CMV

抑制剂选择性比较

CMV产品

所有产品(11) CMV抑制剂(11)

目录号	产品描述	文献引用	实验数据
S1516	Cidofovir Cidofovir (HPMPC) 通过选择性抑制病毒DNA的合成而抑制病毒复制。	Nat Biotechnol, 2019, 37(3):303-313 J Virol, 2019, 93(4) Antiviral Res, 2019, 162:178-185	The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir.
S1878	Ganciclovir Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine)是一种抗病毒药，作用于猫科动物1型疱疹病毒，无细胞试验中IC50为5.2 μM。	J Cell Physiol, 2021, 10.1002/jcp.30231 Sci Adv, 2020, 6(49)eabd9443 Mol Cancer Ther, 2020, 19(3):966-971	Effect of ganciclovir on viral DNA accumulation (A,B) and induction of TGF-β1 production after human cytomegalovirus infection in human trabecular meshwork cells (C). Cells were harvested at 5 day post-infection at a high multiplicity of infection (MOI 1) under the treatment with different concentrations of ganciclovir (GAN). Treatment with 10 μmol of ganciclovir significantly decreased the viral DNA accumulation (p < 0.001) (A,B). However, treatment with ganciclovir did not affect the TGF-β production using a TGF-β1 luciferase bioassay. Results are expressed as the mean +/− standard deviation of three different experiments.
S1299	Floxuridine Floxuridine (Deoxyfluorouridine, FUDR, NSC 27640) 是一种前体药物，在体内可迅速分解为5-fluorouracil。Floxuridine 可用于治疗各种癌症，特别是转移到肝脏的癌症。Floxuridine 可抑制 Poly(ADP-Ribose) polymerase、诱导DNA损伤和凋亡。Floxuridine 对HSV和CMV具有抗病毒作用。	Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00425-8 Hum Cell, 2020, 10.1007/s13577-020-00420-z
S4050	Valganciclovir HCl Valganciclovir HCl是一种ganciclovir 的前体药物，具有抗病毒活性，用于治疗巨细胞病毒感染。	bioRxiv, 2020, 2020.08.12.246389 Transl Res, 2016, 177:113-126
S7296	ML324 ML324是一种选择性的jumonji histone demethylase (JMJD2)抑制剂，其对JMJD2E的IC50为920 nM。	ACS Infect Dis, 2020, 8;6(5):1058-1075 Oncogene, 2019, 38(28):5643-5657 Cancer Res, 2018, 78(20):5731-5740
S4454^New	FIT-039 FIT-039 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9), suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription.
S0754^New	Bisindolylmaleimide IV Bisindolylmaleimide IV (Arcyriarubin A) is a potent inhibitor of protein kinase C (PKC) with IC50 ranging from 0.1 μM to 0.55 μM. Bisindolylmaleimide IV inhibits PKA with IC50 ranging from 3.1μM to 11.8μM. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with IC50 of 0.2 μM.
S8873	Letermovir (AIC246) Letermovir (AIC246, MK-8228)是新型的anti-CMV化合物，靶向病毒末端酶复合体，对DNA聚合酶抑制剂具有抗性的病毒也具有活性。	bioRxiv, 2020, 2020.08.12.246389
S5065	Ganciclovir sodium Ganciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) 是ganciclovir的钠盐形式，ganciclovir 是一种合成的抗病毒嘌呤核苷类似物，具有抗病毒活性，尤其是针对巨细胞病毒(CMV)。	Sci Adv, 2020, 6(49)eabd9443 Neuroendocrinology, 2019,
S7889	Xanthohumol Xanthohumol，来自啤酒花的一种异戊烯化查耳酮，抑制COX-1和COX-2活性，并表现出化学预防作用。Xanthohumol 可抑制 diacylglycerol acyltransferase 1 (DGAT1) 和 DGAT2，对应的IC50值均为40 μM。Xanthohumol 也是一种有效的针对一系列DNA和RNA病毒的抗病毒药剂。Xanthohumol 在肿瘤细胞中可诱导生长阻滞和凋亡。Phase 1。	J-Cancer, 2020, 6;11-14-:4047-4058 Oncol Rep, 2020, 44(4):1365-1374 Int J Biol Sci, 2019, 15(11):2497-2508
S5009	Brivudine Brivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.

目录号	产品描述	文献引用	实验数据
S1516	Cidofovir Cidofovir (HPMPC) 通过选择性抑制病毒DNA的合成而抑制病毒复制。	Nat Biotechnol,2019, 37(3):303-313 J Virol,2019, 93(4) Antiviral Res,2019, 162:178-185	The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir.
S1878	Ganciclovir Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine)是一种抗病毒药，作用于猫科动物1型疱疹病毒，无细胞试验中IC50为5.2 μM。	J Cell Physiol,2021, 10.1002/jcp.30231 Sci Adv,2020, 6(49)eabd9443 Mol Cancer Ther,2020, 19(3):966-971	Effect of ganciclovir on viral DNA accumulation (A,B) and induction of TGF-β1 production after human cytomegalovirus infection in human trabecular meshwork cells (C). Cells were harvested at 5 day post-infection at a high multiplicity of infection (MOI 1) under the treatment with different concentrations of ganciclovir (GAN). Treatment with 10 μmol of ganciclovir significantly decreased the viral DNA accumulation (p < 0.001) (A,B). However, treatment with ganciclovir did not affect the TGF-β production using a TGF-β1 luciferase bioassay. Results are expressed as the mean +/− standard deviation of three different experiments.
S1299	Floxuridine Floxuridine (Deoxyfluorouridine, FUDR, NSC 27640) 是一种前体药物，在体内可迅速分解为5-fluorouracil。Floxuridine 可用于治疗各种癌症，特别是转移到肝脏的癌症。Floxuridine 可抑制 Poly(ADP-Ribose) polymerase、诱导DNA损伤和凋亡。Floxuridine 对HSV和CMV具有抗病毒作用。	Cancer Cell Int,2020, 19;20:58 Hum Cell,2020, 10.1007/s13577-020-00425-8 Hum Cell,2020, 10.1007/s13577-020-00420-z
S4050	Valganciclovir HCl Valganciclovir HCl是一种ganciclovir 的前体药物，具有抗病毒活性，用于治疗巨细胞病毒感染。	bioRxiv,2020, 2020.08.12.246389 Transl Res,2016, 177:113-126
S7296	ML324 ML324是一种选择性的jumonji histone demethylase (JMJD2)抑制剂，其对JMJD2E的IC50为920 nM。	ACS Infect Dis,2020, 8;6(5):1058-1075 Oncogene,2019, 38(28):5643-5657 Cancer Res,2018, 78(20):5731-5740
S4454^New	FIT-039 FIT-039 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9), suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription.
S0754^New	Bisindolylmaleimide IV Bisindolylmaleimide IV (Arcyriarubin A) is a potent inhibitor of protein kinase C (PKC) with IC50 ranging from 0.1 μM to 0.55 μM. Bisindolylmaleimide IV inhibits PKA with IC50 ranging from 3.1μM to 11.8μM. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with IC50 of 0.2 μM.
S8873	Letermovir (AIC246) Letermovir (AIC246, MK-8228)是新型的anti-CMV化合物，靶向病毒末端酶复合体，对DNA聚合酶抑制剂具有抗性的病毒也具有活性。	bioRxiv,2020, 2020.08.12.246389
S5065	Ganciclovir sodium Ganciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) 是ganciclovir的钠盐形式，ganciclovir 是一种合成的抗病毒嘌呤核苷类似物，具有抗病毒活性，尤其是针对巨细胞病毒(CMV)。	Sci Adv,2020, 6(49)eabd9443 Neuroendocrinology,2019,
S7889	Xanthohumol Xanthohumol，来自啤酒花的一种异戊烯化查耳酮，抑制COX-1和COX-2活性，并表现出化学预防作用。Xanthohumol 可抑制 diacylglycerol acyltransferase 1 (DGAT1) 和 DGAT2，对应的IC50值均为40 μM。Xanthohumol 也是一种有效的针对一系列DNA和RNA病毒的抗病毒药剂。Xanthohumol 在肿瘤细胞中可诱导生长阻滞和凋亡。Phase 1。	J-Cancer,2020, 6;11-14-:4047-4058 Oncol Rep,2020, 44(4):1365-1374 Int J Biol Sci,2019, 15(11):2497-2508
S5009	Brivudine Brivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.