CMV

抑制剂选择性比较

CMV产品

目录号 产品描述 文献引用 实验数据
S1516

Cidofovir

Cidofovir (HPMPC) 通过选择性抑制病毒DNA的合成而抑制病毒复制。

S1878

Ganciclovir

Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine)是一种抗病毒药,作用于猫科动物1型疱疹病毒,无细胞试验中IC50为5.2 μM。

S1299

Floxuridine

Floxuridine (Deoxyfluorouridine, FUDR, NSC 27640) 是一种前体药物,在体内可迅速分解为5-fluorouracil。Floxuridine 可用于治疗各种癌症,特别是转移到肝脏的癌症。Floxuridine 可抑制 Poly(ADP-Ribose) polymerase、诱导DNA损伤和凋亡。Floxuridine 对HSV和CMV具有抗病毒作用。

S4050

Valganciclovir HCl

Valganciclovir HCl是一种ganciclovir 的前体药物,具有抗病毒活性,用于治疗巨细胞病毒感染。

S7296

ML324

ML324是一种选择性的jumonji histone demethylase (JMJD2)抑制剂, 其对JMJD2E的IC50为920 nM。

S4454New

FIT-039

FIT-039 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9), suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription.

S0754New

Bisindolylmaleimide IV

Bisindolylmaleimide IV (Arcyriarubin A) is a potent inhibitor of protein kinase C (PKC) with IC50 ranging from 0.1 μM to 0.55 μM. Bisindolylmaleimide IV inhibits PKA with IC50 ranging from 3.1μM to 11.8μM. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with IC50 of 0.2 μM.

S8873

Letermovir (AIC246)

Letermovir (AIC246, MK-8228)是新型的anti-CMV化合物,靶向病毒末端酶复合体,对DNA聚合酶抑制剂具有抗性的病毒也具有活性。

S5065

Ganciclovir sodium

Ganciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) 是ganciclovir的钠盐形式,ganciclovir 是一种合成的抗病毒嘌呤核苷类似物,具有抗病毒活性,尤其是针对巨细胞病毒(CMV)。

S7889

Xanthohumol

Xanthohumol,来自啤酒花的一种异戊烯化查耳酮,抑制COX-1和COX-2活性,并表现出化学预防作用。Xanthohumol 可抑制 diacylglycerol acyltransferase 1 (DGAT1)DGAT2,对应的IC50值均为40 μM。Xanthohumol 也是一种有效的针对一系列DNA和RNA病毒的抗病毒药剂。Xanthohumol 在肿瘤细胞中可诱导生长阻滞和凋亡。Phase 1。

S5009

Brivudine

Brivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.

目录号 产品描述 文献引用 实验数据
S1516

Cidofovir

Cidofovir (HPMPC) 通过选择性抑制病毒DNA的合成而抑制病毒复制。

S1878

Ganciclovir

Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine)是一种抗病毒药,作用于猫科动物1型疱疹病毒,无细胞试验中IC50为5.2 μM。

S1299

Floxuridine

Floxuridine (Deoxyfluorouridine, FUDR, NSC 27640) 是一种前体药物,在体内可迅速分解为5-fluorouracil。Floxuridine 可用于治疗各种癌症,特别是转移到肝脏的癌症。Floxuridine 可抑制 Poly(ADP-Ribose) polymerase、诱导DNA损伤和凋亡。Floxuridine 对HSV和CMV具有抗病毒作用。

S4050

Valganciclovir HCl

Valganciclovir HCl是一种ganciclovir 的前体药物,具有抗病毒活性,用于治疗巨细胞病毒感染。

S7296

ML324

ML324是一种选择性的jumonji histone demethylase (JMJD2)抑制剂, 其对JMJD2E的IC50为920 nM。

S4454New

FIT-039

FIT-039 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9), suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription.

S0754New

Bisindolylmaleimide IV

Bisindolylmaleimide IV (Arcyriarubin A) is a potent inhibitor of protein kinase C (PKC) with IC50 ranging from 0.1 μM to 0.55 μM. Bisindolylmaleimide IV inhibits PKA with IC50 ranging from 3.1μM to 11.8μM. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with IC50 of 0.2 μM.

S8873

Letermovir (AIC246)

Letermovir (AIC246, MK-8228)是新型的anti-CMV化合物,靶向病毒末端酶复合体,对DNA聚合酶抑制剂具有抗性的病毒也具有活性。

S5065

Ganciclovir sodium

Ganciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) 是ganciclovir的钠盐形式,ganciclovir 是一种合成的抗病毒嘌呤核苷类似物,具有抗病毒活性,尤其是针对巨细胞病毒(CMV)。

S7889

Xanthohumol

Xanthohumol,来自啤酒花的一种异戊烯化查耳酮,抑制COX-1和COX-2活性,并表现出化学预防作用。Xanthohumol 可抑制 diacylglycerol acyltransferase 1 (DGAT1)DGAT2,对应的IC50值均为40 μM。Xanthohumol 也是一种有效的针对一系列DNA和RNA病毒的抗病毒药剂。Xanthohumol 在肿瘤细胞中可诱导生长阻滞和凋亡。Phase 1。

S5009

Brivudine

Brivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.