Ganciclovir (BW 759)

目录号:S1878 别名: RS-21592, 2'-Nor-2'-deoxyguanosine 中文名称:更昔洛韦

仅限科研使用

Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine)是一种抗病毒药,作用于猫科动物1型疱疹病毒,无细胞试验中IC50为5.2 μM。

Ganciclovir (BW 759) Chemical Structure

CAS: 82410-32-0

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 732.15 现货
RMB 565.06 现货
RMB 2212.74 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Ganciclovir (BW 759)发表文献13篇:

产品安全说明书

CMV抑制剂选择性比较

生物活性

产品描述 Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine)是一种抗病毒药,作用于猫科动物1型疱疹病毒,无细胞试验中IC50为5.2 μM。
体外研究

Ganciclovir由3种主要细胞酶代谢成三磷酸形式:(1)诱导的巨细胞病毒感染的细胞的脱氧鸟苷激酶; (2)鸟苷酸激酶;和(3)磷酸甘油酸激酶。[1] 在与HSV-TK表达细胞共同培养的大部分旁观者细胞中, Ganciclovir足以诱导细胞死亡。[2] Ganciclovir显著减少转化的细胞中DNA合成,而Ganciclovir对在非转化细胞的DNA合成的影响不大。Ganciclovir表现出浓度依赖性降低成熟的DNA中的伸长率。[3] 在HSVtk所转导的B16F10黑色素瘤细胞中,Ganciclovir诱导细胞周期阻滞,而不是直接的化学效应。[4]Ganciclovir轻度抑制DNA合成。Ganciclovir处理的细胞积聚在早S期并保持直到细胞死亡,这表明Ganciclovir掺入DNA模板中对细胞毒性很重要。[5]Ganciclovir诱导的凋亡是由于药物插入DNA导致复制依赖性的DNA双链断裂的形成,并在稍后的阶段产生S和G2 / M期阻滞。Ganciclovir激起的DNA不稳定性可能是Bcl-2的水平和caspase-9/-3活化水平降低的原因。[6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
E6SM cell lines NFfW[mxHfW6ldHnvckBie3OjeR?= NXjQblNGTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgeI8hcW6qaXLpeEBJ\XKyZYOgd4lueGyneDD2bZJ2ey1{IDjIV3YuOiliaX7keYNm\CCleYTvdIF1cGmlaYT5JIJ6KDVyJTDpckBGPlOPIHPlcIwhdGmwZYOsJGVEPTB;MT6yJI5O Ml[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF2OUW1PFYoRjFzNEm1OVg3RC:jPh?=
OST TK- cells Ml\NR5l1d3SxeHnjbZR6KGG|c3H5 M3vDUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9UXCCWSz2gZ4VtdHNiZYjwdoV{e2mwZzDIV3YyKFSNLDDJR|UxRTBwMECxPe69VS5? M{S4[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVU5Lz5zN{G4NVE2QDxxYU6=
HEL NFSy[XVCdnSrdnnyZYwh[XO|YYm= MkPVRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCJIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiTVnDQVAvODB4NN88UU4> NGT4U2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[3NlQ1PSd-MUe2O|I1PDV:L3G+
HEL MYHBcpRqfmm{YXygZZN{[Xl? NF7jeWtCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUCuNFHPxE1w MnnJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{M{K4NlgoRjJzMkOyPFI5RC:jPh?=
HEL NGLWbpFCdnSrdnnyZYwh[XO|YYm= NVL1eplLSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYLUKgS{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcE1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuNFHPxE1w Mnv2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5OUWyN|goRjJ|N{m1NlM5RC:jPh?=
HEL M{Kz[WFvfGm4aYLhcEBie3OjeR?= M1nTeGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXi1zIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcE1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuNFHPxE1w NVnHcGNxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3PVUzOzhpPkKzO|k2OjN6PD;hQi=>
HEL NHraO2lCdnSrdnnyZYwh[XO|YYm= M4XKdlMh\GG7cx?= M3XXdGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhOyCmYYnzJIJ6KG2rY4Lvd4NweGmlIH3leIhw\CxiRVO1NF0xNjBzzszNMi=> NUPCZ5B3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyPFY6PTJpPkOwNlg3QTV{PD;hQi=>
HEL NFO2eXdCdnSrdnnyZYwh[XO|YYm= M{XCOVMh\GG7cx?= Mn7JRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgNkB{fHKjaX6gS{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHHmeIVzKDNiZHH5d{BjgSCvaXPyc5Nkd3CrYzDt[ZRpd2RuIFXDOVA:OC5yMd88UU4> NHPqU2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK4Olk2Oid-M{CyPFY6PTJ:L3G+
HEL NYfsfFg3SW62aY\pdoFtKGG|c3H5 MofORY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RuIFXDOVA:OC5yMUROwG0v NFPRXVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C5PVA6Pyd-MkOwPVkxQTd:L3G+
HEL MWnBcpRqfmm{YXygZZN{[Xl? NGTYRndCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUCuNFE2|ryPLh?= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB7OUC5O{c,OjNyOUmwPVc9N2F-
OST TK- cells M4e4[2N6fG:2b4jpZ4l1gSCjc4PhfS=> MnHER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3NVKFSNLTDj[YxteyCneIDy[ZN{cW6pIFjTWlEhXEtiaX6gdJJme2WwY3Wgc4YhOi53IIXNJFEuYzZvKITybZBp\W67bH3leIhwgHlraHX4fYxefGi7bXnu[UwhUUN3ME2wMlAyQM7:TT6= NFHIZpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE2QCd-MUexPFEyPTh:L3G+
HEL NXL4T2pZSW62aY\pdoFtKGG|c3H5 NFL1VnNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{BqdiCKRVygZ4VtdHNuIFXDOVA:OC5yMUpOwG0v MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG2Nkc,OTdzOEGxOlI9N2F-
HEL NXPReVluSW62aY\pdoFtKGG|c3H5 MnzGNkB1dyB|IHThfZM> M3z1ZmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBxdGGzdXWg[o9zdWG2aX;uJI1m[XO3cnXkJIFnfGW{IEKgeI8hOyCmYYnzJJBwe3RiaX7m[YN1cW:wLDDFR|UxRTBwMEG5{txONg>? NWTwPHU1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVA4OzRpPkK5OVUxPzN2PD;hQi=>
HEL Mn;2RY51cX[rcnHsJIF{e2G7 NVuz[ll7SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5Rm[3Srb36gZYdicW6|dDD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;MD6wNu69VS5? M4XrSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkixNlI2Lz5zOUK4NVIzPTxxYU6=
HEL NX3Mfop2SW62aY\pdoFtKGG|c3H5 M3jwelQh\GG7cx?= M1GydWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZYZ1\XJiNDDkZZl{NCCHQ{WwQVAvODMQvF2u MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR3OUi3Okc,OjJ2NUm4O|Y9N2F-
HEL Ml\ORY51cX[rcnHsJIF{e2G7 MWfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OC5yMt88UU4> NFfQb4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwNVM1PCd-Mk[wNFE{PDR:L3G+
HEL MVzBcpRqfmm{YXygZZN{[Xl? MkfaRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVAvODMQvF2u NY\mNlVkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PFAzPTFpPkK5PFgxOjVzPD;hQi=>
HEL NYPBXpdCSW62aY\pdoFtKGG|c3H5 MULBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPUCuNFLPxE1w NWjxWHRbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PFAzPTFpPkK5PFgxOjVzPD;hQi=>
Vero Mkn2RY51cX[rcnHsJIF{e2G7 MmPGO|IhcHK| NFfEdmRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZvMTDpcoZm[3SnZDDpckBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiR1\QJIV5eHKnc4Ppc44h[W[2ZYKgO|IhcHK|IHL5JGdHWC2kYYPl[EBndHWxcnXzZ4Vv[2VibXnjdo9{[2:yaXOgZY5idHm|aYOsJGVEPTB;MD6wNlXPxE1w Mni1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3MEO0O|YoRjNzNUCzOFc3RC:jPh?=
HEL MkS0RY51cX[rcnHsJIF{e2G7 NEfwSotCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDo[ZJx\XO4aYL1d{AzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHC{b4TlZ5Rqd25iYXfhbY5{fCC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:OC5yMkhOwG0v M1LDOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNU[1OVE3Lz5{MUW2OVUyPjxxYU6=
HEL M1HtPGFvfGm4aYLhcEBie3OjeR?= MWTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[nlidnnyZYwhS1CHIHHzd4F6NCCHQ{WwQVAvODJ5zszNMi=> Mom2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NUiyNlIoRjJ{OEW4NlIzRC:jPh?=
HEL Mlr4RY51cX[rcnHsJIF{e2G7 NYrPPWF5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCkeTD2bZJidCCFUFWgZZN{[XluIFXDOVA:OC5yMkpOwG0v NFfXXYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki1PFIzOid-MkK4OVgzOjJ:L3G+
HEL M4\ZVWFvfGm4aYLhcEBie3OjeR?= NVn1c4pGOiC2bzCzJIRigXN? NXXISotrSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WO7Y3zveolzNXOnboPpeIl3\SCKZYLw[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCocn;tJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliYX\0[ZIhOiC2bzCzJIRigXNiYomgUXRVKGG|c3H5MEBGSzVyPUCuNFPPxE1w M3TiZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEO0O|EyLz5{MECzOFcyOTxxYU6=
HEL NWrSfXViSW62aY\pdoFtKGG|c3H5 MonSNkB1dyB|IHThfZM> MlvDRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5Rm[3Srb36g[pJwdSC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IEKgeI8hOyCmYYnzJIJ6KE2WVDDhd5NigSxiRVO1NF0xNjB|zszNMi=> M1X6WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEO0O|EyLz5{MECzOFcyOTxxYU6=
HEL NX3ROIgySW62aY\pdoFtKGG|c3H5 NFj4emczKHSxIEOg[IF6ew>? NW\He4V5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDwdo91\WO2aX;uJIZzd21idnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjCyJJRwKDNiZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:OC5yM988UU4> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB|NEexNUc,OjByM{S3NVE9N2F-
HEL NUjYVnU6SW62aY\pdoFtKGG|c3H5 MWO0JIRigXN? MUXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFQh\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB|zszNMi=> NVf2Z4tbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2PVY6PjNpPkKxOlk3QTZ|PD;hQi=>
HEL MVHBcpRqfmm{YXygZZN{[Xl? MUnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF0xNjB|zszNMi=> NF:3VnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUW2OVUyPid-MkG1OlU2OTZ:L3G+
HEL NEnFXZJCdnSrdnnyZYwh[XO|YYm= MUC0JIRigXN? M2LYS2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{NTJiRzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFQh\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB|zszNMi=> M4jPRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkm2PVY{Lz5{MU[5Olk3OzxxYU6=
HEL NYHWT|I4SW62aY\pdoFtKGG|c3H5 MlryOEBl[Xm| MVjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCjZoTldkA1KGSjeYOsJGVEPTB;MD6wN:69VS5? M3K0[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEW5PFc3Lz5{MkS1PVg4PjxxYU6=
HEL MkPiRY51cX[rcnHsJIF{e2G7 NWjsOJVmSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNvMjDHJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF0xNjB|zszNMi=> NGjifZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ixNVA6Oyd-MkO4NVExQTN:L3G+
HEL NFWxRXVCdnSrdnnyZYwh[XO|YYm= MXnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{0yKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJktKEWFNUC9NE4xO87:TT6= NEfCTZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ixNVA6Oyd-MkO4NVExQTN:L3G+
HEL MUHBcpRqfmm{YXygZZN{[Xl? NEi2c3BCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDFR|UxRTBwMEROwG0v M1:3O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MECxN|Q1Lz5{NkCwNVM1PDxxYU6=
HEL Mn[5RY51cX[rcnHsJIF{e2G7 M2X4[GFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3czDwcIFyfWViZn;ycYF1cW:wLDDFR|UxRTBwMEROwG0v NHexUFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[zPVM3QCd-Mke2N|k{Pjh:L3G+
HELF MoXFRY51cX[rcnHsJIF{e2G7 MUPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czCxJGtQWyC|dILhbY4hcW6oZXP0[YQhcW5iSFXMSkBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJktKEWFNUC9NE4xO87:TT6= M{fL[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm4OFgyLz5|MEC5PFQ5OTxxYU6=
HELF MnG1RY51cX[rcnHsJIF{e2G7 MnexRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgNkBIKHO2cnHpckBqdm[nY4Tl[EBqdiCKRVzGJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME2wMlA{|ryPLh?= NE\RUVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFQ5OSd-M{CwPVg1QDF:L3G+
HEL MUTBcpRqfmm{YXygZZN{[Xl? MVTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1NCCHQ{WwQVAvODQQvF2u NUXkc4wxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4Nlk6OTNpPkK4PFI6QTF|PD;hQi=>
HEL MnXvRY51cX[rcnHsJIF{e2G7 NXnYWpNPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;MD6wN:69VS5? M{fPOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{W3NVAzLz5{OEe1O|ExOjxxYU6=
HEL M{focWFvfGm4aYLhcEBie3OjeR?= NV\CdoxQSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMjDpckBJTUxiY3XscJMtKEWFNUC9NE4xOzMQvF2u M1rtdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVYzLz5zN{G4NVE3OjxxYU6=
HEL M{nDUmFvfGm4aYLhcEBie3OjeR?= M2nNbmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjFiS1;TJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTygUWlERTBwMEOy{txONg>? M33B[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkeyOFQ2Lz5zN{[3NlQ1PTxxYU6=
HEL NFjoUohCdnSrdnnyZYwh[XO|YYm= NImwN45CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;MD6wN|LPxE1w Mmj2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NUCxOVQoRjJ5N{WwNVU1RC:jPh?=
OST TK- cells NGDhNJdEgXSxdH;4bYNqfHliYYPzZZk> M{j0RWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9UXCCWSz2gZ4VtdHNiZYjwdoV{e2mwZzDIV3YyKFSNIHnuJJBz\XOnbnPlJI9nKDVidV2gNU1cPi1qdILpdIhmdnmubXX0bI95gSmqZYj5cH11cHmvaX7lMEBKSzVyPUCuNFM{|ryPLh?= NFvuc5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE2QCd-MUexPFEyPTh:L3G+
fibroblast cells NFi5PYdCdnSrdnnyZYwh[XO|YYm= MVHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hcHWvYX6g[o9z\XOtaX6g[oljem:kbHHzeEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9NE4xPM7:TT6= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN7N{K3NUc,OTl|OUeyO|E9N2F-
HEL M4LxXmFvfGm4aYLhcEBie3OjeR?= Mlq0RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RuIFXDOVA:OC5yNN88UU4> MoDEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{M{K4NlgoRjJzMkOyPFI5RC:jPh?=
HFF MkXPRY51cX[rcnHsJIF{e2G7 NV7kcYVNOSCqch?= NUnLUnlOSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IDjzeJJicW5iQVSxOlkqKGmwZnXjeIVlKGmwIEGgbJIheHKndILlZZRm\CCqdX3hckBJTkZiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqemGuLXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYomgcoV2fHKjbDDy[YQhfXC2YXvlJIF{e2G7LDDFR|UxRTBwMEVOwG0v MkLLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|N{[0NlkoRjJzM{e2OFI6RC:jPh?=
HEL NVfwVoJuSW62aY\pdoFtKGG|c3H5 NIjFW4JCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCxiRVO1NF0xNjB2zszNMi=> NWTNW3BNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4Nlk6OTNpPkK4PFI6QTF|PD;hQi=>
HEL M1qwcGFvfGm4aYLhcEBie3OjeR?= M{LVdmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUCuNFTPxE1w NXHBbYJGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVcyODJpPkK4O|U4OTB{PD;hQi=>
Vero MoPoRY51cX[rcnHsJIF{e2G7 NGW5[oQ{PiCqcoO= MoPsRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXKDFiaX7m[YN1\WRiaX6gRYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4heGyjcYXlJIZwem2jdHnvckBqdmO3YnH0[YQh\m:{IEO2JIhzeyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yCkYYPl[EBie3OjeTygSWM2OD1yLkC0{txONg>? MoC1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzJzOUG0OVYoRjN{MUmxOFU3RC:jPh?=
OST TK- cells NFLXb3JEgXSxdH;4bYNqfHliYYPzZZk> NHXo[FhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQW1RiVFutJINmdGy|IHX4dJJme3OrbnegTHNXOSCWSzDpckBxemW|ZX7j[UBw\iBzMDD1UUAyNVt4LTj0dolxcGWweXzt[ZRpd3i7KXjlfJltZXSqeX3pcoUtKEmFNUC9NE4xPDIQvF2u NI[wTWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE2QCd-MUexPFEyPTh:L3G+
HEL MULBcpRqfmm{YXygZZN{[Xl? NWXkRnhFOiC2bzCzJIRigXN? NX3zO3JGSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicHzhdZVmKG[xcn3heIlwdiCvZXHzeZJm\CCjZoTldkAzKHSxIEOg[IF6eyCyb4P0JIlv\mWldHnvckwhTUN3ME2wMlA1Pc7:TT6= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV3MEezOEc,Ojl3NUC3N|Q9N2F-
OST TK- cells NWnuWldPS3m2b4TvfIlkcXS7IHHzd4F6 MmPMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3NVKFSNLTDj[YxteyCneIDy[ZN{cW6pIFjTWlEhXEtiaX6gdJJme2WwY3Wgc4YhOi53IIXNJFEuYzZvW{GsNU0p\GmyaHXufYwqNTFvKEStdJlzcWS7bDnt[ZRpd3i7XXjlfJltZXSqeX3pcoUtKEmFNUC9NE4xPc7:TT6= M2m1V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVU5Lz5zN{G4NVE2QDxxYU6=
human M4TudWFvfGm4aYLhcEBie3OjeR?= MonxO{Bl[Xm| NGnwe3hCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1Z{IFegbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6KGGodHXyJFch\GG7czygSWM2OD1yLkC1{txONg>? Ml\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzMki2OlYoRjJzMUK4OlY3RC:jPh?=
HEL MnjXRY51cX[rcnHsJIF{e2G7 MX2yJJRwKDNiZHH5dy=> NWewSYNCSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgcYVie3W{ZXSgZYZ1\XJiMjD0c{A{KGSjeYOgdI9{fC2rbn\lZ5Rqd25uIFXDOVA:OC5yNUJOwG0v M4ny[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkewO|A2Lz5{OU[3NFcxPTxxYU6=
HEL MU\BcpRqfmm{YXygZZN{[Xl? M170OWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OC5yNUZOwG0v NY\VfY1LRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3OVAyPTRpPkK3O|UxOTV2PD;hQi=>
HEL NVu5fGU1SW62aY\pdoFtKGG|c3H5 MXiyJJRwKDNiZHH5dy=> MlPORY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDt[YF{fXKnZDDh[pRmeiB{IITvJFMh\GG7czDwc5N1NWmwZnXjeIlwdixiRVO1NF0xNjB3N988UU4> NYX2TIxrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2O|A4ODVpPkK5OlcxPzB3PD;hQi=>
HEL MVzGeY5kfGmxbjDhd5NigQ>? NUXj[lRrS2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cS24aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXi1zKFepJIlvKEiHTDDj[YxteyxiRVO1NF0xNjB4zszNMi=> M{LoXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2NkSzN|I5Lz5zNE[0N|MzQDxxYU6=
Hel MmrGSpVv[3Srb36gZZN{[Xl? MnKxSYZn\WO2aY\lJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDo[ZJx\XNic3ntdIxmgCC4aYL1d{B1gXCnIEGgT49{KHO2cnHpckBqdmS3Y3XkJIN6fG:yYYTobYNqfHliaX6gTIVtKGOnbHzzMEBGSzVyPUCuNFbPxE1w NGroUnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNU[1PFg2QCd-MUW2OVg5PTh:L3G+
HEL NH;LSJpCdnSrdnnyZYwh[XO|YYm= NF[zeGFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{BqdiCKRVygZ4VtdHNuIFXDOVA:OC5yNt88UU4> NHj6bYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkO5Nlc6OSd-MU[zPVI4QTF:L3G+
HEL Mk\HRY51cX[rcnHsJIF{e2G7 NVvNN|BVSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMjDHJIlvKEiHTDDj[YxteyxiRVO1NF0xNjB4zszNMi=> NYT6W3FCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[zPVI4QTFpPkG2N|kzPzlzPD;hQi=>
HEL MoLJRY51cX[rcnHsJIF{e2G7 NFq3[mw{KGSjeYO= NWnYfG5LSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gbIVzeGW|dnnyeZMhOiC|dILhbY4hTyCrbn\lZ5Rm\CCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhOyCmYYnzJIJ6KGOxbH;ybY1mfHKrYzDmc5Ju[Xqjbj3iZZNm\CCPVGOgZZN{[XluIFXDOVA:OC5yN988UU4> NU\wOVc3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxQ3jFUWJNLz6FaFXNRmw9N2F-
HEL NYnH[WxrSW62aY\pdoFtKGG|c3H5 NF7Qb4RCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBp\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZpkhdWmlcn;zZ49xcWNiYX7hcJl{cXNuIFXDOVA:OC5yN988UU4> NUP0[VZmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3N|g3PTNpPkOwO|M5PjV|PD;hQi=>
HELF NFSzUoVCdnSrdnnyZYwh[XO|YYm= NILVXZo4KGSjeYO= MkjCRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCrbnP1ZoF1\WRiZn;yJFch\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB5zszNMi=> MlfzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3OE[4N|IoRjNzNUi2PFMzRC:jPh?=
HEL Moj4RY51cX[rcnHsJIF{e2G7 Mn;jO{Bl[Xm| MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgO{Bl[Xm|LDDFR|UxRTBwMElOwG0v NXnHenhwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNlg3PjZpPkKxNVI5PjZ4PD;hQi=>
HEL MUPBcpRqfmm{YXygZZN{[Xl? Mnz3N{Bl[Xm| NXPQcG05SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gbIVzeGW|dnnyeZMhOiC|dILhbY4hTyCrbn\lZ5Rm\CCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGVEPTB;MD6wPO69VS5? NVP5TG9JRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxQ3jFUWJNLz6FaFXNRmw9N2F-
HEL M3jqdWFvfGm4aYLhcEBie3OjeR?= NV7p[GxrOyCmYYnz M3v1[2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFEhe3S{YXnuJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBOXFRiYYPzZZktKEWFNUC9NE4xQM7:TT6= MnPvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
OST TK- cells NYPqR3hNS3m2b4TvfIlkcXS7IHHzd4F6 NIjwdlhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQW1RiVFutJINmdGy|IHX4dJJme3OrbnegTHNXOSCWSzDpckBxemW|ZX7j[UBw\iB3IIXNJFEuYzZvW{GsNU0p\GmyaHXufYwqNTFvKEStdJlzcWS7bDnt[ZRpd3i7XXjlfJltZXSqeX3pcoUtKEmFNUC9NE4xQDIQvF2u M2\RXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVU5Lz5zN{G4NVE2QDxxYU6=
HEL M2rz[WFvfGm4aYLhcEBie3OjeR?= NXe1Z3hPOyCmYYnz MUPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czCxJJN1emGrbjDLU3MhcW6oZXP0[YQhcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBkd2yxcnnt[ZRzcWNiZn;ycYF7[W5vYnHz[YQhVVSVIHHzd4F6NCCHQ{WwQVAvODoQvF2u MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek9EcEWPQlynQmNpTU2ETEyvZV4>
HEL NVXMZmhZSW62aY\pdoFtKGG|c3H5 MmXaRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjygSWM2OD1yLkC5{txONg>? NHP3Z5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[zPVM3QCd-Mke2N|k{Pjh:L3G+
E6SM M4rwZWFvfGm4aYLhcEBie3OjeR?= NES0WI1CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIlvKEV4U12gZ4VtdHNuIF3JR|0xNjB7Nt88UU4> NVzDT3l{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewPVI4OjhpPkG3NFkzPzJ6PD;hQi=>
E6SM NY\zWmJbSW62aY\pdoFtKGG|c3H5 MofCRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCJLXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliaX6gSVZUVSClZXzsd{whVUmFPUCuNFk3|ryPLh?= M4T1TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEmyO|I5Lz5zN{C5NlczQDxxYU6=
HEL M{XZVmFvfGm4aYLhcEBie3OjeR?= MlTlRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZTDk[YZq[2mnboSgZYN6[2yxdnnyMZJme2m|dHHueEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUCuNe69VS5? NUfVcIhCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyN|I5OjhpPkKxNlMzQDJ6PD;hQi=>
HEL NYX0O2RLSW62aY\pdoFtKGG|c3H5 NVrxdoo1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfGi7bXnkbY5mKGurbnHz[U1l\W[rY3nlcpQhSUOYLYLld4l{fGGwdDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTBwMd88UU4> NYjFSo5NRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVcyODJpPkK4O|U4OTB{PD;hQi=>
OST TK- cells M2G0fGN6fG:2b4jpZ4l1gSCjc4PhfS=> M1jMPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9UXCCWSz2gZ4VtdHNiZYjwdoV{e2mwZzDIV3YyKFSNIHnuJJBz\XOnbnPlJI9nKDFyIIXNJFEuYzZvW{GsNU0p\GmyaHXufYwqNTFvKEStdJlzcWS7bDnt[ZRpd3i7XXjlfJltZXSqeX3pcoUtKEmFNUC9NE4yOc7:TT6= NGLiOG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE2QCd-MUexPFEyPTh:L3G+
HFF M2i0NGFvfGm4aYLhcEBie3OjeR?= NWrYbHh5OTBiZHH5dy=> NULY[oFPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDUc5dv\SCrbn\lZ5Rm\CCrbjDISmYh[2WubIOgbY5kfWKjdHXkJIZweiBzMDDkZZl{KGK7IIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUC9NE4yPM7:TT6= NFztfFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUixNlQzOCd-MkG4NVI1OjB:L3G+
HFF M{Pz[GZ2dmO2aX;uJIF{e2G7 NU\acIFKUW6qaXLpeIlwdiCxZjDIR21XKEGGMU[5JJJmeGyrY3H0bY9vKGmwIFjGSkBk\WyuczDifUBkgXSxcHH0bIlkKGWoZnXjeEBie3OjeTygSWM2OD1yLkG1{txONg>? MnfzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyMES3NlYoRjF5MEC0O|I3RC:jPh?=
MCA-TK NGm0XIlEgXSxdH;4bYNqfHliYYPzZZk> M2T2RmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2FQT3UT{Bk\WyuczygTWM2OD1yLkG1{txONg>? NUH4WnhjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5OlA6OjZpPkG3PVYxQTJ4PD;hQi=>
vero M2LMV2FvfGm4aYLhcEBie3OjeR?= NESzdolCdnSrdnnyZYwh[WO2aY\peJkhf2G|IHTleIVzdWmwZXSgbY4heGyjcYXlJJJm\HWldHnvckBie3OjeTDpckB3\XKxIHPlcIx{KGGpYXnud5QhUFOYLUGgSkB{fHKjaX6sJGlFPTB;MD6y{txONg>? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{QDdzOE[wK|4{QDdzOE[wQE9iRg>?
Vero M{nWWWFvfGm4aYLhcEBie3OjeR?= MkKzTY4hfmm2cn:gZY51cX[rcnHsJIFkfGm4aYT5JJdieyCvZXHzeZJm\CCjZ3HpcpN1KEiVVj2xLGYqKGmwIG\ldo8h[2WubIOsJGlFPTB;MD6y{txONg>? NI\0RnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFEyLz5|MEC5PFEyRC:jPh?=
Vero M{HXdWFvfGm4aYLhcEBie3OjeR?= M1G3cGFvfGm4aYLhcEBi[3Srdnn0fUBl\XSncn3pcoVlKGGpYXnud5QhcGW{cHXzJJNqdXCuZYigeJlx\SBzIDjGJJN1emGrbjmgZpkheGyjcYXlJJJm\HWldHnvckBqdiCYZYLvJINmdGy|LDDJSFUxRTBwMt88UU4> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF4Mk[zK|4{ODF4Mk[zQE9iRg>?
HEL MXfBcpRqfmm{YXygZZN{[Xl? MYHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKEdiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h[WejaX7zeEB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9NE4z|ryPLh?= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ6MUKyOUc,OTl{OEGyNlU9N2F-
HEL NWHadWljSW62aY\pdoFtKGG|c3H5 Mmf0N{Bl[Xm| NIPpd3VCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi[3mlbH;2bZIuemW|aYP0ZY51KFSNLXTl[oVkcWWwdDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBucWO{b4Pjc5Bq[yCvZYToc4QtKEWFNUC9NE4z|ryPLh?= MnKyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{OE[5OVIoRjNyMki2PVUzRC:jPh?=
fibroblast cells MkfKSpVv[3Srb36gZZN{[Xl? NFfJWmtKdmirYnn0bY9vKG:oII\pdoFtKGO7dH;wZZRpcWNiZX\m[YN1KGmwIHnu[oVkfGWmIHj1cYFvKG[xcnXzb4lvKG[rYoLvZoxie3RiY3XscEBqdiCvb37vcIF6\XK|IH;mJGhUXi1{IFHEJHZmem9iY3XscJMh[nliNUClMEBGSzVyPUCuNlPPxE1w MmTNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF3OEW0OVcoRjFzNUi1OFU4RC:jPh?=
HEL NWHHT2ZmSW62aY\pdoFtKGG|c3H5 M1fVVmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDBSFE3QSCrbn\lZ5Rm\CCrbjDISWwh[2WubIOsJGVEPTB;MD6yOe69VS5? MnrwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMkixO|goRjJ5MUK4NVc5RC:jPh?=
vero NGrkSHhCdnSrdnnyZYwh[XO|YYm= NHTkWVFKdiC4aYTyc{BidnSrdnnyZYwh[W6mIHHueIlk\WyudXzhdkBi[3Srdnn0fUB4[XNiZY\hcJVifGWmIHHnZYlve3RiaHXydIV{KHOrbYDs[Zghfmm{dYOgTHNXNTFiKF[gd5Rz[WmwKTDpckB3\XKxIHPlcIx{KHSrc4P1[UBkfWy2dYLlMEBKTDVyPUCuN:69VS5? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTl|NkG1K|4zQTl|NkG1QE9iRg>?
HELF NXm0U5pzSW62aY\pdoFtKGG|c3H5 MWC3JIRigXN? M3HC[2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBpfW2jbjDISWxHKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6KGmwY4XiZZRm\CCob4KgO{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVAvO87:TT6= M3i0XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi2PFMzLz5|MUW4Olg{OjxxYU6=
HS27 M4fVfWFvfGm4aYLhcEBie3OjeR?= M1rheFch\GG7cx?= MYLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhcW6oZXP0[YQhcW5iaIXtZY4hUFN{NzDj[YxteyCjZoTldkA4KGSjeYOgZpkhT0[SLXLhd4VlKG[udX;y[ZNk\W62IILl[JVkfGmxbjDhd5NigSxiRVO1NF0xNjN{zszNMi=> NUC1PVhSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOFc6OTFpPkKwNFQ4QTFzPD;hQi=>
HEL NWftbWR{SW62aY\pdoFtKGG|c3H5 M3HReGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDEZZZqeyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;MD6zPO69VS5? M1frTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUGxPFU3Lz5{M{mxNVg2PjxxYU6=
HEL MVPBcpRqfmm{YXygZZN{[Xl? NWTON3F{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGRifmm|IEC3M|EhcW6oZXP0[YQhcW5iSFXMJINmdGy|LDDFR|UxRTBwNN88UU4> M1;pe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUK4NVc5Lz5{N{GyPFE4QDxxYU6=
HEL NXniepVjSW62aY\pdoFtKGG|c3H5 MmC4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbIVzeGW|IIPpcZBt\XhidnnyeZMhOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCkeTDtbYNzd3Olb4DpZ{BidmGueYPpd{whTUN3ME2wMlTPxE1w MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd|OE[1N{c,OzB5M{i2OVM9N2F-
HEL NXLoU2dJSW62aY\pdoFtKGG|c3H5 MnHtRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOSCNT2OgbY4hUEWOIHPlcIx{NCCHQ{WwQVAvPDkQvF2u MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG2Nkc,OTdzOEGxOlI9N2F-
HFF NF;DW5pHfW6ldHnvckBie3OjeR?= M120e2lvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDv[kB1cGViZIL1[{Bi\2GrboP0JJRp\SCleYTvdIF1cGmlIHXm[oVkfCCob4KgRWQyPjlic4TyZYlvKG:oIHXwd5RmcW5iYnHydkB3cXK3cz2yJEhJS02YKTDpckBpfW2jbjDISmYh[2WubIOsJGVEPTB;MD61{txONg>? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85Ozl2OUOzK|45Ozl2OUOzQE9iRg>?
HEL MnL6SpVv[3Srb36gZZN{[Xl? NYfjTW56UW6qaXLpeIlwdiCxZjDoeY1idiCFTW[gSG5CKHO7boTo[ZNqeyCrbjDDUXYucW6oZXP0[YQhUEWOIHPlcIx{NCCLQ{WwQVAvPc7:TT6= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PzV{MkC1K|44PzV{MkC1QE9iRg>?
HEL NInxdm5CdnSrdnnyZYwh[XO|YYm= NF;BVFdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1cHmvaXTpcoUhc2mwYYPlMYRm\mmlaXXueEBi[3mlbH;2bZIuemW|aYP0ZY51KEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME2wMlXPxE1w MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByMUO0OEc,OjZyMEGzOFQ9N2F-
HELF M3m2SWFvfGm4aYLhcEBie3OjeR?= MoXNRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZT3k[YZq[2mnboSgZYN6[2yxdnnyMZJme2m|dHHueEBJfW2jbjDo[ZJx\XO4aYL1d{AyKEuRUzDzeJJicW5iaX7m[YN1\WRiaX6gTGVNTiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OC53zszNMi=> NWm2U4Y1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVg1QDFpPkOwNFk5PDhzPD;hQi=>
Vero NHTufWtCdnSrdnnyZYwh[XO|YYm= MknXN|YhcHK| NIHod4lCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZiMjDpcoZm[3SnZDDpckBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCybHHxeYUh\m:{bXH0bY9vKGmwY4XiZZRm\CCob4KgN|YhcHK|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pIHLhd4VlKGG|c3H5MEBGSzVyPUCuOVjPxE1w MoO3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzJzOUG0OVYoRjN{MUmxOFU3RC:jPh?=
HEL NUj1cZVsSW62aY\pdoFtKGG|c3H5 MUC1JIRigXN? MW\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDWZZJq[2WubHGgfo9{fGW{II\pdpV{KE:NQTDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImgZYZ1\XJiNTDkZZl{NCCHQ{WwQVAvPToQvF2u NYnxSmV7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzN|kxQDJpPkG5N|M6ODh{PD;hQi=>
HEL MXHBcpRqfmm{YXygZZN{[Xl? NYnEU3RqSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiFTW[gSIF3cXNiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPUCuOlbPxE1w M{C4O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HEL Mm\YRY51cX[rcnHsJIF{e2G7 Mo\CRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYN6[2yxdnnyMZJme2m|dHHueEBJS02YIFHENVY6KGOub37lJFEhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTBwNkpOwG0v NGrvfYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyOlE1OCd-MUmyNlYyPDB:L3G+
HEL NELGUJpCdnSrdnnyZYwh[XO|YYm= M1u3VmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJS02YIFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLkhOwG0v MnLMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{Mk[xOFAoRjF7MkK2NVQxRC:jPh?=
Vero NY\tWHZtSW62aY\pdoFtKGG|c3H5 NHfkWGQ{PiC2bzC0PEBpenN? MV\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEZiaX7m[YN1\WRiaX6gZYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDj[YxteyCjc4Pld5Nm\CCjczDwcIFyfWVicnXkeYN1cW:wIHHmeIVzKDN4IITvJFQ5KGi{czygSWM2OD1yLkhOwG0v NVTuSXdkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0N|gxPjFpPkG3OFM5ODZzPD;hQi=>
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fibroblast cells MmPERY51cX[rcnHsJIF{e2G7 NVLMfFlTOSCqb4Xy MYrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhSWRzNkmgLHdVMSCybHHxeYUh\m:{bXnu[{B2dmm2IHfyc5dvKG:wIFj1cYFvKG[xcnXzb4lvKG[rYoLvZoxie3RiY3XscJMhfXCxbjDpcoN2[mG2aX;uJIZweiBzIHjveZIh[XRiM{eg[IVoemWnczDDJJdqfGhiY3;tdI92dmRiZHnzd49tfmWmIHnuJGROW09uIFnDOVA:OC56zszNMi=> NIXjS5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkGzOFk1Pid-MU[xN|Q6PDZ:L3G+
fibroblast cells MlH6RY51cX[rcnHsJIF{e2G7 M2LDR|EhcG:3ch?= NY\QeJpSSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHkNVY6KCiYOEKzRUkheGyjcYXlJIZwem2rbnegeY5qfCCpcn;3ckBwdiCKdX3hckBnd3Knc3vpckBncWK{b3LsZZN1KGOnbHzzJJVxd25iaX7jeYJifGmxbjDmc5IhOSCqb4XyJIF1KDN5IHTl[5Jm\XNiQzD3bZRpKGOxbYDveY5lKGSrc4PvcJZm\CCrbjDEUXNQNCCLQ{WwQVAvQM7:TT6= NED5XnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkGzOFk1Pid-MU[xN|Q6PDZ:L3G+
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HEL NV\ud5MySW62aY\pdoFtKGG|c3H5 MoPXOEBl[Xm| MVrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDhZ5lkdG:4aYKtdoV{cXO2YX70JHRMNWSnZnnjbYVvfCCKZYLw[ZMhe2mvcHzlfEB3cXK3cz2xJGtQWyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIFnfGW{IESg[IF6eyCkeTDtbYNzd3Olb4DpZ{BidmGueYPpd{whTUN3ME2wMljPxE1w M4jOSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkm2PVY{Lz5{MU[5Olk3OzxxYU6=
HEL M4DSbWFvfGm4aYLhcEBie3OjeR?= NVvINFdRSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WO7Y3zveolzNXKnc3nzeIFvfCC2aIntbYRqdmVia3nuZZNmKGSnZnnjbYVvfCCKZYLw[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;MD64{txONg>? MnPLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl6OECyOVEoRjJ7OEiwNlUyRC:jPh?=
HEL MmnjRY51cX[rcnHsJIF{e2G7 MUXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnIHTl[olkcWWwdDDhcoQh[WOrY3zveolzKHKnc3nzeIFvfCCqZYLw[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[nlibXnjdo9{[2:yaXOgZY5idHm|aYOsJGVEPTB;MD64{txONg>? Mn;QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB5M{i2OVMoRjNyN{O4OlU{RC:jPh?=
HELF MYfBcpRqfmm{YXygZZN{[Xl? NVvLN2hxPyCmYYnz MmHMRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCWSz3LU3MuSUOYIHnu[oVkfGWmIHnuJIh2dWGwIFjFUGYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkhcW6ldXLheIVlKG[xcjC3JIRigXNiYomgcYlkem:|Y3;wbYMh[W6jbInzbZMtKEWFNUC9NE45|ryPLh?= MlfRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3OE[4N|IoRjNzNUi2PFMzRC:jPh?=
HEL MYjBcpRqfmm{YXygZZN{[Xl? MX;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{0zKEdiaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuPe69VS5? NX;y[m1TRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5NVE5PTZpPkKzPVEyQDV4PD;hQi=>
CRFK NHryXHNCdnSrdnnyZYwh[XO|YYm= NGW1bppCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBH\WyrbnWgTIVzeGW|II\pdpV{KGmwZnXjeIVlKGmwIHPheEBEWk[NIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDifUBOXFNiYYPzZZktKEWFNUC9NE46|ryPLh?= NHLzUJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mxNVg2Pid-MkO5NVE5PTZ:L3G+
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HEL MYPBcpRqfmm{YXygZZN{[Xl? M3;4TVQh\GG7cx?= NGfzelBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgRWQuOTZ7IHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|IIDsZZF2\SCob4LtZZRqd25iYX\0[ZIhPCCmYYnzMEBGSzVyPUGuOlXPxE1w NVva[m9RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OVk5PzZpPkKyOFU6QDd4PD;hQi=>
HEL MXzBcpRqfmm{YXygZZN{[Xl? NE\HTnY1KGSjeYO= M2LIVGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uJIFnfGW{IESg[IF6eyxiRVO1NF0yNjZ3zszNMi=> NYj5SpRmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OVk5PzZpPkKyOFU6QDd4PD;hQi=>
HFF M4K4PWZ2dmO2aX;uJIF{e2G7 NHLqT2hKdmirYnn0bY9vKG:oIFjDUXYhfG:5bnWgdoVxdGmlYYTpc44hcW5iSF\GJINmdGy|IHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFXDOVA:OS56zszNMi=> MmHUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyMES3NlYoRjF5MEC0O|I3RC:jPh?=
HFF MWTBcpRqfmm{YXygZZN{[Xl? NFfYTFFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhSURzNkmgbY4hUE[IIHPlcIx{KGK7IGDSRUwhUUN3ME2xMlnPxE1w MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB2M{GyPEc,OTdyNEOxNlg9N2F-
HEL NXfyboVjSW62aY\pdoFtKGG|c3H5 MorjO{Bl[Xm| Mke4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PUBqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImgZYZ1\XJiNzDkZZl{KHCxc4TpcoZm[3Srb36sJGVEPTB;Mt88UU4> M3HiWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
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HFF MWXBcpRqfmm{YXygZZN{[Xl? NF3qdW45KGSjeYO= NXTReo5oSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDpcoZm[3SnZDDpckBpfW2jbjDISmYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHP5eI9x[XSqaXOg[YZn\WO2IHHmeIVzKDhiZHH5d{BjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5MEBKSzVyPUKuNe69VS5? MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZyN{i4N{c,OjJ4MEe4PFM9N2F-
HEL M1PJd2FvfGm4aYLhcEBie3OjeR?= Mn7TRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;Mj6x{txONg>? M1nxd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkO5N|Y5Lz5{N{[zPVM3QDxxYU6=
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Vero MmX1RY51cX[rcnHsJIF{e2G7 MXSzJIRigXN? MYTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgWnIuQDB5IHnu[oVkfGWmIHnuJGFnemmlYX6g[5Jm\W5ibX;ub4V6KF[ncn:gZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KE2WVDDhd5NigSxiRVO1NF0zNjF2zszNMi=> M3LuTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NE[wPFg{Lz5{NkS2NFg5OzxxYU6=
HFF NIfKSHpHfW6ldHnvckBie3OjeR?= MWHJcohq[mm2aX;uJI9nKEiFTW[gRWQyPjlicnXwcIlk[XSrb36gbY4hUE[IIHPlcIx{KGK7IFPQSUBqdmirYnn0bY9vKGG|c3H5MEBGSzVyPUKuNu69VS5? NEP1N409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNU[xOVU1PSd-MUW2NVU2PDV:L3G+
HEL M1ziRmFvfGm4aYLhcEBie3OjeR?= MknwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF0zNjJ7zszNMi=> NYPBVI5ERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PFAzPTFpPkK5PFgxOjVzPD;hQi=>
HEL NYDnVmZkSW62aY\pdoFtKGG|c3H5 MnHWOUBl[Xm| NV64b21mSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhXEttIG\aWkB[WyCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{KHCuYYH1[UBnd3KvYYTpc44h[W[2ZYKgOUBl[Xm|LDDFR|UxRTJwM988UU4> M1LnSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkKyNVI5Lz5zN{[yNlEzQDxxYU6=
HELF MVHBcpRqfmm{YXygZZN{[Xl? NU\NOINiPyCmYYnz NYrabHRJSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGRifmm|IHnu[oVkfGWmIHnuJIh2dWGwIFjFUGYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkhcW6ldXLheIVlKG[xcjC3JIRigXNiYomgS4lmdXOjIIP0ZYlvcW6pIHLhd4VlKG2rY4Lvd4NweGmlIHHuZYx6e2m|LDDFR|UxRTJwM988UU4> M33kO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi2PFMzLz5|MUW4Olg{OjxxYU6=
HEL299 M4fDTGFvfGm4aYLhcEBie3OjeR?= NIHSfo84KGSjeYO= M3zyRmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCrbn\lZ5Rm\CCrbjDISWwzQTliY3XscJMh[W[2ZYKgO{Bl[Xm|IHL5JGdHWC2kYYPl[EBndHWxcnXzZ4VvfCC{ZXT1Z5Rqd25iYYPzZZktKEWFNUC9Nk4{Qc7:TT6= M1PUTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMES3PVEyLz5{MEC0O|kyOTxxYU6=
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HFF MkLQRY51cX[rcnHsJIF{e2G7 MlXCRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KFSxd37lJIlv\mWldHXkJIlvKEiIRjDj[YxteyCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6NCCHQ{WwQVIvPc7:TT6= NV[5NYhrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiwPFI1OTBpPkG4NFgzPDFyPD;hQi=>
HEL Mon1RY51cX[rcnHsJIF{e2G7 NX\DW29kPyCmYYnz NHP4UHZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6KGGodHXyJFch\GG7czDwc5N1KGmwZnXjeIlwdixiRVO1NF0zNjYQvF2u NHrvW2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOzPVA5Oid-MUmzN|kxQDJ:L3G+
HEL NY\UU3B7SW62aY\pdoFtKGG|c3H5 NEnRZ|c2KGSjeYO= Mn7rRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZTDk[YZq[2mnboSgWoFzcWOnbHzhJJpwe3SncjD2bZJ2eyByNz:xJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUBi\nSncjC1JIRigXNuIFXDOVA:Oi53zszNMi=> NID1OG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOzPVA5Oid-MUmzN|kxQDJ:L3G+
HFF M1nQbGZ2dmO2aX;uJIF{e2G7 M2P0WGlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHj1cYFvKGO7dH;t[YdidG:4aYL1d{Bz\XCuaXPheIlwdiCrbjDISmYh[2WubIOge4F{KGSndHXycYlv\WRiYomgZ5l1d3CjdHjpZ{Bm\m[nY4SgbY5pcWKrdHnvckBie3OjeTygTWM2OD1{LkdOwG0v MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86PDN6MEG3K|46PDN6MEG3QE9iRg>?
HEL M13UO2FvfGm4aYLhcEBie3OjeR?= NEnYfXRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBnd3OlYYLu[ZQuemW|aYP0ZY51KEiFTW[gRWQyPjliY3zvcoUhSyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;Mj62{txONg>? NVvVNWtjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
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HEL MmLoRY51cX[rcnHsJIF{e2G7 MXq3JIRigXN? NXfxcI5CSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS02YIFTheol{KGmwIHj1cYFvKEiHTDDj[YxteyCjZoTldkA4KGSjeYOsJGVEPTB;Mj62{txONg>? M2XjSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkeyOFQ2Lz5zN{[3NlQ1PTxxYU6=
CRFK NH:zfWZCdnSrdnnyZYwh[XO|YYm= M3S3NWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGZmdGmwZTDo[ZJx\XO4aYL1d{Bqdm[nY4Tl[EBqdiClYYSgR3JHUyClZXzsd{Bie3Onc4Pl[EBieyCycn;0[YN1cW:wIH\yc40hfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDifUBOXFRiYYPzZZktKEWFNUC9Nk43|ryPLh?= Mnm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByM{S3NVEoRjJyMEO0O|EyRC:jPh?=
HFF MXzBcpRqfmm{YXygZZN{[Xl? MnGyRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFPNWkBVOjV2MjD3bZRpKHCxbDDUPFE{WyCvdYThcpQhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1{LkhOwG0v NWLTT4tIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFk1PjhpPkG3O|A6PDZ6PD;hQi=>
HEL NF70TWxCdnSrdnnyZYwh[XO|YYm= M4fn[GFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiRHH2bZMhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPUKuO|XPxE1w NUnSV|VtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1NVg1PTlpPkG3OVE5PDV7PD;hQi=>
HEL MYnBcpRqfmm{YXygZZN{[Xl? M2HEN2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUKuPVbPxE1w NWrUV|dDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVcyODJpPkK4O|U4OTB{PD;hQi=>
BSC-1 MYnBcpRqfmm{YXygZZN{[Xl? NX3OfVV4SW62aY\pdoFtKGGldHn2bZR6KG:oIITo[UBkd22yb4Xu[EB4[XNiZY\hcJVifGWmIHHnZYlve3RidHjlJGhmenCnczDzbY1xdGW6II\pdpV{KHS7cHWtNUBqdiCEU1OtNUBk\WyuczygTWM2OD1|zszNMi=> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF|M{CwK|4zQTF|M{CwQE9iRg>?
MRC5 MlXpSpVv[3Srb36gZZN{[Xl? M{W3d2lvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IFHENVY6KHO2cnHpckBw\iCKQ13WJIlvKE2UQ{WgZ4VtdHNuIFnDOVA:O87:TT6= MknuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF2NUS0OlUoRjFzNEW0OFY2RC:jPh?=
HFF MUnBcpRqfmm{YXygZZN{[Xl? MYrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKFSxd37lJIlvKEiIRjDj[YxteyCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6NCCLQ{WwQVPPxE1w Ml;XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzNkG5OFYoRjF5MU[xPVQ3RC:jPh?=
hhTERT-BJ1 MUHBcpRqfmm{YXygZZN{[Xl? M2nOe|Ih\GG7cx?= Ml2xRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KFSxd37lJIlv\mWldHXkJIlvKGi3bXHuJIhpXEWUVD3CTlEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2eyCvZXTpZZRm\CCGTlGgd5lvfGinc3nzJIFnfGW{IEKg[IF6eyxiRVO1NF0{|ryPLh?= NHjrUVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES1PFEzPCd-MUi0OVgyOjR:L3G+
HEL NUXZN5MzSW62aY\pdoFtKGG|c3H5 NFnrZ4I4KGSjeYO= M{X3b2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1z\XOrc4ThcpQhfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQhUFOYMTDLU3MhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHHmeIVzKDdiZHH5d{whTUN3ME2z{txONg>? NF7pb249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGyPFY3Pid-MkGxNlg3PjZ:L3G+
HFF NFrHbpVCdnSrdnnyZYwh[XO|YYm= NGDVU2gyOCCmYYnz M{TndWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCWb4fu[UBqdm[nY4Tl[EBqdiCKRl[gZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKHCuYYH1[UBnd3KvYYTpc44h[W[2ZYKgNVAh\GG7czygTWM2OD1|zszNMi=> M{ThSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkSxNlE5Lz5{MU[0NVIyQDxxYU6=
HEL NFrzT3BCdnSrdnnyZYwh[XO|YYm= NHHqNVNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgRWQuOTZ7IHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMheGyjcYXlJIZwem2jdHnvckwhTUN3ME2zMlHPxE1w NWnkO4ZMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5NVE5PTZpPkKzPVEyQDV4PD;hQi=>
HEL MV\BcpRqfmm{YXygZZN{[Xl? MX;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjygSWM2OD1|LkJOwG0v M{LNVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkO5N|Y5Lz5{N{[zPVM3QDxxYU6=
HELF MkP0RY51cX[rcnHsJIF{e2G7 MoTPO{Bl[Xm| NGXLVXBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgRWQyPjliaX7m[YN1\WRiaX6gbJVu[W5iSFXMSkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBqdmO3YnH0[YQh\m:{IEeg[IF6eyCkeTDHbYVue2Fic4ThbY5qdmdiYnHz[YQhdWmlcn;zZ49xcWNiYX7hcJl{cXNuIFXDOVA:Oy5zNd88UU4> MkntQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3OE[4N|IoRjNzNUi2PFMzRC:jPh?=
HFF MUHBcpRqfmm{YXygZZN{[Xl? Ml3LRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sg[4Fv[2mlbH;2bZIue2Wwc3n0bZZmKEiFTW[xJIl{d2yjdHWgdoVxdGmlYYTpc44hcW5iSF\GJINmdGy|IHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFnDOVA:Oy5{Mt88UU4> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTBzME[4OEc,OTlyMUC2PFQ9N2F-
HFF MkLLSpVv[3Srb36gZZN{[Xl? MVPDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpeolz[WxiYXP0bZZqfHliYXfhbY5{fCC5aXzkMZR6eGViQVSxOlkhe3S{YXnuJI9nKEiFTW[gbY4hgWmnbHSgdoVlfWO2aX;uJIF{e2G7IIXzbY5oKEiIRjDj[YxteyxiSVO5NF0{NjQQvF2u M{HkZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOEiyN|c1Lz5zMEi4NlM4PDxxYU6=
HEL M2nWSWFvfGm4aYLhcEBie3OjeR?= NUjM[W5CPiC2bzC3JIRigXN? MmTiRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgcYVie3W{ZXSgZYZ1\XJiNjD0c{A4KGSjeYOgdI9{fC2rbn\lZ5Rqd25uIFXDOVA:Oy5|Md88UU4> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ5MEewOUc,Ojl4N{C3NFU9N2F-
MEF NFjM[XlHfW6ldHnvckBie3OjeR?= MWXJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCvdYLpcoUh[3m2b33l[4Ftd3[rcoXzJJJmeGyrY3H0bY9vKGmwIF3FSkBk\WyuczD3ZZMh\GW2ZYLtbY5m\CCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6NCCLQ{WwQVMvPM7:TT6= Mm\JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTR|OECxO{c,QTR|OECxO|ww[T5?
BSC-1 MmrFRY51cX[rcnHsJIF{e2G7 MXTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YuOSBqaHXydIV{KHOrbYDs[Zghfmm{dYOpMEBl\XSncn3pcoVlKGK7IFXMTXNCKGmwIIH1ZYRzfXCuaXPheIUhf2WubIOgeZNqdmdiQmPDMVEh[2WubIOsJGlEPTB;Mz61{txONg>? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3NEc,OTB6OEKzO|A9N2F-
BSC-1 MkThSpVv[3Srb36gZZN{[Xl? MlL2SWxKW0FiYYPzZZkhf2G|IIDldoZwem2nZDD1d4lv\yCEU1OtNUBk\WyuczD0c{Bl\XSncn3pcoUh[WO2aY\peJkh[WejaX7zeEBJW1ZvMTygTWM2OD1|LkZOwG0v M1K2e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOEiyN|czLz5zMEi4NlM4OjxxYU6=
BSC-1 MXLBcpRqfmm{YXygZZN{[Xl? NX33S2pKUW5idnn0do8h[W62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYLUGgeolzfXNiaX6gRnNENTFiKH3vcotmgSCtaXTu[ZkqKGOnbHzzMEBKSzVyPUOuOe69VS5? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86ODV5OE[1K|46ODV5OE[1QE9iRg>?
HEL MnHmRY51cX[rcnHsJIF{e2G7 NYrVTnc3SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhWE2HRFHQMZJme2m|dHHueEBJS02YIFHENVY6KGOub37lJFQhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTNwNd88UU4> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{NkG0NEc,OTl{Mk[xOFA9N2F-
HFF M1;WU2FvfGm4aYLhcEBie3OjeR?= NXfvemh[SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiCWMkSyNEB4cXSqIIDvcEBIQDRzQTDteZRidnRiaX7m[YN1\WRiaX6gTGZHKGOnbHzzJIJ6KFOHQWCgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2zMlXPxE1w NYL1VlExRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFk1PjhpPkG3O|A6PDZ6PD;hQi=>
BSC-1 Mk\ISpVv[3Srb36gZZN{[Xl? NWL2SHp7UW6qaXLpeI9zgSClb37j[Y51emG2aX;uJJJmeXWrcnXkJIFo[Wmwc4SgbIVzeGW|IIPpcZBt\XhidnnyeZMhfHmyZT2xJEhJW1ZvMTmg[ZhxemW|c3XkJIlvKEKVQz2xJINmdGy|IIfhd{Bl\XSncn3pcoVlKGK7IFXMTXNCKGG|c3H5MEBKSzVyPUOuOe69VS5? M4DRUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVc1Lz5zNUWwPVE4PDxxYU6=
BSC-1 MXTGeY5kfGmxbjDhd5NigQ>? NGjBc2xKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgZYdicW6|dDDo[ZJx\XNic3ntdIxmgCC4aYL1d{B1gXCnLUGgLGhUXi1zKTDlfJBz\XO|ZXSgbY4hSlOFLUGgZ4VtdHNid3HzJIRmfGW{bXnu[YQh[nliRVzJV2Eh[XO|YYmsJGlEPTB;Mz61{txONg>? MkHIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3MEmxO|UoRjF3NUC5NVc2RC:jPh?=
BSC-1 M4SxVWZ2dmO2aX;uJIF{e2G7 Mo\2TY5pcWKrdH;yfUBkd26lZX70doF1cW:wIILldZVqemWmIHHnZYlve3RiaHXydIV{KHOrbYDs[Zghfmm{dYOgeJlx\S1zIDjIV3YuOSliZYjwdoV{e2WmIHnuJGJUSy1zIHPlcIx{KHejczDk[ZRmem2rbnXkJIJ6KEWOSWPBJIF{e2G7LDDJR|UxRTNwNd88UU4> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG3Okc,OTV3MEmxO|Y9N2F-
HFF MnrTSpVv[3Srb36gZZN{[Xl? MWjDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpeolz[WxiYXP0bZZqfHliYXfhbY5{fCB{OUG2JGFFOTZ7IIP0doFqdiCxZjDIR21XKGmwIInp[YxlKHKnZIXjeIlwdiCjc4PhfUB2e2mwZzDISmYh[2WubIOsJGlEQTB;Mz62{txONg>? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3OEc,OTB6OEKzO|Q9N2F-
HEL NIi3VGpCdnSrdnnyZYwh[XO|YYm= MWe3JIRigXN? Ml31RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCGYY\pd{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImgZYZ1\XJiNzDkZZl{KHCxc4TpcoZm[3Srb36sJGVEPTB;Mz62{txONg>? NILxSHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyOlE1OCd-MUmyNlYyPDB:L3G+
HFF NVHqfGsySW62aY\pdoFtKGG|c3H5 NXvxZVdOSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiCWMkK1PEB4cXSqIGXMPVchSzV7MlegcZV1[W62IHnu[oVkfGWmIHnuJGhHTiClZXzsd{BjgSCVRVHQJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9N{46|ryPLh?= MnjLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5MEm0OlgoRjF5N{C5OFY5RC:jPh?=
HEL MnvRRY51cX[rcnHsJIF{e2G7 MlrMNkB1dyB|IHThfZM> M4jXO2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3Wt[IVncWOrZX70JGFEXi2{ZYPpd5RidnRiSHXydIV{KHOrbYDs[Zghfmm{dYOgNUBMV1NiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdIxieXWnIH\vdo1ifGmxbjDt[YF{fXKnZDDh[pRmeiB{IITvJFMh\GG7czDwc5N1KGmwZnXjeIlwdixiRVO1NF0{NjlzzszNMi=> M{D1eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUWwO|M1Lz5{OUW1NFc{PDxxYU6=
MRC-5 MULBcpRqcGW{cHXzeolzfXNiYYPzZZk> NIT0V3pKdiC4aYTyc{BidnSraHXydIV{fmm{dYOgZYN1cX[rdImgZYdicW6|dDDNVmMuPSClZXzsd{Bqdm[nY4Tl[EB4cXSqIFjDUXYhMEGGLUG2PUB{fHKjaX6pMEBKSzVyPUVOwG0v MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOzJ|Nke4K|4yOzJ|Nke4QE9iRg>?
HEL MYDBcpRqfmm{YXygZZN{[Xl? MYPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDjbYRw\m:4aYKgTGNOXiCDREG2PUBkdG:wZTC1JIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUwhTUN3ME20{txONg>? NVXrUIp{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
HEL MlHWRY51cX[rcnHsJIF{e2G7 NVi5[mROSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQh[W6mIHHjfYNtd3[rcj3y[ZNqe3SjboSgTHNXOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDygSWM2OD12zszNMi=> MknVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOUmwPVcoRjJ|MEm5NFk4RC:jPh?=
HEL MUTBcpRqfmm{YXygZZN{[Xl? NGO3Nm9CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBVUy2wZXfheIl3\SCKZYLw[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;NN88UU4> M4HNS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEGxNFk{Lz5{M{ixNVA6OzxxYU6=
HEL NFrtPJpCdnSrdnnyZYwh[XO|YYm= M{TRXWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3Wt[IVncWOrZX70JIFkgWOub4\pdk1z\XOrc4ThcpQhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUVOwG0v M2P3OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{WwNVU1Lz5{N{e1NFE2PDxxYU6=
HEL NF\B[o1CdnSrdnnyZYwh[XO|YYm= NXnS[25kSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9OE4xPc7:TT6= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTRyN{m5NEc,Ojl2MEe5PVA9N2F-
HFF NYHHS|Q6TnWwY4Tpc44h[XO|YYm= NEe5UYJEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDhcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDMVQhXG:5bnWgd5Rz[WmwIH;mJGhEVVZiaX6gfYlmdGRicnXkeYN1cW:wIHHzd4F6KHW|aX7nJGhHTiClZXzsd{whUUN3ME20MlHPxE1w MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3OEc,OTB6OEKzO|Q9N2F-
HFF MnrJRY51cX[rcnHsJIF{e2G7 MlLoRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJHQzOjlzIHnuJGhHTiClZXzsd{BjgSCSUlGsJGlEPTB;ND6x{txONg>? M3PlSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MESzNVI5Lz5zN{C0N|EzQDxxYU6=
CRFK Mk\ERY51cX[rcnHsJIF{e2G7 NWSxZ|NwPCCmYYnz M2P0ZWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGZmdGmwZTDo[ZJx\XO4aYL1d{Bqdm[nY4Tl[EBqdiClYYSgR3JHUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhPCCmYYnzJIJ6KGOxbH;ybY1mfHKrYzDmc5Ju[Xqjbj3iZZNm\CCPVGOgZZN{[XluIFXDOVA:PC5zzszNMi=> M2PhVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEW5PFc3Lz5{MkS1PVg4PjxxYU6=
CRFK NYDTfoM1SW62aY\pdoFtKGG|c3H5 M2S5b2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIZmdGmwZTDo[ZJx\XO4aYL1d{Bqdm[nY4Tl[EBqdiClYYSgR3JHUyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCkeTDNWHMh[XO|YYmsJGVEPTB;ND6x{txONg>? M4\4W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEGxNFk{Lz5{M{ixNVA6OzxxYU6=
HEL MmfnRY51cX[rcnHsJIF{e2G7 NYXw[41lSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh\2GwY3njcI93cXJvcnXzbZN1[W62IFjDUXYhSURzNkmgZ4xwdmViNDDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9OE4{|ryPLh?= MlnqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{Mk[xOFAoRjF7MkK2NVQxRC:jPh?=
HEL MVXBcpRqfmm{YXygZZN{[Xl? MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDBR3YuemW|aYP0ZY51KHSqeX3p[Ilv\SCtaX7hd4Uh\GWoaXPp[Y51KEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;ND6z{txONg>? NX\lcIMyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4Nlk6OTNpPkK4PFI6QTF|PD;hQi=>
HFF NYnSOoZ7TnWwY4Tpc44h[XO|YYm= NUDUfIpYS2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\C22eYDlJHRwf26nIIP0doFqdiCxZjDIR21XKGmwIInp[YxlKHKnZIXjeIlwdiCjc4PhfUB2e2mwZzDISmYh[2WubIOsJGlEPTB;ND61{txONg>? NGXhPFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4PCd-MUC4PFI{PzR:L3G+
HEL Mlq5RY51cX[rcnHsJIF{e2G7 MUK3JIRigXN? NVz3[pl3SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGW6cILld5Nm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIIDsZZF2\SCob4LtZZRqd25iaX7jeYJifGWmIH\vdkA4KGSjeYOgZpkhT2mnbYPhJJN1[WmwIHLhd4VlKG2rY4Lvd4NweHluIFXDOVA:PC55Mt88UU4> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ7MUCzPEc,OjZ{OUGwN|g9N2F-
HEL NIjoOHZCdnSrdnnyZYwh[XO|YYm= MUW3JIRigXN? M3[0c2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKHCuYYH1[UBnd3KvYYTpc44h[W[2ZYKgO{Bl[Xm|LDDFR|UxRTRwON88UU4> NXXWbJZ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1N|k3OjJpPkG3OVM6PjJ{PD;hQi=>
HEL M3zKXWFvfGm4aYLhcEBie3OjeR?= NH;obJc{KGSjeYO= NWLp[odmSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDBSFE3QSCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgN{Bl[Xm|LDDFR|UxRTRwON88UU4> M2TzT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OU[xPFUyLz5zN{m2NVg2OTxxYU6=
HEL NXy0d4lVSW62aY\pdoFtKGG|c3H5 NUG1TJJ2PiC2bzC3JIRigXN? NFm0Z5lCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicHzhdZVmKG[xcn3heIlwdiCvZXHzeZJm\CCjZoTldkA3KHSxIEeg[IF6eyCyb4P0JIlv\mWldHnvckwhTUN3ME20Mlg{|ryPLh?= M2jiZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUWwO|M1Lz5{OUW1NFc{PDxxYU6=
MRC5 NHPadYZCdnSrdnnyZYwh[XO|YYm= MXrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWI94dmViaX6gUXJEPSClZXzsd{BjgSCSUlGsJGlEPTB;ND65{txONg>? M{PvdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MESzNVI5Lz5zN{C0N|EzQDxxYU6=
MRC5 Mmq5RY51cX[rcnHsJIF{e2G7 MmLRTY4hfmm2cn:gZY51cX[rcnHsJIFkfGm4aYT5JJdieyCvZXHzeZJm\CCjZ3HpcpN1KEiFTW[oRWQuOTZ7KTDpckBOWkN3IHPlcIx{NCCLREWwQVXPxE1w M4HkbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm4NVEoRjNyMEm4NVE9N2F-
H-1 M{XUeWZ2dmO2aX;uJIF{e2G7 NYjuXo5lTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgeI8hcW6qaXLpeEBGeHO2ZXnuMYJienJidnnyeZMhemWybHnjZZRqd25iaX6gTE0yKGOnbHzzJIlvKESQQTDofYJzcWSrenH0bY9vKGG|c3H5MEBGSzVyPUZOwG0v M3v2SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkO0NFA{Lz5zNU[zOFAxOzxxYU6=
H1 NHjGSGZHfW6ldHnvckBie3OjeR?= NG\6fW9KdmirYnn0bY9vKG:oIFXCWkBz\XCuaXPheIlwdiCrbjDINUBk\WyuczDifUBFVkFiaInidollcXqjdHnvckBie3OjeTygSWM2OD13zszNMi=> NFPTSGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{CwOFczPid-MUewNFQ4OjZ:L3G+
H1 MWXGeY5kfGmxbjDhd5NigQ>? MULJcohq[mm2aX;uJI9nKEWEVjDy[ZBtcWOjdHnvckBqdiCKMTDj[YxteyCkeTDEUmEhcHmkcnnkbZpifGmxbjDhd5NigSxiRVO1NF02|ryPLh?= Mme4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV4MUW1OFUoRjF3NkG1OVQ2RC:jPh?=
CEM MUnDfZRwfG:6aXPpeJkh[XO|YYm= MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBETU1iY3XscJMtKEOFNUC9Oe69VS5? NWTxSoZKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW2NVU2PDVpPkG1OlE2PTR3PD;hQi=>
HFF MVLBcpRqfmm{YXygZZN{[Xl? NIjTTos2KHSxIEeg[IF6ew>? MYTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKGmwZnXjeIVlKEiIRjDj[YxteyCjZoTldkA2KHSxIEeg[IF6eyCkeTD2bZJidCC7aXXs[EBie3OjeTygSWM6QS57PUZOwG0v MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN{OUGwN{c,OTd|MkmxNFM9N2F-
HEL Mk\JRY51cX[rcnHsJIF{e2G7 MkS0O{Bl[Xm| Mk\BRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PUBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36gZYZ1\XJiNzDkZZl{NCCHQ{WwQVUvOc7:TT6= NFfofWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[yNlEzQCd-MUe2NlIyOjh:L3G+
HEL M2TwZ2FvfGm4aYLhcEBie3OjeR?= MoPlO{Bl[Xm| NGXCfYVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFHENVY6N0SjdnnzJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCjZoTldkA4KGSjeYOsJGVEPTB;NT6y{txONg>? NFnXdFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGyPFY3Pid-MkGxNlg3PjZ:L3G+
AKATA MlfkRY51cX[rcnHsJIF{e2G7 MnGwOFghcHK| MUDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDFRnYhcW6oZXP0[YQhcW5iaIXtZY4hSUuDVFGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKEmpRz3pcoR2[2WmIHz5eIlkKH[rcoXzJJJmeGyrY3H0bY9vKG2nYYP1doVlKGG2IES4JIhzeyCyb4P0MYx6fGmlIHnu[JVkfGmxbjDifUByWlRvUFPSJIFv[Wy7c3nzMEBGSzVyPUWuNu69VS5? MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OjF7MUS1Okc,OzJzOUG0OVY9N2F-
MRC5 NE\lNGJCdnSrdnnyZYwh[XO|YYm= NIXnUJBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXDJ{OU[gbY4hVVKFNTDj[YxteyCkeTDQVmEtKEmFNUC9OU41|ryPLh?= M{H0WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MESzNVI5Lz5zN{C0N|EzQDxxYU6=
fibroblast cells M4TMeWFvfGm4aYLhcEBie3OjeR?= MVfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDNeZJqdmViY4n0c41m\2Gub4\pdpV{KGmwZnXjeIVlKGmwIH3veZNmKGWvYoL5c45q[yCoaXLyc4Jt[XO2IHPlcIx{KGK7IIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZktKEWFNUC9OU42|ryPLh?= NWLUPGhzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzPVczPzFpPkG5N|k4OjdzPD;hQi=>
HFF NVLSPFc2SW62aY\pdoFtKGG|c3H5 NEPqbIpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXDJ{OUOgbY4hUE[IIHPlcIx{KGK7IGPFRXAh[XO|YYmsJGlEPTB;NT62{txONg>? MoruQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNEOxNlgoRjF5MESzNVI5RC:jPh?=
HEL M1zyOGFvfGm4aYLhcEBie3OjeR?= NWrJXWVWSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9OU43O87:TT6= M4POdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEC3PVkxLz5{OUSwO|k6ODxxYU6=
NIH 3T3 MWfBcpRqfmm{YXygZZN{[Xl? MYi0JJRwKDViZHH5dy=> Mkf6RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgUZVzcW6nIHP5eI9u\WejbH;2bZJ2eyC|dILhbY4hW22rdHigbY5n\WO2ZXSgbY4hdW:3c3WgUmlJKDOWMzDj[YxteyCjZoTldkA1KHSxIEWg[IF6eyCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6NCCHQ{WwQVUvP87:TT6= MlLWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2NUixNlQoRjF6NEW4NVI1RC:jPh?=
RG2TK+ MmXXR5l1d3SxeHnjbZR6KGG|c3H5 Ml3YO|IhcHK| MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBJW1ZzLYTrJIdmdmVib4\ldoV5eHKnc4PpcochWkd{VFurJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFPDOVA:PS56Nt88UU4> MnnIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6MEC3OlQoRjF6OECwO|Y1RC:jPh?=
MRC-5 MlHlSpVv[3Srb36gZZN{[Xl? NI\Cc2lEd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTD2bZJidCCybHHxeYUh\m:{bXH0bY9vKGK7IFj1cYFvKEO7dH;t[YdidG:4aYL1d{ApUEOPVjmgLJN1emGrbjDBSE0yPjlrIHnuJG1TSy13IHPlcIx{NCCLQ{WwQVUvQc7:TT6= NEKyUVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEm2Olc1OCd-MUC5OlY4PDB:L3G+
HEL NF3tcpNCdnSrdnnyZYwh[XO|YYm= NFy0OZZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDifUB3cXKjbDDDVGUh[XO|YYmsJGVEPTB;NT65{txONg>? MljuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NUiyNlIoRjJ{OEW4NlIzRC:jPh?=
HEL NGXTSlhCdnSrdnnyZYwh[XO|YYm= NILXSpBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgSIF3cXNiaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCybHHxeYUh\m:{bXH0bY9vNCCHQ{WwQVUvQTkQvF2u NXHEb25WRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NVExQTNpPkKzPFEyODl|PD;hQi=>
HCMV AD 169 MXrBcpRqfmm{YXygZZN{[Xl? MkTwTY4hfmm2cn:gZY51cX[rcnHsJIFv\CCjboTpZ4VtdHWuYYKgZYN1cX[rdImge4F{KGW4YXz1ZZRm\CCjZ3HpcpN1KGi3bXHuJIN6fG:vZXfhcI93cXK3czCoTGNOXiCDRDCxOlkqKGmwIDjIR21XKEGGIEG2PUkh[2WubIOsJGlFPTB;Nt88UU4> MkDHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7M{[xOUc,Ojl7M{[xOVww[T5?
HEL NGXTfXVCdnSrdnnyZYwh[XO|YYm= NH;TZ3RCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h[WejaX7zeEB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9Ou69VS5? MoqxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NkW1NVYoRjJzNU[1OVE3RC:jPh?=
HEL MnnERY51cX[rcnHsJIF{e2G7 MkHMN{Bl[Xm| M2TzPGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1z\XOrc4ThcpQhXEtvZHXmbYNq\W62IFjldJJmeyC|aX3wcIV5KH[rcoXzJFEhU0:VIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhOyCmYYnzJIJ6KE2WVDDhd5NigSxiRVO1NF03|ryPLh?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek9EcEWPQlynQmNpTU2ETEyvZV4>
HFF M1zPWGFvfGm4aYLhcEBie3OjeR?= M1;3NGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDDUXYhXDJ5OESge4l1cCCyb3ygRVgxQVZiVVy5O{BEPTl{RzDkc5VjdGVibYX0ZY51KGmwZnXjeIVlKGmwIFjGSkBk\WyuczDifUBUTUGSIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;Nj6x{txONg>? NYn6Wmp5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFk1PjhpPkG3O|A6PDZ6PD;hQi=>
HEL NGTTPG5CdnSrdnnyZYwh[XO|YYm= M4\QNlch\GG7cx?= M4PyTGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBmgHC{ZYPz[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCybHHxeYUh\m:{bXH0bY9vKGmwY4XiZZRm\CCob4KgO{Bl[Xm|IHL5JGdq\W2|YTDzeIFqdiCkYYPl[EBucWO{b4Pjc5B6NCCHQ{WwQVYvOTMQvF2u NYizW3hzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yPVExOzhpPkK2NlkyODN6PD;hQi=>
MRC-5 MVTGeY5kfGmxbjDhd5NigQ>? M3uzWGlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDmc5Ih[W62aT3IR21XKGGldHn2bZR6KGGpYXnud5QhSURvMU[5JJN1emGrbjDpckBOWkNvNTDj[YxteyxiSVO1NF03NjQQvF2u MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QDN4NkGzK|46QDN4NkGzQE9iRg>?
HEL MUTBcpRqfmm{YXygZZN{[Xl? MYrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKEGGMU[5JIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjygSWM2OD14LkROwG0v NILmeWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WxPFQ2QSd-MUe1NVg1PTl:L3G+
HEL NV\Qb4lHSW62aY\pdoFtKGG|c3H5 M1rSOGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDBSE0yPjliaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6NCCHQ{WwQVYvO87:TT6= MlnBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEGzOFQoRjJ4MECxN|Q1RC:jPh?=
HEL NV;uclk1SW62aY\pdoFtKGG|c3H5 NE\QNoU3KHSxIEeg[IF6ew>? MV;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheGyjcYXlJIZwem2jdHnvckBu\WG|dYLl[EBi\nSncjC2JJRwKDdiZHH5d{Bxd3O2IHnu[oVkfGmxbjygSWM2OD14LkS2{txONg>? M4\4ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUWwO|M1Lz5{OUW1NFc{PDxxYU6=
HEL MUfBcpRqfmm{YXygZZN{[Xl? NWPXNIZxPyCmYYnz MYHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDUXYhSURzNkmgbY4hcHWvYX6gTGVNKGOnbHzzJIFnfGW{IEeg[IF6eyxiRVO1NF03NjYQvF2u MnG5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4N{K0OFUoRjF5NkeyOFQ2RC:jPh?=
HEL NH;lb2ZCdnSrdnnyZYwh[XO|YYm= MYDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPU[uOe69VS5? M3PpV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{WwNVU1Lz5{N{e1NFE2PDxxYU6=
HELF MYHBcpRqfmm{YXygZZN{[Xl? NXXhS2t1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KHO2cnHpckBqdm[nY4Tl[EBqdiCKRVzGJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME22MlUz|ryPLh?= M4LjVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm4OFgyLz5|MEC5PFQ5OTxxYU6=
HEL NWL3e5JRSW62aY\pdoFtKGG|c3H5 M2Wx[2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdJJwfGWldHnvckBi\2GrboP0JJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUwhTUN3ME22MlU1|ryPLh?= NYjxPJQ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OlU2OTZpPkKxOVY2PTF4PD;hQi=>
HFF NEDsOYpCdnSrdnnyZYwh[XO|YYm= MkLuRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFPNWkBVOjd7ODD3bZRpKHCxbDDUPFE{WyCXTEm3JGM2QTKJIHTveYJt\SCvdYThcpQhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD14LkdOwG0v MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzdyOUS2PEc,OTd5MEm0Olg9N2F-
HEL Ml74RY51cX[rcnHsJIF{e2G7 Ml3DRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;Nj63Pe69VS5? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd3N{GwNkc,Ojh5NUexNFI9N2F-
HEL NYTqbZBbTnWwY4Tpc44h[XO|YYm= NFXNepJKdmirYnn0bY9vKGGpYXnud5QhTE6DIH;mJJVvcW6oZXP0[YQhUEWOIHPlcIx{KGK7IHnuZ49zeG:{YYTpc44hd2ZiW{PIYXRlWixiSVO1NF04|ryPLh?= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PzV{MkC1K|44PzV{MkC1QE9iRg>?
HFF NFXQXZNCdnSrdnnyZYwh[XO|YYm= MV;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWFIzQTFiaX6gTGZHKGOnbHzzJIJ6KFOHQWCgZZN{[XluIFnDOVA:Py5zzszNMi=> M2HMZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MESzNVI5Lz5zN{C0N|EzQDxxYU6=
HEL M4\COWFvfGm4aYLhcEBie3OjeR?= NITyfVVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:Py5zzszNMi=> Ml;LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3N{i3PFMoRjJ{NUe4O|g{RC:jPh?=
HEL M4PIZWFvfGm4aYLhcEBie3OjeR?= MV7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUeuNe69VS5? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByMUO0OEc,OjZyMEGzOFQ9N2F-
CRFK M3rzemFvfGm4aYLhcEBie3OjeR?= MYOzJIRigXN? MVnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDG[Yxq\CCqZYLw[ZN3cXK3czCxJIlv\mWldHXkJINifCCFUl\LJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIFnfGW{IEOg[IF6eyCkeTDjc4xwemmvZYTybYMh\m:{bXH6ZY4u[mG|ZXSgUXRUKGG|c3H5MEBGSzVyPUeuN:69VS5? MojVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
HEL MlfFRY51cX[rcnHsJIF{e2G7 MWrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCxiRVO1NF04NjQQvF2u M2LmPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEK5PVE{Lz5{OEiyPVkyOzxxYU6=
HFF MlP2RY51cX[rcnHsJIF{e2G7 NV;UcGN{UW5idnn0do8h[W62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjCoWI94dmVic4TyZYlvMSCrbjDISmYhMGi3bXHuJIZq[nKxYnzhd5QqKGOnbHzzMEBKSzVyPUeuOO69VS5? M4rMdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzlyNUe4OlUoRjlyNUe4OlU9N2F-
HFF NFHCeYpHfW6ldHnvckBie3OjeR?= MkX3TY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiaIXtZY4h[3m2b33l[4Ftd3[rcoXzJJJmeGyrY3H0bY9vKGmwIFjGSkBk\WyuczD3ZZMh\GW2ZYLtbY5m\CCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6NCCLQ{WwQVcvPM7:TT6= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86PDN6MEG3K|46PDN6MEG3QE9iRg>?
HFF M1LY[WZ2dmO2aX;uJIF{e2G7 M{nOXGNwdXCxdX7kJJdieyC2ZYP0[YQh\m:{IHHueIl3cXKjbDDhZ5Rqfmm2eTDh[4FqdnO2IGTve45mKHO2cnHpckBw\iCKQ13WJIlvKGFicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUB2e2mwZzDISmYh[2WubIOsJGlEPTB;Nz60{txONg>? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3OEc,OTB6OEKzO|Q9N2F-
HFF NGjteo1HfW6ldHnvckBie3OjeR?= MW\Dc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpeolz[WxiYXP0bZZqfHliYXfhbY5{fCCqdX3hckBkgXSxbXXnZYxwfmm{dYOgLGhEVVZrIHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XlidYPpcochUE[IIHPlcIx{NCCLQ{WwQVcvPM7:TT6= NXr6VnAzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzVpPkGwPFgzOzd3PD;hQi=>
HFF MnHRRY51cX[rcnHsJIF{e2G7 NWrJ[WhWSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfG:5bnWgd5Rz[WmwIFjDUXYhf2G|IHTleIVzdWmwZXSgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTDpckBlfXCuaXPheIUhf2WubIOgeZNqdmdiSF\GJINmdGy|LDDJR|UxRTdwNN88UU4> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3NEc,OTB6OEKzO|A9N2F-
HFF NWe3VolySW62aY\pdoFtKGG|c3H5 MkHmRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiC5YYOg[IV1\XKvaX7l[EBjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5JJV{cW6pIFjGSkBk\WyuczygTWM2OD15LkVOwG0v MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3Nkc,OTB6OEKzO|I9N2F-
HFF MVPGeY5kfGmxbjDhd5NigQ>? NWPxUYFuUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJJJmeXWrcnXkJIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KCiKQ13WLUBmgHC{ZYPz[YQhcW5iSF\GJINmdGy|IIfhd{Bl\XSncn3pcoVlKGK7IIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUC9O{41|ryPLh?= NIfuWnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE4PCd-MUW1NFkyPzR:L3G+
HFF MnjUSpVv[3Srb36gZZN{[Xl? NIftWFJKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhMEiFTW[pJIV5eHKnc4Pl[EBqdiCKRl[gZ4VtdHNid3HzJIRmfGW{bXnu[YQh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME23MlTPxE1w M{PaWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVc2Lz5zNUWwPVE4PTxxYU6=
HFF MXfGeY5kfGmxbjDhd5NigQ>? NFOwUJhKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhMEiFTW[pJIV5eHKnc4Pl[EBqdiCKRl[gZ4VtdHNid3HzJIRmfGW{bXnu[YQh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME23MlTPxE1w NF7WPWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE4Pid-MUW1NFkyPzZ:L3G+
HEL M1n3fmFvfGm4aYLhcEBie3OjeR?= NIHOcJhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiQVStNVY6KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;Nz60{txONg>? MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh{OUmxN{c,Ojh6Mkm5NVM9N2F-
HEL M3jGTmFvfGm4aYLhcEBie3OjeR?= NEjzV4g3KHSxIEeg[IF6ew>? MWfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDt[YF{fXKnZDDh[pRmeiB4IITvJFch\GG7czDwc5N1NWmwZnXjeIlwdixiRVO1NF04NjRzzszNMi=> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ5MEewOUc,Ojl4N{C3NFU9N2F-
HEL MUHBcpRqfmm{YXygZZN{[Xl? Mmj1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVcvPc7:TT6= NXnGbGVzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1O|g4QDNpPkKyOVc5Pzh|PD;hQi=>
HFF NFLNcWRCdnSrdnnyZYwh[XO|YYm= NEjFSWNCdnSrdnnyZYwh[WO2aY\peJkhf2G|IHTleIVzdWmwZXSgZpkhfGinIFjDUXYheGyjcYXlJIF{e2G7IIXzbY5oKEiIRjDj[YxteyxiSVO1NF04NjgQvF2u MlfEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTB3N{i2Okc,QTB3N{i2Olww[T5?
HEL MXjBcpRqfmm{YXygZZN{[Xl? M1;MNmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcnHsJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;Nz64{txONg>? M4j4VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NESzOVUxLz5{NkS0N|U2ODxxYU6=
HEL M{LZbmFvfGm4aYLhcEBie3OjeR?= NIe2c3ZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgRWQuOTZ7IHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZicHzhdZVmKG[xcn3heIlwdixiRVO1NF04Njh5zszNMi=> MoPHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MUGwPVMoRjJ|OEGxNFk{RC:jPh?=
CRFK MV;BcpRqfmm{YXygZZN{[Xl? M{THW2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGZmdGmwZTDo[ZJx\XO4aYL1d{Bqdm[nY4Tl[EBqdiCFUl\LJINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h[WejaX7zeEB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9PE4y|ryPLh?= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV4NUWxOkc,OjF3NkW1NVY9N2F-
HEL MWLBcpRqfmm{YXygZZN{[Xl? NYftN41HSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gR5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTDh[pRmeixiRVO1NF05NjMQvF2u NES0Z2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mxNVg2PCd-MkO5NVE5PTR:L3G+
HFF M2jyOWZ2dmO2aX;uJIF{e2G7 NYjQfphiUW5idnn0do8hcW6qaXLpeIlwdiCxZjDoeY1idiCleYTvcYVo[WyxdnnyeZMhcW5iSF\GJINmdGy|IHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFnDOVA:QC52zszNMi=> NWf0S21VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxQ3jFUWJNLz6FaFXNRmw9N2F-
HFF MV3BcpRqfmm{YXygZZN{[Xl? M1ixXWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDDUXYhOjhzNzD3bZRpKHCxbDDHPFQySSCXTEm3JGM2QTKJIHTveYJt\SCvdYThcpQhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD16LkVOwG0v MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzdyOUS2PEc,OTd5MEm0Olg9N2F-
HEL NWfRVWZsSW62aY\pdoFtKGG|c3H5 NXr1UYFYPyCmYYnz MUXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKESjdnnzJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjDh[pRmeiB5IHThfZMtKEWFNUC9PE44|ryPLh?= NHqyO4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[yNlEzQCd-MUe2NlIyOjh:L3G+
HEL MmGyRY51cX[rcnHsJIF{e2G7 MlG1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;OD63{txONg>? MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ6MkC2O{c,Ojh4OEKwOlc9N2F-
HEL NIPFXopCdnSrdnnyZYwh[XO|YYm= NWfrUoVKSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQh[W6mIHHjfYNtd3[rcjDy[ZNqe3SjboSgTHNXOSCNT2OgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHC{b4TlZ5Rqd25iYXfhbY5{fCC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:Qc7:TT6= NGHidmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUK4NVIzPSd-MUmyPFEzOjV:L3G+
HEL MkHPRY51cX[rcnHsJIF{e2G7 MXLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCkeTD2bZJidCCFUFWgZZN{[XluIFXDOVA:QS5zzszNMi=> M{XXdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEW4NlIzLz5{Mki1PFIzOjxxYU6=
MRC-5 MVTGeY5kfGmxbjDhd5NigQ>? MW\Jcohq[mm2b4L5JIFkfGm4aYT5JI9nKGOxbYDveY5lKGGpYXnud5QhcHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IDjIR21XMSCrbjDNVmMuPSClZXzsd{whTUN3ME25MlTPxE1w MlOwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ5MkO5OVEoRjF{N{KzPVUyRC:jPh?=
Vero MkLBRY51cX[rcnHsJIF{e2G7 MXzJckB3cXS{bzDhcpRqfmm{YXygZYN1cX[rdImge4F{KG2nYYP1doVlKGGpYXnud5QhUFOYLUGgLGYh\GWudHGgN|A2MSCrbjDW[ZJwKGOnbHzzMEBKTDVyPUGw{txONg>? Mn3JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOUixNUc,OzByOUixNVww[T5?
HFF NV;wS|JjSW62aY\pdoFtKGG|c3H5 NFy5RoJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXDJ{OUOgbY4hUE[IIHPlcIx{KGK7IGDSRUwhUUN3ME2xNO69VS5? NGnhU2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C0N|EzQCd-MUewOFMyOjh:L3G+
Vero NULQZ5JsSW62aY\pdoFtKGG|c3H5 MmK3N{Bl[Xm| NFrlc|BCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBX[XKrY3XscIEugm:|dHXyJJZqenW|IFXscIVvKF[ULUGzOlchcW6oZXP0[YQhcW5iQX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBGSzVyPUGxMlHPxE1w NED6PJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS2NFg5Oyd-Mk[0OlA5QDN:L3G+
HEL MmXWRY51cX[rcnHsJIF{e2G7 MWTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVEyNjR|zszNMi=> NUPoOFJyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PFAzPTFpPkK5PFgxOjVzPD;hQi=>
HELF NXLNS4pISW62aY\pdoFtKGG|c3H5 NYrX[5oySW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KHO2cnHpckBqdm[nY4Tl[EBqdiCKRVzGJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME2xNU44Pc7:TT6= NIT6XYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFQ5OSd-M{CwPVg1QDF:L3G+
HFF MkXRRY51cX[rcnHsJIF{e2G7 NILVT3BCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXDJ|MUGgbY4hUE[IIHPlcIx{KGK7IGDSRUwhUUN3ME2xNk41|ryPLh?= M1HMU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MESzNVI5Lz5zN{C0N|EzQDxxYU6=
HEL NU\GcHRXSW62aY\pdoFtKGG|c3H5 NULJTGx2PyCmYYnz NIjXSXVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6KGGodHXyJFch\GG7czDwc5N1KGmwZnXjeIlwdixiRVO1NF0yOi54zszNMi=> NF3oboM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOzPVA5Oid-MUmzN|kxQDJ:L3G+
HEL MnfiRY51cX[rcnHsJIF{e2G7 MoHFRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXygdIxieXWnIH\vdo1ifGmxbjygSWM2OD1zMz65{txONg>? MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR2M{W1NEc,OjZ2NEO1OVA9N2F-
Vero MkP3RY51cX[rcnHsJIF{e2G7 MU[zOkB1dyB2ODDodpM> NHXFd3VCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgRkB3cXK3czCyOFExPSCrbn\lZ5Rm\CCrbjDh[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIHPlcIx{KGG|c3Xzd4VlKGG|IIDsZZF2\SC{ZXT1Z5Rqd25iYX\0[ZIhOzZidH:gOFghcHK|LDDFR|UxRTF2LkZOwG0v MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR|OEC2NUc,OTd2M{iwOlE9N2F-
HEL MX\BcpRqfmm{YXygZZN{[Xl? NFvieopCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1cHmvaXTpcoUhc2mwYYPlJI5m\2G2aY\lJIFv\CCDQ2[gdoV{cXO2YX70JGhUXjFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCkeTD2bZJidCCFUFWgZZN{[XluIFXDOVA:OTRwN988UU4> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh3OEKyNkc,OjJ6NUiyNlI9N2F-
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Assay
Methods Test Index PMID
Growth inhibition assay Cell viability 29845211
体内研究 抗病毒药物ganciclovir (GCV)在实验性自身免疫性脑脊髓炎模型中抑制小神经胶质的增殖。GCV减轻神经炎症,而且并不显著抑制外周免疫反应[7]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[7]

  • Cell lines: BV-2 cells 
  • Concentrations: --
  • Incubation Time: 24 h
  • Method:

    将总量为2 × 10<sup>4</sup>的BV-2细胞接种于96孔板,置于含10%FBS的DMEM中培养12小时、然后血清饥饿12小时,加入不同浓度的GCV进行处理,处理24小时。在处理期间的最后8小时,将1 µCi/孔的[3H]thymidine通过脉冲加入到培养基中。最后通过β plate scintillation counter检测掺入的放射性。

动物实验:

[7]

  • Animal Models: C57BL/6小鼠
  • Dosages: 100 mg/kg
  • Administration: i.p.

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
4% DMSO+30% PEG 300+ddH2O

2mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 255.23
化学式

C9H13N5O4

CAS号 82410-32-0
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04706507 Recruiting Drug: IV Ganciclovir Acute Respiratory Failure Fred Hutchinson Cancer Center|National Heart Lung and Blood Institute (NHLBI) June 29 2021 Phase 3
NCT04478474 Unknown status Drug: Ganciclovir Cytomegalovirus Infections New York Medical College|Merck Sharp & Dohme LLC September 15 2020 --
NCT03698435 Unknown status Drug: Ganciclovir|Drug: Valganciclovir Cytomegalovirus Infections University Medical Center Groningen May 25 2018 --
NCT02606266 Terminated Drug: Valganciclovir Congenital Cytomegalovirus (CMV) Assistance Publique - Hôpitaux de Paris July 11 2017 Phase 2|Phase 3
NCT03088553 Unknown status Drug: Therapeutic Drug Monitoring Solid Organ Transplantation Rennes University Hospital February 22 2017 --
NCT02943057 Recruiting Drug: 2% guttae ganciclovir Cytomegalovirus Infections Singapore National Eye Centre October 2016 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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