPFEyPjJ:L3G+
HEL MXHBcpRqfmm{YXygZZN{[Xl? MYHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YyKEuRUzDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIF3JR|0xNjB|Mt88UU4> NIH5R4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[3NlQ1PSd-MUe2O|I1PDV:L3G+
HEL NVvDepJtSW62aY\pdoFtKGG|c3H5 NVznVWJqSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuNFMz|ryPLh?= MlTSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NUCxOVQoRjJ5N{WwNVU1RC:jPh?=
OST TK- cells NGHtRphEgXSxdH;4bYNqfHliYYPzZZk> M2jwc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9UXCCWSz2gZ4VtdHNiZYjwdoV{e2mwZzDIV3YyKFSNIHnuJJBz\XOnbnPlJI9nKDVidV2gNU1cPi1qdILpdIhmdnmubXX0bI95gSmqZYj5cH11cHmvaX7lMEBKSzVyPUCuNFM{|ryPLh?= NFe1V4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE2QCd-MUexPFEyPTh:L3G+
fibroblast cells NIPzUGdCdnSrdnnyZYwh[XO|YYm= NI[2UXZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iaIXtZY4h\m:{ZYPrbY4h\mmkcn;icIF{fCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RuIFXDOVA:OC5yNN88UU4> MorsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|OUeyO|EoRjF7M{m3NlcyRC:jPh?=
HEL MmXZRY51cX[rcnHsJIF{e2G7 M{S0fGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTBwMEVOwG0v M3TBUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkOyPFI5Lz5{MUKzNlgzQDxxYU6=
HFF MYTBcpRqfmm{YXygZZN{[Xl? NH3nW4UyKGi{ MYrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhMHO2cnHpckBCTDF4OTmgbY5n\WO2ZXSgbY4hOSCqcjDwdoV1emWjdHXkJIh2dWGwIFjGSkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBjgSCwZYX0doFtKHKnZDD1dJRic2ViYYPzZZktKEWFNUC9NE4xPM7:TT6= NULQbJFERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzO|Y1OjlpPkKxN|c3PDJ7PD;hQi=>
HEL NGf2W3NCdnSrdnnyZYwh[XO|YYm= MoXnRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOiCJIHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9NE4xPM7:TT6= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh{OUmxN{c,Ojh6Mkm5NVM9N2F-
HEL MoXoRY51cX[rcnHsJIF{e2G7 MoTkRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\CC2eYDlJGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;MD6wOO69VS5? NF7TXW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEe1O|ExOid-Mki3OVcyODJ:L3G+
Vero NGLhOlRCdnSrdnnyZYwh[XO|YYm= M2\XVVM3KGi{cx?= NVm3RmxsSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYIEGgbY5n\WO2ZXSgbY4hSW[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5icHzhdZVmKG[xcn3heIlwdiCrbnP1ZoF1\WRiZn;yJFM3KGi{czDifUBkenm|dHHsJJZqd2yndDDzeIFqdmmwZzDiZZNm\CCjc4PhfUwhTUN3ME2wMlA1|ryPLh?= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OjF7MUS1Okc,OzJzOUG0OVY9N2F-
OST TK- cells MVXDfZRwfG:6aXPpeJkh[XO|YYm= MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDPV3QhXEtvIHPlcIx{KGW6cILld5NqdmdiSGPWNUBVUyCrbjDwdoV{\W6lZTDv[kAyOCC3TTCxMXs3NSi2cnnwbIVvgWyvZYToc5h6MWineInsYZRpgW2rbnWsJGlEPTB;MD6wOFHPxE1w NXjWfXpyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPThpPkG3NVgyOTV6PD;hQi=>
HEL NWLOSZBSSW62aY\pdoFtKGG|c3H5 MnrINkB1dyB|IHThfZM> MVvBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBxdGGzdXWg[o9zdWG2aX;uJI1m[XO3cnXkJIFnfGW{IEKgeI8hOyCmYYnzJJBwe3RiaX7m[YN1cW:wLDDFR|UxRTBwMES1{txONg>? Mn3pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NUC3N|QoRjJ7NUWwO|M1RC:jPh?=
OST TK- cells M1vyZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2HmPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9UXCCWSz2gZ4VtdHNiZYjwdoV{e2mwZzDIV3YyKFSNIHnuJJBz\XOnbnPlJI9nKDJwNTD1UUAyNVt4LWuxMFEuMGSrcHjlcpltMS1zLTi0MZB6emmmeXypcYV1cG:6eW3o[Zh6dF22aIntbY5mNCCLQ{WwQVAvODYQvF2u M4nqPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVU5Lz5zN{G4NVE2QDxxYU6=
human MV3BcpRqfmm{YXygZZN{[Xl? M2npT|ch\GG7cx?= MXvBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKEdiaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IEeg[IF6eyxiRVO1NF0xNjB3zszNMi=> NG\H[Iw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGyPFY3Pid-MkGxNlg3PjZ:L3G+
HEL NXnNfVZXSW62aY\pdoFtKGG|c3H5 M3fZSFIhfG9iMzDkZZl{ Mn;MRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RibXXhd5Vz\WRiYX\0[ZIhOiC2bzCzJIRigXNicH;zeE1qdm[nY4Tpc44tKEWFNUC9NE4xPTIQvF2u NWTqfGNERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2O|A4ODVpPkK5OlcxPzB3PD;hQi=>
HEL Mo\5RY51cX[rcnHsJIF{e2G7 MWrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6NCCHQ{WwQVAvODV3zszNMi=> NGnKTYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e1NFE2PCd-Mke3OVAyPTR:L3G+
HEL NHL0fGFCdnSrdnnyZYwh[XO|YYm= Mn[3NkB1dyB|IHThfZM> M{L4W2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgcYVie3W{ZXSgZYZ1\XJiMjD0c{A{KGSjeYOgdI9{fC2rbn\lZ5Rqd25uIFXDOVA:OC5yNUhOwG0v NYnhdZpxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2O|A4ODVpPkK5OlcxPzB3PD;hQi=>
HEL NUXLPWFGTnWwY4Tpc44h[XO|YYm= MoHMR49ueG:3bnSge4F{KHSnc4Tl[EBnd3JiYX70bU13cXKjbDDhZ5Rqfmm2eTDh[4FqdnO2IFjTWk0yMEdrIHnuJGhGVCClZXzsd{whTUN3ME2wMlA3|ryPLh?= NELJcGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNE[0N|MzQCd-MUS2OFM{Ojh:L3G+
Hel NFHkd|hHfW6ldHnvckBie3OjeR?= Ml:5SYZn\WO2aY\lJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDo[ZJx\XNic3ntdIxmgCC4aYL1d{B1gXCnIEGgT49{KHO2cnHpckBqdmS3Y3XkJIN6fG:yYYTobYNqfHliaX6gTIVtKGOnbHzzMEBGSzVyPUCuNFbPxE1w M1\DXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkW4PFU5Lz5zNU[1PFg2QDxxYU6=
HEL Mn\kRY51cX[rcnHsJIF{e2G7 MYPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YyKEuRUzDpckBJTUxiY3XscJMtKEWFNUC9NE4xPs7:TT6= NWfTfFBwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[zPVI4QTFpPkG2N|kzPzlzPD;hQi=>
HEL M1XLUmFvfGm4aYLhcEBie3OjeR?= NGfEdlBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1Z{IFegbY4hUEWOIHPlcIx{NCCHQ{WwQVAvODcQvF2u NVW1TlB[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[zPVI4QTFpPkG2N|kzPzlzPD;hQi=>
HEL MUjBcpRqfmm{YXygZZN{[Xl? NXXi[FVbOyCmYYnz M{\yb2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFIhe3S{YXnuJGchcW6oZXP0[YQhcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBkd2yxcnnt[ZRzcWNiZn;ycYF7[W5vYnHz[YQhVVSVIHHzd4F6NCCHQ{WwQVAvODgQvF2u MmX5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
HEL NVHxVGNbSW62aY\pdoFtKGG|c3H5 M4PueWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB5zszNMi=> Ml7QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB5M{i2OVMoRjNyN{O4OlU{RC:jPh?=
HELF NWK0W3doSW62aY\pdoFtKGG|c3H5 NHLWTJA4KGSjeYO= MoHYRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCrbnP1ZoF1\WRiZn;yJFch\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB5zszNMi=> MoHTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3OE[4N|IoRjNzNUi2PFMzRC:jPh?=
HEL MXrBcpRqfmm{YXygZZN{[Xl? MWG3JIRigXN? M3HBT2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjFiS1;TJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCjZoTldkA4KGSjeYOsJGVEPTB;MD6wPO69VS5? M1fmXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUK4OlY3Lz5{MUGyPFY3PjxxYU6=
HEL M3S2W2FvfGm4aYLhcEBie3OjeR?= NYfuS25YOyCmYYnz M4\SPGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFIhe3S{YXnuJGchcW6oZXP0[YQhUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB|IHThfZMh[nliTWTUJIF{e2G7LDDFR|UxRTBwMElOwG0v MoDjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
HEL NHHUN|NCdnSrdnnyZYwh[XO|YYm= NF\RVXY{KGSjeYO= MYrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czCxJJN1emGrbjDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBGSzVyPUCuNFjPxE1w MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek9EcEWPQlynQmNpTU2ETEyvZV4>
OST TK- cells MV\DfZRwfG:6aXPpeJkh[XO|YYm= NHvaW|hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQW1RiVFutJINmdGy|IHX4dJJme3OrbnegTHNXOSCWSzDpckBxemW|ZX7j[UBw\iB3IIXNJFEuYzZvW{GsNU0p\GmyaHXufYwqNTFvKEStdJlzcWS7bDnt[ZRpd3i7XXjlfJltZXSqeX3pcoUtKEmFNUC9NE4xQDIQvF2u NWTSOos3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPThpPkG3NVgyOTV6PD;hQi=>
HEL NITOZ2RCdnSrdnnyZYwh[XO|YYm= M{OyWVMh\GG7cx?= MmTnRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgNUB{fHKjaX6gT29UKGmwZnXjeIVlKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA{KGSjeYOgZpkh[2:ub4LpcYV1emmlIH\vdo1igmGwLXLhd4VlKE2WUzDhd5NigSxiRVO1NF0xNjB7zszNMi=> NUXMfm1RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxQ3jFUWJNLz6FaFXNRmw9N2F-
HEL M2S1W2FvfGm4aYLhcEBie3OjeR?= MUjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3czDwcIFyfWViZn;ycYF1cW:wLDDFR|UxRTBwMEpOwG0v MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ|OUO2PEc,Ojd4M{mzOlg9N2F-
E6SM M3;CV2FvfGm4aYLhcEBie3OjeR?= NH;BSm5CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIlvKEV4U12gZ4VtdHNuIF3JR|0xNjB7Nt88UU4> M2PP[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEmyO|I5Lz5zN{C5NlczQDxxYU6=
E6SM M4DQUmFvfGm4aYLhcEBie3OjeR?= NFnmSVlCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1Z{IFetbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDpckBGPlOPIHPlcIx{NCCPSVO9NE4xQTcQvF2u MljSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyOUK3NlgoRjF5MEmyO|I5RC:jPh?=
HEL MYDBcpRqfmm{YXygZZN{[Xl? NWXjVFB1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQh[WO7Y3zveolzNXKnc3nzeIFvfCCKU2[xJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1NCCHQ{WwQVAvOc7:TT6= NGXRfng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUKzNlgzQCd-MkGyN|I5Ojh:L3G+
HEL MVTBcpRqfmm{YXygZZN{[Xl? Mlf1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZT3k[YZq[2mnboSgRWNXNXKnc3nzeIFvfCCKZYLw[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1NCCHQ{WwQVAvOc7:TT6= NWfkR2V4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVcyODJpPkK4O|U4OTB{PD;hQi=>
OST TK- cells MYLDfZRwfG:6aXPpeJkh[XO|YYm= NXzUdoVkS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hV1OWIGTLMUBk\WyuczDlfJBz\XO|aX7nJGhUXjFiVFugbY4heHKnc3XuZ4Uhd2ZiMUCgeW0hOS2dNj3bNUwyNSimaYDo[Y56dClvMT2oOE1xgXKrZInsLY1mfGixeIndbIV5gWyfdHj5cYlv\SxiSVO1NF0xNjFzzszNMi=> Mof0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOVgoRjF5MUixNVU5RC:jPh?=
HFF MWrBcpRqfmm{YXygZZN{[Xl? NUn4VWhjOTBiZHH5dy=> M{PZUGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiVH;3coUhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHnuZ5Vj[XSnZDDmc5IhOTBiZHH5d{BjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5MEBKSzVyPUCuNVTPxE1w MojDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6MUK0NlAoRjJzOEGyOFIxRC:jPh?=
HFF MUjGeY5kfGmxbjDhd5NigQ>? MXTJcohq[mm2aX;uJI9nKEiFTW[gRWQyPjlicnXwcIlk[XSrb36gbY4hUE[IIHPlcIx{KGK7IHP5eI9x[XSqaXOg[YZn\WO2IHHzd4F6NCCHQ{WwQVAvOTYQvF2u NVHhUIdIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewNFQ4OjZpPkG3NFA1PzJ4PD;hQi=>
MCA-TK Mnm2R5l1d3SxeHnjbZR6KGG|c3H5 Mkj0R5l1d3SxeHnjbZR6KGGpYXnud5QhVUODLWTLJINmdGy|LDDJR|UxRTBwMUZOwG0v NIXjNlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m2NFkzPid-MUe5OlA6OjZ:L3G+
vero M2TjVGFvfGm4aYLhcEBie3OjeR?= M1X3d2FvfGm4aYLhcEBi[3Srdnn0fUB4[XNiZHX0[ZJucW6nZDDpckBxdGGzdXWgdoVlfWO2aX;uJIF{e2G7IHnuJJZmem9iY3XscJMh[WejaX7zeEBJW1ZvMTDGJJN1emGrbjygTWQ2OD1yLkNOwG0v NH\LNZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|OEexPFYxLz5|OEexPFYxRC:jPh?=
Vero NGPINGVCdnSrdnnyZYwh[XO|YYm= MV7JckB3cXS{bzDhcpRqfmm{YXygZYN1cX[rdImge4F{KG2nYYP1doVlKGGpYXnud5QhUFOYLUGoSkkhcW5iVnXyc{Bk\WyuczygTWQ2OD1yLkNOwG0v MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7OEGxK|4{ODB7OEGxQE9iRg>?
Vero MXLBcpRqfmm{YXygZZN{[Xl? M3r6XmFvfGm4aYLhcEBi[3Srdnn0fUBl\XSncn3pcoVlKGGpYXnud5QhcGW{cHXzJJNqdXCuZYigeJlx\SBzIDjGJJN1emGrbjmgZpkheGyjcYXlJJJm\HWldHnvckBqdiCYZYLvJINmdGy|LDDJSFUxRTBwMt88UU4> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF4Mk[zK|4{ODF4Mk[zQE9iRg>?
HEL M1Twe2FvfGm4aYLhcEBie3OjeR?= MoS5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCJIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVAvOs7:TT6= NVf5enlWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyPFEzOjVpPkG5NlgyOjJ3PD;hQi=>
HEL M376RmFvfGm4aYLhcEBie3OjeR?= MXizJIRigXN? NX\xdJExSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WO7Y3zveolzNXKnc3nzeIFvfCCWSz3k[YZm[2mnboSgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA{KGSjeYOgZpkhdWmlcn;zZ49xcWNibXX0bI9lNCCHQ{WwQVAvOs7:TT6= NGLN[Vg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK4Olk2Oid-M{CyPFY6PTJ:L3G+
fibroblast cells MmDaSpVv[3Srb36gZZN{[Xl? NXLyRnNwUW6qaXLpeIlwdiCxZjD2bZJidCCleYTvdIF1cGmlIHXm[oVkfCCrbjDpcoZm[3SnZDDoeY1idiCob4Lld4tqdiCoaXLyc4Jt[XO2IHPlcIwhcW5ibX;uc4xigWW{czDv[kBJW1ZvMjDBSEBX\XKxIHPlcIx{KGK7IEWwKUwhTUN3ME2wMlI{|ryPLh?= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTV6NUS1O{c,OTF3OEW0OVc9N2F-
HEL NVvQTJNVSW62aY\pdoFtKGG|c3H5 MV;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iSFXMJINmdGy|LDDFR|UxRTBwMkZOwG0v MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF{OEG3PEc,OjdzMkixO|g9N2F-
vero M4nXcmFvfGm4aYLhcEBie3OjeR?= MX\JckB3cXS{bzDhcpRqfmm{YXygZY5lKGGwdHnj[YxtfWyjcjDhZ5Rqfmm2eTD3ZZMh\X[jbIXheIVlKGGpYXnud5QhcGW{cHXzJJNqdXCuZYigeolzfXNiSGPWMVEhMEZic4TyZYlvMSCrbjD2[ZJwKGOnbHzzJJRqe3O3ZTDjeYx1fXKnLDDJSFUxRTBwM988UU4> MofvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7M{[xOUc,Ojl7M{[xOVww[T5?
HELF MXvBcpRqfmm{YXygZZN{[Xl? MlXEO{Bl[Xm| MUHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gbJVu[W5iSFXMSkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBqdmO3YnH0[YQh\m:{IEeg[IF6eyCkeTDtbYNzd3Olb4DpZ{BidmGueYPpd{whTUN3ME2wMlPPxE1w M1r1WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi2PFMzLz5|MUW4Olg{OjxxYU6=
HS27 MVzBcpRqfmm{YXygZZN{[Xl? NUPrOYllPyCmYYnz NW\wXVJiSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IHnu[oVkfGWmIHnuJIh2dWGwIFjTNlch[2WubIOgZYZ1\XJiNzDkZZl{KGK7IFfGVE1j[XOnZDDmcJVwemW|Y3XueEBz\WS3Y4Tpc44h[XO|YYmsJGVEPTB;MD6zNu69VS5? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB2N{mxNUc,OjByNEe5NVE9N2F-
HEL NYjX[HZLSW62aY\pdoFtKGG|c3H5 NHrXTFNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgSIF3cXNiaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPUCuN|jPxE1w MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzlzMUi1Okc,OjN7MUG4OVY9N2F-
HEL MYPBcpRqfmm{YXygZZN{[Xl? MX7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiRHH2bZMhODdxMTDpcoZm[3SnZDDpckBJTUxiY3XscJMtKEWFNUC9NE41|ryPLh?= NVnOT2NXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNlgyPzhpPkK3NVI5OTd6PD;hQi=>
HEL MWPBcpRqfmm{YXygZZN{[Xl? MXnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDo[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6KGK7IH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzMEBGSzVyPUCuOO69VS5? NVThcJFuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3N|g3PTNpPkOwO|M5PjV|PD;hQi=>
HEL MXfBcpRqfmm{YXygZZN{[Xl? NH;DXWRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{BqdiCKRVygZ4VtdHNuIFXDOVA:OC52ON88UU4> M3WxbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVYzLz5zN{G4NVE3OjxxYU6=
HFF M4PWR2Z2dmO2aX;uJIF{e2G7 MWDJcohq[mm2b4L5JINwdmOnboTyZZRqd25ib3[geIhmKGS{dXegZYdicW6|dDD0bIUh[3m2b4DheIhq[yCnZn\lZ5Qh\m:{IFHENVY6KHO2cnHpckBw\iCncIP0[YlvKGKjcoKgeolzfXNvMjCoTGNOXiliaX6gbJVu[W5iSF\GJINmdGy|LDDFR|UxRTBwNd88UU4> NIiwVGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96M{m0PVM{Lz56M{m0PVM{RC:jPh?=
HEL M{nFV2Z2dmO2aX;uJIF{e2G7 MljGTY5pcWKrdHnvckBw\iCqdX3hckBEVVZiRF7BJJN6dnSqZYPpd{BqdiCFTW[tbY5n\WO2ZXSgTGVNKGOnbHzzMEBKSzVyPUCuOe69VS5? NILUVng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95N{WyNlA2Lz55N{WyNlA2RC:jPh?=
HEL NXzHe|FJSW62aY\pdoFtKGG|c3H5 M37ySWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3Wt[IVncWOrZX70JIFkgWOub4\pdk1z\XOrc4ThcpQhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuOe69VS5? NGj1bpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwNVM1PCd-Mk[wNFE{PDR:L3G+
HELF NVjWZ|lVSW62aY\pdoFtKGG|c3H5 MojXRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZT3k[YZq[2mnboSgZYN6[2yxdnnyMZJme2m|dHHueEBJfW2jbjDo[ZJx\XO4aYL1d{AyKEuRUzDzeJJicW5iaX7m[YN1\WRiaX6gTGVNTiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OC53zszNMi=> NFWyRZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFQ5OSd-M{CwPVg1QDF:L3G+
Vero NGDXTZZCdnSrdnnyZYwh[XO|YYm= MWOzOkBpenN? NFyzR5lCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZiMjDpcoZm[3SnZDDpckBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCybHHxeYUh\m:{bXH0bY9vKGmwY4XiZZRm\CCob4KgN|YhcHK|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pIHLhd4VlKGG|c3H5MEBGSzVyPUCuOVjPxE1w MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OjF7MUS1Okc,OzJzOUG0OVY9N2F-
HEL M{jWPGFvfGm4aYLhcEBie3OjeR?= NIjNb|E2KGSjeYO= NEXpZ2xCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBX[XKrY3XscIEhgm:|dHXyJJZqenW|IF;LRUBqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJkh[W[2ZYKgOUBl[Xm|LDDFR|UxRTBwNUpOwG0v MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN|OUC4Nkc,OTl|M{mwPFI9N2F-
HEL M1zhcWFvfGm4aYLhcEBie3OjeR?= M4m5UWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJS02YIFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLk[2{txONg>? NYm1OJlFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
HEL MYPBcpRqfmm{YXygZZN{[Xl? NXW2foxNSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WO7Y3zveolzNXKnc3nzeIFvfCCKQ13WJGFFOTZ7IHPsc45mKDFiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPUCuOlnPxE1w NF21[WM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyOlE1OCd-MUmyNlYyPDB:L3G+
HEL M4nNTGFvfGm4aYLhcEBie3OjeR?= NWiye5JSSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiFTW[gRWQyPjliaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPUCuO:69VS5? M4jINVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
Vero NIjWOG9CdnSrdnnyZYwh[XO|YYm= Ml\zN|YhfG9iNEigbJJ{ M4HMTmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiRjDpcoZm[3SnZDDpckBi\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHzd4V{e2WmIHHzJJBt[XG3ZTDy[YR2[3Srb36gZYZ1\XJiM{[geI8hPDhiaILzMEBGSzVyPUCuO:69VS5? NFXjfW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SzPFA3OSd-MUe0N|gxPjF:L3G+
HFF M{LpUGFvfGm4aYLhcEBie3OjeR?= MYO4JJRwKDFyIHThfZM> M{\lN2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiVFK0NEBqdm[nY4Tl[EBqdiCqdX3hckBJTkZiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJBt[XG3ZTDmc5Ju[XSrb36geJJm[XSnZDD3bZRpKGOxbYDveY5lKG[xbHzve4lv\yC4aYLhcEBqdm[nY4Tpc44h[W6mIHnuZ5Vj[XSnZDDmc5IhQCC2bzCxNEBl[Xm|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pIHLhd4VlKGG|c3H5MEBGSzVyPUCuO|LPxE1w NIr3O4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MkG5NVQ2Pid-M{KxPVE1PTZ:L3G+
fibroblast cells NX:xbmo3SW62aY\pdoFtKGG|c3H5 MWqxJIhwfXJ? MlfyRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KEGmMU[5JEhYXClicHzhdZVmKG[xcn3pcochfW6rdDDndo94diCxbjDIeY1idiCob4Lld4tqdiCoaXLyc4Jt[XO2IHPlcIx{KHWyb36gbY5kfWKjdHnvckBnd3JiMTDoc5VzKGG2IEO3JIRm\3KnZYOgR{B4cXSqIHPvcZBwfW6mIHTpd5NwdH[nZDDpckBFVVORLDDJR|UxRTBwON88UU4> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjF|NEm0Okc,OTZzM{S5OFY9N2F-
fibroblast cells MVzBcpRqfmm{YXygZZN{[Xl? M4HVZlEhcG:3ch?= NVjLPGRPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHkNVY6KCiYOEKzRUkheGyjcYXlJIZwem2rbnegeY5qfCCpcn;3ckBwdiCKdX3hckBnd3Knc3vpckBncWK{b3LsZZN1KGOnbHzzJJVxd25iaX7jeYJifGmxbjDmc5IhOSCqb4XyJIF1KDN5IHTl[5Jm\XNiQzD3bZRpKGOxbYDveY5lKGSrc4PvcJZm\CCrbjDEUXNQNCCLQ{WwQVAvQM7:TT6= M4DWWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MUO0PVQ3Lz5zNkGzOFk1PjxxYU6=
E6SM M1jFO2FvfGm4aYLhcEBie3OjeR?= MmfwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOSCWSz2gT29UKEGFVj3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHnuJGU3W01iY3XscJMtKE2LQ{2wMljPxE1w NX61SVdpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewPVI4OjhpPkG3NFkzPzJ6PD;hQi=>
HEL MlPVRY51cX[rcnHsJIF{e2G7 NFvue3M1KGSjeYO= M1PrZmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1z\XOrc4ThcpQhXEtvZHXmbYNq\W62IFjldpBmeyC|aX3wcIV5KH[rcoXzMVEhU0:VIHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgOEBl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVAvQM7:TT6= M1jVNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkm2PVY{Lz5{MU[5Olk3OzxxYU6=
HEL NV75[ld2SW62aY\pdoFtKGG|c3H5 MV3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDhZ5lkdG:4aYKtdoV{cXO2YX70JJRpgW2rZHnu[UBscW6jc3Wg[IVncWOrZX70JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF0xNjkQvF2u NYK3PVVGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PFAzPTFpPkK5PFgxOjVzPD;hQi=>
HEL M3TCN2FvfGm4aYLhcEBie3OjeR?= MUnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnIHTl[olkcWWwdDDhcoQh[WOrY3zveolzKHKnc3nzeIFvfCCqZYLw[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[nlibXnjdo9{[2:yaXOgZY5idHm|aYOsJGVEPTB;MD64{txONg>? NGnDW5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEezPFY2Oyd-M{C3N|g3PTN:L3G+
HELF NVO2dpp2SW62aY\pdoFtKGG|c3H5 NHPTSFg4KGSjeYO= MYfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKFSNLVvPV{1CS1ZiaX7m[YN1\WRiaX6gbJVu[W5iSFXMSkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBqdmO3YnH0[YQh\m:{IEeg[IF6eyCkeTDtbYNzd3Olb4DpZ{BidmGueYPpd{whTUN3ME2wMljPxE1w MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV6NkizNkc,OzF3OE[4N|I9N2F-
HEL NVvL[49nSW62aY\pdoFtKGG|c3H5 M2\BXmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{NTJiRzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJktKEWFNUC9NE46|ryPLh?= M4fzXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUGxPFU3Lz5{M{mxNVg2PjxxYU6=
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Vero MoWwRY51cX[rcnHsJIF{e2G7 MUCzJIRigXN? M2DM[GFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFic4TyZYlvKEZiVmKtO|M{KGmwZnXjeIVlKGmwIFHmdolk[W5iZ4Ll[Y4hdW:wa3X5JHZmem9iY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME2wMlnPxE1w NH3lRpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS2NFg5Oyd-Mk[0OlA5QDN:L3G+
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HEL Mn\CRY51cX[rcnHsJIF{e2G7 MUW0JIRigXN? NEXFOIxCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgRWQuOTZ7IHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|IIDsZZF2\SCob4LtZZRqd25iYX\0[ZIhPCCmYYnzMEBGSzVyPUGuOlXPxE1w NU[yS29ORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OVk5PzZpPkKyOFU6QDd4PD;hQi=>
HEL M1zVS2FvfGm4aYLhcEBie3OjeR?= M4\lZlQh\GG7cx?= NX7RfmE1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{KHCuYYH1[UBnd3KvYYTpc44h[W[2ZYKgOEBl[Xm|LDDFR|UxRTFwNkZOwG0v MmHnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NUm4O|YoRjJ{NEW5PFc3RC:jPh?=
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HEL NYfLelAzSW62aY\pdoFtKGG|c3H5 MY[3JIRigXN? NXXRT2dLSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDBSFE3QSCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJkh[W[2ZYKgO{Bl[Xm|IIDvd5Rqdm[nY4Tpc44tKEWFNUC9Nu69VS5? NUPPeIYyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
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HFF NXjIXnhTSW62aY\pdoFtKGG|c3H5 NHjKSJQ5KGSjeYO= NUe5UG5uSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDpcoZm[3SnZDDpckBpfW2jbjDISmYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHP5eI9x[XSqaXOg[YZn\WO2IHHmeIVzKDhiZHH5d{BjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5MEBKSzVyPUKuNe69VS5? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZyN{i4N{c,OjJ4MEe4PFM9N2F-
HEL M3;RN2FvfGm4aYLhcEBie3OjeR?= MVPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjygSWM2OD1{LkJOwG0v NXrvbGpSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2N|k{PjhpPkK3OlM6OzZ6PD;hQi=>
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HEL MVnBcpRqfmm{YXygZZN{[Xl? NIfyXHBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTJwMkpOwG0v MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTh6MEK1NUc,Ojl6OECyOVE9N2F-
HEL Ml\vRY51cX[rcnHsJIF{e2G7 MUO1JIRigXN? NEnOR5hCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBVUytiVmrWJHlUKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMheGyjcYXlJIZwem2jdHnvckBi\nSncjC1JIRigXNuIFXDOVA:Oi5|zszNMi=> M3PHRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkKyNVI5Lz5zN{[yNlEzQDxxYU6=
HELF NVnRXppoSW62aY\pdoFtKGG|c3H5 MVm3JIRigXN? M3LZd2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDEZZZqeyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVzGJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIlv[3WkYYTl[EBnd3JiNzDkZZl{KGK7IFfp[Y1{[SC|dHHpcolv\yCkYYPl[EBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0zNjQQvF2u M4G2[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi2PFMzLz5|MUW4Olg{OjxxYU6=
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HEL M3;KZWFvfGm4aYLhcEBie3OjeR?= MWS3JIRigXN? NGnzOo9CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEVVZiRHH2bZMhcW5iaIXtZY4hUEWOIHPlcIx{KGGodHXyJFch\GG7czygSWM2OD1{LkdOwG0v M1nMSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkeyOFQ2Lz5zN{[3NlQ1PTxxYU6=
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HFF NH;nT|RCdnSrdnnyZYwh[XO|YYm= MUPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQ13WJHQzPTR{IIfpeIgheG:uIGS4NVNUKG23dHHueEBqdm[nY4Tl[EBqdiCKRl[gZ4VtdHNiYomgV2VCWCC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTJwN988UU4> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzdyOUS2PEc,OTd5MEm0Olg9N2F-
HEL NXWwPHZZSW62aY\pdoFtKGG|c3H5 MonBRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCGYY\pd{BqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;Mj63Oe69VS5? M3HNPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUG4OFU6Lz5zN{WxPFQ2QTxxYU6=
HEL M1i4VWFvfGm4aYLhcEBie3OjeR?= MoDORY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;Mj65Ou69VS5? NUXscGpFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVcyODJpPkK4O|U4OTB{PD;hQi=>
BSC-1 NEXC[lRCdnSrdnnyZYwh[XO|YYm= M2OxN2FvfGm4aYLhcEBi[3Srdnn0fUBw\iC2aHWgZ49ueG:3bnSge4F{KGW4YXz1ZZRm\CCjZ3HpcpN1KHSqZTDI[ZJx\XNic3ntdIxmgCC4aYL1d{B1gXCnLUGgbY4hSlOFLUGgZ4VtdHNuIFnDOVA:O87:TT6= NHf4PG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGzN|AxLz5{OUGzN|AxRC:jPh?=
MRC5 NFr1TY1HfW6ldHnvckBie3OjeR?= NHnBXlFKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDBSFE3QSC|dILhbY4hd2ZiSFPNWkBqdiCPUlO1JINmdGy|LDDJR|UxRTQQvF2u M4\I[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNEW0OFY2Lz5zMUS1OFQ3PTxxYU6=
HFF M3j6dWFvfGm4aYLhcEBie3OjeR?= MkjyRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCWb4fu[UBqdiCKRl[gZ4VtdHNiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiSVO1NF0{|ryPLh?= MorWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzNkG5OFYoRjF5MU[xPVQ3RC:jPh?=
hhTERT-BJ1 M2HTWmFvfGm4aYLhcEBie3OjeR?= MWmyJIRigXN? NEO2UnpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiVH;3coUhcW6oZXP0[YQhcW5iaIXtZY4hcGiWRWLUMWJLOSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|IH3l[IlifGWmIFTORUB{gW62aHXzbZMh[W[2ZYKgNkBl[Xm|LDDFR|UxRTQQvF2u MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR3OEGyOEc,OTh2NUixNlQ9N2F-
HEL NXLyUYc4SW62aY\pdoFtKGG|c3H5 M1vaVFch\GG7cx?= MUjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDhZ5lkdG:4aYKtdoV{cXO2YX70JJRpgW2rZHnu[UBscW6jc3Wg[IVncWOrZX70JGhUXjFiS1;TJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCjZoTldkA4KGSjeYOsJGVEPTB;M988UU4> MoLwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzMki2OlYoRjJzMUK4OlY3RC:jPh?=
HFF M13JTmFvfGm4aYLhcEBie3OjeR?= NWTPfHZqOTBiZHH5dy=> NYPMSHlESW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IGTve45mKGmwZnXjeIVlKGmwIFjGSkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5icHzhdZVmKG[xcn3heIlwdiCjZoTldkAyOCCmYYnzMEBKSzVyPUROwG0v NE\hWWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[0NVIyQCd-MkG2OFEzOTh:L3G+
HEL NIfsNI9CdnSrdnnyZYwh[XO|YYm= MkXGRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFHEMVE3QSCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;Mz6x{txONg>? MnnJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7MUG4OVYoRjJ|OUGxPFU3RC:jPh?=
HEL M2rHTmFvfGm4aYLhcEBie3OjeR?= MYXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjygSWM2OD1|LkJOwG0v NF7hUJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[zPVM3QCd-Mke2N|k{Pjh:L3G+
HELF MlfORY51cX[rcnHsJIF{e2G7 M2Lm[Fch\GG7cx?= M4\GU2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDBSFE3QSCrbn\lZ5Rm\CCrbjDoeY1idiCKRVzGJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIlv[3WkYYTl[EBnd3JiNzDkZZl{KGK7IFfp[Y1{[SC|dHHpcolv\yCkYYPl[EBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0{NjF3zszNMi=> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV6NkizNkc,OzF3OE[4N|I9N2F-
HFF Mn7tRY51cX[rcnHsJIF{e2G7 MoTsRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sg[4Fv[2mlbH;2bZIue2Wwc3n0bZZmKEiFTW[xJIl{d2yjdHWgdoVxdGmlYYTpc44hcW5iSF\GJINmdGy|IHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFnDOVA:Oy5{Mt88UU4> M1;uUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEGwOlg1Lz5zOUCxNFY5PDxxYU6=
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HEL M4fUV2FvfGm4aYLhcEBie3OjeR?= M4foSFYhfG9iNzDkZZl{ MXPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDt[YF{fXKnZDDh[pRmeiB4IITvJFch\GG7czDwc5N1NWmwZnXjeIlwdixiRVO1NF0{NjNzzszNMi=> NX7weJlvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2O|A4ODVpPkK5OlcxPzB3PD;hQi=>
MEF Mn3QSpVv[3Srb36gZZN{[Xl? MVzJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCvdYLpcoUh[3m2b33l[4Ftd3[rcoXzJJJmeGyrY3H0bY9vKGmwIF3FSkBk\WyuczD3ZZMh\GW2ZYLtbY5m\CCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6NCCLQ{WwQVMvPM7:TT6= MmTyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTR|OECxO{c,QTR|OECxO|ww[T5?
BSC-1 MYXBcpRqfmm{YXygZZN{[Xl? NHr4ZYZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZvMTCobIVzeGW|IIPpcZBt\XhidnnyeZMqNCCmZYTldo1qdmWmIHL5JGVNUVODIHnuJJF2[WS{dYDsbYNifGVid3XscJMhfXOrbnegRnNENTFiY3XscJMtKEmFNUC9N{42|ryPLh?= NES5eGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4OCd-MUC4PFI{PzB:L3G+
BSC-1 Mn\SSpVv[3Srb36gZZN{[Xl? M1TSd2VNUVODIHHzd4F6KHejczDw[ZJnd3KvZXSgeZNqdmdiQmPDMVEh[2WubIOgeI8h\GW2ZYLtbY5mKGGldHn2bZR6KGGpYXnud5QhUFOYLUGsJGlEPTB;Mz61{txONg>? NV3iboh4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzJpPkGwPFgzOzd{PD;hQi=>
BSC-1 M2\EN2FvfGm4aYLhcEBie3OjeR?= NV7CfY1YUW5idnn0do8h[W62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYLUGgeolzfXNiaX6gRnNENTFiKH3vcotmgSCtaXTu[ZkqKGOnbHzzMEBKSzVyPUOuOe69VS5? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86ODV5OE[1K|46ODV5OE[1QE9iRg>?
HEL M1K3TmFvfGm4aYLhcEBie3OjeR?= MULBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDQUWVFSVBvcnXzbZN1[W62IFjDUXYhSURzNkmgZ4xwdmViNDDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9N{42|ryPLh?= M3HE[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HFF M{HDd2FvfGm4aYLhcEBie3OjeR?= M2q5NWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDDUXYhXDJ2MkCge4l1cCCyb3ygS|g1OUFibYX0ZY51KGmwZnXjeIVlKGmwIFjGSkBk\WyuczDifUBUTUGSIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;Mz61{txONg>? NWr3VVFiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFk1PjhpPkG3O|A6PDZ6PD;hQi=>
BSC-1 M1LTNmZ2dmO2aX;uJIF{e2G7 Mk\ETY5pcWKrdH;yfUBkd26lZX70doF1cW:wIILldZVqemWmIHHnZYlve3RiaHXydIV{KHOrbYDs[Zghfmm{dYOgeJlx\S1zIDjIV3YuOSliZYjwdoV{e2WmIHnuJGJUSy1zIHPlcIx{KHejczDk[ZRmem2rbnXkJIJ6KEWOSWPBJIF{e2G7LDDJR|UxRTNwNd88UU4> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG3OEc,OTV3MEmxO|Q9N2F-
BSC-1 NUO0SXhwTnWwY4Tpc44h[XO|YYm= NH\J[3VKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgZYdicW6|dDDo[ZJx\XNic3ntdIxmgCC4aYL1d{B1gXCnLUGgLGhUXi1zKTDlfJBz\XO|ZXSgbY4hSlOFLUGgZ4VtdHNid3HzJIRmfGW{bXnu[YQh[nliRVzJV2Eh[XO|YYmsJGlEPTB;Mz61{txONg>? NXXy[4FwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1NFkyPzVpPkG1OVA6OTd3PD;hQi=>
BSC-1 MYTGeY5kfGmxbjDhd5NigQ>? NF;1V4ZKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgZYdicW6|dDDo[ZJx\XNic3ntdIxmgCC4aYL1d{B1gXCnLUGgLGhUXi1zKTDlfJBz\XO|ZXSgbY4hSlOFLUGgZ4VtdHNid3HzJIRmfGW{bXnu[YQh[nliRVzJV2Eh[XO|YYmsJGlEPTB;Mz61{txONg>? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG3Okc,OTV3MEmxO|Y9N2F-
HFF MnrESpVv[3Srb36gZZN{[Xl? MnK4R49ueG:3bnSge4F{KHSnc4Tl[EBnd3JiYX70bZZqemGuIHHjeIl3cXS7IHHnZYlve3RiMkmxOkBCTDF4OTDzeJJicW5ib3[gTGNOXiCrbjD5bYVt\CC{ZXT1Z5Rqd25iYYPzZZkhfXOrbnegTGZHKGOnbHzzMEBKSzlyPUOuOu69VS5? M1jxeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOEiyN|c1Lz5zMEi4NlM4PDxxYU6=
HEL NUHQUFJzSW62aY\pdoFtKGG|c3H5 MkLHO{Bl[Xm| MYfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKESjdnnzJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTDh[pRmeiB5IHThfZMheG:|dHnu[oVkfGmxbjygSWM2OD1|LkdOwG0v NUHNXpZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
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HEL NGPxbJVCdnSrdnnyZYwh[XO|YYm= NFnROIEzKHSxIEOg[IF6ew>? MYPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnLXTl[olkcWWwdDDBR3YuemW|aYP0ZY51KEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIDsZZF2\SCob4LtZZRqd25ibXXhd5Vz\WRiYX\0[ZIhOiC2bzCzJIRigXNicH;zeEBqdm[nY4Tpc44tKEWFNUC9N{46Oc7:TT6= NWLrOlRCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVA4OzRpPkK5OVUxPzN2PD;hQi=>
MRC-5 MULBcpRqcGW{cHXzeolzfXNiYYPzZZk> Mnv5TY4hfmm2cn:gZY51cWincoDld5ZqenW|IHHjeIl3cXS7IHHnZYlve3RiTWLDMVUh[2WubIOgbY5n\WO2ZXSge4l1cCCKQ13WJEhCTC1zNkmgd5Rz[WmwKTygTWM2OD12zszNMi=> NVOx[VE5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUOyN|Y4QCd-MUOyN|Y4QDxxYU6=
HEL M4jvbmFvfGm4aYLhcEBie3OjeR?= NXLHW5ZkSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[2mmb3\veolzKEiFTW[gRWQyPjliY3zvcoUhPSCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:PM7:TT6= MoLWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{Mk[xOFAoRjF7MkK2NVQxRC:jPh?=
HEL MUPBcpRqfmm{YXygZZN{[Xl? NIW0W5FCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1cHmvaXTpcoUhc2mwYYPlJIRm\mmlaXXueEBidmRiYXP5Z4xwfmm{LYLld4l{fGGwdDDIV3YyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTUQvF2u M{nnTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEm5NFk4Lz5{M{C5PVA6PzxxYU6=
HEL NYD5bXl{SW62aY\pdoFtKGG|c3H5 MoSzRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgWGsudmWpYYTpeoUhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDFR|UxRTUQvF2u M4nQ[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEGxNFk{Lz5{M{ixNVA6OzxxYU6=
HEL NIjrUVVCdnSrdnnyZYwh[XO|YYm= MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnLXTl[olkcWWwdDDhZ5lkdG:4aYKtdoV{cXO2YX70JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTygSWM2OD12zszNMi=> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd3MEG1OEc,Ojd5NUCxOVQ9N2F-
HEL MYHBcpRqfmm{YXygZZN{[Xl? MlGzRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXygZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;ND6wOe69VS5? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTRyN{m5NEc,Ojl2MEe5PVA9N2F-
HFF MXHGeY5kfGmxbjDhd5NigQ>? NFfMc45Ed22yb4Xu[EB4[XNidHXzeIVlKG[xcjDhcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDMVQhXG:5bnWgd5Rz[WmwIH;mJGhEVVZiaX6gfYlmdGRicnXkeYN1cW:wIHHzd4F6KHW|aX7nJGhHTiClZXzsd{whUUN3ME20MlHPxE1w NXruVY9RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzRpPkGwPFgzOzd2PD;hQi=>
HFF MXPBcpRqfmm{YXygZZN{[Xl? MVfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWFIzQTFiaX6gTGZHKGOnbHzzJIJ6KFCUQTygTWM2OD12LkJOwG0v MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB2M{GyPEc,OTdyNEOxNlg9N2F-
CRFK NH7TXYRCdnSrdnnyZYwh[XO|YYm= NFLJZpk1KGSjeYO= NHXuPZZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBH\WyrbnWgbIVzeGW|dnnyeZMhcW6oZXP0[YQhcW5iY3H0JGNTTktiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHHmeIVzKDRiZHH5d{BjgSClb3zvdolu\XS{aXOg[o9zdWG8YX6tZoF{\WRiTWTTJIF{e2G7LDDFR|UxRTRwMd88UU4> MkLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NUm4O|YoRjJ{NEW5PFc3RC:jPh?=
CRFK NV6wNHB7SW62aY\pdoFtKGG|c3H5 NU\FZ3RuSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh\mWuaX7lJIhmenCnc4\pdpV{KGmwZnXjeIVlKGmwIHPheEBEWk[NIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHL5JG1VWyCjc4PhfUwhTUN3ME20MlHPxE1w NGrrelE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ixNVA6Oyd-MkO4NVExQTN:L3G+
HEL NY[zblZvSW62aY\pdoFtKGG|c3H5 NULt[IdDSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh\2GwY3njcI93cXJvcnXzbZN1[W62IFjDUXYhSURzNkmgZ4xwdmViNDDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9OE4{|ryPLh?= NInKTG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyOlE1OCd-MUmyNlYyPDB:L3G+
HEL NInQNmdCdnSrdnnyZYwh[XO|YYm= MnLKRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgRWNXNXKnc3nzeIFvfCC2aIntbYRqdmVia3nuZZNmKGSnZnnjbYVvfCCKZYLw[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUSuN:69VS5? NEPjeoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEiyPVkyOyd-Mki4Nlk6OTN:L3G+
HFF NUTEOmRtTnWwY4Tpc44h[XO|YYm= Mn3nR49ueG:3bnSge4F{KHSnc4Tl[EBnd3JiYX70bZZqemGuIHHjeIl3cXS7IHHnZYlve3Rid3ns[E11gXCnIGTve45mKHO2cnHpckBw\iCKQ13WJIlvKHmrZXzkJJJm\HWldHnvckBie3OjeTD1d4lv\yCKRl[gZ4VtdHNuIFnDOVA:PC53zszNMi=> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3OEc,OTB6OEKzO|Q9N2F-
HEL NVXuOVZuSW62aY\pdoFtKGG|c3H5 MUS3JIRigXN? NWGzWYV2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGW6cILld5Nm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIIDsZZF2\SCob4LtZZRqd25iaX7jeYJifGWmIH\vdkA4KGSjeYOgZpkhT2mnbYPhJJN1[WmwIHLhd4VlKG2rY4Lvd4NweHluIFXDOVA:PC55Mt88UU4> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ7MUCzPEc,OjZ{OUGwN|g9N2F-
HEL MWDBcpRqfmm{YXygZZN{[Xl? MkPKO{Bl[Xm| NYDhV3MxSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZicHzhdZVmKG[xcn3heIlwdiCjZoTldkA4KGSjeYOsJGVEPTB;ND64{txONg>? NYHrVFhXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1N|k3OjJpPkG3OVM6PjJ{PD;hQi=>
HEL M136O2FvfGm4aYLhcEBie3OjeR?= NX[ycG9HOyCmYYnz NV7mSpFKSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDBSFE3QSCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgN{Bl[Xm|LDDFR|UxRTRwON88UU4> NXTyRVF2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5OlE5PTFpPkG3PVYyQDVzPD;hQi=>
HEL MmjyRY51cX[rcnHsJIF{e2G7 MYG2JJRwKDdiZHH5dy=> NVrTVZRnSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIDsZZF2\SCob4LtZZRqd25ibXXhd5Vz\WRiYX\0[ZIhPiC2bzC3JIRigXNicH;zeEBqdm[nY4Tpc44tKEWFNUC9OE45O87:TT6= NXf2ZmdURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVA4OzRpPkK5OVUxPzN2PD;hQi=>
MRC5 MYLBcpRqfmm{YXygZZN{[Xl? NIC5cW5CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXG:5bnWgbY4hVVKFNTDj[YxteyCkeTDQVmEtKEmFNUC9OE46|ryPLh?= NXr6dWd[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewOFMyOjhpPkG3NFQ{OTJ6PD;hQi=>
MRC5 MXrBcpRqfmm{YXygZZN{[Xl? MVnJckB3cXS{bzDhcpRqfmm{YXygZYN1cX[rdImge4F{KG2nYYP1doVlKGGpYXnud5QhUEOPVjjBSE0yPjlrIHnuJG1TSzViY3XscJMtKEmGNUC9Oe69VS5? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7OEGxK|4{ODB7OEGxQE9iRg>?
H-1 MnvvSpVv[3Srb36gZZN{[Xl? MmPLSYZn\WO2aY\lJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDFdJN1\WmwLXLhdpIhfmm{dYOgdoVxdGmlYYTpc44hcW5iSD2xJINmdGy|IHnuJGRPSSCqeXLybYRqgmG2aX;uJIF{e2G7LDDFR|UxRTYQvF2u Mnu2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV4M{SwNFMoRjF3NkO0NFA{RC:jPh?=
H1 MknpSpVv[3Srb36gZZN{[Xl? MnzWTY5pcWKrdHnvckBw\iCHQm[gdoVxdGmlYYTpc44hcW5iSEGgZ4VtdHNiYomgSG5CKGi7YoLp[Il7[XSrb36gZZN{[XluIFXDOVA:Pc7:TT6= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzByNEeyOkc,OTdyMES3NlY9N2F-
H1 MkO3SpVv[3Srb36gZZN{[Xl? MmLDTY5pcWKrdHnvckBw\iCHQm[gdoVxdGmlYYTpc44hcW5iSEGgZ4VtdHNiYomgSG5CKGi7YoLp[Il7[XSrb36gZZN{[XluIFXDOVA:Pc7:TT6= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZzNUW0OUc,OTV4MUW1OFU9N2F-
CEM MVzDfZRwfG:6aXPpeJkh[XO|YYm= M1\rS2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KEOHTTDj[YxteyxiQ1O1NF02|ryPLh?= NEfJXZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNU[xOVU1PSd-MUW2NVU2PDV:L3G+
HFF Ml;hRY51cX[rcnHsJIF{e2G7 MnLuOUB1dyB5IHThfZM> NEG4cXJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIHnu[oVkfGWmIFjGSkBk\WyuczDh[pRmeiB3IITvJFch\GG7czDifUB3cXKjbDD5bYVt\CCjc4PhfUwhTUN7OT65QVXPxE1w M4nuT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{K5NVA{Lz5zN{OyPVExOzxxYU6=
HEL NVy5XHNYSW62aY\pdoFtKGG|c3H5 M2TybFch\GG7cx?= NYL0eIdiSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDBSFE3QSCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{KHCuYYH1[UBnd3KvYYTpc44h[W[2ZYKgO{Bl[Xm|LDDFR|UxRTVwMd88UU4> MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ{MkGyPEc,OTd4MkKxNlg9N2F-
HEL NVG4UoVrSW62aY\pdoFtKGG|c3H5 NF[0XmQ4KGSjeYO= NWj5NlQ2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDBSFE3QS:GYY\pd{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliYX\0[ZIhPyCmYYnzMEBGSzVyPUWuNu69VS5? NFP4R3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGyPFY3Pid-MkGxNlg3PjZ:L3G+
AKATA MWDBcpRqfmm{YXygZZN{[Xl? M1P5eFQ5KGi{cx?= NXfMWWNESW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhTUKYIHnu[oVkfGWmIHnuJIh2dWGwIFHLRXRCKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDJ[2cucW6mdXPl[EBtgXSrYzD2bZJ2eyC{ZYDsbYNifGmxbjDt[YF{fXKnZDDheEA1QCCqcoOgdI9{fC2ueYTpZ{BqdmS3Y4Tpc44h[nlicWLUMXBEWiCjbnHsfZNqeyxiRVO1NF02NjMQvF2u NGH2cHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MkG5NVQ2Pid-M{KxPVE1PTZ:L3G+
MRC5 NIr3UpNCdnSrdnnyZYwh[XO|YYm= NGmxeppCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXDJ{OU[gbY4hVVKFNTDj[YxteyCkeTDQVmEtKEmFNUC9OU41|ryPLh?= M2jUN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MESzNVI5Lz5zN{C0N|EzQDxxYU6=
fibroblast cells MYjBcpRqfmm{YXygZZN{[Xl? NWPQUWU1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhVXW{aX7lJIN6fG:vZXfhcI93cXK3czDpcoZm[3SnZDDpckBud3W|ZTDlcYJzgW:waXOg[oljem:kbHHzeEBk\WyuczDifUBxdGGzdXWgdoVlfWO2aX;uJIF{e2G7LDDFR|UxRTVwNd88UU4> Ml3NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|OUeyO|EoRjF7M{m3NlcyRC:jPh?=
HFF MYjBcpRqfmm{YXygZZN{[Xl? MX;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWFIzQTNiaX6gTGZHKGOnbHzzJIJ6KFOHQWCgZZN{[XluIFnDOVA:PS54zszNMi=> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB2M{GyPEc,OTdyNEOxNlg9N2F-
HEL MmPGRY51cX[rcnHsJIF{e2G7 NUno[YxqSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9OU43O87:TT6= NGO4O|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSwO|k6OCd-Mkm0NFc6QTB:L3G+
NIH 3T3 MYjBcpRqfmm{YXygZZN{[Xl? NV7RR2UxPCC2bzC1JIRigXN? M1PCS2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JG12emmwZTDjfZRwdWWpYXzveolzfXNic4TyZYlvKFOvaYToJIlv\mWldHXkJIlvKG2xdYPlJG5KUCB|VEOgZ4VtdHNiYX\0[ZIhPCC2bzC1JIRigXNiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiRVO1NF02NjgQvF2u Mlr0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2NUixNlQoRjF6NEW4NVI1RC:jPh?=
RG2TK+ MmC4R5l1d3SxeHnjbZR6KGG|c3H5 NEDKO4E4OiCqcoO= MkXJR5l1d3SxeHnjbZR6KGGpYXnud5QhUFOYMT30b{Bo\W6nIH;2[ZJmgHC{ZYPzbY5oKFKJMmTLL{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDDR|UxRTVwOEdOwG0v MkH4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6MEC3OlQoRjF6OECwO|Y1RC:jPh?=
MRC-5 NXr2dWQ2TnWwY4Tpc44h[XO|YYm= NGn0dXlEd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTD2bZJidCCybHHxeYUh\m:{bXH0bY9vKGK7IFj1cYFvKEO7dH;t[YdidG:4aYL1d{ApUEOPVjmgLJN1emGrbjDBSE0yPjlrIHnuJG1TSy13IHPlcIx{NCCLQ{WwQVUvQc7:TT6= NIn6dos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEm2Olc1OCd-MUC5OlY4PDB:L3G+
HEL NXjOVZc{SW62aY\pdoFtKGG|c3H5 M3W1SGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHL5JJZqemGuIFPQSUBie3OjeTygSWM2OD13LkpOwG0v MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh3OEKyNkc,OjJ6NUiyNlI9N2F-
HEL NVvMTHRySW62aY\pdoFtKGG|c3H5 MVHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kBxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPUWuPVjPxE1w MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzMUC5N{c,OjN6MUGwPVM9N2F-
HCMV AD 169 NVrLeFBHSW62aY\pdoFtKGG|c3H5 MnHMTY4hfmm2cn:gZY51cX[rcnHsJIFv\CCjboTpZ4VtdHWuYYKgZYN1cX[rdImge4F{KGW4YXz1ZZRm\CCjZ3HpcpN1KGi3bXHuJIN6fG:vZXfhcI93cXK3czCoTGNOXiCDRDCxOlkqKGmwIDjIR21XKEGGIEG2PUkh[2WubIOsJGlFPTB;Nt88UU4> NGG3bYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUmzOlE2Lz5{OUmzOlE2RC:jPh?=
HEL MX;BcpRqfmm{YXygZZN{[Xl? MmnsRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDwdo91\WO2aX;uJIFo[Wmwc4SgeolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPUdOwG0v MnG1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NkW1NVYoRjJzNU[1OVE3RC:jPh?=
HEL NWDEVGh3SW62aY\pdoFtKGG|c3H5 MoXPN{Bl[Xm| MVfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDhZ5lkdG:4aYKtdoV{cXO2YX70JHRMNWSnZnnjbYVvfCCKZYDy[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBOXFRiYYPzZZktKEWFNUC9Ou69VS5? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek9EcEWPQlynQmNpTU2ETEyvZV4>
HFF M1jGWGFvfGm4aYLhcEBie3OjeR?= MlXWRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFPNWkBVOjd6NDD3bZRpKHCxbDDBPFA6XiCXTEm3JGM2QTKJIHTveYJt\SCvdYThcpQhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD14LkJOwG0v M2jWTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{C5OFY5Lz5zN{ewPVQ3QDxxYU6=
HEL M2jwbGFvfGm4aYLhcEBie3OjeR?= NET0TpU4KGSjeYO= M2DUNGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBmgHC{ZYPz[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCybHHxeYUh\m:{bXH0bY9vKGmwY4XiZZRm\CCob4KgO{Bl[Xm|IHL5JGdq\W2|YTDzeIFqdiCkYYPl[EBucWO{b4Pjc5B6NCCHQ{WwQVYvOTMQvF2u Mn2wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{OUGwN|goRjJ4MkmxNFM5RC:jPh?=
MRC-5 NEnSeXdHfW6ldHnvckBie3OjeR?= NEjMTpVKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36g[o9zKGGwdHmtTGNOXiCjY4Tpeol1gSCjZ3HpcpN1KEGGLUG2PUB{fHKjaX6gbY4hVVKFLUWgZ4VtdHNuIFnDOVA:Pi5|zszNMi=> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QDN4NkGzK|46QDN4NkGzQE9iRg>?
HEL MnfpRY51cX[rcnHsJIF{e2G7 MonmRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PUBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;Nj6z{txONg>? M3Swc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUG4OFU6Lz5zN{WxPFQ2QTxxYU6=
HEL MoXCRY51cX[rcnHsJIF{e2G7 MmW2RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFHEMVE3QSCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJktKEWFNUC9Ok4{|ryPLh?= MmL5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEGzOFQoRjJ4MECxN|Q1RC:jPh?=
HEL NYK5XXM2SW62aY\pdoFtKGG|c3H5 NIDXTYE3KHSxIEeg[IF6ew>? NY\re4kySW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIDsZZF2\SCob4LtZZRqd25ibXXhd5Vz\WRiYX\0[ZIhPiC2bzC3JIRigXNicH;zeEBqdm[nY4Tpc44tKEWFNUC9Ok41Ps7:TT6= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV3MEezOEc,Ojl3NUC3N|Q9N2F-
HEL M1LCU2FvfGm4aYLhcEBie3OjeR?= MoD3O{Bl[Xm| MYPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDUXYhSURzNkmgbY4hcHWvYX6gTGVNKGOnbHzzJIFnfGW{IEeg[IF6eyxiRVO1NF03NjYQvF2u MofXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4N{K0OFUoRjF5NkeyOFQ2RC:jPh?=
HEL NYrTNWcxSW62aY\pdoFtKGG|c3H5 MVfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPU[uOe69VS5? NV3SZ3I3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3OVAyPTRpPkK3O|UxOTV2PD;hQi=>
HELF M4WzbGFvfGm4aYLhcEBie3OjeR?= MUfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgd5Rz[WmwIHnu[oVkfGWmIHnuJGhGVEZiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDFR|UxRTZwNUNOwG0v M1uzd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm4OFgyLz5|MEC5PFQ5OTxxYU6=
HEL NVnobXdTSW62aY\pdoFtKGG|c3H5 MVfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5Rm[3Srb36gZYdicW6|dDD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;Nj61OO69VS5? NYTUS45wRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OlU2OTZpPkKxOVY2PTF4PD;hQi=>
HFF M1PWcmFvfGm4aYLhcEBie3OjeR?= NWfB[4U4SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiCWMke5PEB4cXSqIIDvcEBVQDF|UzDVUFk4KEN3OULHJIRwfWKuZTDteZRidnRiaX7m[YN1\WRiaX6gTGZHKGOnbHzzJIJ6KFOHQWCgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME22MlbPxE1w M1e2c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{C5OFY5Lz5zN{ewPVQ3QDxxYU6=
HEL M2PuUGFvfGm4aYLhcEBie3OjeR?= M1XSNGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPU[uO|nPxE1w M2\vO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{W3NVAzLz5{OEe1O|ExOjxxYU6=
HEL NIjHfYJHfW6ldHnvckBie3OjeR?= MlHaTY5pcWKrdHnvckBi\2GrboP0JGRPSSCxZjD1colv\mWldHXkJGhGVCClZXzsd{BjgSCrbnPvdpBwemG2aX;uJI9nKFt|SG3U[HItKEmFNUC9O:69VS5? NXLvN2lbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{e1NlIxPSd-N{e1NlIxPTxxYU6=
HFF MVnBcpRqfmm{YXygZZN{[Xl? MlPyRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJHQzOjlzIHnuJGhHTiClZXzsd{BjgSCVRVHQJIF{e2G7LDDJR|UxRTdwMd88UU4> M4LnVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MESzNVI5Lz5zN{C0N|EzQDxxYU6=
HEL M3HIZmFvfGm4aYLhcEBie3OjeR?= M4L6OGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF04NjIQvF2u M4PPZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUe4O|g{Lz5{MkW3PFc5OzxxYU6=
HEL NIP4ZVJCdnSrdnnyZYwh[XO|YYm= MYPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUeuNe69VS5? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByMUO0OEc,OjZyMEGzOFQ9N2F-
CRFK Mlq1RY51cX[rcnHsJIF{e2G7 NIX3bWE{KGSjeYO= NEXoPVhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBH\WyrZDDo[ZJx\XO4aYL1d{AyKGmwZnXjeIVlKGOjdDDDVmZMKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBkd2yxcnnt[ZRzcWNiZn;ycYF7[W5vYnHz[YQhVVSVIHHzd4F6NCCHQ{WwQVcvO87:TT6= NVfkb5JjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxQ3jFUWJNLz6FaFXNRmw9N2F-
HEL NXLsZ5M4SW62aY\pdoFtKGG|c3H5 MkDuRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RuIFXDOVA:Py5|zszNMi=> M2j0VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEK5PVE{Lz5{OEiyPVkyOzxxYU6=
HFF MUTBcpRqfmm{YXygZZN{[Xl? MVTJckB3cXS{bzDhcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKCiWb4fu[UB{fHKjaX6pJIlvKEiIRjCobJVu[W5iZnnido9jdGG|dDmgZ4VtdHNuIFnDOVA:Py52zszNMi=> NWHpWJZLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUC1O|g3PSd-OUC1O|g3PTxxYU6=
HFF MkTHSpVv[3Srb36gZZN{[Xl? M3T4RmlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHj1cYFvKGO7dH;t[YdidG:4aYL1d{Bz\XCuaXPheIlwdiCrbjDISmYh[2WubIOge4F{KGSndHXycYlv\WRiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiSVO1NF04NjUQvF2u NUXx[oJ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUSzPFAyPyd-OUSzPFAyPzxxYU6=
HFF MlSxSpVv[3Srb36gZZN{[Xl? NUDkdIN2S2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgWI94dmVic4TyZYlvKG:oIFjDUXYhcW5iYTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6KHW|aX7nJGhHTiClZXzsd{whUUN3ME23MlTPxE1w M2PSWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOEiyN|c1Lz5zMEi4NlM4PDxxYU6=
HFF MVPGeY5kfGmxbjDhd5NigQ>? NV20Rnc3S2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KCiKQ13WLUBjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5JJV{cW6pIFjGSkBk\WyuczygTWM2OD15LkVOwG0v MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3OUc,OTB6OEKzO|U9N2F-
HFF M4j2eWFvfGm4aYLhcEBie3OjeR?= MlTLRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeI94dmVic4TyZYlvKEiFTW[ge4F{KGSndHXycYlv\WRiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSCrbjDkeZBtcWOjdHWge4VtdHNidYPpcochUE[IIHPlcIx{NCCLQ{WwQVcvPM7:TT6= NVfRRoRZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzBpPkGwPFgzOzdyPD;hQi=>
HFF M{nuVGFvfGm4aYLhcEBie3OjeR?= NUDmbWdOSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjD3ZZMh\GW2ZYLtbY5m\CCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6KHW|aX7nJGhHTiClZXzsd{whUUN3ME23MlTPxE1w MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3Nkc,OTB6OEKzO|I9N2F-
HFF MnztSpVv[3Srb36gZZN{[Xl? NEDnS5FKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhMEiFTW[pJIV5eHKnc4Pl[EBqdiCKRl[gZ4VtdHNid3HzJIRmfGW{bXnu[YQh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME23MlTPxE1w NFGwTYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE4PCd-MUW1NFkyPzR:L3G+
HFF M{THWGZ2dmO2aX;uJIF{e2G7 NWXuVnB[UW6qaXLpeI9zgSClb37j[Y51emG2aX;uJJJmeXWrcnXkJIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KCiKQ13WLUBmgHC{ZYPz[YQhcW5iSF\GJINmdGy|IIfhd{Bl\XSncn3pcoVlKGK7IIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUC9O{41|ryPLh?= M4S3fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVc2Lz5zNUWwPVE4PTxxYU6=
HFF Mnq4SpVv[3Srb36gZZN{[Xl? MUHJcohq[mm2b4L5JINwdmOnboTyZZRqd25icnXxeYlz\WRiYXfhbY5{fCCqdX3hckBkgXSxbXXnZYxwfmm{dYOgLGhEVVZrIHX4dJJme3OnZDDpckBJTkZiY3XscJMhf2G|IHTleIVzdWmwZXSgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTygTWM2OD15LkVOwG0v M1joNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVc3Lz5zNUWwPVE4PjxxYU6=
HEL MmHMRY51cX[rcnHsJIF{e2G7 MkfCRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGLUG2PUBqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTdwNN88UU4> NEPtTIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEiyPVkyOyd-Mki4Nlk6OTN:L3G+
HEL MVnBcpRqfmm{YXygZZN{[Xl? MWW2JJRwKDdiZHH5dy=> M{fQW2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JI1m[XO3cnXkJIFnfGW{IE[geI8hPyCmYYnzJJBwe3RvaX7m[YN1cW:wLDDFR|UxRTdwNEJOwG0v Mo\qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{C3NFUoRjJ7NkewO|A2RC:jPh?=
HEL MXzBcpRqfmm{YXygZZN{[Xl? M4fzNWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF04NjYQvF2u NYnHXo4xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1O|g4QDNpPkKyOVc5Pzh|PD;hQi=>
HFF MorvRY51cX[rcnHsJIF{e2G7 M{\6emFvfGm4aYLhcEBi[3Srdnn0fUB4[XNiZHX0[ZJucW6nZDDifUB1cGViSFPNWkBxdGGzdXWgZZN{[XlidYPpcochUE[IIHPlcIx{NCCLQ{WwQVcvP87:TT6= NFv3OJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97MEW3PFY3Lz57MEW3PFY3RC:jPh?=
HEL MXTBcpRqfmm{YXygZZN{[Xl? NW\xd5N7SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwheGyjcYXlJIZwem2jdHnvckwhTUN3ME23MljPxE1w NUXPS3BtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OFM2PTBpPkK2OFQ{PTVyPD;hQi=>
HEL NH7TbZlCdnSrdnnyZYwh[XO|YYm= Moq2RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFHEMVE3QSCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKHCuYYH1[UBnd3KvYYTpc44tKEWFNUC9O{45P87:TT6= NUHIR3BDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NVExQTNpPkKzPFEyODl|PD;hQi=>
CRFK M1LpUWFvfGm4aYLhcEBie3OjeR?= M2HvXmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGZmdGmwZTDo[ZJx\XO4aYL1d{Bqdm[nY4Tl[EBqdiCFUl\LJINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h[WejaX7zeEB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9PE4y|ryPLh?= M3\E[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNU[1OVE3Lz5{MUW2OVUyPjxxYU6=
HEL MYrBcpRqfmm{YXygZZN{[Xl? Ml;HRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSCjZoTldkwhTUN3ME24MlLPxE1w M16wXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUGxPFU1Lz5{M{mxNVg2PDxxYU6=
HFF MnvRSpVv[3Srb36gZZN{[Xl? NFT6cWJKdiC4aYTyc{BqdmirYnn0bY9vKG:oIHj1cYFvKGO7dH;t[YdidG:4aYL1d{BqdiCKRl[gZ4VtdHNiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiSVO1NF05NjUQvF2u NWrZNlBkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxQ3jFUWJNLz6FaFXNRmw9N2F-
HFF NYfYZmt5SW62aY\pdoFtKGG|c3H5 NV\vZpp1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiB{OEG3JJdqfGhicH;sJGc5PDGDIGXMPVchSzV7Mleg[I92[mynIH31eIFvfCCrbn\lZ5Rm\CCrbjDISmYh[2WubIOgZpkhW0WDUDDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUiuOO69VS5? MlnuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5MEm0OlgoRjF5N{C5OFY5RC:jPh?=
HEL MWrBcpRqfmm{YXygZZN{[Xl? NYDwfYlEPyCmYYnz MmP0RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCGYY\pd{BqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36gZYZ1\XJiNzDkZZl{NCCHQ{WwQVgvP87:TT6= MonoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4MkKxNlgoRjF5NkKyNVI5RC:jPh?=
HEL M1vEN2FvfGm4aYLhcEBie3OjeR?= MontRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;OD63{txONg>? NF;GVVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[4NlA3Pyd-Mki2PFIxPjd:L3G+
HEL NGnYbZFCdnSrdnnyZYwh[XO|YYm= MlfXRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZTDk[YZq[2mnboSgZY5lKGGleXPsc5ZqeiC{ZYPpd5RidnRiSGPWNUBMV1NiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h[WejaX7zeEB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9Pe69VS5? NUnpVmlIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyPFEzOjVpPkG5NlgyOjJ3PD;hQi=>
HEL MWDBcpRqfmm{YXygZZN{[Xl? MnXoRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYomgeolz[WxiQ2DFJIF{e2G7LDDFR|UxRTlwMd88UU4> M2XXUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEW4NlIzLz5{Mki1PFIzOjxxYU6=
MRC-5 NIX0XJJHfW6ldHnvckBie3OjeR?= NVTjSVgxUW6qaXLpeI9zgSCjY4Tpeol1gSCxZjDjc41xd3WwZDDh[4FqdnO2IHj1cYFvKGO7dH;t[YdidG:4aYL1d{ApUEOPVjmgbY4hVVKFLUWgZ4VtdHNuIFXDOVA:QS52zszNMi=> M3jkSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{N{KzPVUyLz5zMkeyN|k2OTxxYU6=
Vero MnzsRY51cX[rcnHsJIF{e2G7 M2rhTWlvKH[rdILvJIFvfGm4aYLhcEBi[3Srdnn0fUB4[XNibXXhd5Vz\WRiYXfhbY5{fCCKU2[tNUApTiCmZXz0ZUA{ODVrIHnuJHZmem9iY3XscJMtKEmGNUC9NVDPxE1w NUSxNZo{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVgyOSd-M{CwPVgyOTxxYU6=
HFF NXrhWVlqSW62aY\pdoFtKGG|c3H5 M{nOdWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIFPNWkBVOjJ7MzDpckBJTkZiY3XscJMh[nliUGLBMEBKSzVyPUGw{txONg>? MoP4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNEOxNlgoRjF5MESzNVI5RC:jPh?=
Vero NXzP[nlTSW62aY\pdoFtKGG|c3H5 NHjKR2o{KGSjeYO= NHmzTodCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBX[XKrY3XscIEugm:|dHXyJJZqenW|IFXscIVvKF[ULUGzOlchcW6oZXP0[YQhcW5iQX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBGSzVyPUGxMlHPxE1w NH;HNIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS2NFg5Oyd-Mk[0OlA5QDN:L3G+
HEL MVPBcpRqfmm{YXygZZN{[Xl? NYDtWlVYSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1zMT60N:69VS5? NVjMZpNGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PFAzPTFpPkK5PFgxOjVzPD;hQi=>
HELF M3zkWGFvfGm4aYLhcEBie3OjeR?= M1vrWWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUB{fHKjaX6gbY5n\WO2ZXSgbY4hUEWORjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;MUGuO|XPxE1w NU\VU3IxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVg1QDFpPkOwNFk5PDhzPD;hQi=>
HFF NGDDcHVCdnSrdnnyZYwh[XO|YYm= NFrBW2lCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXDJ|MUGgbY4hUE[IIHPlcIx{KGK7IGDSRUwhUUN3ME2xNk41|ryPLh?= NYLafJpvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewOFMyOjhpPkG3NFQ{OTJ6PD;hQi=>
HEL NIfpS45CdnSrdnnyZYwh[XO|YYm= NWLRdXM6PyCmYYnz M1m1NGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJkh[W[2ZYKgO{Bl[Xm|IIDvd5QhcW6oZXP0bY9vNCCHQ{WwQVEzNjcQvF2u NHP3[oU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOzPVA5Oid-MUmzN|kxQDJ:L3G+
HEL M{fFOGFvfGm4aYLhcEBie3OjeR?= MnLiRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXygdIxieXWnIH\vdo1ifGmxbjygSWM2OD1zMz65{txONg>? MkLTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2NEO1OVAoRjJ4NESzOVUxRC:jPh?=
Vero MYXBcpRqfmm{YXygZZN{[Xl? M2D6U|M3KHSxIES4JIhzew>? Mk\uRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IFKgeolzfXNiMkSxNFUhcW6oZXP0[YQhcW5iYX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{Bie3Onc4Pl[EBieyCybHHxeYUhemWmdXP0bY9vKGGodHXyJFM3KHSxIES4JIhzeyxiRVO1NF0yPC53zszNMi=> NV[4OHpHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0N|gxPjFpPkG3OFM5ODZzPD;hQi=>
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Growth inhibition assay
Cell viability; 

PubMed: 29845211     


(A) HSV-TK-positive (HSV-TK: pLenO-GTP-HSV-TK) or negative (CON: pLenO-GTP) HXO-RB44 cells were treated with GCV at 0, 10, 20 or 40 µg/ml respectively. After 24 h post-transfection, cell viability was measured by MTT assay. (B) HSV-TK-positive (HSV-TK: pLenO-GTP-HSV-TK) or negative (CON: pLenO-GTP) HXO-RB44 cells were treated with GCV at 0, 10, 20 or 40 µg/ml, respectively for 48 h. Cell viability was also measured by MTT assay.

29845211
体内研究 抗病毒药物ganciclovir (GCV)在实验性自身免疫性脑脊髓炎模型中抑制小神经胶质的增殖。GCV减轻神经炎症,而且并不显著抑制外周免疫反应[7]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[7]

- 合并
  • Cell lines: BV-2 cells 
  • Concentrations: --
  • Incubation Time: 24 h
  • Method:

    将总量为2 × 10<sup>4</sup>的BV-2细胞接种于96孔板,置于含10%FBS的DMEM中培养12小时、然后血清饥饿12小时,加入不同浓度的GCV进行处理,处理24小时。在处理期间的最后8小时,将1 µCi/孔的[3H]thymidine通过脉冲加入到培养基中。最后通过β plate scintillation counter检测掺入的放射性。


    (Only for Reference)
动物实验:

[7]

- 合并
  • Animal Models: C57BL/6小鼠
  • Dosages: 100 mg/kg
  • Administration: i.p.
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 27 mg/mL warmed (105.78 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
4% DMSO+30% PEG 300+ddH2O
2mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 255.23
化学式

C9H13N5O4

CAS号 82410-32-0
储存条件 粉状
溶于溶剂
别名 RS-21592, 2'-Nor-2'-deoxyguanosine

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04478474 Not yet recruiting Drug: Ganciclovir Cytomegalovirus Infections New York Medical College|Merck Sharp & Dohme Corp. September 15 2020 --
NCT03698435 Recruiting Drug: Ganciclovir|Drug: Valganciclovir Cytomegalovirus Infections University Medical Center Groningen May 25 2018 --
NCT02606266 Terminated Drug: Valganciclovir Congenital Cytomegalovirus (CMV) Assistance Publique - Hôpitaux de Paris July 11 2017 Phase 2|Phase 3
NCT03088553 Unknown status Drug: Therapeutic Drug Monitoring Solid Organ Transplantation Rennes University Hospital February 22 2017 --
NCT02943057 Recruiting Drug: 2% guttae ganciclovir Cytomegalovirus Infections Singapore National Eye Centre October 2016 Phase 4
NCT02152358 Unknown status Drug: Aciclovir|Drug: Ganciclovir|Drug: Placebo Viral Pneumonia Assistance Publique Hopitaux De Marseille March 2014 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID