Captisol (SBE-β-CD)

For research use only. Not for use in humans.

目录号:S4592 别名: Sulfobutylether-β-Cyclodextrin 中文名称:磺丁基环糊精

Captisol (SBE-β-CD) Chemical Structure

CAS No. 182410-00-0

Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) 是一种新型的、化学修饰过的环糊精,具有比较好的稳定性和溶解性。

规格 价格 库存 购买数量  
RMB 794.86 现货
RMB 958.74 现货
RMB 1532.18 现货
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客户使用Selleck生产的Captisol (SBE-β-CD)发表文献8篇:

质量管理及产品安全说明书

Hydrotropic Agents抑制剂选择性比较

生物活性

产品描述 Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) 是一种新型的、化学修饰过的环糊精,具有比较好的稳定性和溶解性。
Assay
Methods Test Index PMID
Western blot
DII1 / Jag1 / N1ICD / β-actin; 

PubMed: 30407728     


Cisplatin induces Notch signaling in mouse kidneys. A‐D, Western blot images and bar graphs showing Dll1 and Jag1 protein expression levels in the kidneys of mice 5 days after treatment with Captisol (vehicle control; IP) and cisplatin (15 mg/kg; IP). E and F, Western blot images and bar graphs illustrating N1ICD protein expression levels in the kidneys of Captisol‐, cisplatin‐, and DAPT (15 mg/kg; IP) + cisplatin‐treated mice.

DII1 / N1ICD / Jag1 / β-actin; 

PubMed: 30407728     


Cisplatin increases Dll1 and N1ICD but decreases Jag1 protein expression in HK‐2 cells. A‐F: Western blot images and bar graphs showing A and B, Dll1; C and D, N1ICD; and E and F, Jag1 protein expression levels in HK‐2 cells treated (12 h) with Captisol (vehicle control) and cisplatin (30 μmol L−1).

AKT / Cyclin D3 / Grb2; 

PubMed: 30082822     


Captisol (vehicle) or 120 mg/kg MK-2206 were administered to CALRdel52 mice by oral gavage for four weeks, five days a week, beginning 20 weeks post-transplant. Hematopoiesis was analyzed at 24 weeks post-transplant. h) Western blot evaluating the levels of AKT, p-AKT and cyclinD3 in treated mice. Grb2 is included as a loading control.

PARP / c-myc / CIP2A / E2F1 / β-Actin; 

PubMed: 26459601     


Antagomir-9-3p restores AZD8055-suppressed growth and survival of tumor xenografts. (C) MDA-MB-231 xenografts treated as described in A were either analyzed for the indicated proteins by Western blotting.

30407728 30082822 26459601
PAS staining
tubular injury; 

PubMed: 30407728     


DAPT protects against renal morphological changes induced by cisplatin. A, kidney‐to‐terminal body weight ratio (n = 11 each; data were obtained from all groups, except mice used for multiphoton microscopy); B, images (PAS staining) and C, average tubular injury score (n = 4 each) in Captisol (vehicle control; IP)‐, cisplatin (15 mg/kg; IP)‐, DAPT (15 mg/kg; IP)‐, and DAPT + cisplatin‐treated mice. Average tubular injury scores in Captisol‐ and DAPT‐treated mice were zero. Arrows identify tubular injury in the form of vacuolar degeneration and necrosis.

30407728
Immunofluorescence
MOG / GSTπ / pCXCR4; 

PubMed: 24733828     


Quantitative confocal imaging of immunostained CC sections for MOG, GSTπ, and pCXCR4. Data are expressed as the mean positive area (MOG and pCXCR4) or mean number of cells (GSTπ) for mice treated with captisol, CCX771 alone, CCX771 and saline, and CCX771 and AMD3100.

24733828

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

体外 Water 100 mg/mL
DMSO Insoluble
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量
化学式

C42H70-nO35.nNa.n(C4H8O3S)

CAS号 182410-00-0
储存条件 粉状
溶于溶剂
别名 Sulfobutylether-β-Cyclodextrin

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID