CMV
抑制剂选择性比较
特异性亚型抑制剂
CMV产品
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1516 |
CidofovirCidofovir (HPMPC) 通过选择性抑制病毒DNA的合成而抑制病毒复制。 |
The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir. |
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| S1878 |
Ganciclovir (BW 759)Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine)是一种抗病毒药，作用于猫科动物1型疱疹病毒，无细胞试验中IC50为5.2 μM。 |
Effect of ganciclovir on viral DNA accumulation (A,B) and induction of TGF-β1 production after human cytomegalovirus infection in human trabecular meshwork cells (C). Cells were harvested at 5 day post-infection at a high multiplicity of infection (MOI 1) under the treatment with different concentrations of ganciclovir (GAN). Treatment with 10 μmol of ganciclovir significantly decreased the viral DNA accumulation (p < 0.001) (A,B). However, treatment with ganciclovir did not affect the TGF-β production using a TGF-β1 luciferase bioassay. Results are expressed as the mean +/− standard deviation of three different experiments.
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| S1299 |
Floxuridine (NSC 27640)Floxuridine (NSC 27640, Deoxyfluorouridine, FUDR) 是一种前体药物，在体内可迅速分解为5-fluorouracil。Floxuridine 可用于治疗各种癌症，特别是转移到肝脏的癌症。Floxuridine 可抑制 Poly(ADP-Ribose) polymerase、诱导DNA损伤和凋亡。Floxuridine 对HSV和CMV具有抗病毒作用。 |
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| S4050 |
Valganciclovir HClValganciclovir HCl是一种ganciclovir 的前体药物，具有抗病毒活性，用于治疗巨细胞病毒感染。 |
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| S7296 |
ML324ML324是一种选择性的jumonji histone demethylase (JMJD2)抑制剂， 其对JMJD2E的IC50为920 nM。 |
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| S0754 |
Bisindolylmaleimide IVBisindolylmaleimide IV (Arcyriarubin A, BIM IV, Compound 5/1a) 是一种有效的 protein kinase C (PKC) 的抑制剂，其IC50值为0.55 μM。Bisindolylmaleimide IV 也可抑制 PKA，对应的IC50值为11.8 μM。 Bisindolylmaleimide IV 是一种有效的、选择性的细胞培养中针对人巨细胞病毒 human cytomegalovirus (HCMV) 复制的抑制剂，IC50值为0.2 μM。 |
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| S8873 |
Letermovir (AIC246)Letermovir (AIC246, MK-8228)是新型的anti-CMV化合物，靶向病毒末端酶复合体，对DNA聚合酶抑制剂具有抗性的病毒也具有活性。 |
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| S4454 |
FIT-039FIT-039 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9), suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription. |
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| S5065 |
Ganciclovir sodiumGanciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) 是ganciclovir的钠盐形式，ganciclovir 是一种合成的抗病毒嘌呤核苷类似物，具有抗病毒活性，尤其是针对巨细胞病毒(CMV)。 |
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| S7889 |
XanthohumolXanthohumol，来自啤酒花的一种异戊烯化查耳酮，抑制COX-1和COX-2活性，并表现出化学预防作用。Xanthohumol 可抑制 diacylglycerol acyltransferase 1 (DGAT1) 和 DGAT2，对应的IC50值均为40 μM。Xanthohumol 也是一种有效的针对一系列DNA和RNA病毒的抗病毒药剂。Xanthohumol 在肿瘤细胞中可诱导生长阻滞和凋亡。Phase 1。 |
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| S5009 |
BrivudineBrivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication. |
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1516 |
CidofovirCidofovir (HPMPC) 通过选择性抑制病毒DNA的合成而抑制病毒复制。 |
The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir. |
|
| S1878 |
Ganciclovir (BW 759)Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine)是一种抗病毒药，作用于猫科动物1型疱疹病毒，无细胞试验中IC50为5.2 μM。 |
Effect of ganciclovir on viral DNA accumulation (A,B) and induction of TGF-β1 production after human cytomegalovirus infection in human trabecular meshwork cells (C). Cells were harvested at 5 day post-infection at a high multiplicity of infection (MOI 1) under the treatment with different concentrations of ganciclovir (GAN). Treatment with 10 μmol of ganciclovir significantly decreased the viral DNA accumulation (p < 0.001) (A,B). However, treatment with ganciclovir did not affect the TGF-β production using a TGF-β1 luciferase bioassay. Results are expressed as the mean +/− standard deviation of three different experiments.
|
|
| S1299 |
Floxuridine (NSC 27640)Floxuridine (NSC 27640, Deoxyfluorouridine, FUDR) 是一种前体药物，在体内可迅速分解为5-fluorouracil。Floxuridine 可用于治疗各种癌症，特别是转移到肝脏的癌症。Floxuridine 可抑制 Poly(ADP-Ribose) polymerase、诱导DNA损伤和凋亡。Floxuridine 对HSV和CMV具有抗病毒作用。 |
||
| S4050 |
Valganciclovir HClValganciclovir HCl是一种ganciclovir 的前体药物，具有抗病毒活性，用于治疗巨细胞病毒感染。 |
||
| S7296 |
ML324ML324是一种选择性的jumonji histone demethylase (JMJD2)抑制剂， 其对JMJD2E的IC50为920 nM。 |
||
| S0754 |
Bisindolylmaleimide IVBisindolylmaleimide IV (Arcyriarubin A, BIM IV, Compound 5/1a) 是一种有效的 protein kinase C (PKC) 的抑制剂，其IC50值为0.55 μM。Bisindolylmaleimide IV 也可抑制 PKA，对应的IC50值为11.8 μM。 Bisindolylmaleimide IV 是一种有效的、选择性的细胞培养中针对人巨细胞病毒 human cytomegalovirus (HCMV) 复制的抑制剂，IC50值为0.2 μM。 |
||
| S8873 |
Letermovir (AIC246)Letermovir (AIC246, MK-8228)是新型的anti-CMV化合物，靶向病毒末端酶复合体，对DNA聚合酶抑制剂具有抗性的病毒也具有活性。 |
||
| S4454 |
FIT-039FIT-039 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9), suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription. |
||
| S5065 |
Ganciclovir sodiumGanciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) 是ganciclovir的钠盐形式，ganciclovir 是一种合成的抗病毒嘌呤核苷类似物，具有抗病毒活性，尤其是针对巨细胞病毒(CMV)。 |
||
| S7889 |
XanthohumolXanthohumol，来自啤酒花的一种异戊烯化查耳酮，抑制COX-1和COX-2活性，并表现出化学预防作用。Xanthohumol 可抑制 diacylglycerol acyltransferase 1 (DGAT1) 和 DGAT2，对应的IC50值均为40 μM。Xanthohumol 也是一种有效的针对一系列DNA和RNA病毒的抗病毒药剂。Xanthohumol 在肿瘤细胞中可诱导生长阻滞和凋亡。Phase 1。 |
||
| S5009 |
BrivudineBrivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication. |
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