Cidofovir

For research use only. Not for use in humans.

目录号:S1516 别名: HPMPC

Cidofovir Chemical Structure

CAS No. 113852-37-2

Cidofovir (HPMPC) 通过选择性抑制病毒DNA的合成而抑制病毒复制。

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客户使用Selleck生产的Cidofovir发表文献8篇:

客户使用该产品的2个实验数据:

  • The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir.

    Viruses 2015, 7, 2268-2287. . Cidofovir purchased from Selleck.

    Triptolide reduces lytic and latent replication of KSHV in BCBL-1 cells. Uninduced and induced BCBL-1 cells were treated with vehicle control or indicated concentrations of triptolide for 48 h. The whole cell supernatants, genomic DNA and lysates were prepared. (A) The copy numbers of the intracellular viral DNA were quantified by qRT-PCR, each sample was normalized to the amount of the GAPDH gene. *p<0.05, compared to control.

    Int J Oncol, 2016, 48(4):1519-30. . Cidofovir purchased from Selleck.

产品安全说明书

DNA/RNA Synthesis抑制剂选择性比较

生物活性

产品描述 Cidofovir (HPMPC) 通过选择性抑制病毒DNA的合成而抑制病毒复制。
体外研究

Cidofovir处理培养的细胞,抑制人类巨细胞病毒(HCMV)感染。Cidofovir抑制巨细胞病毒(CMV)蚀斑形成,即使是感染后48小时后加入到细胞中,作用于Davis和AD-169株时IC50分别为0.9 μg/mL和1.6 μg/mL。[1] Cidofovir也抑制单纯疱疹病毒感染。此外,Cidofovir作用于猴肾细胞,抑制HSV-1诱导的细胞融合,也抑制HSV-1特异性蛋白的表达和病毒DNA的合成。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEL cells MkXXSpVv[3Srb36gZZN{[Xl? MkD3R49ueG:3bnSge4F{KHSnc4Tl[EBnd3JiYX70bU13cXKjbDDhZ5Rqfmm2eTDh[4FqdnO2IFjTWk0yMEuRUzmgbY4hUEWOIHPlcIx{NCCHQ{WwQVAvPTdizszN MVexOFY1OzN{OB?=
MRC-5 cells NWjMVXc5TnWwY4Tpc44h[XO|YYm= NFv0e|JKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5Qh[3m2b4DheIhq[yCnZn\lZ5Qhd2ZiSGPWMVIpTSBzOUSpJIlvKE2UQz21JINmdGy|LDDJR|UxRTFyIN88US=> Ml63PFY{OjR|OR?=
NHDF cells MoH4SpVv[3Srb36gZZN{[Xl? MWrJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgdoVxdGmlYYTpc44hd2ZiSFPNWkBqdiCQSFTGJINmdGy|LDDJR|UxRTBwNTFOwG0> MX[4OlMzPDN7
HFF cells NYq3T2VtTnWwY4Tpc44h[XO|YYm= NX;sV2hVSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhXmGlY3nubYEhfmm{dYOgR49x\W6qYXflckBqdiCKRl[gZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGO7dH;wZZRpd2enbnnjbZR6NCCHQ{WwQVMvOiEQvF2= NF7vc3EyPjZyM{O1NS=>
HFF cells M1zXeWZ2dmO2aX;uJIF{e2G7 NXfiSpM2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS2:5cH;4JJZqenW|IFLybYdpfG:wIHnuJGhHTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;Nz6xJO69VQ>? NIS2ZWYyPjZyM{O1NS=>
HFF cells MnLVSpVv[3Srb36gZZN{[Xl? MlqyRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeoFk[2mwaXGgeolzfXNiQ3;w[Y5p[WenbjDt[YF{fXKnZDDhd{BkgXSxcHH0bI9o\W6rY3n0fUBqdiCKRl[gZ4VtdHNuIFXDOVA:Pi57IN88US=> MVqxOlczOjZ3Nx?=
bone marrow cells NFnrOXVEgXSxdH;4bYNqfHliYYPzZZk> MnXmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gZo9v\SCvYYLyc5ch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDjc4xwdnliZn;ycYlv\yC3bnn0JI9nKGe{YX71cI9kgXSnL33hZ5JweGijZ3WsJGlEPTB;MUCg{txO NF3GOVYyPjhzNEW0OS=>
HFF cells MYTGeY5kfGmxbjDhd5NigQ>? NXfxVXFUSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gR21XKFR{MkSxJIlvKEiIRjDj[YxteyCkeTDTSWFRKGG|c3H5MEBKSzVyPUCuN{DPxE1? Mo\GNVcxPDNzMki=
MRC5 cells MVLGeY5kfGmxbjDhd5NigQ>? NXi5TINVSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gR21XKFSxd37lJIlvKE2UQ{WgZ4VtdHNiYomgVHJCNCCLQ{WwQVAvOyEQvF2= MkTVNVcxPDNzMki=
UC1B cells M4Txe2Z2dmO2aX;uJIF{e2G7 MUXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDNeZJqdmVicH;sfY9u[X[rcoXzJG1PN1KGRTDUc5JwdnSxIHnuJI1wfXOnIGXDNWIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJktKEWFNUC9NVMh|ryP M2TwelE4PDJyMkG0
african green monkey Vero cells MljPSpVv[3Srb36gZZN{[Xl? NH3iXoVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIF[gbY5n\WO2ZXSgbY4h[W[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{BxdGGzdXWgdoVlfWO2aX;uJIFnfGW{IEO2JJRwKDR6IHjyd{whTUN3ME2xOE41KM7:TR?= NYjldm5ZOTd2M{iwOlE>
HEL cells M3XMSmZ2dmO2aX;uJIF{e2G7 NVf2[IprOyCmYYnz NGXhUY9CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjCzJIRigXNuIFXDOVA:OC52MTFOwG0> M3;YcVE4QTZzOEWx
HEL cells NYPJXWk4TnWwY4Tpc44h[XO|YYm= MnWyN{Bl[Xm| MmjrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZYZ1\XJiMzDkZZl{NCCHQ{WwQVAvPDFizszN NXzzZnhUOTd7NkG4OVE>
HFF cells MYTGeY5kfGmxbjDhd5NigQ>? NG\5PWNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgR21XKFR{MkGxJIlv\mWldHXkJIlvKEiIRjDj[YxteyCkeTDTSWFRKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5{MjFOwG0> NY\jT2h5OTd5MEm0Olg>
HEL cells MlLpSpVv[3Srb36gZZN{[Xl? M3LW[mFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIdidmOrY3zveolzNXKnc3nzeIFvfCCKQ13WJGFFOTZ7IHPsc45mKDRiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPUCuO|Qh|ryP MX2xPVIzPjF2MB?=
HEL cells M3PoZ2Z2dmO2aX;uJIF{e2G7 MWfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKESjdnnzJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTDh[pRmeiB5IHThfZMheG:|dHnu[oVkfGmxbjygSWM2OD1yLkWg{txO M3fsUlE6OjJ4MUSw
HEL cells NFPm[3NHfW6ldHnvckBie3OjeR?= M3fkTGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiQVSxOlkhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEeg[IF6eyCyb4P0bY5n\WO2aX;uMEBGSzVyPUCuN{DPxE1? MVqxPVIzPjF2MB?=
HEL cells NXj3e4tLTnWwY4Tpc44h[XO|YYm= MULBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDmc5Nk[XKwZYStdoV{cXO2YX70JGhEVVZiQVSxOlkh[2yxbnWgR{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFnDOVA:OC5yNEWg{txO NILpdm8yQTJ{NkG0NC=>
HFF MnTaVJJwdGmoZYLheIlwdiCjc4PhfS=> NFrZeFE{KGSjeYO= NEnWRmtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGhHTiCjZoTldkA{KGSjeYOgZpkh[2:3bITldkBkd3WwdHXyJIF{e2G7LDDFR|UxRTFwOTFOwG0> NGi3fVMyQTB{OUOyNi=>
HeLaS3 cells MVrGeY5kfGmxbjDhd5NigQ>? NI\kNms{NTViZHH5dy=> MVzBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDWZYNkcW6rYTD2bZJ2eyCLSFStTkBCXEOFIG\SMVE2PiCrbn\lZ5Rm\CCrbjDI[WxiWzNiY3XscJMh[W[2ZYKgN{B1dyB3IHThfZMh[nlicHzhdZVmKGG|c3H5MEBGSzVyPUG4Mlc1KM7:TR?= M4W0blE5QDV{Mkex
HSB2 cells MlzFSpVv[3Srb36gZZN{[Xl? MlnwO{Bl[Xm| NYjROWtXSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gbIVzeGW|dnnyeZMhPiCJUzDpcoZm[3SnZDDpckBpfW2jbjDIV2IzKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwII\pdoFtKESQQTDhZ4N2dXWuYYTpc44h[W[2ZYKgO{Bl[Xm|LDDFR|UxRTJwNzFOwG0> M{PwXVE6PzdyMke0
A549 cells NFrOeYRHfW6ldHnvckBie3OjeR?= NYLPe|ZwSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZYRmdm:4aYL1d{B1gXCnIEGxdEB{dG:kaYTzb4khcW6oZXP0[YQhcW5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFTORUBz\XCuaXPheIlwdiCkeTDRVGNTKGG|c3H5MEBGSzVyPUG2MlUh|ryP Ml;LNlA2QDVzMUK=
HFF cells M{fKfGZ2dmO2aX;uJIF{e2G7 MnLzRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR494eG:6II\pdpV{KCiEcnnnbJRwdiCUZXSpJIlv\mWldHXkJIlvKGi3bXHuJGhHTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCkeTDu[ZV1emGuIILl[EB2eHSja3WgZZN{[XluIFXDOVA:Pi55IN88US=> NUjofG9POjF|N{[0Nlk>

... Click to View More Cell Line Experimental Data

体内研究 Cidofovir 每天按5 mg/kg剂量皮下注射给药受感染的豚鼠,持续给药5天,显著降低血,脾,肺,和唾液腺中病毒传染力。Cidofovir处理受感染的动物,显著降低淋巴细胞增多和脾脏的平均组织指数。[2] Cidofovir作用于皮内感染与HSV-1或HSV-2的无毛小鼠,抑制所有临床表现(皮肤损伤,后腿瘫痪,和死亡)。Cidofovir最显着的特点是感染后到直至第4天才单独给药,也显著抗HSV-1或HSV-2感染。[4] Cidofovir作用于皮下移植小鼠黑色素瘤B16细胞的C57B16/J小鼠,抑制产生的高度侵袭性的黑色素瘤的生长。[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 Water 12 mg/mL (42.98 mM)
DMSO 2 mg/mL (7.16 mM)
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 279.19
化学式

C8H14N3O6P

CAS号 113852-37-2
储存条件 粉状
溶于溶剂
别名 HPMPC

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04542252 Completed Drug: SyB V-1901|Drug: Cyclosporine Drug Drug Interaction SymBio Pharmaceuticals November 9 2020 Phase 1
NCT01610765 Withdrawn Drug: Novel Antiviral Drug|Drug: Placebo Herpes Simplex Virus University of Alabama at Birmingham January 2016 Phase 1|Phase 2
NCT01816646 Completed Drug: Cidofovir|Drug: Probenecid Blood And Marrow Transplantation M.D. Anderson Cancer Center|Gilead Sciences September 2013 Phase 1
NCT00780182 Completed Drug: CMX001 Healthy Chimerix|National Institutes of Health (NIH) October 2008 Phase 1

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操作手册

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DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID