Favipiravir (T-705)

For research use only. Not for use in humans.

目录号:S7975 中文名称:法匹拉韦

Favipiravir (T-705) Chemical Structure

CAS No. 259793-96-9

Favipiravir (T-705)是一种有效的选择性RNA-dependent RNA polymerase抑制剂,用于治疗流感病毒感染。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 975.42 现货
RMB 877.01 现货
RMB 3233.53 现货
RMB 8169.44 现货
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客户使用Selleck生产的Favipiravir (T-705)发表文献13篇:

客户使用该产品的2个实验数据:

  • (A) BoDV-1 infection was measured by IFA. BoDV-1 P40 was detected with a primary monoclonal antibody (red), nuclei were stained with DAPI (blue), merged image (scale bars: 50 μm). Favipiravir: T-705

    Cell Physiol Biochem, 2018, 49(1):381-394. Favipiravir (T-705) purchased from Selleck.

  • (B) IFA of Vero-rBoDV-1-Gluc cells treated with T-705. Vero-rBoDV-1-Gluc cells were treated as indicated and the cells were stained with an anti-P antibody (shown in green) and DAPI (shown in blue). Bars, 50 μm.

    Antiviral Res, 2017, 143:237-245. Favipiravir (T-705) purchased from Selleck.

产品安全说明书

DNA/RNA Synthesis抑制剂选择性比较

生物活性

产品描述 Favipiravir (T-705)是一种有效的选择性RNA-dependent RNA polymerase抑制剂,用于治疗流感病毒感染。
靶点
RNA-dependent RNA polymerase [1]
体外研究

Favipiravir表现出抗流感病毒活性,对甲型流感病毒,乙型流感病毒和丙型流感病毒的IC50 范围分别为0.013-0.48 μg/ml,0.039-0.089 μg/ml,和0.030-0.057 μg/ml。在哺乳动物细胞系 (MDCK细胞,Vero细胞,HEL细胞,A549细胞,HeLa细胞,和HEp-2 细胞) 中,高达1,000 μg/ml 浓度的Favipiravir没有表现出毒性。[1]在接种季节性甲型流感(H1N1)病毒的MDCK细胞中,Favipiravir诱导致死性突变发生。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDCK MUPBcpRqfmm{YXygZZN{[Xl? MVezJIRigXN? NVjYfHhPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S2{ZYPpd5RidnRienHuZY1qfmm{LTzvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;O[ZchYW:{az:zOE8zODB6KFixUlEqMSCqYYLic5JqdmdiTUKgUFI3USCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCvaXPyc5Nkd3CrYzDhcoFtgXOrLDDFR|UxKD1iMD6xPUDPxE1w NHfzToQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK NYjYcohLSW62aY\pdoFtKGG|c3H5 Mlj5N{Bl[Xm| MYLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IFu[W62YX7lMUwhd3OnbIThcYl3cXJvLDD6ZY5idWm4aYKtd5V{[2WydHnicIUhUW6obIXlcppiKEFidnnyeZMhMEFxQX7uJGFz[m:{L{[vNVk3OCiKMl6yLUkhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCvaXPyc5Nkd3CrYzDhcoFtgXOrczD1d4lv\yClconzeIFtKH[rb3zleEB{fGGrbjygSWM2OCB;IECuN|gh|ryPLh?= M4X6N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK M{HiOmFvfGm4aYLhcEBie3OjeR?= Mo\ON{Bl[Xm| MnzpRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U1z\XOrc4ThcpQhgmGwYX3peolzNSyxc3XseIFucX[rcj3zeZNk\XC2aXLs[UBKdm[udXXufoEhSSC4aYL1d{ApSS:IbH;ybYRiNzBzL{KwNFkpUDOQMjmpJIhiemKxcnnu[{BOOiCVM{HOJI12fGGwdDDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[W[2ZYKgN{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwJF0hOC52NTFOwG0v M{XybFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK NILIe3JCdnSrdnnyZYwh[XO|YYm= MnfVN{Bl[Xm| M3TscGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JI9{\Wy2YX3peolzNXO3c3PldJRq[mynIIrhcoFucX[rcj2sJIFl[W2jboThcoUuemW|aYP0ZY51KEmwZnz1[Y57[SCEII\pdpV{KEJxTXXtdIhqey9{MD:xPVk3KGijcnLvdolv\yCwZYXyZY1qdmmmYYPlJHIyPTKNIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxcHnjJIFv[SxiRVO1NEA:KDBwNUeg{txONg>? NYjrcpM5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK NWX1e2x[SW62aY\pdoFtKGG|c3H5 MXKzJIRigXN? NULUbJZ5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S1uIH;z[Yx1[W2rdnnyMUwhgmGwYX3peolzNXO3c3PldJRq[mynIFnu[ox2\W68YTDBJJZqenW|IDjBM3N4cW6nL2PveZRpKESja3;0ZU8xOy9{MEC4LGgyVjFrKTDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[W[2ZYKgN{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{KHW|aX7nJINzgXO2YXygeolwdGW2LDDFR|UxKD1iMD64N{DPxE1w NXHrbFZ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK NXnIb2FWSW62aY\pdoFtKGG|c3H5 NX7sZpBiOyCmYYnz M1fhNGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUue3W|Y3XweIljdGVienHuZY1qfmm{LTygc5NmdHSjbXn2bZIuemW|aYP0ZY51KEmwZnz1[Y57[SCDII\pdpV{KCiDL1LyZZpqdC9zNkOzM|IxODhqSEHONUkqKGijcnLvdolv\yCwZYXyZY1qdmmmYYPlJHEyOz[NIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5JweyxiRVO1NEA:KDBwOEOg{txONg>? M1LtWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK MWTBcpRqfmm{YXygZZN{[Xl? M{nXSlMh\GG7cx?= MUTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IFu[W62YX7lMZJme2m|dHHueEB7[W6jbXn2bZIuNG:|ZXz0ZY1qfmm{LYP1d4NmeHSrYnzlJGlv\my3ZX76ZUBCKH[rcoXzJEhCN3CmbT;DZYxq\m:{bnnhM|A2NzJyMEmgLGgyVjFrKTDoZZJjd3KrbnegUVIhXjJ6STygV|MyViCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCvaXPyc5MtKEWFNUCgQUAxNjh|IN88UU4> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK M1fjZmFvfGm4aYLhcEBie3OjeR?= MWGzJIRigXN? M2nGVWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuemW|aYP0ZY51KHqjbnHtbZZqei1ub4PlcJRidWm4aYKtd5V{[2WydHnicIUhUW6obIXlcppiKEFidnnyeZMhMEFxcHTtM25mfyC\b4LrM|E5NzJyMEmgLGgyVjFrKTDoZZJjd3KrbnegUVIhXjJ6STygV|MyViCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCvaXPyc5NkdyxiRVO1NEA:KDBwOEmg{txONg>? MoXQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK M{fZcWFvfGm4aYLhcEBie3OjeR?= MmnHN{Bl[Xm| M{TsTGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuNCC8YX7hcYl3cXJvc4XzZ4VxfGmkbHWgc5NmdHSjbXn2bZIuemW|aYP0ZY51KEmwZnz1[Y57[SCDII\pdpV{KCiDL4T1dotmgS:PaX7u[ZNwfGFxOEOzM|E6QDBqSETONkkqKGijcnLvdolv\yCwZYXyZY1qdmmmYYPlJGUyOTmJIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KCxiRVO1NEA:KDBwOEmg{txONg>? NFrhOGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK NFraTW1CdnSrdnnyZYwh[XO|YYm= MYizJIRigXN? MlXnRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U0tKG:|ZXz0ZY1qfmm{LTygfoFv[W2rdnnyMZN2e2OncITpZoxmKEmwZnz1[Y57[SCDII\pdpV{KCiDL4T1dotmgS:PaX7u[ZNwfGFxOEOzM|E6QDBqSETONkkqKGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB|IHThfZMh[nlibXnjdo9{[2:yaXOgZY5idHm|aYOgeZNqdmdiY4L5d5RidCC4aX;s[ZQhNCCHQ{WwJF0hOC57NjFOwG0v NHfIV2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK MUfBcpRqfmm{YXygZZN{[Xl? MVzBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SC8YX7hcYl3cXJvLDDh[IFu[W62YX7lMZJme2m|dHHueEBKdm[udXXufoEhSSC4aYL1d{ApSS:EZYTo[ZNl[S97NU[vNlAxPiiKM16yLUkhcGG{Yn;ybY5oKG6ndYLhcYlvcWSjc3WgVlI6OktibYX0ZY51KGGwZDDNNkBUOzGQIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYYtKEWFNUCgQUAyNjJzIN88UU4> NWj0UY9HRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK MVjBcpRqfmm{YXygZZN{[Xl? MVizJIRigXN? MkLERY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U1z\XOrc4ThcpQhgmGwYX3peolzNSyxc3XseIFucX[rcj3zeZNk\XC2aXLs[UBKdm[udXXufoEhSSC4aYL1d{ApSS:yZH2vUYV5cWOxL{S2NFQwOjByOTCoTFFPOSlrIHjhdoJwemmwZzDNNkBXOjiLLDDTN|FPKG23dHHueEBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhOyCmYYnzJIJ6KG2rY4Lvd4NwNCCHQ{WwJF0hOS5{MTFOwG0v NX3odngxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK M1XhSmFvfGm4aYLhcEBie3OjeR?= MofsN{Bl[Xm| NXq5bZVuSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S2{ZYPpd5RidnRienHuZY1qfmm{LTzvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQjD2bZJ2eyCEL13lcZBpcXNxMkCvNVk6PiCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzJJV{cW6pIHPyfZN1[WxidnnvcIV1KHO2YXnuMEBGSzVyIE2gNU4zOSEQvF2u M3z5S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK MlPyRY51cX[rcnHsJIF{e2G7 MVfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IFu[W62YX7lMUwhd3OnbIThcYl3cXJvLDD6ZY5idWm4aYKtd5V{[2WydHnicIUhUW6obIXlcppiKEFidnnyeZMhMEFxY3jpZ4tmdi:YaXX0coFuN06FVlSxNFMwOjByNzDjcIFl\SB{LkOuOEApUDWQMTmpJIhiemKxcnnu[{Bv\XW{YX3pcoll[XOnIFmyNlJVKG23dHHueEBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZItKEWFNUCgQUAyNjJ5IN88UU4> MoPCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK NYG1TFIySW62aY\pdoFtKGG|c3H5 NIDvRXFKdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIH;mJIlv\my3ZX76ZUBCKH[rcoXzJEhCN0ixbnegT49v\y9{MUOvNFMpUDWQMTmpJIFv\CCrbn\seYVvgmFiQTD2bZJ2eyBqQT;Bco4hSXKkb4KvOk83OCiKMl6yLUkhcHmkcnnkJJZqenW|IHnuJG1FS0tiY3XscJMh[nlidnnyeZMhgWmnbHSgdoVlfWO2aX;uJIF{e2G7LDDFR|kxKD1iMT6zJO69VS5? NVHVdopURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPVQ5OzJpPkG3NVk1QDN{PD;hQi=>
MDCK NWTDbmpPSW62aY\pdoFtKGG|c3H5 NVXLWm16OSCqch?= MmDyRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTY5ndHWnborhJGIhfmm{dYOgLGIwSnKrc3LhcoUwPjBxMkCwPEkhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[XRiMTDodkBxd3O2LXnu[oVkfGmxbjDt[YF{fXKnZDDh[pRmeiB|IHThfZMh[nliZnz1c5Jme2OnaX6t[Ili[2W2YYTlJIJie2WmIH\seY9zcW2ndILpZ{BidmGueYPpd{whTUN3MDC9JFEvOzJizszNMi=> NV;4N4xbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVk4OzhpPkKzOFE6PzN6PD;hQi=>
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MDCK NVqyWHV6SW62aY\pdoFtKGG|c3H5 MXSzJIRigXN? Ml\5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTY5ndHWnborhJJZqenW|IFGvXE0{OSCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidCC{ZYDsbYNifGmxbjDheEA{KGSjeYOgdI9{fCCrbn\lZ5Rqd25iYomg[o9zdWG8YX6tZoF{\WRiTWTTJIF{e2G7LDDFR|UxKD1iMk[g{txONg>? M1PQc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUC2N|kzLz5{OUmwOlM6OjxxYU6=
MDCK NWXHflZjSW62aY\pdoFtKGG|c3H5 M2DMbWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JFAvODBzIF3PTUBi\GGvYX70ZY5mNXKnc3nzeIFvfCC8YX7hcYl3cXJvLH;z[Yx1[W2rdnnyMZN2e2OncITpZoxmKEmwZnz1[Y57[SCDII\pdpV{KCiDL4DkcU9O\XirY3:vOFYxPC9{MEC5LGgyVjFrKTDoZZJjd3KrbnegUVIhXjJ6STygV|MyViCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{Bl\XSncn3pcoF1cW:wIH;mJJZqemGuIITpeIVzKGmwIHPlcIwh[3WudIXy[UBifCxiTmXMUEA:KE6XTFyg{txONg>? NYSxOJJyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK M4\tdWFvfGm4aYLhcEBie3OjeR?= NVrxc4JbSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhOC5yMEGgUW9KKGGmYX3hcpRidmVvcnXzbZN1[W62IIrhcoFucX[rcj2sc5NmdHSjbXn2bZIue3W|Y3XweIljdGViSX7mcJVmdnqjIFGgeolzfXNiKFGvdIRuN0OjbHnmc5JvcWFxMESvNlAxQSiKMV6xLUkhcGG{Yn;ybY5oKE1{IG[yPGktKFN|MV6gcZV1[W62IHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiZHX0[ZJucW6jdHnvckBw\iC4aYLhcEB1cXSncjDpckBk\WyuIHP1cJR2emViLDDOWWxNKD1iTmXMUEDPxE1w NWDBPXFYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK NWXjeHRNSW62aY\pdoFtKGG|c3H5 NIW0[5UyOjhidV2= NG[1dJBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GGvYX70ZY5mNXKnc3nzeIFvfCC8YX7hcYl3cXJvLH;z[Yx1[W2rdnnyMZN2e2OncITpZoxmKEmwZnz1[Y57[SCDII\pdpV{KCiDL4DkcU9O\XirY3:vOFYxPC9{MEC5LGgyVjFrKTDoZZJjd3KrbnegUVIhXjJ6STygV|MyViCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{Bl\XSncn3pcoF1cW:wIH;mJJZqemGuIITpeIVzKGmwIHPlcIwh[3WudIXy[UBifCBzMkigeW0h[WZuIF7VUGwhRSCQVVzMJO69VS5? MoPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK Mn64RY51cX[rcnHsJIF{e2G7 M{XTRlEzQCC3TR?= M{HZPGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuemW|aYP0ZY51KHqjbnHtbZZqei1ub4PlcJRidWm4aYKtd5V{[2WydHnicIUhUW6obIXlcppiKEFidnnyeZMhMEFxcHTtM2NidGmob4LubYEwODRxMkCwPUhJOU5zKTmgbIFz[m:{aX7nJG0zKFZ{OFmsJHM{OU5ibYX0ZY51KGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMh\GW2ZYLtbY5ifGmxbjDv[kB3cXKjbDD0bZRmeiCrbjDj[YxtKGO3bIT1doUh[XRiMUK4JJVOKCxiTmXMUEA:KE6XTFyg{txONg>? MkHGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
Vero M4Xa[GFvfGm4aYLhcEBie3OjeR?= NITyfm03PDByIIXN NVPyVo9QfXBidH:gNVIhcHK| M3f0RWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHlmdGyxdzDm[ZZmeiC4aYL1d{AyP0RiaX7m[YN1\WRiaX6gRYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDj[YxteyCjc4Pld5Nm\CCjczD0bY1mKHKncYXpdoVlKG[xcjDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGG2IE[0NFAhfU1idYCgeI8hOTJiaILzJJBwe3RvdnnyZYwhcW6oZXP0bY9vNCCQVVzMJF0hVlWOTDFOwG0v M2S0[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OUW1OVM3Lz5zOEm1OVU{PjxxYU6=
MDCK MYHBcpRqfmm{YXygZZN{[Xl? MV[wJJRwKDJiaILz MXPJcohq[mm2aX;uJI9nKGmwZnz1[Y57[SCDII\pdpV{KGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCCub3HkJJRz\WG2ZXSge4l1cCClb33wc5Vv\CCjdDCwJJRwKDJiaILzJJBwe3RvaX7m[YN1cW:wIHL5JHJVNXGSQ2KgcYV1cG:mIHLhd4VlKHSrbXWgc4Yh[WSmaYTpc44h[XO|YYmsJG5WVExiPTDOWWxNKM7:TT6= M1\lXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUmyOVQ1Lz5|MEG5NlU1PDxxYU6=
MDCK MYnBcpRqfmm{YXygZZN{[Xl? M2Lm[VUhfG9iODDodpM> NGjTOoRKdmirYnn0bY9vKG:oIHnu[ox2\W68YTDBJJZqenW|IHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDsc4FlKHS{ZXH0[YQhf2m2aDDjc41xd3WwZDDheEA2KHSxIEigbJJ{KHCxc4StbY5n\WO2aX;uJIJ6KFKWLYHQR3IhdWW2aH;kJIJie2WmIITpcYUhd2ZiYXTkbZRqd25iYYPzZZktKE6XTFygQUBPXUyOIN88UU4> MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF7MkW0OEc,OzBzOUK1OFQ9N2F-
MDCK M1\rUmFvfGm4aYLhcEBie3OjeR?= NFnEOnAxKHSxIEGwJIhzew>? MVLJcohq[mm2aX;uJI9nKGmwZnz1[Y57[SCDII\pdpV{KGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCCub3HkJJRz\WG2ZXSge4l1cCClb33wc5Vv\CCjdDCwJJRwKDFyIHjyd{Bxd3O2LXnu[oVkfGmxbjDifUBTXC2zUFPSJI1mfGixZDDiZZNm\CC2aX3lJI9nKGGmZHn0bY9vKGG|c3H5MEBPXUyOIE2gUnVNVCEQvF2u NYrt[GVxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxPVI2PDRpPkOwNVkzPTR2PD;hQi=>
MDCK NX[5eIVUSW62aY\pdoFtKGG|c3H5 MoqzNkB1dyB3IHjydy=> NEnIXYZKdmirYnn0bY9vKG:oIHnu[ox2\W68YTDBJJZqenW|IHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDsc4FlKHS{ZXH0[YQhf2m2aDDjc41xd3WwZDDheEAzKHSxIEWgbJJ{KHCxc4StbY5n\WO2aX;uJIJ6KFKWLYHQR3IhdWW2aH;kJIJie2WmIITpcYUhd2ZiYXTkbZRqd25iYYPzZZktKE6XTFygQUBPXUyOIN88UU4> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF7MkW0OEc,OzBzOUK1OFQ9N2F-
MDCK NHnWb2JCdnSrdnnyZYwh[XO|YYm= NUKyZoVVOTBidV2= NW\Q[ng2fXBidH:gPEBpenN? M2rCT2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGlv\my3ZX76ZUBCKH[rcoXzJEhCN2OqaXPr[Y4wUHWkZXmvN|I4NzJyMESoTFVPOSlrIHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBm[XKueTDzeIFo\XNib3[geolz[WxicnXwcIlk[XSrb36gZZQhOTBidV2geZAhfG9iODDodpMh[nliY4L5d5RidCC4aX;s[ZQhe3SjaX7pcoch[mG|ZXSgdIxieXWnIILl[JVkfGmxbjDhd5NigSCmZYDlcoRmdnRidHnt[U1w\ixiTmXMUEA:KE6XTFyg{txONg>? NE\JdYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK5Nlg6Pyd-M{CyPVI5QTd:L3G+
MDCK M4nRW2FvfGm4aYLhcEBie3OjeR?= MoHpNVAxKHWP NHT4bmoyOiCqcoO= MmHXRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTY5ndHWnborhJJZqenW|IFGvXE0{OSCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gc45mKGO7Y3zlJJZqemGuIGLORUB{gW62aHXzbZMh[XRiMUCwJJVOKHC{ZXnuZ5Vj[XSnZDD3bZRpKGOnbHzzJIZweiBzMjDodpMh\m:ubH;3[YQh[nlidnnyZYwhcW6oZXP0bY9vKG2nYYP1doVlKGGodHXyJFExKGi{czDwc5N1KGmwZnXjeIlwdiCkeTDSWE1yWEOUIH3leIhwNCCQVVzMJF0hVlWOTDFOwG0v M1qyWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUC2N|kzLz5{OUmwOlM6OjxxYU6=
MDCK M3jsb2FvfGm4aYLhcEBie3OjeR?= NGrDZ24zPTBidV2= MXmxNEBpenN? NH\zW3lCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBKdm[udXXufoEhfmm{dYOgRU9ZNTNzIHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBwdmViY4njcIUhfmm{YXygVm5CKHO7dHjlbZMh[XRiMkWwJJVOKGGmZHXkJJRw\2W2aHXyJJdqfGhidnnyeZMh[W6mIH3lZZN2emWmIHH0JFExKGi{czDwc5N1KGmwZnXjeIlwdiCkeTDSWE1yWEOUIH3leIhw\CxiTmXMUEA:KE6XTFyg{txONg>? M{\Sd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUC2N|kzLz5{OUmwOlM6OjxxYU6=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Growth inhibition assay
Survival; 

PubMed: 26711718     


Initial dose-ranging study of ribavirin/favipiravir treatment of JUNV-infected guinea pigs. Animals in each group (n=6) were infected with 100 PFU of JUNV and treated i.p. with the indicated doses of favipiravir, ribavirin, a combination of both compounds, or placebo twice daily for 2 weeks starting 3 days p.i. Kaplan-Meier survival curves are shown. **P < 0.01, ***P < 0.001, compared to placebo-treated animals. Tx, treatment; p.i., postinfection.

Cell viability; 

PubMed: 28848019     


Reduction of WNV yield and cytotoxicity of favipiravir. (B) Percentage of viable Vero cells after favipiravir treatment. The 50% cytotoxic concentration was determined by measuring the cellular ATP content at 48 h posttreatment. Data are presented as the mean ± standard deviation (SD) from three independent determinations of both IC50 and CC50.

26711718 28848019
IHC
H&E Staining; 

PubMed: 29765101     


Histopathology and immunohistochemistry. (a) Formalin fixed tissues were embedded in paraffin and H&E stained. Images represent brains, lungs, and spleens of vehicle control animals, favipiravir p.o. and favipiravir s.c.

NiV nucleoprotein; 

PubMed: 29765101     


Histopathology and immunohistochemistry. (b) Formalin fixed tissues were embedded in paraffin and stained with anti-NiV nucleoprotein antibodies. Images represent brains, lungs, and spleens of vehicle control animals, favipiravir p.o. and favipiravir s.c. V, blood vessels; Br, bronchioles; Fo, follicles; Arrows, NiV nucleoprotein antigens.

LASV antigen; 

PubMed: 26456301     


Immunohistochemical analysis of tissues from animals infected with GPA-LASV and treated daily with favipiravir, ribavirin or placebo. Tissue samples from infected guinea pigs treated daily with favipiravir (150 or 300 mg/kg/d), ribavirin (50 mg/kg/d) or placebo were collected at 12 days post-infection and examined for the presence of LASV antigen (glycoprotein, GP) using a GP-specific monoclonal antibody according to standard immunohistochemistry techniques.

H&E stain; 

PubMed: 33037151     


(F) Representative H&E images of lungs at day 4 pi of SARS-CoV-2−infected hamsters and treated with favipiravir. At day 4, lungs of untreated hamsters show significant inflammation in bronchial wall (blue arrows) with apoptotic bodies in respiratory epithelium and extension into adjacent alveoli (orange arrow) and inflammatory cells in arterial wall (red arrow). Lungs of infected hamsters treated with 600 mg⋅kg−1⋅d−1 favipiravir still show a few inflammatory cells in the bronchial wall (blue arrows) and a few focal perivascular lymphocytes (red arrow), whereas lungs of hamsters treated with 1,000 mg⋅kg−1⋅d−1 favipiravir contain even less inflammatory cells in the bronchial wall, but no perivascular inflammation. Apoptotic bodies (black circles) were present in bronchial walls of hamsters from all three groups (Scale bars, 100 µm.)

29765101 26456301 33037151
Immunofluorescence
rNiV-Gluc; 

PubMed: 29765101     


Delayed treatment in vitro efficacy of favipiravir against NiV infection. (a) Microscopic analysis of Vero cells infected with rNiV-Gluc-eGFP (MOI 0.01). Favipiravir (250 μM) was added at 1, 12, and 24 HPI; eGFP expression, development of syncytia, and cytopathic effect were monitored by microscopy at 24, 48 and 72 HPI.

29765101
体内研究 在流感病毒感染的小鼠中,Favipiravir (200 mg/kg/day, p.o.)保护小鼠不被流感病毒感染而死亡。[1]在人工感染Ebola病毒的小鼠中,Favipiravir有效阻断病毒产生,在治疗起始2天和6天后分别达到95%和99.6%的抗病毒效果。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[1]
- 合并
  • Cell lines: MDCK细胞,Vero细胞,HEL细胞,A549细胞,HeLa细胞,和 HEp-2 细胞
  • Concentrations: 1000 μg/mL
  • Incubation Time: 3天
  • Method: T-705的毒性通过XTT试验评估。在MDCK细胞,Vero细胞,HEL 细胞,A549细胞,HeLa 细胞,和HEp-2细胞中,XTT通过酶转化为含水的甲臜。化合物用测试培养基(包含10% FCS的EMEM)在96孔板中(2 × 103细胞/100 μL)稀释为适当的浓度(体积,100 μl)。测试板在37°C,100% 湿度和5% CO2中培育3天。3天后,加入50 μl XTT试剂(在包含5 mM吩嗪硫酸甲酯的无FCS的EMEM中浓度为1 mg/ml),反应产物使用酶标仪测量450 nm下的吸光度测定。细胞毒性表示为50% 细胞抑制浓度(CC50)。
    (Only for Reference)
动物实验:[1]
- 合并
  • Animal Models: 感染流感病毒 A/PR/8/34的小鼠
  • Dosages: 200 mg/kg/day
  • Administration: p.o.
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 31 mg/mL (197.32 mM)
Water 5 mg/mL warmed (31.82 mM)
Ethanol ''22 mg/mL warmed

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 157.1
化学式

C5H4FN3O2

CAS号 259793-96-9
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04907682 Recruiting Drug: Ribavirin iv|Drug: Favipiravir Lassa Fever Bernhard Nocht Institute for Tropical Medicine|University of Hamburg-Eppendorf|Alliance for International Medical Action|Institut National de la Santé Et de la Recherche Médicale France|University of Bordeaux|Federal Medical Centre Owo|Irrua Specialist Teaching Hospital July 30 2021 Phase 2
NCT04464408 Recruiting Drug: Favipiravir|Drug: Placebo COVID-19 King Abdullah International Medical Research Center|Ministry of Health Saudi Arabia July 23 2020 Phase 2|Phase 3

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DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID