Anti-infection
抑制剂选择性比较
Anti-infection产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S5001 |
Tofacitinib (CP-690550) CitrateTofacitinib citrate (CP-690550, Tasocitinib)是一种新型JAK抑制剂,对JAK3,JAK2,JAK1的IC50分别为1 nM, 20 nM 和112 nM。Tofacitinib citrate 还具有抗感染的活性。 |
![]() ![]() CP-690550 reduced the severity of ischemic damage. (A) CP-690550 (10 μM) suppressed IL-17 production by cdT cells and activated memory T cells. cdT cells and CD4+ CD44+ memory T cells isolated from C5BL6J mice through flow cytometry were stimulated for 24 h with plate-bound monoclonal antibodies to CD3 (2 ng/ml) and CD28 (1 ng/ml) in the presence or absence of IL-23 (25 ng/ml). IL-17A production and IL-17A expression level were measured by quantitative RT-PCR (a) and ELISA (b). (B) CBF reduction after brain ischemia. (C) Time-dependent changes in neurological score. *p < 0.05. (D) Infarct volume as visualized through TTC staining on day 3 in CP-690550 (CP)- and vehicle-treated mice.
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S4157 |
Chloroquine diphosphateChloroquine diphosphate是一种4-氨基喹啉的抗疟疾和抗风湿药,也是一种ATM激活剂。Chloroquine 也是一种toll-like receptors (TLRs)的抑制剂。 |
![]() ![]() NCI-H929 EV and miR-137 OE cells were treated with ATM activator Chloroquine Phosphate (CQ), specific ATM inhibitor KU-55933, and ATR inhibitor AZ20 for 12 hr. Immunoblotting showed the expression of p-ATM, p-Chk2, p-BRCA1, p-ATR and p-Chk1. |
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E0206New |
GinkgetinGinkgetin 是一种来自银杏叶的双黄酮,具有抗癌、抗炎、抗微生物、抗脂肪生成和神经保护作用。 |
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S2572 |
Streptomycin sulfateStreptomycin sulfate是Streptomycin的硫酸盐形式,是一种蛋白质合成抑制剂。 |
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S8279 |
Shikonin (C.I. 75535)Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844)是一种 Pyruvate kinase M2 (PKM2) 有效的、特异的抑制剂。它是紫草的主要成分,紫草是一种中草药,具有多种生物活性。在细胞荧光淬灭试验中,Shikonin也是TMEM16A氯离子通道的抑制剂。Shikonin 通过抑制 tumor necrosis factor-α (TNF-α) 发挥抗炎作用,并可通过抑制 proteasome 来阻止 nuclear factor-κB (NF-κB) 信号途径的激活。 |
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S3226 |
Dehydroabietic acidDehydroabietic acid (DAA, DHAA) 是一种天然的二萜树脂酸,衍生自针叶植物(如 Pinus 和 Picea)通过抑制 Src、Syk 和 TAK1 介导的通路来产生抗炎活性。 |
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S4945 |
Ethacridine lactateEthacridine lactate (Acrinol) 是一种基于acridine的芳香族有机化合物,可用作防腐剂。Ethacridine lactate 也是一种 poly(ADP-ribose) glycohydrolase (PARG) 抑制剂。 |
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S5184 |
Dexamethasone palmitateDexamethasone palmitate (DXP),是 Dexamethasone (DXM) 的亲脂性前药,是一种 glucocorticoid receptor 的激动剂,其对糖皮质激素受体的亲和力比DXM低47倍。Dexamethasone palmitate (DXP) 具有抗炎活性。 |
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S3308 |
Caftaric acidCaftaric acid (CA, Caffeoyl tartaric acid) 是一种具有抗氧化和抗炎作用的天然产物。 |
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S1553 |
Delafloxacin (ABT-492)Delafloxacin (ABT-492, RX-3341, WQ-3034)是一种氟喹诺酮,抗155需氧和171厌氧病原体。 |
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S4946 |
2,3-Dihydroxybenzoic acid2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) 是一种天然酚类,存在于西印度醋栗和水生蕨类Salvinia molesta,也是人体中阿司匹林的代谢产物。它是一种潜在的铁螯合药物,具有抗菌特性。 |
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S8068 |
ChaetocinChaetocin,一类来自毛壳菌属的天然产物,是一类 histone methyltransferase 抑制剂,其对dSU(VAR)3-9,小鼠G9a和粗糙链孢霉 DIM5的IC50分别为0.8 μM, 2.5 μM和3 μM。Chaetocin是一种抗癌药物并是 thioredoxin reductase (TrxR) 的抑制剂。 |
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S4430 |
Hydroxychloroquine Sulfate (NSC 4375)Hydroxychloroquine Sulfate (NSC 4375, HCQ)是一种抗疟疾药,用于治疗系统性红斑狼疮,类风湿关节炎等自身免疫病,炎症以及皮肤病。它也是autophagy和toll-like receptor (TLR) 7/9的抑制剂。 |
![]() ![]() C, SA-beta gal staining results of A549-LKB1 cells treated by trametinib (30 nmol/L), radiotherapy (2 Gy), and HCQ (50 μmol/L). Cells were treated by HCQ and/or trametinib 4 hours prior to radiotherapy. Drugs were washed out 24 hours after radiotherapy. Cells were incubated for additional 48 hours before staining. D, Clonogenic survival assay of A549-LKB1 cells treated with trametinib (30 nmol/L) and HCQ (50 μmol/L).
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S4303 |
9-Aminoacridine9-Aminoacridine (Aminacrine)是一种高荧光染料,在临床上用作局部防腐剂,在实验中用作诱变剂、细胞内pH指示剂和负模小分子MALDI基质。 |
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S5927 |
ProguanilProguanil (chlorguanide, chloroguanide) 是预防性抗疟药。它能抑制疟原虫的二氢叶酸还原酶,阻止嘌呤和嘧啶的合成。 |
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S4417 |
Ceftaroline FosamilCeftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) 是一种头孢菌素,对 Gram-positive pathogens (包括耐甲氧西林的金黄色葡萄球菌(MRSA))具有活性。 |
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S6771 |
MAC-545496MAC-545496是一种纳摩尔浓度的glycopeptide-resistance-associated protein R(GraR)抑制剂,对全长GraR蛋白(Kd≤0.1 nM)具有很强的结合亲和力。 MAC-545496可以逆转耐甲氧西林菌株中的β-内酰胺耐药性,并与CAMP协同作用。 MAC-545496在巨噬细胞中显示出显着的活性,并减弱了苜蓿根瘤菌幼虫感染模型中的金黄色葡萄球菌毒力。 |
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S3711 |
Carbasalate CalciumCarbasalate calcium (Iromin, Alcacyl, Omegin, Rheomin, Solupsan) 是一种止痛剂、退热剂,是一种抗炎药物以及血小板聚集的抑制剂。 |
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S9341 |
3,4-Dimethoxycinnamic acid3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM. |
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S4515 |
Ademetionine disulfate tosylateAdemetionine Disulfate Tosylate是腺苷蛋氨酸离子的非对映异构体的硫酸氢盐-甲苯磺酸盐混合盐形式。Ademetionine(腺苷蛋氨酸)具有抗炎活性,被用于治疗慢性肝疾病。 |
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S2430 |
AzodicarbonamideAzodicarbonamide是第一个已知的通过靶向 nucleocapsid CCHC domains 来抑制 HIV-1 和多种逆转录病毒的核衣壳抑制剂。在标准的基于细胞的抗病毒试验中,Azodicarbonamide抑制HIV-1RF诱导的CEM-SS细胞病变,EC50为38 µM。 |
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S6802 |
EtosalamideEtosalamide (Ethosalamide)是一种具有退烧和镇痛作用的抗炎药。 |
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S7867 |
OleuropeinOleuropein 是一种从橄榄叶中分离出的抗氧化多酚。Oleuropein 具有抗氧化、抗炎和抗动脉粥样硬化的作用,并在体外抑制脂肪细胞的分化。Oleuropein 抑制 PPARγ 活性。Oleuropein 通过直接抑制PPARγ转录活性发挥抗脂肪形成作用。Oleuropein 还可抑制aromatase。Oleuropein 可诱导凋亡。Phase 2。 |
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S3261 |
MyrislignanMyrislignan 是一种分离自Myristica fragrans Houtt的木脂素并具有抗炎活性。Myrislignan 可抑制 interleukin-6 (IL-6) 和 tumour necrosis factor-α (TNF-α)。Myrislignan 剂量依赖性地抑制LPS刺激的巨噬细胞中 inducible NO synthase (iNOS) 和 cyclooxygenase-2 (COX-2) 的表达。Myrislignan 可抑制 NF-κB 信号通路的激活。 |
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S4549 |
Antimonyl potassium tartrate trihydrateAntimonyl potassium tartrate trihydrate (Tartar emetic) 是一种有效的催吐剂,同样也用于治疗血吸虫病和利什曼病。 |
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S7465 |
FTI 277 HClFTI 277 HCl是FTI 277的甲酯,是一种有效的选择性farnesyltransferase (FTase)抑制剂,IC50为500 pM,选择性比密切相关的GGTase I 高100倍。FTI 277 HCl可抑制细胞生长并诱导凋亡。FTI 277 HCl可有效清除HDV病毒血症。 |
![]() ![]() (A) HCT 116 cells were treated with Tram (0, 30, or 60 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD. (B) SW480 and MDA-MB-231 cells were treated with Tram (0, 80, 160 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD.
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S1958 |
SulbactamSulbactam 是β-内酰胺酶抑制剂,IC50为0.8 μM。 |
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S3269 |
AcetylcorynolineAcetylcorynoline 是衍生自中草药 Corydalis bungeana 的主要生物碱成分,具有抗炎特性。Acetylcorynoline 可能通过降低 egl-1 的表达来抑制细胞凋亡通路,并增加 rpn5 的表达来增强 proteasomes 的活性。 |
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S3270 |
Genipin 1-O-beta-D-gentiobiosideGenipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) 是从栀子 Gardenia jasminoides Ellis 中分离到的一种生物活性类环烷苷,具有保肝、抗炎、抗氧化和抗血栓形成的功能。 |
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S3279 |
Polyphyllin B (Formosanin C)Polyphyllin B (Formosanin C, FC) 是一种从Paris formosana分离得到的薯蓣皂苷,也是一种具有抗肿瘤活性的免疫调节剂。Polyphyllin B (Formosanin C, FC) 可诱导凋亡。 |
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S1282 |
ArtemisininArtemisinin (Qinghaosu, Artemisinine)青蒿素用于治疗耐多药的恶性疟疾菌株。 |
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S2264 |
ArtemetherArtemether (SM-224, CGP 56696) 是一种抗疟药,用于治疗恶性疟疾的耐药菌株。 |
![]() ![]() Schistosomicidal effects of PZQ, ART(Artemether) and OXA on 14-day schistosomula. Magnification of the in vitro-cultured schistosomula treated with PZQ, ART, and OXA at 10 μM. Drugs were added at day 14 and schistosomula were analyzed at day 21 (late treatment). 0.1% DMSO in medium (solvent of the drugs; used as negative control) had no effect on schistosomula development. |
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S2479 |
Lincomycin HClLincomycin hydrochloride (Lincocin, NSC 70731) 是Lincomycin的一水盐, 是Lincolnensis链霉菌属的成员生长所产生的物质。 |
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S1644 |
NitrofuralNitrofural (Nitrofurazone) 是外用的抗感染剂,IC50为22.83±1.2 μM,作用于大鼠,LD50为590 mg/kg。 |
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S4237 |
Primaquine DiphosphatePrimaquine Diphosphate是一种临床有效的阻断传播的抗疟疾药,对人类疟疾的的配子体具有明显的抵抗活性。 |
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S2469 |
FleroxacinFleroxacin (Ro 23-6240, AM-833) 是一种新型广谱喹诺酮类。 |
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S3116 |
SulfathiazoleSulfathiazole是一种有机硫化合物,已被用来作为一种短效的磺胺类药物。 |
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S2511 |
SulfadoxineSulfadoxine (Sulphadoxine) 是一种超长效磺胺类药物,作用于P. Vivax,IC50为249 μg/ml。 |
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S3067 |
Chlorhexidine 2HClChlorhexidine hydrochloride (NSC-185) 是一种防腐剂,可以有效抵抗大多数革兰氏阴性和阳性有机体。 |
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S4147 |
Azithromycin DihydrateAzithromycin Dihydrate 是对酸稳定的,口服的,大环内酯类抗菌药物,结构与红霉素相关。 |
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S4191 |
BetamipronBetamipron (CS-443)是一种化学化合物,与Panipenem一起使用,抑制Panipenem吸收进肾小管,防止肾毒性。 |
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S2537 |
SecnidazoleSecnidazole (Flagentyl, PM 185184, RP 14539) 是一种硝基咪唑类抗感染剂。 |
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S4195 |
BroxyquinolineBroxyquinoline是一种抗原虫剂,作用于粘膜,可以从水中释放氧自由基。 |
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S4196 |
Ethacridine lactate monohydrateEthacridine lactate monohydrate是一种芳香族有机化合物,用作防腐剂。 |
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S2612 |
RibitolRibitol (Adonitol) 是一种戊糖醇结晶,通过核糖还原形成,在Adonis vernalis植物中自然发生。 |
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S4726 |
Lauric AcidLauric Acid (dodecanoic acid, N-Dodecanoic acid, Dodecylic acid)是饱和中链脂肪酸,在多种植物、动物油脂中都天然存在,是椰子油和棕榈仁油的主要成分。 |
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S3288 |
AbsinthinAbsinthin (Absynthine) 是一种来自 Artemisia absinthium 的天然三萜内酯,具有抗炎特性。Absinthin (Absynthine) 可显著地增强 matrix metalloproteinase-8 (MMP-8) 的表达,并且是潜在的急性肺损伤(ALI)的候选治疗药物。 |
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S3941 |
PinocembrinPinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone)是制药工业中多功能黄酮类分子,它具有很多药学活性,如抗菌、消炎、抗氧化和抗癌活性。 |
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S4573 |
m-Tolyl acetatem-Tolyl acetate是一种药物中间体和防腐剂。 |
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S4579 |
ResorcinolResorcinol是一种用作防腐剂、消毒剂的化合物,是很多药物合成的中间产物。 |
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S9564 |
p-Hydroxy-cinnamic Acidp-Hydroxy-cinnamic Acid在体外具有抗疟活性和体内抗骨质疏松活性。 |
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S6288 |
Chlorhexidine diacetateChlorhexidine diacetate (Hibitane diacetate)是一种消毒剂和局部抗感染剂,也用于漱口水中防止口腔菌斑。 |
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S5366 |
FipronilFipronil (Fluocyanobenpyrazole, Termidor) is a recalcitrant phenylpyrazole-based pesticide used for flea/tick treatment and termite control that is distributed in urban aquatic environments via stormwater and contributes to stream toxicity. |
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S9094 |
PogostonePogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity. |
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S4420 |
Mefloquine HClMefloquine HCl是一种血液裂殖体杀灭剂,抑制疟原虫色素的形成,用作抗疟疾药物。 |
![]() ![]() BALB/c mice, orally infected with E. multilocularis eggs, were treated by either mefloquine (100 mg/kg twice per week, n = 9), ABZ (200 mg/kg, 5 times per week, n = 8) or control-treated (placebo, n = 9). After 12 weeks of treatment, parasite lesion numbers in the liver were assessed microscopically (A).
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S4142 |
ClopidolClopidol (WR 61112)是一种抗原虫药剂。 |
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S4592 |
Captisol (SBE-β-CD)Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) 是一种新型的、化学修饰过的环糊精,具有比较好的稳定性和溶解性。 |
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S5700 |
PhthalylsulfathiazolePhthalylsulfathiazole (Sulfathalidine) is a broad-spectrum antimicrobial that can treat different types of infections including intestinal. |
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S4041 |
Olsalazine SodiumOlsalazine Sodium 是一种抗炎症前体药,包含2个5-ASA部分,通过偶氮键相连。 |
![]() ![]() Values represent the average scores for each group ± S.E. (N = 10 per group). The differences between individual experimental groups and 17 days DSS only group were statistically significant (p < 0.05) for all groups.
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S6136 |
(±)-α-Bisabololα-bisabolol是一种植物来源的油性倍半萜烯醇,具有抗炎和抗菌活性。 |
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S5757 |
IsoeugenolIsoeugenol (4-Propenylguaiacol), an essential oil constituent of nutmeg, clove, and cinnamon, shows antimicrobial activity. |
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S4250 |
SulfamethoxypyridazineSulfamethoxypyridazine (CL 13494)是长效磺胺类药物,用于治疗疱疹样皮炎。 |
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S5397 |
ChlorhexidineChlorhexidine is a disinfectant and topical anti-infective agent that is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes, and yeasts. |
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S6173 |
AmylmetacresolAmylmetacresol是一种防腐杀菌剂,用于治疗口腔和喉咙的感染。 |
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S6185 |
Arachidonic acidArachidonic acid (Arachidonate)是非饱和必需脂肪酸,在动物和人类肝脏、脑部和腺器官脂肪中都有发现。它是前列腺素、凝血噁烷和白细胞三烯的生物合成的前体化合物。 |
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S2271 |
Berberine chloride (NSC 646666)Berberine chloride (NSC 646666, Natural Yellow 18)是异喹啉类生物碱的季铵盐。Berberine chloride 可激活 caspase 3 和 caspase 8,分裂 poly ADP-ribose polymerase (PARP) 和释放 cytochrome c。Berberine chloride 可降低 c-IAP1,Bcl-2 和 Bcl-XL 的表达。Berberine chloride 可通过 JNK 和 p38 MAPK 的持续磷酸化以及产生 ROS 来诱导凋亡。Berberine chloride 是一个 topoisomerase I 和 II 的双效抑制剂。Berberine chloride 也是一个潜在的自噬调节剂。 |
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S2282 |
CinchonidineCinchonidine是一种生物碱,在有机化学中用于不对称合成。 |
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S5475 |
NovaluronNovaluron (Rimon) belongs to the class of insecticides called insect growth regulators with pesticide properties. |
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S3218 |
AmiloxateAmiloxate (Amiloxiate, Isoamyl Methoxycinnamate, Isopentyl 4-methoxycinnamate, Isoamyl 4-methoxycinnamate, Isoamyl p-methoxycinnamate, Isopentyl p-methoxycinnamate) 是一种EMA批准的可用于化妆品的化学紫外线过滤剂。Amiloxate 是一种具有抗炎活性的肉桂酸衍生物。 |
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S5963 |
Sulfathiazole sodiumSulfathiazole sodium,一种抗菌剂,也是一种可被用作短效磺胺药的有机硫化合物。 |
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S5967 |
Berberine chloride hydrateBerberine (Natural Yellow 18) chloride hydrate 是属于异喹啉生物碱的季铵盐。Berberine 可激活 caspase 3 和 caspase 8,poly ADP-ribose polymerase (PARP) 的切割和 cytochrome c 的释放。Berberine chloride 可降低 c-IAP1、Bcl-2 和 Bcl-XL 的表达。Berberine chloride 通过 JNK 和 p38 MAPK 的持续磷酸化以及 ROS的生成来诱导凋亡。Berberine chloride 是一种 topoisomerase I 和 II 的双重抑制剂。Berberine chloride 也是一种潜在的自噬调节剂。 |
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S4172 |
Cetylpyridinium ChlorideCetylpyridinium chloride是一种阳离子季铵化合物,作为口咽消毒剂。 |
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S6243 |
Ethyl pyruvateEthyl pyruvate (CTI-01)是丙酮酸一种简单的脂肪族酯,通过发挥消炎、抗氧化和抗凋亡活性而具有神经保护作用。 |
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S3695 |
Cystamine dihydrochlorideCystamine dihydrochloride (Decarboxycystine, 2-Aminoethyl disulfide, 2,2'-Dithiobisethanamine) acts as an anti-infective agent, which is used in the treatment of urinary tract infections and also as a radiation-protective agent that interferes with sulfhydryl enzymes. |
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S4175 |
SulfaguanidineSulfaguanidine是一种磺胺药物,作为抗感染剂。 |
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S2395 |
RheochrysidinRheochrysidin (Physcione)是大承气汤的主要成分之一,用于治疗炎症。 |
![]() ![]() AmpC β-lactamase and MDH inhibition dose-response curves in the absence (black circles) and presence (red triangles) of DTT for (C and D) physcion. |
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S3787 |
Picroside IPicroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B. |
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S9016 |
Dipsacoside BDipsacoside B, extracted from the flowerbuds of Lonicera confusa DC, shows strong antimicrobial activity. |
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S5908 |
GarenoxacinGarenoxacin (T-3811ME, BMS-284756)是一种新型的des-F(6)喹诺酮,在体外对许多病原体具有有效作用,包括gram-positive和gram-negative的需氧菌和厌氧菌。 |
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S3649 |
CeftazidimeCeftazidime is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa. |
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S4062 |
RonidazoleRonidazole 是一种抗原生动物药剂。 |
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S4971 |
BuparvaquoneBuparvaquone (Butalex)是第二代羟基萘醌化合物,有希望治疗和预防泰勒虫病。 |
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S6761 |
DalfopristinDalfopristin (RP54476) 是ostreogyrcin A的半合成类似物。Quinupristin/dalfopristin (Q/D) 是一种亲本链霉菌素,其活性范围包括革兰氏阳性病原体,及对其他种类的抗菌化合物具有抗性的病原体。 |
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S4192 |
ChlorquinaldolChlorquinaldol是一种抗微生物药剂。 |
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S5292 |
Diazolidinyl ureaDiazolidinyl urea (Germall II) is an antimicrobial preservative used in cosmetics. |
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S3210 |
3'-Hydroxy-4'-methoxyacetophenone3'-Hydroxy-4'-methoxyacetophenone (Acetoisovanillone, Isoacetovanillone, Diosmin EP Impurity A) 是一种具有消炎潜能的活性多刺疟原虫提取物。 |
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S5961 |
Prednisolone disodium phosphatePrednisolone disodium phosphate (Hydeltrasol, Prednisolone 21-phosphate disodium) 是一种具有抗炎和免疫调节特性的合成糖皮质激素,可对耐药性急性淋巴细胞白血病细胞发挥晚期有丝分裂和双向作用。 |
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S5887 |
KhellinKhellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Kalangin)分离自阿密茴(伞形科)种子,被用于治疗多种疾病。 |
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S4081 |
Sulfacetamide SodiumSulfacetamide Sodium是一种抗生素。 |
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S4759 |
p-Coumaric Acidp-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid)是肉桂酸的羟基衍生物。肉桂酸存在于多种可食用植物,具有抗氧化、消炎和抗菌活性。 |
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S7411 |
Ascomycin (FK520)Ascomycin (FK520, FR 900520, Immunomycin), FK-506的一种类似物, 是中性的大环内酯类 immunosuppressant, 能够防止器官移植后的排斥反应。 |
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S0146 |
BroxaldineBroxaldine (Brobenzoxaldine, AL307) 是一种抗原生动物药,可用于麻风病治疗。 |
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S6019 |
2-Phenylphenol2-Phenylphenol,在柠檬中发现,是一种抗真菌剂和防腐剂,用于食品调味剂中。 |
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S9387 |
MaackiainMaackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects. |
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S3364 |
3-Hydroxyphenylacetic acid3-Hydroxyphenylacetic acid (3-HPAA) 是一种酚酸,主要存在于橄榄油废水中,也是膳食类黄酮槲皮素flavonoid quercetin的肠道代谢产物。3-Hydroxyphenylacetic acid 具有抗菌性能。 |
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S9084 |
RhoifolinRhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects. |
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S3801 |
Sodium HouttuyfonateSodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis. |
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S2613 |
ClorsulonClorsulon (MK-401) 用于治疗小牛和羊的肝片吸虫感染。 |
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S6442 |
ChlorphenesinChlorphenesin是一种合成的防腐剂,被用于护肤品中,是一种化妆品抗微生物剂。 |
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S9342 |
1,4-Naphthoquinone1,4-Naphthoquinone (α-Naphthoquinone, para-naphthoquinone, P-Naphthoquinone), found in diesel exhaust particles and it is an active metabolite of naphthalene, is a fumigant insecticide. |
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S2564 |
Cloxacillin SodiumCloxacillin Sodium是Cloxacillin的钠盐形式,是一种耐青霉素酶,耐酸,半合成的青霉素。 |
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S9112 |
KaempferitrinKaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities. |
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S5096 |
SulfadiMethoxine sodiumSulfadimethoxine (Sulfadimethoxydiazine)是一种长效的磺胺类抗菌剂,用于治疗多种感染,如呼吸道、尿道、肠道和软组织感染。 |
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S9113 |
OnoninOnonin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects. |
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S5099 |
4-Aminophenylarsonic acid4-Aminophenylarsonic acid (Arsanilic Acid)是一种有机砷化合物,具有抗感染活性。 |
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S6459 |
NifurtimoxNifurtimox (BAY-2502) 是一种抗原虫剂。 |
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S4232 |
NithiamideNithiamide (CL 5279) 是一种非5-硝基咪唑类药物。 |
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S3618 |
Acetylspiramycin (ASPM)Acetylspiramycin (ASPM, Spiramycin II, Foromacidin B)是大环内酯物抗菌剂。 |
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P1201 |
LL37 (Human cathelicidin)LL37 (Human cathelicidin, Ropocamptide) 是与Cathelicidin相关的 antimicrobial 抗菌肽,具有强大的趋化和免疫调节特性。 |
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S4236 |
Proflavine HemisulfateProflavine Hemisulfate是一种外用防腐剂,通过与DNA螯合从而破坏DNA合成,且导致复制的DNA链发生高水平的突变。 |
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S3746 |
LumefantrineLumefantrine (benflumetol) 是一种抗疟疾剂,用于治疗急性无并发症的疟疾。 |
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S5212 |
Imidazolidinyl UreaImidazolidinyl Urea (Imidurea)是一种抗菌剂,在化妆品中被用作防腐剂。 |
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S5210 |
Sulfamethazine Sodium SaltSulfamethazine (Sulfadimethyldiazine) 是磺胺类抗感染试剂,用于畜牧业。 |
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S0443 |
DesciclovirDesciclovir (DCV, 6-Deoxyacyclovir, BW A515U)是一种 抗疱疹antiherpetic 药物无环鸟苷acyclovir (ACV)的前药,在人体内通过黄嘌呤氧化酶转化为ACV。 |
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S4678 |
Povidone iodinePovidone iodine (Betadine, PVP iodine, PVP-I, Isodine)是聚乙烯吡咯烷酮(PVP)和碘元素的稳定化合复合体。在外科手术中被用作是局部消毒剂,防止皮肤及黏膜感染。 |
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S9131 |
PunicalaginPunicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects. |
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S3139 |
MethenamineMethenamine是一种抗生素,用于治疗尿路感染。 |
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S5405 |
PropylparabenPropylparaben (Propyl 4-hydroxybenzoate, Propyl p-hydroxybenzoate, nipasol), a natural substance found in many plants and some insects, is an antimicrobial, preservative and flavouring agent. |
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S4242 |
Cetrimonium Bromide (CTAB)Cetrimonium Bromide (CTAB)是广谱防腐剂西曲溴铵的一种已知组分,西曲溴铵是不同季铵盐的混合物。 |
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S5214 |
Imidocarb dipropionateImidocarb是一种抗原虫剂,在治疗巴贝西虫病和埃里希体病中被用作二丙酸盐使用。 |
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S6461 |
PermethrinPermethrin是一种合成的I型拟除虫菊酯、具有神经毒性的杀虫剂。 |
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S3978 |
5-Phenyl-2,4-pentadienoic acid5-Phenyl-2,4-pentadienoic acid (5-Phenylpenta-2,4-dienoic acid) is used as Synthetic building block, anti-malarial agent. |
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S3220 |
TrigonellineTrigonelline (Trigenolline) 是一种植物生物碱,是咖啡和葫芦巴的主要成分,具有抗脱粒、抗糖尿病、抗氧化、抗炎和神经保护的作用。 Trigonelline 可抑制FcεRI介导的细胞内信号通路,例如 PLCγ1、PI3K 和 Akt 的磷酸化。Trigonelline (Trigenolline) 还可抑制RBL-2H3细胞中 microtubule 的形成。 |
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S5390 |
N-(Hytroxymethy)micotinamideN-(Hydroxymethyl)nicotinamide (Nikomethamide, Bilamid, N-hydroxymethylnicotinamide) is an antimicrobial agent. |
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S5355 |
Piperaquine phosphatePiperaquine phosphate is an orally active bisquinolone antimalarial drug. |
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S9560 |
Anisodamine HydrobromideAnisodamine (6-Hydroxyhyoscyamine)是天然存在的阿托品(atropine)衍生物,具有消炎活性。它能抑制α1-adrenergic receptors和mAChRs。 |
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S5005 |
Cefotiam hydrochlorideCefotiam hydrochloride (Halospor, Pansporin, Pansporine) is the hydrochloride salt form of cefotiam and has a broad spectrum of activity against both gram-positive and gram-negative microorganisms. |
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S1962 |
SulphadimethoxineSulphadimethoxine 是一种非还原性的葡糖苷酸。 |
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S4555 |
CarsalamCarsalam (Carbonylsalicylamide) 是一种非类固醇的消炎药。 |
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S7896 |
Sodium Tauroursodeoxycholate (TUDC)Sodium Tauroursodeoxycholate (TUDC)是一种水溶性胆汁酸,用于治疗胆结石和肝硬化。 |
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S4521 |
DEETDEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) 是一种常见的杀虫剂的活性成分。 |
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S9185 |
Nitidine ChlorideNitidine Chloride, a benzophenanthridine alkaloid found in species of the genus Zanthoxylum, has an anti-malarial activity. |
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S5001 |
Tofacitinib (CP-690550) CitrateTofacitinib citrate (CP-690550, Tasocitinib)是一种新型JAK抑制剂,对JAK3,JAK2,JAK1的IC50分别为1 nM, 20 nM 和112 nM。Tofacitinib citrate 还具有抗感染的活性。 |
![]() ![]() CP-690550 reduced the severity of ischemic damage. (A) CP-690550 (10 μM) suppressed IL-17 production by cdT cells and activated memory T cells. cdT cells and CD4+ CD44+ memory T cells isolated from C5BL6J mice through flow cytometry were stimulated for 24 h with plate-bound monoclonal antibodies to CD3 (2 ng/ml) and CD28 (1 ng/ml) in the presence or absence of IL-23 (25 ng/ml). IL-17A production and IL-17A expression level were measured by quantitative RT-PCR (a) and ELISA (b). (B) CBF reduction after brain ischemia. (C) Time-dependent changes in neurological score. *p < 0.05. (D) Infarct volume as visualized through TTC staining on day 3 in CP-690550 (CP)- and vehicle-treated mice.
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S4157 |
Chloroquine diphosphateChloroquine diphosphate是一种4-氨基喹啉的抗疟疾和抗风湿药,也是一种ATM激活剂。Chloroquine 也是一种toll-like receptors (TLRs)的抑制剂。 |
![]() ![]() NCI-H929 EV and miR-137 OE cells were treated with ATM activator Chloroquine Phosphate (CQ), specific ATM inhibitor KU-55933, and ATR inhibitor AZ20 for 12 hr. Immunoblotting showed the expression of p-ATM, p-Chk2, p-BRCA1, p-ATR and p-Chk1. |
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E0206New |
GinkgetinGinkgetin 是一种来自银杏叶的双黄酮,具有抗癌、抗炎、抗微生物、抗脂肪生成和神经保护作用。 |
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S2572 |
Streptomycin sulfateStreptomycin sulfate是Streptomycin的硫酸盐形式,是一种蛋白质合成抑制剂。 |
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S8279 |
Shikonin (C.I. 75535)Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844)是一种 Pyruvate kinase M2 (PKM2) 有效的、特异的抑制剂。它是紫草的主要成分,紫草是一种中草药,具有多种生物活性。在细胞荧光淬灭试验中,Shikonin也是TMEM16A氯离子通道的抑制剂。Shikonin 通过抑制 tumor necrosis factor-α (TNF-α) 发挥抗炎作用,并可通过抑制 proteasome 来阻止 nuclear factor-κB (NF-κB) 信号途径的激活。 |
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S3226 |
Dehydroabietic acidDehydroabietic acid (DAA, DHAA) 是一种天然的二萜树脂酸,衍生自针叶植物(如 Pinus 和 Picea)通过抑制 Src、Syk 和 TAK1 介导的通路来产生抗炎活性。 |
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S4945 |
Ethacridine lactateEthacridine lactate (Acrinol) 是一种基于acridine的芳香族有机化合物,可用作防腐剂。Ethacridine lactate 也是一种 poly(ADP-ribose) glycohydrolase (PARG) 抑制剂。 |
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S5184 |
Dexamethasone palmitateDexamethasone palmitate (DXP),是 Dexamethasone (DXM) 的亲脂性前药,是一种 glucocorticoid receptor 的激动剂,其对糖皮质激素受体的亲和力比DXM低47倍。Dexamethasone palmitate (DXP) 具有抗炎活性。 |
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S3308 |
Caftaric acidCaftaric acid (CA, Caffeoyl tartaric acid) 是一种具有抗氧化和抗炎作用的天然产物。 |
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S1553 |
Delafloxacin (ABT-492)Delafloxacin (ABT-492, RX-3341, WQ-3034)是一种氟喹诺酮,抗155需氧和171厌氧病原体。 |
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S4946 |
2,3-Dihydroxybenzoic acid2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) 是一种天然酚类,存在于西印度醋栗和水生蕨类Salvinia molesta,也是人体中阿司匹林的代谢产物。它是一种潜在的铁螯合药物,具有抗菌特性。 |
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S8068 |
ChaetocinChaetocin,一类来自毛壳菌属的天然产物,是一类 histone methyltransferase 抑制剂,其对dSU(VAR)3-9,小鼠G9a和粗糙链孢霉 DIM5的IC50分别为0.8 μM, 2.5 μM和3 μM。Chaetocin是一种抗癌药物并是 thioredoxin reductase (TrxR) 的抑制剂。 |
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S4430 |
Hydroxychloroquine Sulfate (NSC 4375)Hydroxychloroquine Sulfate (NSC 4375, HCQ)是一种抗疟疾药,用于治疗系统性红斑狼疮,类风湿关节炎等自身免疫病,炎症以及皮肤病。它也是autophagy和toll-like receptor (TLR) 7/9的抑制剂。 |
![]() ![]() C, SA-beta gal staining results of A549-LKB1 cells treated by trametinib (30 nmol/L), radiotherapy (2 Gy), and HCQ (50 μmol/L). Cells were treated by HCQ and/or trametinib 4 hours prior to radiotherapy. Drugs were washed out 24 hours after radiotherapy. Cells were incubated for additional 48 hours before staining. D, Clonogenic survival assay of A549-LKB1 cells treated with trametinib (30 nmol/L) and HCQ (50 μmol/L).
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S4303 |
9-Aminoacridine9-Aminoacridine (Aminacrine)是一种高荧光染料,在临床上用作局部防腐剂,在实验中用作诱变剂、细胞内pH指示剂和负模小分子MALDI基质。 |
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S5927 |
ProguanilProguanil (chlorguanide, chloroguanide) 是预防性抗疟药。它能抑制疟原虫的二氢叶酸还原酶,阻止嘌呤和嘧啶的合成。 |
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S4417 |
Ceftaroline FosamilCeftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) 是一种头孢菌素,对 Gram-positive pathogens (包括耐甲氧西林的金黄色葡萄球菌(MRSA))具有活性。 |
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S6771 |
MAC-545496MAC-545496是一种纳摩尔浓度的glycopeptide-resistance-associated protein R(GraR)抑制剂,对全长GraR蛋白(Kd≤0.1 nM)具有很强的结合亲和力。 MAC-545496可以逆转耐甲氧西林菌株中的β-内酰胺耐药性,并与CAMP协同作用。 MAC-545496在巨噬细胞中显示出显着的活性,并减弱了苜蓿根瘤菌幼虫感染模型中的金黄色葡萄球菌毒力。 |
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S3711 |
Carbasalate CalciumCarbasalate calcium (Iromin, Alcacyl, Omegin, Rheomin, Solupsan) 是一种止痛剂、退热剂,是一种抗炎药物以及血小板聚集的抑制剂。 |
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S9341 |
3,4-Dimethoxycinnamic acid3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM. |
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S4515 |
Ademetionine disulfate tosylateAdemetionine Disulfate Tosylate是腺苷蛋氨酸离子的非对映异构体的硫酸氢盐-甲苯磺酸盐混合盐形式。Ademetionine(腺苷蛋氨酸)具有抗炎活性,被用于治疗慢性肝疾病。 |
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S2430 |
AzodicarbonamideAzodicarbonamide是第一个已知的通过靶向 nucleocapsid CCHC domains 来抑制 HIV-1 和多种逆转录病毒的核衣壳抑制剂。在标准的基于细胞的抗病毒试验中,Azodicarbonamide抑制HIV-1RF诱导的CEM-SS细胞病变,EC50为38 µM。 |
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S6802 |
EtosalamideEtosalamide (Ethosalamide)是一种具有退烧和镇痛作用的抗炎药。 |
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S7867 |
OleuropeinOleuropein 是一种从橄榄叶中分离出的抗氧化多酚。Oleuropein 具有抗氧化、抗炎和抗动脉粥样硬化的作用,并在体外抑制脂肪细胞的分化。Oleuropein 抑制 PPARγ 活性。Oleuropein 通过直接抑制PPARγ转录活性发挥抗脂肪形成作用。Oleuropein 还可抑制aromatase。Oleuropein 可诱导凋亡。Phase 2。 |
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S3261 |
MyrislignanMyrislignan 是一种分离自Myristica fragrans Houtt的木脂素并具有抗炎活性。Myrislignan 可抑制 interleukin-6 (IL-6) 和 tumour necrosis factor-α (TNF-α)。Myrislignan 剂量依赖性地抑制LPS刺激的巨噬细胞中 inducible NO synthase (iNOS) 和 cyclooxygenase-2 (COX-2) 的表达。Myrislignan 可抑制 NF-κB 信号通路的激活。 |
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S4549 |
Antimonyl potassium tartrate trihydrateAntimonyl potassium tartrate trihydrate (Tartar emetic) 是一种有效的催吐剂,同样也用于治疗血吸虫病和利什曼病。 |
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S7465 |
FTI 277 HClFTI 277 HCl是FTI 277的甲酯,是一种有效的选择性farnesyltransferase (FTase)抑制剂,IC50为500 pM,选择性比密切相关的GGTase I 高100倍。FTI 277 HCl可抑制细胞生长并诱导凋亡。FTI 277 HCl可有效清除HDV病毒血症。 |
![]() ![]() (A) HCT 116 cells were treated with Tram (0, 30, or 60 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD. (B) SW480 and MDA-MB-231 cells were treated with Tram (0, 80, 160 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD.
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S1958 |
SulbactamSulbactam 是β-内酰胺酶抑制剂,IC50为0.8 μM。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S3269 |
AcetylcorynolineAcetylcorynoline 是衍生自中草药 Corydalis bungeana 的主要生物碱成分,具有抗炎特性。Acetylcorynoline 可能通过降低 egl-1 的表达来抑制细胞凋亡通路,并增加 rpn5 的表达来增强 proteasomes 的活性。 |
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S3270 |
Genipin 1-O-beta-D-gentiobiosideGenipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) 是从栀子 Gardenia jasminoides Ellis 中分离到的一种生物活性类环烷苷,具有保肝、抗炎、抗氧化和抗血栓形成的功能。 |
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S3279 |
Polyphyllin B (Formosanin C)Polyphyllin B (Formosanin C, FC) 是一种从Paris formosana分离得到的薯蓣皂苷,也是一种具有抗肿瘤活性的免疫调节剂。Polyphyllin B (Formosanin C, FC) 可诱导凋亡。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S1282 |
ArtemisininArtemisinin (Qinghaosu, Artemisinine)青蒿素用于治疗耐多药的恶性疟疾菌株。 |
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S2264 |
ArtemetherArtemether (SM-224, CGP 56696) 是一种抗疟药,用于治疗恶性疟疾的耐药菌株。 |
![]() ![]() Schistosomicidal effects of PZQ, ART(Artemether) and OXA on 14-day schistosomula. Magnification of the in vitro-cultured schistosomula treated with PZQ, ART, and OXA at 10 μM. Drugs were added at day 14 and schistosomula were analyzed at day 21 (late treatment). 0.1% DMSO in medium (solvent of the drugs; used as negative control) had no effect on schistosomula development. |
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S2479 |
Lincomycin HClLincomycin hydrochloride (Lincocin, NSC 70731) 是Lincomycin的一水盐, 是Lincolnensis链霉菌属的成员生长所产生的物质。 |
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S1644 |
NitrofuralNitrofural (Nitrofurazone) 是外用的抗感染剂,IC50为22.83±1.2 μM,作用于大鼠,LD50为590 mg/kg。 |
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S4237 |
Primaquine DiphosphatePrimaquine Diphosphate是一种临床有效的阻断传播的抗疟疾药,对人类疟疾的的配子体具有明显的抵抗活性。 |
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S2469 |
FleroxacinFleroxacin (Ro 23-6240, AM-833) 是一种新型广谱喹诺酮类。 |
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S3116 |
SulfathiazoleSulfathiazole是一种有机硫化合物,已被用来作为一种短效的磺胺类药物。 |
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S2511 |
SulfadoxineSulfadoxine (Sulphadoxine) 是一种超长效磺胺类药物,作用于P. Vivax,IC50为249 μg/ml。 |
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S3067 |
Chlorhexidine 2HClChlorhexidine hydrochloride (NSC-185) 是一种防腐剂,可以有效抵抗大多数革兰氏阴性和阳性有机体。 |
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S4147 |
Azithromycin DihydrateAzithromycin Dihydrate 是对酸稳定的,口服的,大环内酯类抗菌药物,结构与红霉素相关。 |
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S4191 |
BetamipronBetamipron (CS-443)是一种化学化合物,与Panipenem一起使用,抑制Panipenem吸收进肾小管,防止肾毒性。 |
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S2537 |
SecnidazoleSecnidazole (Flagentyl, PM 185184, RP 14539) 是一种硝基咪唑类抗感染剂。 |
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S4195 |
BroxyquinolineBroxyquinoline是一种抗原虫剂,作用于粘膜,可以从水中释放氧自由基。 |
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S4196 |
Ethacridine lactate monohydrateEthacridine lactate monohydrate是一种芳香族有机化合物,用作防腐剂。 |
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S2612 |
RibitolRibitol (Adonitol) 是一种戊糖醇结晶,通过核糖还原形成,在Adonis vernalis植物中自然发生。 |
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S4726 |
Lauric AcidLauric Acid (dodecanoic acid, N-Dodecanoic acid, Dodecylic acid)是饱和中链脂肪酸,在多种植物、动物油脂中都天然存在,是椰子油和棕榈仁油的主要成分。 |
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S3288 |
AbsinthinAbsinthin (Absynthine) 是一种来自 Artemisia absinthium 的天然三萜内酯,具有抗炎特性。Absinthin (Absynthine) 可显著地增强 matrix metalloproteinase-8 (MMP-8) 的表达,并且是潜在的急性肺损伤(ALI)的候选治疗药物。 |
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S3941 |
PinocembrinPinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone)是制药工业中多功能黄酮类分子,它具有很多药学活性,如抗菌、消炎、抗氧化和抗癌活性。 |
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S4573 |
m-Tolyl acetatem-Tolyl acetate是一种药物中间体和防腐剂。 |
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S4579 |
ResorcinolResorcinol是一种用作防腐剂、消毒剂的化合物,是很多药物合成的中间产物。 |
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S9564 |
p-Hydroxy-cinnamic Acidp-Hydroxy-cinnamic Acid在体外具有抗疟活性和体内抗骨质疏松活性。 |
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S6288 |
Chlorhexidine diacetateChlorhexidine diacetate (Hibitane diacetate)是一种消毒剂和局部抗感染剂,也用于漱口水中防止口腔菌斑。 |
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S5366 |
FipronilFipronil (Fluocyanobenpyrazole, Termidor) is a recalcitrant phenylpyrazole-based pesticide used for flea/tick treatment and termite control that is distributed in urban aquatic environments via stormwater and contributes to stream toxicity. |
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S9094 |
PogostonePogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity. |
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S4420 |
Mefloquine HClMefloquine HCl是一种血液裂殖体杀灭剂,抑制疟原虫色素的形成,用作抗疟疾药物。 |
![]() ![]() BALB/c mice, orally infected with E. multilocularis eggs, were treated by either mefloquine (100 mg/kg twice per week, n = 9), ABZ (200 mg/kg, 5 times per week, n = 8) or control-treated (placebo, n = 9). After 12 weeks of treatment, parasite lesion numbers in the liver were assessed microscopically (A).
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S4142 |
ClopidolClopidol (WR 61112)是一种抗原虫药剂。 |
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S4592 |
Captisol (SBE-β-CD)Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) 是一种新型的、化学修饰过的环糊精,具有比较好的稳定性和溶解性。 |
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S5700 |
PhthalylsulfathiazolePhthalylsulfathiazole (Sulfathalidine) is a broad-spectrum antimicrobial that can treat different types of infections including intestinal. |
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S4041 |
Olsalazine SodiumOlsalazine Sodium 是一种抗炎症前体药,包含2个5-ASA部分,通过偶氮键相连。 |
![]() ![]() Values represent the average scores for each group ± S.E. (N = 10 per group). The differences between individual experimental groups and 17 days DSS only group were statistically significant (p < 0.05) for all groups.
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S6136 |
(±)-α-Bisabololα-bisabolol是一种植物来源的油性倍半萜烯醇,具有抗炎和抗菌活性。 |
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S5757 |
IsoeugenolIsoeugenol (4-Propenylguaiacol), an essential oil constituent of nutmeg, clove, and cinnamon, shows antimicrobial activity. |
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S4250 |
SulfamethoxypyridazineSulfamethoxypyridazine (CL 13494)是长效磺胺类药物,用于治疗疱疹样皮炎。 |
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S5397 |
ChlorhexidineChlorhexidine is a disinfectant and topical anti-infective agent that is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes, and yeasts. |
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S6173 |
AmylmetacresolAmylmetacresol是一种防腐杀菌剂,用于治疗口腔和喉咙的感染。 |
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S6185 |
Arachidonic acidArachidonic acid (Arachidonate)是非饱和必需脂肪酸,在动物和人类肝脏、脑部和腺器官脂肪中都有发现。它是前列腺素、凝血噁烷和白细胞三烯的生物合成的前体化合物。 |
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S2271 |
Berberine chloride (NSC 646666)Berberine chloride (NSC 646666, Natural Yellow 18)是异喹啉类生物碱的季铵盐。Berberine chloride 可激活 caspase 3 和 caspase 8,分裂 poly ADP-ribose polymerase (PARP) 和释放 cytochrome c。Berberine chloride 可降低 c-IAP1,Bcl-2 和 Bcl-XL 的表达。Berberine chloride 可通过 JNK 和 p38 MAPK 的持续磷酸化以及产生 ROS 来诱导凋亡。Berberine chloride 是一个 topoisomerase I 和 II 的双效抑制剂。Berberine chloride 也是一个潜在的自噬调节剂。 |
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S2282 |
CinchonidineCinchonidine是一种生物碱,在有机化学中用于不对称合成。 |
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S5475 |
NovaluronNovaluron (Rimon) belongs to the class of insecticides called insect growth regulators with pesticide properties. |
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S3218 |
AmiloxateAmiloxate (Amiloxiate, Isoamyl Methoxycinnamate, Isopentyl 4-methoxycinnamate, Isoamyl 4-methoxycinnamate, Isoamyl p-methoxycinnamate, Isopentyl p-methoxycinnamate) 是一种EMA批准的可用于化妆品的化学紫外线过滤剂。Amiloxate 是一种具有抗炎活性的肉桂酸衍生物。 |
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S5963 |
Sulfathiazole sodiumSulfathiazole sodium,一种抗菌剂,也是一种可被用作短效磺胺药的有机硫化合物。 |
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S5967 |
Berberine chloride hydrateBerberine (Natural Yellow 18) chloride hydrate 是属于异喹啉生物碱的季铵盐。Berberine 可激活 caspase 3 和 caspase 8,poly ADP-ribose polymerase (PARP) 的切割和 cytochrome c 的释放。Berberine chloride 可降低 c-IAP1、Bcl-2 和 Bcl-XL 的表达。Berberine chloride 通过 JNK 和 p38 MAPK 的持续磷酸化以及 ROS的生成来诱导凋亡。Berberine chloride 是一种 topoisomerase I 和 II 的双重抑制剂。Berberine chloride 也是一种潜在的自噬调节剂。 |
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S4172 |
Cetylpyridinium ChlorideCetylpyridinium chloride是一种阳离子季铵化合物,作为口咽消毒剂。 |
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S6243 |
Ethyl pyruvateEthyl pyruvate (CTI-01)是丙酮酸一种简单的脂肪族酯,通过发挥消炎、抗氧化和抗凋亡活性而具有神经保护作用。 |
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S3695 |
Cystamine dihydrochlorideCystamine dihydrochloride (Decarboxycystine, 2-Aminoethyl disulfide, 2,2'-Dithiobisethanamine) acts as an anti-infective agent, which is used in the treatment of urinary tract infections and also as a radiation-protective agent that interferes with sulfhydryl enzymes. |
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S4175 |
SulfaguanidineSulfaguanidine是一种磺胺药物,作为抗感染剂。 |
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S2395 |
RheochrysidinRheochrysidin (Physcione)是大承气汤的主要成分之一,用于治疗炎症。 |
![]() ![]() AmpC β-lactamase and MDH inhibition dose-response curves in the absence (black circles) and presence (red triangles) of DTT for (C and D) physcion. |
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S3787 |
Picroside IPicroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B. |
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S9016 |
Dipsacoside BDipsacoside B, extracted from the flowerbuds of Lonicera confusa DC, shows strong antimicrobial activity. |
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S5908 |
GarenoxacinGarenoxacin (T-3811ME, BMS-284756)是一种新型的des-F(6)喹诺酮,在体外对许多病原体具有有效作用,包括gram-positive和gram-negative的需氧菌和厌氧菌。 |
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S3649 |
CeftazidimeCeftazidime is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa. |
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S4062 |
RonidazoleRonidazole 是一种抗原生动物药剂。 |
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S4971 |
BuparvaquoneBuparvaquone (Butalex)是第二代羟基萘醌化合物,有希望治疗和预防泰勒虫病。 |
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S6761 |
DalfopristinDalfopristin (RP54476) 是ostreogyrcin A的半合成类似物。Quinupristin/dalfopristin (Q/D) 是一种亲本链霉菌素,其活性范围包括革兰氏阳性病原体,及对其他种类的抗菌化合物具有抗性的病原体。 |
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S4192 |
ChlorquinaldolChlorquinaldol是一种抗微生物药剂。 |
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S5292 |
Diazolidinyl ureaDiazolidinyl urea (Germall II) is an antimicrobial preservative used in cosmetics. |
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S3210 |
3'-Hydroxy-4'-methoxyacetophenone3'-Hydroxy-4'-methoxyacetophenone (Acetoisovanillone, Isoacetovanillone, Diosmin EP Impurity A) 是一种具有消炎潜能的活性多刺疟原虫提取物。 |
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S5961 |
Prednisolone disodium phosphatePrednisolone disodium phosphate (Hydeltrasol, Prednisolone 21-phosphate disodium) 是一种具有抗炎和免疫调节特性的合成糖皮质激素,可对耐药性急性淋巴细胞白血病细胞发挥晚期有丝分裂和双向作用。 |
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S5887 |
KhellinKhellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Kalangin)分离自阿密茴(伞形科)种子,被用于治疗多种疾病。 |
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S4081 |
Sulfacetamide SodiumSulfacetamide Sodium是一种抗生素。 |
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S4759 |
p-Coumaric Acidp-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid)是肉桂酸的羟基衍生物。肉桂酸存在于多种可食用植物,具有抗氧化、消炎和抗菌活性。 |
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S7411 |
Ascomycin (FK520)Ascomycin (FK520, FR 900520, Immunomycin), FK-506的一种类似物, 是中性的大环内酯类 immunosuppressant, 能够防止器官移植后的排斥反应。 |
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S0146 |
BroxaldineBroxaldine (Brobenzoxaldine, AL307) 是一种抗原生动物药,可用于麻风病治疗。 |
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S6019 |
2-Phenylphenol2-Phenylphenol,在柠檬中发现,是一种抗真菌剂和防腐剂,用于食品调味剂中。 |
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S9387 |
MaackiainMaackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects. |
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S3364 |
3-Hydroxyphenylacetic acid3-Hydroxyphenylacetic acid (3-HPAA) 是一种酚酸,主要存在于橄榄油废水中,也是膳食类黄酮槲皮素flavonoid quercetin的肠道代谢产物。3-Hydroxyphenylacetic acid 具有抗菌性能。 |
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S9084 |
RhoifolinRhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects. |
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S3801 |
Sodium HouttuyfonateSodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis. |
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S2613 |
ClorsulonClorsulon (MK-401) 用于治疗小牛和羊的肝片吸虫感染。 |
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S6442 |
ChlorphenesinChlorphenesin是一种合成的防腐剂,被用于护肤品中,是一种化妆品抗微生物剂。 |
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S9342 |
1,4-Naphthoquinone1,4-Naphthoquinone (α-Naphthoquinone, para-naphthoquinone, P-Naphthoquinone), found in diesel exhaust particles and it is an active metabolite of naphthalene, is a fumigant insecticide. |
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S2564 |
Cloxacillin SodiumCloxacillin Sodium是Cloxacillin的钠盐形式,是一种耐青霉素酶,耐酸,半合成的青霉素。 |
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S9112 |
KaempferitrinKaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities. |
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S5096 |
SulfadiMethoxine sodiumSulfadimethoxine (Sulfadimethoxydiazine)是一种长效的磺胺类抗菌剂,用于治疗多种感染,如呼吸道、尿道、肠道和软组织感染。 |
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S9113 |
OnoninOnonin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects. |
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S5099 |
4-Aminophenylarsonic acid4-Aminophenylarsonic acid (Arsanilic Acid)是一种有机砷化合物,具有抗感染活性。 |
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S6459 |
NifurtimoxNifurtimox (BAY-2502) 是一种抗原虫剂。 |
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S4232 |
NithiamideNithiamide (CL 5279) 是一种非5-硝基咪唑类药物。 |
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S3618 |
Acetylspiramycin (ASPM)Acetylspiramycin (ASPM, Spiramycin II, Foromacidin B)是大环内酯物抗菌剂。 |
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P1201 |
LL37 (Human cathelicidin)LL37 (Human cathelicidin, Ropocamptide) 是与Cathelicidin相关的 antimicrobial 抗菌肽,具有强大的趋化和免疫调节特性。 |
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S4236 |
Proflavine HemisulfateProflavine Hemisulfate是一种外用防腐剂,通过与DNA螯合从而破坏DNA合成,且导致复制的DNA链发生高水平的突变。 |
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S3746 |
LumefantrineLumefantrine (benflumetol) 是一种抗疟疾剂,用于治疗急性无并发症的疟疾。 |
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S5212 |
Imidazolidinyl UreaImidazolidinyl Urea (Imidurea)是一种抗菌剂,在化妆品中被用作防腐剂。 |
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S5210 |
Sulfamethazine Sodium SaltSulfamethazine (Sulfadimethyldiazine) 是磺胺类抗感染试剂,用于畜牧业。 |
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S0443 |
DesciclovirDesciclovir (DCV, 6-Deoxyacyclovir, BW A515U)是一种 抗疱疹antiherpetic 药物无环鸟苷acyclovir (ACV)的前药,在人体内通过黄嘌呤氧化酶转化为ACV。 |
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S4678 |
Povidone iodinePovidone iodine (Betadine, PVP iodine, PVP-I, Isodine)是聚乙烯吡咯烷酮(PVP)和碘元素的稳定化合复合体。在外科手术中被用作是局部消毒剂,防止皮肤及黏膜感染。 |
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S9131 |
PunicalaginPunicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects. |
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S3139 |
MethenamineMethenamine是一种抗生素,用于治疗尿路感染。 |
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S5405 |
PropylparabenPropylparaben (Propyl 4-hydroxybenzoate, Propyl p-hydroxybenzoate, nipasol), a natural substance found in many plants and some insects, is an antimicrobial, preservative and flavouring agent. |
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S4242 |
Cetrimonium Bromide (CTAB)Cetrimonium Bromide (CTAB)是广谱防腐剂西曲溴铵的一种已知组分,西曲溴铵是不同季铵盐的混合物。 |
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S5214 |
Imidocarb dipropionateImidocarb是一种抗原虫剂,在治疗巴贝西虫病和埃里希体病中被用作二丙酸盐使用。 |
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S6461 |
PermethrinPermethrin是一种合成的I型拟除虫菊酯、具有神经毒性的杀虫剂。 |
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S3978 |
5-Phenyl-2,4-pentadienoic acid5-Phenyl-2,4-pentadienoic acid (5-Phenylpenta-2,4-dienoic acid) is used as Synthetic building block, anti-malarial agent. |
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S3220 |
TrigonellineTrigonelline (Trigenolline) 是一种植物生物碱,是咖啡和葫芦巴的主要成分,具有抗脱粒、抗糖尿病、抗氧化、抗炎和神经保护的作用。 Trigonelline 可抑制FcεRI介导的细胞内信号通路,例如 PLCγ1、PI3K 和 Akt 的磷酸化。Trigonelline (Trigenolline) 还可抑制RBL-2H3细胞中 microtubule 的形成。 |
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S5390 |
N-(Hytroxymethy)micotinamideN-(Hydroxymethyl)nicotinamide (Nikomethamide, Bilamid, N-hydroxymethylnicotinamide) is an antimicrobial agent. |
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S5355 |
Piperaquine phosphatePiperaquine phosphate is an orally active bisquinolone antimalarial drug. |
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S9560 |
Anisodamine HydrobromideAnisodamine (6-Hydroxyhyoscyamine)是天然存在的阿托品(atropine)衍生物,具有消炎活性。它能抑制α1-adrenergic receptors和mAChRs。 |
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S5005 |
Cefotiam hydrochlorideCefotiam hydrochloride (Halospor, Pansporin, Pansporine) is the hydrochloride salt form of cefotiam and has a broad spectrum of activity against both gram-positive and gram-negative microorganisms. |
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S1962 |
SulphadimethoxineSulphadimethoxine 是一种非还原性的葡糖苷酸。 |
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S4555 |
CarsalamCarsalam (Carbonylsalicylamide) 是一种非类固醇的消炎药。 |
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S7896 |
Sodium Tauroursodeoxycholate (TUDC)Sodium Tauroursodeoxycholate (TUDC)是一种水溶性胆汁酸,用于治疗胆结石和肝硬化。 |
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S4521 |
DEETDEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) 是一种常见的杀虫剂的活性成分。 |
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S9185 |
Nitidine ChlorideNitidine Chloride, a benzophenanthridine alkaloid found in species of the genus Zanthoxylum, has an anti-malarial activity. |