Anti-infection

抑制剂选择性比较

Anti-infection产品

所有产品(132) Anti-infection抑制剂(27) Anti-infection调节剂(3)

目录号	产品描述	文献引用	实验数据
S5001	Tofacitinib (CP-690550) Citrate Tofacitinib citrate (CP-690550, Tasocitinib)是一种新型JAK抑制剂，对JAK3，JAK2，JAK1的IC50分别为1 nM, 20 nM 和112 nM。Tofacitinib citrate 还具有抗感染的活性。	Blood, 2022, blood.2021012366 J Control Release, 2022, S0168-3659(22)00163-8 Mol Neurodegener, 2022, 17(1):7	CP-690550 reduced the severity of ischemic damage. (A) CP-690550 (10 μM) suppressed IL-17 production by cdT cells and activated memory T cells. cdT cells and CD4+ CD44+ memory T cells isolated from C5BL6J mice through flow cytometry were stimulated for 24 h with plate-bound monoclonal antibodies to CD3 (2 ng/ml) and CD28 (1 ng/ml) in the presence or absence of IL-23 (25 ng/ml). IL-17A production and IL-17A expression level were measured by quantitative RT-PCR (a) and ELISA (b). (B) CBF reduction after brain ischemia. (C) Time-dependent changes in neurological score. *p < 0.05. (D) Infarct volume as visualized through TTC staining on day 3 in CP-690550 (CP)- and vehicle-treated mice.
S4157	Chloroquine diphosphate Chloroquine diphosphate是一种4-氨基喹啉的抗疟疾和抗风湿药，也是一种ATM激活剂。Chloroquine 也是一种toll-like receptors (TLRs)的抑制剂。	Phytomedicine, 2022, 98:153958 Bone, 2022, 154:116262 Cancer Cell, 2021, S1535-6108(21)00659-0	NCI-H929 EV and miR-137 OE cells were treated with ATM activator Chloroquine Phosphate (CQ), specific ATM inhibitor KU-55933, and ATR inhibitor AZ20 for 12 hr. Immunoblotting showed the expression of p-ATM, p-Chk2, p-BRCA1, p-ATR and p-Chk1.
E0206^New	Ginkgetin Ginkgetin 是一种来自银杏叶的双黄酮，具有抗癌、抗炎、抗微生物、抗脂肪生成和神经保护作用。
S2572	Streptomycin sulfate Streptomycin sulfate是Streptomycin的硫酸盐形式，是一种蛋白质合成抑制剂。	Front Microbiol, 2021, 12:761113 Life Sci, 2021, 282:119798 Biosci Rep, 2021, BSR20200842
S8279	Shikonin (C.I. 75535) Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844)是一种 Pyruvate kinase M2 (PKM2) 有效的、特异的抑制剂。它是紫草的主要成分，紫草是一种中草药，具有多种生物活性。在细胞荧光淬灭试验中，Shikonin也是TMEM16A氯离子通道的抑制剂。Shikonin 通过抑制 tumor necrosis factor-α (TNF-α) 发挥抗炎作用，并可通过抑制 proteasome 来阻止 nuclear factor-κB (NF-κB) 信号途径的激活。	Adv Sci (Weinh), 2022, 10.1002/advs.202104055 Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Bioengineered, 2022, 13(3):5928-5941
S3226	Dehydroabietic acid Dehydroabietic acid (DAA, DHAA) 是一种天然的二萜树脂酸，衍生自针叶植物（如 Pinus 和 Picea）通过抑制 Src、Syk 和 TAK1 介导的通路来产生抗炎活性。
S4945	Ethacridine lactate Ethacridine lactate (Acrinol) 是一种基于acridine的芳香族有机化合物，可用作防腐剂。Ethacridine lactate 也是一种 poly(ADP-ribose) glycohydrolase (PARG) 抑制剂。
S5184	Dexamethasone palmitate Dexamethasone palmitate (DXP)，是 Dexamethasone (DXM) 的亲脂性前药，是一种 glucocorticoid receptor 的激动剂，其对糖皮质激素受体的亲和力比DXM低47倍。Dexamethasone palmitate (DXP) 具有抗炎活性。	Dis Model Mech, 2022, dmm.049109 Hematology, 2022, 27(1):32-42
S3308	Caftaric acid Caftaric acid (CA, Caffeoyl tartaric acid) 是一种具有抗氧化和抗炎作用的天然产物。
S1553	Delafloxacin (ABT-492) Delafloxacin (ABT-492, RX-3341, WQ-3034)是一种氟喹诺酮，抗155需氧和171厌氧病原体。
S4946	2,3-Dihydroxybenzoic acid 2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) 是一种天然酚类，存在于西印度醋栗和水生蕨类Salvinia molesta，也是人体中阿司匹林的代谢产物。它是一种潜在的铁螯合药物，具有抗菌特性。
S8068	Chaetocin Chaetocin，一类来自毛壳菌属的天然产物，是一类 histone methyltransferase 抑制剂，其对dSU(VAR)3-9，小鼠G9a和粗糙链孢霉 DIM5的IC50分别为0.8 μM, 2.5 μM和3 μM。Chaetocin是一种抗癌药物并是 thioredoxin reductase (TrxR) 的抑制剂。	Eye Vis (Lond), 2022, 9(1):4 Free Radic Biol Med, 2021, 178:147-160 Cancer Discov, 2021, candisc.0872.2020
S4430	Hydroxychloroquine Sulfate (NSC 4375) Hydroxychloroquine Sulfate (NSC 4375, HCQ)是一种抗疟疾药，用于治疗系统性红斑狼疮，类风湿关节炎等自身免疫病，炎症以及皮肤病。它也是autophagy和toll-like receptor (TLR) 7/9的抑制剂。	Cell Death Dis, 2022, 13(3):197 Neurosci Bull, 2022, 10.1007/s12264-022-00818-9 Autophagy, 2021, 1-14	C, SA-beta gal staining results of A549-LKB1 cells treated by trametinib (30 nmol/L), radiotherapy (2 Gy), and HCQ (50 μmol/L). Cells were treated by HCQ and/or trametinib 4 hours prior to radiotherapy. Drugs were washed out 24 hours after radiotherapy. Cells were incubated for additional 48 hours before staining. D, Clonogenic survival assay of A549-LKB1 cells treated with trametinib (30 nmol/L) and HCQ (50 μmol/L).
S4303	9-Aminoacridine 9-Aminoacridine (Aminacrine)是一种高荧光染料，在临床上用作局部防腐剂，在实验中用作诱变剂、细胞内pH指示剂和负模小分子MALDI基质。
S5927	Proguanil Proguanil (chlorguanide, chloroguanide) 是预防性抗疟药。它能抑制疟原虫的二氢叶酸还原酶，阻止嘌呤和嘧啶的合成。	Sci Adv, 2021, 7(27)eabh3032
S4417	Ceftaroline Fosamil Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) 是一种头孢菌素，对 Gram-positive pathogens (包括耐甲氧西林的金黄色葡萄球菌(MRSA))具有活性。
S6771	MAC-545496 MAC-545496是一种纳摩尔浓度的glycopeptide-resistance-associated protein R(GraR)抑制剂，对全长GraR蛋白(Kd≤0.1 nM)具有很强的结合亲和力。 MAC-545496可以逆转耐甲氧西林菌株中的β-内酰胺耐药性，并与CAMP协同作用。 MAC-545496在巨噬细胞中显示出显着的活性，并减弱了苜蓿根瘤菌幼虫感染模型中的金黄色葡萄球菌毒力。
S3711	Carbasalate Calcium Carbasalate calcium (Iromin, Alcacyl, Omegin, Rheomin, Solupsan) 是一种止痛剂、退热剂，是一种抗炎药物以及血小板聚集的抑制剂。
S9341	3,4-Dimethoxycinnamic acid 3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.
S4515	Ademetionine disulfate tosylate Ademetionine Disulfate Tosylate是腺苷蛋氨酸离子的非对映异构体的硫酸氢盐-甲苯磺酸盐混合盐形式。Ademetionine（腺苷蛋氨酸）具有抗炎活性，被用于治疗慢性肝疾病。
S2430	Azodicarbonamide Azodicarbonamide是第一个已知的通过靶向 nucleocapsid CCHC domains 来抑制 HIV-1 和多种逆转录病毒的核衣壳抑制剂。在标准的基于细胞的抗病毒试验中，Azodicarbonamide抑制HIV-1_RF诱导的CEM-SS细胞病变，EC50为38 µM。
S6802	Etosalamide Etosalamide (Ethosalamide)是一种具有退烧和镇痛作用的抗炎药。
S7867	Oleuropein Oleuropein 是一种从橄榄叶中分离出的抗氧化多酚。Oleuropein 具有抗氧化、抗炎和抗动脉粥样硬化的作用，并在体外抑制脂肪细胞的分化。Oleuropein 抑制 PPARγ 活性。Oleuropein 通过直接抑制PPARγ转录活性发挥抗脂肪形成作用。Oleuropein 还可抑制aromatase。Oleuropein 可诱导凋亡。Phase 2。	J Med Virol, 2019, 91(8):1440-1447
S3261	Myrislignan Myrislignan 是一种分离自Myristica fragrans Houtt的木脂素并具有抗炎活性。Myrislignan 可抑制 interleukin-6 (IL-6) 和 tumour necrosis factor-α (TNF-α)。Myrislignan 剂量依赖性地抑制LPS刺激的巨噬细胞中 inducible NO synthase (iNOS) 和 cyclooxygenase-2 (COX-2) 的表达。Myrislignan 可抑制 NF-κB 信号通路的激活。
S4549	Antimonyl potassium tartrate trihydrate Antimonyl potassium tartrate trihydrate (Tartar emetic) 是一种有效的催吐剂，同样也用于治疗血吸虫病和利什曼病。
S7465	FTI 277 HCl FTI 277 HCl是FTI 277的甲酯，是一种有效的选择性farnesyltransferase (FTase)抑制剂，IC50为500 pM，选择性比密切相关的GGTase I 高100倍。FTI 277 HCl可抑制细胞生长并诱导凋亡。FTI 277 HCl可有效清除HDV病毒血症。	PLoS Biol, 2021, 19(4):e3001134 Cell Struct Funct, 2021, 46(1):1-9 Nat Commun, 2019, 10(1):273	(A) HCT 116 cells were treated with Tram (0, 30, or 60 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD. (B) SW480 and MDA-MB-231 cells were treated with Tram (0, 80, 160 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD.
S1958	Sulbactam Sulbactam 是β-内酰胺酶抑制剂，IC50为0.8 μM。
S3269	Acetylcorynoline Acetylcorynoline 是衍生自中草药 Corydalis bungeana 的主要生物碱成分，具有抗炎特性。Acetylcorynoline 可能通过降低 egl-1 的表达来抑制细胞凋亡通路，并增加 rpn5 的表达来增强 proteasomes 的活性。
S3270	Genipin 1-O-beta-D-gentiobioside Genipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) 是从栀子 Gardenia jasminoides Ellis 中分离到的一种生物活性类环烷苷，具有保肝、抗炎、抗氧化和抗血栓形成的功能。
S3279	Polyphyllin B (Formosanin C) Polyphyllin B (Formosanin C, FC) 是一种从Paris formosana分离得到的薯蓣皂苷，也是一种具有抗肿瘤活性的免疫调节剂。Polyphyllin B (Formosanin C, FC) 可诱导凋亡。	Oncol Lett, 2021, 22(1):550
S1282	Artemisinin Artemisinin (Qinghaosu, Artemisinine)青蒿素用于治疗耐多药的恶性疟疾菌株。	Front Immunol, 2021, 12:634368 Int Immunopharmacol, 2021, 95:107541 Antiviral Res, 2020, 29:104810
S2264	Artemether Artemether (SM-224, CGP 56696) 是一种抗疟药，用于治疗恶性疟疾的耐药菌株。	Hum Cell, 2022, 10.1007/s13577-022-00671-y Sci Rep, 2021, 11(1):14571 Hum Cell, 2021, 34(6):1911-1918	Schistosomicidal effects of PZQ, ART(Artemether) and OXA on 14-day schistosomula. Magnification of the in vitro-cultured schistosomula treated with PZQ, ART, and OXA at 10 μM. Drugs were added at day 14 and schistosomula were analyzed at day 21 (late treatment). 0.1% DMSO in medium (solvent of the drugs; used as negative control) had no effect on schistosomula development.
S2479	Lincomycin HCl Lincomycin hydrochloride (Lincocin, NSC 70731) 是Lincomycin的一水盐, 是Lincolnensis链霉菌属的成员生长所产生的物质。	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 10.1007/s13577-021-00639-4 Hum Cell, 2021, 34(6):1911-1918
S1644	Nitrofural Nitrofural (Nitrofurazone) 是外用的抗感染剂，IC50为22.83±1.2 μM，作用于大鼠，LD50为590 mg/kg。
S4237	Primaquine Diphosphate Primaquine Diphosphate是一种临床有效的阻断传播的抗疟疾药，对人类疟疾的的配子体具有明显的抵抗活性。	Front Pharmacol, 2021, 12:695009 Cell Syst, 2019, 8(2):97-108
S2469	Fleroxacin Fleroxacin (Ro 23-6240, AM-833) 是一种新型广谱喹诺酮类。
S3116	Sulfathiazole Sulfathiazole是一种有机硫化合物，已被用来作为一种短效的磺胺类药物。
S2511	Sulfadoxine Sulfadoxine (Sulphadoxine) 是一种超长效磺胺类药物，作用于P. Vivax，IC50为249 μg/ml。
S3067	Chlorhexidine 2HCl Chlorhexidine hydrochloride (NSC-185) 是一种防腐剂，可以有效抵抗大多数革兰氏阴性和阳性有机体。	BMC Microbiol, 2020, 20(1):275
S4147	Azithromycin Dihydrate Azithromycin Dihydrate 是对酸稳定的，口服的，大环内酯类抗菌药物，结构与红霉素相关。	J Cell Biochem, 2022, 10.1002/jcb.30213 PLoS Comput Biol, 2020, 16(12):e1008489 bioRxiv, 2020, 2020.10.02.324228
S4191	Betamipron Betamipron (CS-443)是一种化学化合物，与Panipenem一起使用，抑制Panipenem吸收进肾小管，防止肾毒性。
S2537	Secnidazole Secnidazole (Flagentyl, PM 185184, RP 14539) 是一种硝基咪唑类抗感染剂。
S4195	Broxyquinoline Broxyquinoline是一种抗原虫剂，作用于粘膜，可以从水中释放氧自由基。
S4196	Ethacridine lactate monohydrate Ethacridine lactate monohydrate是一种芳香族有机化合物，用作防腐剂。	Carcinogenesis, 2014, 35(12):2822-30
S2612	Ribitol Ribitol (Adonitol) 是一种戊糖醇结晶，通过核糖还原形成，在Adonis vernalis植物中自然发生。
S4726	Lauric Acid Lauric Acid (dodecanoic acid, N-Dodecanoic acid, Dodecylic acid)是饱和中链脂肪酸，在多种植物、动物油脂中都天然存在，是椰子油和棕榈仁油的主要成分。
S3288	Absinthin Absinthin (Absynthine) 是一种来自 Artemisia absinthium 的天然三萜内酯，具有抗炎特性。Absinthin (Absynthine) 可显著地增强 matrix metalloproteinase-8 (MMP-8) 的表达，并且是潜在的急性肺损伤(ALI)的候选治疗药物。
S3941	Pinocembrin Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone)是制药工业中多功能黄酮类分子，它具有很多药学活性，如抗菌、消炎、抗氧化和抗癌活性。	J Neuroinflammation, 2020, 17(1):337
S4573	m-Tolyl acetate m-Tolyl acetate是一种药物中间体和防腐剂。
S4579	Resorcinol Resorcinol是一种用作防腐剂、消毒剂的化合物，是很多药物合成的中间产物。
S9564	p-Hydroxy-cinnamic Acid p-Hydroxy-cinnamic Acid在体外具有抗疟活性和体内抗骨质疏松活性。
S6288	Chlorhexidine diacetate Chlorhexidine diacetate (Hibitane diacetate)是一种消毒剂和局部抗感染剂，也用于漱口水中防止口腔菌斑。	BMC Microbiol, 2020, 20(1):275
S5366	Fipronil Fipronil (Fluocyanobenpyrazole, Termidor) is a recalcitrant phenylpyrazole-based pesticide used for flea/tick treatment and termite control that is distributed in urban aquatic environments via stormwater and contributes to stream toxicity.
S9094	Pogostone Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity.	J Ethnopharmacol, 2021, 278:114250
S4420	Mefloquine HCl Mefloquine HCl是一种血液裂殖体杀灭剂，抑制疟原虫色素的形成，用作抗疟疾药物。	Mol Med Rep, 2021, 23(1)40 bioRxiv, 2020, 2020/9/20.4.7.30734 Int J Parasitol Drugs Drug Resist, 2018, 8(2):331-340	BALB/c mice, orally infected with E. multilocularis eggs, were treated by either mefloquine (100 mg/kg twice per week, n = 9), ABZ (200 mg/kg, 5 times per week, n = 8) or control-treated (placebo, n = 9). After 12 weeks of treatment, parasite lesion numbers in the liver were assessed microscopically (A).
S4142	Clopidol Clopidol (WR 61112)是一种抗原虫药剂。
S4592	Captisol (SBE-β-CD) Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) 是一种新型的、化学修饰过的环糊精，具有比较好的稳定性和溶解性。	Cell Metab, 2022, S1550-4131(22)00083-3 Cell Metab, 2022, 34(1):171-183.e6 Cell, 2021, S0092-8674(21)00690-5
S5700	Phthalylsulfathiazole Phthalylsulfathiazole (Sulfathalidine) is a broad-spectrum antimicrobial that can treat different types of infections including intestinal.
S4041	Olsalazine Sodium Olsalazine Sodium 是一种抗炎症前体药，包含2个5-ASA部分，通过偶氮键相连。	Oncotarget, 2017, 8(1):228-237	Values represent the average scores for each group ± S.E. (N = 10 per group). The differences between individual experimental groups and 17 days DSS only group were statistically significant (p < 0.05) for all groups.
S6136	(±)-α-Bisabolol α-bisabolol是一种植物来源的油性倍半萜烯醇，具有抗炎和抗菌活性。
S5757	Isoeugenol Isoeugenol (4-Propenylguaiacol), an essential oil constituent of nutmeg, clove, and cinnamon, shows antimicrobial activity.
S4250	Sulfamethoxypyridazine Sulfamethoxypyridazine (CL 13494)是长效磺胺类药物，用于治疗疱疹样皮炎。
S5397	Chlorhexidine Chlorhexidine is a disinfectant and topical anti-infective agent that is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes, and yeasts.	J Cell Mol Med, 2021, 10.1111/jcmm.16673 BMC Microbiol, 2020, 20(1):275
S6173	Amylmetacresol Amylmetacresol是一种防腐杀菌剂，用于治疗口腔和喉咙的感染。
S6185	Arachidonic acid Arachidonic acid (Arachidonate)是非饱和必需脂肪酸，在动物和人类肝脏、脑部和腺器官脂肪中都有发现。它是前列腺素、凝血噁烷和白细胞三烯的生物合成的前体化合物。	Bone Res, 2022, 10(1):20
S2271	Berberine chloride (NSC 646666) Berberine chloride (NSC 646666, Natural Yellow 18)是异喹啉类生物碱的季铵盐。Berberine chloride 可激活 caspase 3 和 caspase 8，分裂 poly ADP-ribose polymerase (PARP) 和释放 cytochrome c。Berberine chloride 可降低 c-IAP1，Bcl-2 和 Bcl-XL 的表达。Berberine chloride 可通过 JNK 和 p38 MAPK 的持续磷酸化以及产生 ROS 来诱导凋亡。Berberine chloride 是一个 topoisomerase I 和 II 的双效抑制剂。Berberine chloride 也是一个潜在的自噬调节剂。	Front Pharmacol, 2021, 12:632201 Molecules, 2021, 26(5)1210 Biology (Basel), 2021, 10(3)250
S2282	Cinchonidine Cinchonidine是一种生物碱，在有机化学中用于不对称合成。	J Med Virol, 2019, 91(8):1440-1447
S5475	Novaluron Novaluron (Rimon) belongs to the class of insecticides called insect growth regulators with pesticide properties.
S3218	Amiloxate Amiloxate (Amiloxiate, Isoamyl Methoxycinnamate, Isopentyl 4-methoxycinnamate, Isoamyl 4-methoxycinnamate, Isoamyl p-methoxycinnamate, Isopentyl p-methoxycinnamate) 是一种EMA批准的可用于化妆品的化学紫外线过滤剂。Amiloxate 是一种具有抗炎活性的肉桂酸衍生物。
S5963	Sulfathiazole sodium Sulfathiazole sodium，一种抗菌剂，也是一种可被用作短效磺胺药的有机硫化合物。
S5967	Berberine chloride hydrate Berberine (Natural Yellow 18) chloride hydrate 是属于异喹啉生物碱的季铵盐。Berberine 可激活 caspase 3 和 caspase 8，poly ADP-ribose polymerase (PARP) 的切割和 cytochrome c 的释放。Berberine chloride 可降低 c-IAP1、Bcl-2 和 Bcl-XL 的表达。Berberine chloride 通过 JNK 和 p38 MAPK 的持续磷酸化以及 ROS的生成来诱导凋亡。Berberine chloride 是一种 topoisomerase I 和 II 的双重抑制剂。Berberine chloride 也是一种潜在的自噬调节剂。	Front Pharmacol, 2021, 12:632201
S4172	Cetylpyridinium Chloride Cetylpyridinium chloride是一种阳离子季铵化合物，作为口咽消毒剂。
S6243	Ethyl pyruvate Ethyl pyruvate (CTI-01)是丙酮酸一种简单的脂肪族酯，通过发挥消炎、抗氧化和抗凋亡活性而具有神经保护作用。
S3695	Cystamine dihydrochloride Cystamine dihydrochloride (Decarboxycystine, 2-Aminoethyl disulfide, 2,2'-Dithiobisethanamine) acts as an anti-infective agent, which is used in the treatment of urinary tract infections and also as a radiation-protective agent that interferes with sulfhydryl enzymes.
S4175	Sulfaguanidine Sulfaguanidine是一种磺胺药物，作为抗感染剂。
S2395	Rheochrysidin Rheochrysidin (Physcione)是大承气汤的主要成分之一，用于治疗炎症。	ACS Chem Biol, 2015, 10.1021/cb5009487	AmpC β-lactamase and MDH inhibition dose-response curves in the absence (black circles) and presence (red triangles) of DTT for (C and D) physcion.
S3787	Picroside I Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.
S9016	Dipsacoside B Dipsacoside B, extracted from the flowerbuds of Lonicera confusa DC, shows strong antimicrobial activity.
S5908	Garenoxacin Garenoxacin (T-3811ME, BMS-284756)是一种新型的des-F(6)喹诺酮，在体外对许多病原体具有有效作用，包括gram-positive和gram-negative的需氧菌和厌氧菌。
S3649	Ceftazidime Ceftazidime is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa.
S4062	Ronidazole Ronidazole 是一种抗原生动物药剂。
S4971	Buparvaquone Buparvaquone (Butalex)是第二代羟基萘醌化合物，有希望治疗和预防泰勒虫病。
S6761	Dalfopristin Dalfopristin (RP54476) 是ostreogyrcin A的半合成类似物。Quinupristin/dalfopristin (Q/D) 是一种亲本链霉菌素，其活性范围包括革兰氏阳性病原体，及对其他种类的抗菌化合物具有抗性的病原体。
S4192	Chlorquinaldol Chlorquinaldol是一种抗微生物药剂。
S5292	Diazolidinyl urea Diazolidinyl urea (Germall II) is an antimicrobial preservative used in cosmetics.
S3210	3'-Hydroxy-4'-methoxyacetophenone 3'-Hydroxy-4'-methoxyacetophenone (Acetoisovanillone, Isoacetovanillone, Diosmin EP Impurity A) 是一种具有消炎潜能的活性多刺疟原虫提取物。
S5961	Prednisolone disodium phosphate Prednisolone disodium phosphate (Hydeltrasol, Prednisolone 21-phosphate disodium) 是一种具有抗炎和免疫调节特性的合成糖皮质激素，可对耐药性急性淋巴细胞白血病细胞发挥晚期有丝分裂和双向作用。	J Immunotoxicol, 2021, 18(1):154-162 Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
S5887	Khellin Khellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Kalangin)分离自阿密茴（伞形科）种子，被用于治疗多种疾病。
S4081	Sulfacetamide Sodium Sulfacetamide Sodium是一种抗生素。	G3 (Bethesda), 2020, 4;10(5):1585-1597
S4759	p-Coumaric Acid p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid)是肉桂酸的羟基衍生物。肉桂酸存在于多种可食用植物，具有抗氧化、消炎和抗菌活性。	Exp Ther Med, 2021, 21(5):503 J Nutr Biochem, 2015, 26(11):1379-84
S7411	Ascomycin (FK520) Ascomycin (FK520, FR 900520, Immunomycin), FK-506的一种类似物, 是中性的大环内酯类 immunosuppressant, 能够防止器官移植后的排斥反应。	Melanoma Res, 2020, 30(4):325-335 Virol Sin, 2019, 34(6):648-661
S0146	Broxaldine Broxaldine (Brobenzoxaldine, AL307) 是一种抗原生动物药，可用于麻风病治疗。
S6019	2-Phenylphenol 2-Phenylphenol，在柠檬中发现，是一种抗真菌剂和防腐剂，用于食品调味剂中。
S9387	Maackiain Maackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects.
S3364	3-Hydroxyphenylacetic acid 3-Hydroxyphenylacetic acid (3-HPAA) 是一种酚酸，主要存在于橄榄油废水中，也是膳食类黄酮槲皮素flavonoid quercetin的肠道代谢产物。3-Hydroxyphenylacetic acid 具有抗菌性能。
S9084	Rhoifolin Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.
S3801	Sodium Houttuyfonate Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis.
S2613	Clorsulon Clorsulon (MK-401) 用于治疗小牛和羊的肝片吸虫感染。	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918 Hum Cell, 2021, 10.1007/s13577-021-00579-z
S6442	Chlorphenesin Chlorphenesin是一种合成的防腐剂，被用于护肤品中，是一种化妆品抗微生物剂。
S9342	1,4-Naphthoquinone 1,4-Naphthoquinone (α-Naphthoquinone, para-naphthoquinone, P-Naphthoquinone), found in diesel exhaust particles and it is an active metabolite of naphthalene, is a fumigant insecticide.
S2564	Cloxacillin Sodium Cloxacillin Sodium是Cloxacillin的钠盐形式，是一种耐青霉素酶，耐酸，半合成的青霉素。
S9112	Kaempferitrin Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.
S5096	SulfadiMethoxine sodium Sulfadimethoxine (Sulfadimethoxydiazine)是一种长效的磺胺类抗菌剂，用于治疗多种感染，如呼吸道、尿道、肠道和软组织感染。	Cell Death Dis, 2018, 9(6):646
S9113	Ononin Ononin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects.
S5099	4-Aminophenylarsonic acid 4-Aminophenylarsonic acid (Arsanilic Acid)是一种有机砷化合物，具有抗感染活性。
S6459	Nifurtimox Nifurtimox (BAY-2502) 是一种抗原虫剂。
S4232	Nithiamide Nithiamide (CL 5279) 是一种非5-硝基咪唑类药物。
S3618	Acetylspiramycin (ASPM) Acetylspiramycin (ASPM, Spiramycin II, Foromacidin B)是大环内酯物抗菌剂。
P1201	LL37 (Human cathelicidin) LL37 (Human cathelicidin, Ropocamptide) 是与Cathelicidin相关的 antimicrobial 抗菌肽，具有强大的趋化和免疫调节特性。
S4236	Proflavine Hemisulfate Proflavine Hemisulfate是一种外用防腐剂，通过与DNA螯合从而破坏DNA合成，且导致复制的DNA链发生高水平的突变。
S3746	Lumefantrine Lumefantrine (benflumetol) 是一种抗疟疾剂，用于治疗急性无并发症的疟疾。	Antimicrob Agents Chemother, 2021, AAC.02137-20 ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00522
S5212	Imidazolidinyl Urea Imidazolidinyl Urea (Imidurea)是一种抗菌剂，在化妆品中被用作防腐剂。
S5210	Sulfamethazine Sodium Salt Sulfamethazine (Sulfadimethyldiazine) 是磺胺类抗感染试剂，用于畜牧业。
S0443	Desciclovir Desciclovir (DCV, 6-Deoxyacyclovir, BW A515U)是一种抗疱疹antiherpetic 药物无环鸟苷acyclovir (ACV)的前药，在人体内通过黄嘌呤氧化酶转化为ACV。
S4678	Povidone iodine Povidone iodine (Betadine, PVP iodine, PVP-I, Isodine)是聚乙烯吡咯烷酮（PVP）和碘元素的稳定化合复合体。在外科手术中被用作是局部消毒剂，防止皮肤及黏膜感染。
S9131	Punicalagin Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.	Cell, 2020, 30;181(3):637-652.e15. Cell, 2020, 30;181(3):637-652e15
S3139	Methenamine Methenamine是一种抗生素，用于治疗尿路感染。
S5405	Propylparaben Propylparaben (Propyl 4-hydroxybenzoate, Propyl p-hydroxybenzoate, nipasol), a natural substance found in many plants and some insects, is an antimicrobial, preservative and flavouring agent.
S4242	Cetrimonium Bromide (CTAB) Cetrimonium Bromide (CTAB)是广谱防腐剂西曲溴铵的一种已知组分，西曲溴铵是不同季铵盐的混合物。	Biochem Cell Biol, 2021, 10.1139/bcb-2020-0570 Micromachines (Basel), 2018, 9(6)
S5214	Imidocarb dipropionate Imidocarb是一种抗原虫剂，在治疗巴贝西虫病和埃里希体病中被用作二丙酸盐使用。	Nat Commun, 2017, 8(1):823
S6461	Permethrin Permethrin是一种合成的I型拟除虫菊酯、具有神经毒性的杀虫剂。
S3978	5-Phenyl-2,4-pentadienoic acid 5-Phenyl-2,4-pentadienoic acid (5-Phenylpenta-2,4-dienoic acid) is used as Synthetic building block, anti-malarial agent.
S3220	Trigonelline Trigonelline (Trigenolline) 是一种植物生物碱，是咖啡和葫芦巴的主要成分，具有抗脱粒、抗糖尿病、抗氧化、抗炎和神经保护的作用。 Trigonelline 可抑制FcεRI介导的细胞内信号通路，例如 PLCγ1、PI3K 和 Akt 的磷酸化。Trigonelline (Trigenolline) 还可抑制RBL-2H3细胞中 microtubule 的形成。	Biomed Pharmacother, 2021, 143:112204
S5390	N-(Hytroxymethy)micotinamide N-(Hydroxymethyl)nicotinamide (Nikomethamide, Bilamid, N-hydroxymethylnicotinamide) is an antimicrobial agent.
S5355	Piperaquine phosphate Piperaquine phosphate is an orally active bisquinolone antimalarial drug.
S9560	Anisodamine Hydrobromide Anisodamine (6-Hydroxyhyoscyamine)是天然存在的阿托品（atropine）衍生物，具有消炎活性。它能抑制α1-adrenergic receptors和mAChRs。
S5005	Cefotiam hydrochloride Cefotiam hydrochloride (Halospor, Pansporin, Pansporine) is the hydrochloride salt form of cefotiam and has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.
S1962	Sulphadimethoxine Sulphadimethoxine 是一种非还原性的葡糖苷酸。
S4555	Carsalam Carsalam (Carbonylsalicylamide) 是一种非类固醇的消炎药。
S7896	Sodium Tauroursodeoxycholate (TUDC) Sodium Tauroursodeoxycholate (TUDC)是一种水溶性胆汁酸，用于治疗胆结石和肝硬化。	Microbiome, 2019, 7(1):145 Int J Biol Sci, 2019, 15(9):1905-1920 EBioMedicine, 2018, 37:269-280
S4521	DEET DEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) 是一种常见的杀虫剂的活性成分。
S9185	Nitidine Chloride Nitidine Chloride, a benzophenanthridine alkaloid found in species of the genus Zanthoxylum, has an anti-malarial activity.	Int Immunopharmacol, 2021, 101(Pt A):108273 Front Cell Neurosci, 2020, 14:216

目录号	产品描述	文献引用	实验数据
S5001	Tofacitinib (CP-690550) Citrate Tofacitinib citrate (CP-690550, Tasocitinib)是一种新型JAK抑制剂，对JAK3，JAK2，JAK1的IC50分别为1 nM, 20 nM 和112 nM。Tofacitinib citrate 还具有抗感染的活性。	Blood,2022, blood.2021012366 J Control Release,2022, S0168-3659(22)00163-8 Mol Neurodegener,2022, 17(1):7	CP-690550 reduced the severity of ischemic damage. (A) CP-690550 (10 μM) suppressed IL-17 production by cdT cells and activated memory T cells. cdT cells and CD4+ CD44+ memory T cells isolated from C5BL6J mice through flow cytometry were stimulated for 24 h with plate-bound monoclonal antibodies to CD3 (2 ng/ml) and CD28 (1 ng/ml) in the presence or absence of IL-23 (25 ng/ml). IL-17A production and IL-17A expression level were measured by quantitative RT-PCR (a) and ELISA (b). (B) CBF reduction after brain ischemia. (C) Time-dependent changes in neurological score. *p < 0.05. (D) Infarct volume as visualized through TTC staining on day 3 in CP-690550 (CP)- and vehicle-treated mice.
S4157	Chloroquine diphosphate Chloroquine diphosphate是一种4-氨基喹啉的抗疟疾和抗风湿药，也是一种ATM激活剂。Chloroquine 也是一种toll-like receptors (TLRs)的抑制剂。	Phytomedicine,2022, 98:153958 Bone,2022, 154:116262 Cancer Cell,2021, S1535-6108(21)00659-0	NCI-H929 EV and miR-137 OE cells were treated with ATM activator Chloroquine Phosphate (CQ), specific ATM inhibitor KU-55933, and ATR inhibitor AZ20 for 12 hr. Immunoblotting showed the expression of p-ATM, p-Chk2, p-BRCA1, p-ATR and p-Chk1.
E0206^New	Ginkgetin Ginkgetin 是一种来自银杏叶的双黄酮，具有抗癌、抗炎、抗微生物、抗脂肪生成和神经保护作用。
S2572	Streptomycin sulfate Streptomycin sulfate是Streptomycin的硫酸盐形式，是一种蛋白质合成抑制剂。	Front Microbiol,2021, 12:761113 Life Sci,2021, 282:119798 Biosci Rep,2021, BSR20200842
S8279	Shikonin (C.I. 75535) Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844)是一种 Pyruvate kinase M2 (PKM2) 有效的、特异的抑制剂。它是紫草的主要成分，紫草是一种中草药，具有多种生物活性。在细胞荧光淬灭试验中，Shikonin也是TMEM16A氯离子通道的抑制剂。Shikonin 通过抑制 tumor necrosis factor-α (TNF-α) 发挥抗炎作用，并可通过抑制 proteasome 来阻止 nuclear factor-κB (NF-κB) 信号途径的激活。	Adv Sci (Weinh),2022, 10.1002/advs.202104055 Nat Chem Biol,2022, 10.1038/s41589-022-00996-7 Bioengineered,2022, 13(3):5928-5941
S3226	Dehydroabietic acid Dehydroabietic acid (DAA, DHAA) 是一种天然的二萜树脂酸，衍生自针叶植物（如 Pinus 和 Picea）通过抑制 Src、Syk 和 TAK1 介导的通路来产生抗炎活性。
S4945	Ethacridine lactate Ethacridine lactate (Acrinol) 是一种基于acridine的芳香族有机化合物，可用作防腐剂。Ethacridine lactate 也是一种 poly(ADP-ribose) glycohydrolase (PARG) 抑制剂。
S5184	Dexamethasone palmitate Dexamethasone palmitate (DXP)，是 Dexamethasone (DXM) 的亲脂性前药，是一种 glucocorticoid receptor 的激动剂，其对糖皮质激素受体的亲和力比DXM低47倍。Dexamethasone palmitate (DXP) 具有抗炎活性。	Dis Model Mech,2022, dmm.049109 Hematology,2022, 27(1):32-42
S3308	Caftaric acid Caftaric acid (CA, Caffeoyl tartaric acid) 是一种具有抗氧化和抗炎作用的天然产物。
S1553	Delafloxacin (ABT-492) Delafloxacin (ABT-492, RX-3341, WQ-3034)是一种氟喹诺酮，抗155需氧和171厌氧病原体。
S4946	2,3-Dihydroxybenzoic acid 2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) 是一种天然酚类，存在于西印度醋栗和水生蕨类Salvinia molesta，也是人体中阿司匹林的代谢产物。它是一种潜在的铁螯合药物，具有抗菌特性。
S8068	Chaetocin Chaetocin，一类来自毛壳菌属的天然产物，是一类 histone methyltransferase 抑制剂，其对dSU(VAR)3-9，小鼠G9a和粗糙链孢霉 DIM5的IC50分别为0.8 μM, 2.5 μM和3 μM。Chaetocin是一种抗癌药物并是 thioredoxin reductase (TrxR) 的抑制剂。	Eye Vis (Lond),2022, 9(1):4 Free Radic Biol Med,2021, 178:147-160 Cancer Discov,2021, candisc.0872.2020
S4430	Hydroxychloroquine Sulfate (NSC 4375) Hydroxychloroquine Sulfate (NSC 4375, HCQ)是一种抗疟疾药，用于治疗系统性红斑狼疮，类风湿关节炎等自身免疫病，炎症以及皮肤病。它也是autophagy和toll-like receptor (TLR) 7/9的抑制剂。	Cell Death Dis,2022, 13(3):197 Neurosci Bull,2022, 10.1007/s12264-022-00818-9 Autophagy,2021, 1-14	C, SA-beta gal staining results of A549-LKB1 cells treated by trametinib (30 nmol/L), radiotherapy (2 Gy), and HCQ (50 μmol/L). Cells were treated by HCQ and/or trametinib 4 hours prior to radiotherapy. Drugs were washed out 24 hours after radiotherapy. Cells were incubated for additional 48 hours before staining. D, Clonogenic survival assay of A549-LKB1 cells treated with trametinib (30 nmol/L) and HCQ (50 μmol/L).
S4303	9-Aminoacridine 9-Aminoacridine (Aminacrine)是一种高荧光染料，在临床上用作局部防腐剂，在实验中用作诱变剂、细胞内pH指示剂和负模小分子MALDI基质。
S5927	Proguanil Proguanil (chlorguanide, chloroguanide) 是预防性抗疟药。它能抑制疟原虫的二氢叶酸还原酶，阻止嘌呤和嘧啶的合成。	Sci Adv,2021, 7(27)eabh3032
S4417	Ceftaroline Fosamil Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) 是一种头孢菌素，对 Gram-positive pathogens (包括耐甲氧西林的金黄色葡萄球菌(MRSA))具有活性。
S6771	MAC-545496 MAC-545496是一种纳摩尔浓度的glycopeptide-resistance-associated protein R(GraR)抑制剂，对全长GraR蛋白(Kd≤0.1 nM)具有很强的结合亲和力。 MAC-545496可以逆转耐甲氧西林菌株中的β-内酰胺耐药性，并与CAMP协同作用。 MAC-545496在巨噬细胞中显示出显着的活性，并减弱了苜蓿根瘤菌幼虫感染模型中的金黄色葡萄球菌毒力。
S3711	Carbasalate Calcium Carbasalate calcium (Iromin, Alcacyl, Omegin, Rheomin, Solupsan) 是一种止痛剂、退热剂，是一种抗炎药物以及血小板聚集的抑制剂。
S9341	3,4-Dimethoxycinnamic acid 3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.
S4515	Ademetionine disulfate tosylate Ademetionine Disulfate Tosylate是腺苷蛋氨酸离子的非对映异构体的硫酸氢盐-甲苯磺酸盐混合盐形式。Ademetionine（腺苷蛋氨酸）具有抗炎活性，被用于治疗慢性肝疾病。
S2430	Azodicarbonamide Azodicarbonamide是第一个已知的通过靶向 nucleocapsid CCHC domains 来抑制 HIV-1 和多种逆转录病毒的核衣壳抑制剂。在标准的基于细胞的抗病毒试验中，Azodicarbonamide抑制HIV-1_RF诱导的CEM-SS细胞病变，EC50为38 µM。
S6802	Etosalamide Etosalamide (Ethosalamide)是一种具有退烧和镇痛作用的抗炎药。
S7867	Oleuropein Oleuropein 是一种从橄榄叶中分离出的抗氧化多酚。Oleuropein 具有抗氧化、抗炎和抗动脉粥样硬化的作用，并在体外抑制脂肪细胞的分化。Oleuropein 抑制 PPARγ 活性。Oleuropein 通过直接抑制PPARγ转录活性发挥抗脂肪形成作用。Oleuropein 还可抑制aromatase。Oleuropein 可诱导凋亡。Phase 2。	J Med Virol,2019, 91(8):1440-1447
S3261	Myrislignan Myrislignan 是一种分离自Myristica fragrans Houtt的木脂素并具有抗炎活性。Myrislignan 可抑制 interleukin-6 (IL-6) 和 tumour necrosis factor-α (TNF-α)。Myrislignan 剂量依赖性地抑制LPS刺激的巨噬细胞中 inducible NO synthase (iNOS) 和 cyclooxygenase-2 (COX-2) 的表达。Myrislignan 可抑制 NF-κB 信号通路的激活。
S4549	Antimonyl potassium tartrate trihydrate Antimonyl potassium tartrate trihydrate (Tartar emetic) 是一种有效的催吐剂，同样也用于治疗血吸虫病和利什曼病。
S7465	FTI 277 HCl FTI 277 HCl是FTI 277的甲酯，是一种有效的选择性farnesyltransferase (FTase)抑制剂，IC50为500 pM，选择性比密切相关的GGTase I 高100倍。FTI 277 HCl可抑制细胞生长并诱导凋亡。FTI 277 HCl可有效清除HDV病毒血症。	PLoS Biol,2021, 19(4):e3001134 Cell Struct Funct,2021, 46(1):1-9 Nat Commun,2019, 10(1):273	(A) HCT 116 cells were treated with Tram (0, 30, or 60 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD. (B) SW480 and MDA-MB-231 cells were treated with Tram (0, 80, 160 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD.
S1958	Sulbactam Sulbactam 是β-内酰胺酶抑制剂，IC50为0.8 μM。

目录号	产品描述	文献引用
S3269	Acetylcorynoline Acetylcorynoline 是衍生自中草药 Corydalis bungeana 的主要生物碱成分，具有抗炎特性。Acetylcorynoline 可能通过降低 egl-1 的表达来抑制细胞凋亡通路，并增加 rpn5 的表达来增强 proteasomes 的活性。
S3270	Genipin 1-O-beta-D-gentiobioside Genipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) 是从栀子 Gardenia jasminoides Ellis 中分离到的一种生物活性类环烷苷，具有保肝、抗炎、抗氧化和抗血栓形成的功能。
S3279	Polyphyllin B (Formosanin C) Polyphyllin B (Formosanin C, FC) 是一种从Paris formosana分离得到的薯蓣皂苷，也是一种具有抗肿瘤活性的免疫调节剂。Polyphyllin B (Formosanin C, FC) 可诱导凋亡。	Oncol Lett, 2021, 22(1):550

目录号

产品描述

文献引用

实验数据

S3269

Acetylcorynoline

Acetylcorynoline 是衍生自中草药 Corydalis bungeana 的主要生物碱成分，具有抗炎特性。Acetylcorynoline 可能通过降低 egl-1 的表达来抑制细胞凋亡通路，并增加 rpn5 的表达来增强 proteasomes 的活性。

S3270

Genipin 1-O-beta-D-gentiobioside

Genipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) 是从栀子 Gardenia jasminoides Ellis 中分离到的一种生物活性类环烷苷，具有保肝、抗炎、抗氧化和抗血栓形成的功能。

S3279

Polyphyllin B (Formosanin C)

Polyphyllin B (Formosanin C, FC) 是一种从Paris formosana分离得到的薯蓣皂苷，也是一种具有抗肿瘤活性的免疫调节剂。Polyphyllin B (Formosanin C, FC) 可诱导凋亡。

Oncol Lett, 2021, 22(1):550

目录号	产品描述	文献引用	实验数据
S1282	Artemisinin Artemisinin (Qinghaosu, Artemisinine)青蒿素用于治疗耐多药的恶性疟疾菌株。	Front Immunol, 2021, 12:634368 Int Immunopharmacol, 2021, 95:107541 Antiviral Res, 2020, 29:104810
S2264	Artemether Artemether (SM-224, CGP 56696) 是一种抗疟药，用于治疗恶性疟疾的耐药菌株。	Hum Cell, 2022, 10.1007/s13577-022-00671-y Sci Rep, 2021, 11(1):14571 Hum Cell, 2021, 34(6):1911-1918	Schistosomicidal effects of PZQ, ART(Artemether) and OXA on 14-day schistosomula. Magnification of the in vitro-cultured schistosomula treated with PZQ, ART, and OXA at 10 μM. Drugs were added at day 14 and schistosomula were analyzed at day 21 (late treatment). 0.1% DMSO in medium (solvent of the drugs; used as negative control) had no effect on schistosomula development.
S2479	Lincomycin HCl Lincomycin hydrochloride (Lincocin, NSC 70731) 是Lincomycin的一水盐, 是Lincolnensis链霉菌属的成员生长所产生的物质。	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 10.1007/s13577-021-00639-4 Hum Cell, 2021, 34(6):1911-1918
S1644	Nitrofural Nitrofural (Nitrofurazone) 是外用的抗感染剂，IC50为22.83±1.2 μM，作用于大鼠，LD50为590 mg/kg。
S4237	Primaquine Diphosphate Primaquine Diphosphate是一种临床有效的阻断传播的抗疟疾药，对人类疟疾的的配子体具有明显的抵抗活性。	Front Pharmacol, 2021, 12:695009 Cell Syst, 2019, 8(2):97-108
S2469	Fleroxacin Fleroxacin (Ro 23-6240, AM-833) 是一种新型广谱喹诺酮类。
S3116	Sulfathiazole Sulfathiazole是一种有机硫化合物，已被用来作为一种短效的磺胺类药物。
S2511	Sulfadoxine Sulfadoxine (Sulphadoxine) 是一种超长效磺胺类药物，作用于P. Vivax，IC50为249 μg/ml。
S3067	Chlorhexidine 2HCl Chlorhexidine hydrochloride (NSC-185) 是一种防腐剂，可以有效抵抗大多数革兰氏阴性和阳性有机体。	BMC Microbiol, 2020, 20(1):275
S4147	Azithromycin Dihydrate Azithromycin Dihydrate 是对酸稳定的，口服的，大环内酯类抗菌药物，结构与红霉素相关。	J Cell Biochem, 2022, 10.1002/jcb.30213 PLoS Comput Biol, 2020, 16(12):e1008489 bioRxiv, 2020, 2020.10.02.324228
S4191	Betamipron Betamipron (CS-443)是一种化学化合物，与Panipenem一起使用，抑制Panipenem吸收进肾小管，防止肾毒性。
S2537	Secnidazole Secnidazole (Flagentyl, PM 185184, RP 14539) 是一种硝基咪唑类抗感染剂。
S4195	Broxyquinoline Broxyquinoline是一种抗原虫剂，作用于粘膜，可以从水中释放氧自由基。
S4196	Ethacridine lactate monohydrate Ethacridine lactate monohydrate是一种芳香族有机化合物，用作防腐剂。	Carcinogenesis, 2014, 35(12):2822-30
S2612	Ribitol Ribitol (Adonitol) 是一种戊糖醇结晶，通过核糖还原形成，在Adonis vernalis植物中自然发生。
S4726	Lauric Acid Lauric Acid (dodecanoic acid, N-Dodecanoic acid, Dodecylic acid)是饱和中链脂肪酸，在多种植物、动物油脂中都天然存在，是椰子油和棕榈仁油的主要成分。
S3288	Absinthin Absinthin (Absynthine) 是一种来自 Artemisia absinthium 的天然三萜内酯，具有抗炎特性。Absinthin (Absynthine) 可显著地增强 matrix metalloproteinase-8 (MMP-8) 的表达，并且是潜在的急性肺损伤(ALI)的候选治疗药物。
S3941	Pinocembrin Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone)是制药工业中多功能黄酮类分子，它具有很多药学活性，如抗菌、消炎、抗氧化和抗癌活性。	J Neuroinflammation, 2020, 17(1):337
S4573	m-Tolyl acetate m-Tolyl acetate是一种药物中间体和防腐剂。
S4579	Resorcinol Resorcinol是一种用作防腐剂、消毒剂的化合物，是很多药物合成的中间产物。
S9564	p-Hydroxy-cinnamic Acid p-Hydroxy-cinnamic Acid在体外具有抗疟活性和体内抗骨质疏松活性。
S6288	Chlorhexidine diacetate Chlorhexidine diacetate (Hibitane diacetate)是一种消毒剂和局部抗感染剂，也用于漱口水中防止口腔菌斑。	BMC Microbiol, 2020, 20(1):275
S5366	Fipronil Fipronil (Fluocyanobenpyrazole, Termidor) is a recalcitrant phenylpyrazole-based pesticide used for flea/tick treatment and termite control that is distributed in urban aquatic environments via stormwater and contributes to stream toxicity.
S9094	Pogostone Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity.	J Ethnopharmacol, 2021, 278:114250
S4420	Mefloquine HCl Mefloquine HCl是一种血液裂殖体杀灭剂，抑制疟原虫色素的形成，用作抗疟疾药物。	Mol Med Rep, 2021, 23(1)40 bioRxiv, 2020, 2020/9/20.4.7.30734 Int J Parasitol Drugs Drug Resist, 2018, 8(2):331-340	BALB/c mice, orally infected with E. multilocularis eggs, were treated by either mefloquine (100 mg/kg twice per week, n = 9), ABZ (200 mg/kg, 5 times per week, n = 8) or control-treated (placebo, n = 9). After 12 weeks of treatment, parasite lesion numbers in the liver were assessed microscopically (A).
S4142	Clopidol Clopidol (WR 61112)是一种抗原虫药剂。
S4592	Captisol (SBE-β-CD) Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) 是一种新型的、化学修饰过的环糊精，具有比较好的稳定性和溶解性。	Cell Metab, 2022, S1550-4131(22)00083-3 Cell Metab, 2022, 34(1):171-183.e6 Cell, 2021, S0092-8674(21)00690-5
S5700	Phthalylsulfathiazole Phthalylsulfathiazole (Sulfathalidine) is a broad-spectrum antimicrobial that can treat different types of infections including intestinal.
S4041	Olsalazine Sodium Olsalazine Sodium 是一种抗炎症前体药，包含2个5-ASA部分，通过偶氮键相连。	Oncotarget, 2017, 8(1):228-237	Values represent the average scores for each group ± S.E. (N = 10 per group). The differences between individual experimental groups and 17 days DSS only group were statistically significant (p < 0.05) for all groups.
S6136	(±)-α-Bisabolol α-bisabolol是一种植物来源的油性倍半萜烯醇，具有抗炎和抗菌活性。
S5757	Isoeugenol Isoeugenol (4-Propenylguaiacol), an essential oil constituent of nutmeg, clove, and cinnamon, shows antimicrobial activity.
S4250	Sulfamethoxypyridazine Sulfamethoxypyridazine (CL 13494)是长效磺胺类药物，用于治疗疱疹样皮炎。
S5397	Chlorhexidine Chlorhexidine is a disinfectant and topical anti-infective agent that is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes, and yeasts.	J Cell Mol Med, 2021, 10.1111/jcmm.16673 BMC Microbiol, 2020, 20(1):275
S6173	Amylmetacresol Amylmetacresol是一种防腐杀菌剂，用于治疗口腔和喉咙的感染。
S6185	Arachidonic acid Arachidonic acid (Arachidonate)是非饱和必需脂肪酸，在动物和人类肝脏、脑部和腺器官脂肪中都有发现。它是前列腺素、凝血噁烷和白细胞三烯的生物合成的前体化合物。	Bone Res, 2022, 10(1):20
S2271	Berberine chloride (NSC 646666) Berberine chloride (NSC 646666, Natural Yellow 18)是异喹啉类生物碱的季铵盐。Berberine chloride 可激活 caspase 3 和 caspase 8，分裂 poly ADP-ribose polymerase (PARP) 和释放 cytochrome c。Berberine chloride 可降低 c-IAP1，Bcl-2 和 Bcl-XL 的表达。Berberine chloride 可通过 JNK 和 p38 MAPK 的持续磷酸化以及产生 ROS 来诱导凋亡。Berberine chloride 是一个 topoisomerase I 和 II 的双效抑制剂。Berberine chloride 也是一个潜在的自噬调节剂。	Front Pharmacol, 2021, 12:632201 Molecules, 2021, 26(5)1210 Biology (Basel), 2021, 10(3)250
S2282	Cinchonidine Cinchonidine是一种生物碱，在有机化学中用于不对称合成。	J Med Virol, 2019, 91(8):1440-1447
S5475	Novaluron Novaluron (Rimon) belongs to the class of insecticides called insect growth regulators with pesticide properties.
S3218	Amiloxate Amiloxate (Amiloxiate, Isoamyl Methoxycinnamate, Isopentyl 4-methoxycinnamate, Isoamyl 4-methoxycinnamate, Isoamyl p-methoxycinnamate, Isopentyl p-methoxycinnamate) 是一种EMA批准的可用于化妆品的化学紫外线过滤剂。Amiloxate 是一种具有抗炎活性的肉桂酸衍生物。
S5963	Sulfathiazole sodium Sulfathiazole sodium，一种抗菌剂，也是一种可被用作短效磺胺药的有机硫化合物。
S5967	Berberine chloride hydrate Berberine (Natural Yellow 18) chloride hydrate 是属于异喹啉生物碱的季铵盐。Berberine 可激活 caspase 3 和 caspase 8，poly ADP-ribose polymerase (PARP) 的切割和 cytochrome c 的释放。Berberine chloride 可降低 c-IAP1、Bcl-2 和 Bcl-XL 的表达。Berberine chloride 通过 JNK 和 p38 MAPK 的持续磷酸化以及 ROS的生成来诱导凋亡。Berberine chloride 是一种 topoisomerase I 和 II 的双重抑制剂。Berberine chloride 也是一种潜在的自噬调节剂。	Front Pharmacol, 2021, 12:632201
S4172	Cetylpyridinium Chloride Cetylpyridinium chloride是一种阳离子季铵化合物，作为口咽消毒剂。
S6243	Ethyl pyruvate Ethyl pyruvate (CTI-01)是丙酮酸一种简单的脂肪族酯，通过发挥消炎、抗氧化和抗凋亡活性而具有神经保护作用。
S3695	Cystamine dihydrochloride Cystamine dihydrochloride (Decarboxycystine, 2-Aminoethyl disulfide, 2,2'-Dithiobisethanamine) acts as an anti-infective agent, which is used in the treatment of urinary tract infections and also as a radiation-protective agent that interferes with sulfhydryl enzymes.
S4175	Sulfaguanidine Sulfaguanidine是一种磺胺药物，作为抗感染剂。
S2395	Rheochrysidin Rheochrysidin (Physcione)是大承气汤的主要成分之一，用于治疗炎症。	ACS Chem Biol, 2015, 10.1021/cb5009487	AmpC β-lactamase and MDH inhibition dose-response curves in the absence (black circles) and presence (red triangles) of DTT for (C and D) physcion.
S3787	Picroside I Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.
S9016	Dipsacoside B Dipsacoside B, extracted from the flowerbuds of Lonicera confusa DC, shows strong antimicrobial activity.
S5908	Garenoxacin Garenoxacin (T-3811ME, BMS-284756)是一种新型的des-F(6)喹诺酮，在体外对许多病原体具有有效作用，包括gram-positive和gram-negative的需氧菌和厌氧菌。
S3649	Ceftazidime Ceftazidime is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa.
S4062	Ronidazole Ronidazole 是一种抗原生动物药剂。
S4971	Buparvaquone Buparvaquone (Butalex)是第二代羟基萘醌化合物，有希望治疗和预防泰勒虫病。
S6761	Dalfopristin Dalfopristin (RP54476) 是ostreogyrcin A的半合成类似物。Quinupristin/dalfopristin (Q/D) 是一种亲本链霉菌素，其活性范围包括革兰氏阳性病原体，及对其他种类的抗菌化合物具有抗性的病原体。
S4192	Chlorquinaldol Chlorquinaldol是一种抗微生物药剂。
S5292	Diazolidinyl urea Diazolidinyl urea (Germall II) is an antimicrobial preservative used in cosmetics.
S3210	3'-Hydroxy-4'-methoxyacetophenone 3'-Hydroxy-4'-methoxyacetophenone (Acetoisovanillone, Isoacetovanillone, Diosmin EP Impurity A) 是一种具有消炎潜能的活性多刺疟原虫提取物。
S5961	Prednisolone disodium phosphate Prednisolone disodium phosphate (Hydeltrasol, Prednisolone 21-phosphate disodium) 是一种具有抗炎和免疫调节特性的合成糖皮质激素，可对耐药性急性淋巴细胞白血病细胞发挥晚期有丝分裂和双向作用。	J Immunotoxicol, 2021, 18(1):154-162 Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
S5887	Khellin Khellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Kalangin)分离自阿密茴（伞形科）种子，被用于治疗多种疾病。
S4081	Sulfacetamide Sodium Sulfacetamide Sodium是一种抗生素。	G3 (Bethesda), 2020, 4;10(5):1585-1597
S4759	p-Coumaric Acid p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid)是肉桂酸的羟基衍生物。肉桂酸存在于多种可食用植物，具有抗氧化、消炎和抗菌活性。	Exp Ther Med, 2021, 21(5):503 J Nutr Biochem, 2015, 26(11):1379-84
S7411	Ascomycin (FK520) Ascomycin (FK520, FR 900520, Immunomycin), FK-506的一种类似物, 是中性的大环内酯类 immunosuppressant, 能够防止器官移植后的排斥反应。	Melanoma Res, 2020, 30(4):325-335 Virol Sin, 2019, 34(6):648-661
S0146	Broxaldine Broxaldine (Brobenzoxaldine, AL307) 是一种抗原生动物药，可用于麻风病治疗。
S6019	2-Phenylphenol 2-Phenylphenol，在柠檬中发现，是一种抗真菌剂和防腐剂，用于食品调味剂中。
S9387	Maackiain Maackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects.
S3364	3-Hydroxyphenylacetic acid 3-Hydroxyphenylacetic acid (3-HPAA) 是一种酚酸，主要存在于橄榄油废水中，也是膳食类黄酮槲皮素flavonoid quercetin的肠道代谢产物。3-Hydroxyphenylacetic acid 具有抗菌性能。
S9084	Rhoifolin Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.
S3801	Sodium Houttuyfonate Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis.
S2613	Clorsulon Clorsulon (MK-401) 用于治疗小牛和羊的肝片吸虫感染。	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918 Hum Cell, 2021, 10.1007/s13577-021-00579-z
S6442	Chlorphenesin Chlorphenesin是一种合成的防腐剂，被用于护肤品中，是一种化妆品抗微生物剂。
S9342	1,4-Naphthoquinone 1,4-Naphthoquinone (α-Naphthoquinone, para-naphthoquinone, P-Naphthoquinone), found in diesel exhaust particles and it is an active metabolite of naphthalene, is a fumigant insecticide.
S2564	Cloxacillin Sodium Cloxacillin Sodium是Cloxacillin的钠盐形式，是一种耐青霉素酶，耐酸，半合成的青霉素。
S9112	Kaempferitrin Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.
S5096	SulfadiMethoxine sodium Sulfadimethoxine (Sulfadimethoxydiazine)是一种长效的磺胺类抗菌剂，用于治疗多种感染，如呼吸道、尿道、肠道和软组织感染。	Cell Death Dis, 2018, 9(6):646
S9113	Ononin Ononin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects.
S5099	4-Aminophenylarsonic acid 4-Aminophenylarsonic acid (Arsanilic Acid)是一种有机砷化合物，具有抗感染活性。
S6459	Nifurtimox Nifurtimox (BAY-2502) 是一种抗原虫剂。
S4232	Nithiamide Nithiamide (CL 5279) 是一种非5-硝基咪唑类药物。
S3618	Acetylspiramycin (ASPM) Acetylspiramycin (ASPM, Spiramycin II, Foromacidin B)是大环内酯物抗菌剂。
P1201	LL37 (Human cathelicidin) LL37 (Human cathelicidin, Ropocamptide) 是与Cathelicidin相关的 antimicrobial 抗菌肽，具有强大的趋化和免疫调节特性。
S4236	Proflavine Hemisulfate Proflavine Hemisulfate是一种外用防腐剂，通过与DNA螯合从而破坏DNA合成，且导致复制的DNA链发生高水平的突变。
S3746	Lumefantrine Lumefantrine (benflumetol) 是一种抗疟疾剂，用于治疗急性无并发症的疟疾。	Antimicrob Agents Chemother, 2021, AAC.02137-20 ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00522
S5212	Imidazolidinyl Urea Imidazolidinyl Urea (Imidurea)是一种抗菌剂，在化妆品中被用作防腐剂。
S5210	Sulfamethazine Sodium Salt Sulfamethazine (Sulfadimethyldiazine) 是磺胺类抗感染试剂，用于畜牧业。
S0443	Desciclovir Desciclovir (DCV, 6-Deoxyacyclovir, BW A515U)是一种抗疱疹antiherpetic 药物无环鸟苷acyclovir (ACV)的前药，在人体内通过黄嘌呤氧化酶转化为ACV。
S4678	Povidone iodine Povidone iodine (Betadine, PVP iodine, PVP-I, Isodine)是聚乙烯吡咯烷酮（PVP）和碘元素的稳定化合复合体。在外科手术中被用作是局部消毒剂，防止皮肤及黏膜感染。
S9131	Punicalagin Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.	Cell, 2020, 30;181(3):637-652.e15. Cell, 2020, 30;181(3):637-652e15
S3139	Methenamine Methenamine是一种抗生素，用于治疗尿路感染。
S5405	Propylparaben Propylparaben (Propyl 4-hydroxybenzoate, Propyl p-hydroxybenzoate, nipasol), a natural substance found in many plants and some insects, is an antimicrobial, preservative and flavouring agent.
S4242	Cetrimonium Bromide (CTAB) Cetrimonium Bromide (CTAB)是广谱防腐剂西曲溴铵的一种已知组分，西曲溴铵是不同季铵盐的混合物。	Biochem Cell Biol, 2021, 10.1139/bcb-2020-0570 Micromachines (Basel), 2018, 9(6)
S5214	Imidocarb dipropionate Imidocarb是一种抗原虫剂，在治疗巴贝西虫病和埃里希体病中被用作二丙酸盐使用。	Nat Commun, 2017, 8(1):823
S6461	Permethrin Permethrin是一种合成的I型拟除虫菊酯、具有神经毒性的杀虫剂。
S3978	5-Phenyl-2,4-pentadienoic acid 5-Phenyl-2,4-pentadienoic acid (5-Phenylpenta-2,4-dienoic acid) is used as Synthetic building block, anti-malarial agent.
S3220	Trigonelline Trigonelline (Trigenolline) 是一种植物生物碱，是咖啡和葫芦巴的主要成分，具有抗脱粒、抗糖尿病、抗氧化、抗炎和神经保护的作用。 Trigonelline 可抑制FcεRI介导的细胞内信号通路，例如 PLCγ1、PI3K 和 Akt 的磷酸化。Trigonelline (Trigenolline) 还可抑制RBL-2H3细胞中 microtubule 的形成。	Biomed Pharmacother, 2021, 143:112204
S5390	N-(Hytroxymethy)micotinamide N-(Hydroxymethyl)nicotinamide (Nikomethamide, Bilamid, N-hydroxymethylnicotinamide) is an antimicrobial agent.
S5355	Piperaquine phosphate Piperaquine phosphate is an orally active bisquinolone antimalarial drug.
S9560	Anisodamine Hydrobromide Anisodamine (6-Hydroxyhyoscyamine)是天然存在的阿托品（atropine）衍生物，具有消炎活性。它能抑制α1-adrenergic receptors和mAChRs。
S5005	Cefotiam hydrochloride Cefotiam hydrochloride (Halospor, Pansporin, Pansporine) is the hydrochloride salt form of cefotiam and has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.
S1962	Sulphadimethoxine Sulphadimethoxine 是一种非还原性的葡糖苷酸。
S4555	Carsalam Carsalam (Carbonylsalicylamide) 是一种非类固醇的消炎药。
S7896	Sodium Tauroursodeoxycholate (TUDC) Sodium Tauroursodeoxycholate (TUDC)是一种水溶性胆汁酸，用于治疗胆结石和肝硬化。	Microbiome, 2019, 7(1):145 Int J Biol Sci, 2019, 15(9):1905-1920 EBioMedicine, 2018, 37:269-280
S4521	DEET DEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) 是一种常见的杀虫剂的活性成分。
S9185	Nitidine Chloride Nitidine Chloride, a benzophenanthridine alkaloid found in species of the genus Zanthoxylum, has an anti-malarial activity.	Int Immunopharmacol, 2021, 101(Pt A):108273 Front Cell Neurosci, 2020, 14:216

研究领域

产品类型

定制您的化合物库

Anti-infection

抑制剂选择性比较

Anti-infection产品