Anti-infection

抑制剂选择性比较

Anti-infection产品

所有产品 Anti-infection抑制剂(140) Anti-infection调节剂(4)

目录号	产品描述	文献引用	实验数据
S1047	Vorinostat (SAHA) Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683)是一种HDAC抑制剂，无细胞试验中IC50为~10 nM。Vorinostat 会抑制高效的HPV-18 DNA扩增。	Nat Biotechnol, 2020, 10.1038/s41587-019-0388-4 Cancer Cell, 2020, 13;37(4):599-617 e7 Nucleic Acids Res, 2020, 10.1093/nar/gkaa088	Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).
S1009	Dactolisib (BEZ235) Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3K 和 mTOR 抑制剂，在无细胞试验中，抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。在 3T3^TopBP1-ER 细胞中抑制 ATR，IC50 为 21 nM，而对 Akt 和 PDK1 的抑制作用很弱。Dactolisib可诱导自噬并抑制HIV-1的复制。Phase 2。	Nat Commun, 2020, 14;11(1):1825 Genome Med, 2020, 18;12(1):17 Biomaterials, 2020, 246:120012	Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.
S1102	U0126-EtOH U0126-EtOH是一种高度选择性的MEK1/2抑制剂，无细胞试验中IC50为0.07 μM/0.06 μM，作用于ΔN3-S218E/S222D MEK的亲和力比PD098059强100倍。U0126可抑制细胞自噬和线粒体自噬并具有抗病毒的活性。	Sci Adv, 2020, 1;6(18):eaaz7001 Autophagy, 2020, 16(6):1061-1076 EMBO Mol Med, 2020, 12(4):e11177	Cells were stimulated with TPA (10 nM) for 15 min in the presence of the indicated concentrations of U0126. Samples were collected and analyzed by Western blot to detect phosphorylated p42/p44 MAPK.
S5001	Tofacitinib (CP-690550) Citrate Tofacitinib (CP-690550) Citrate是一种新型JAK抑制剂，对JAK3，JAK2，JAK1的IC50分别为1 nM, 20 nM 和112 nM。Tofacitinib citrate 还具有抗感染的活性。	J Clin Invest, 2020, 130(2):863-876 Int J Cancer, 2020, 10.1002/ijc.33028 Cancers (Basel), 2020, 12(6):E1603	CP-690550 reduced the severity of ischemic damage. (A) CP-690550 (10 μM) suppressed IL-17 production by cdT cells and activated memory T cells. cdT cells and CD4+ CD44+ memory T cells isolated from C5BL6J mice through flow cytometry were stimulated for 24 h with plate-bound monoclonal antibodies to CD3 (2 ng/ml) and CD28 (1 ng/ml) in the presence or absence of IL-23 (25 ng/ml). IL-17A production and IL-17A expression level were measured by quantitative RT-PCR (a) and ELISA (b). (B) CBF reduction after brain ischemia. (C) Time-dependent changes in neurological score. *p < 0.05. (D) Infarct volume as visualized through TTC staining on day 3 in CP-690550 (CP)- and vehicle-treated mice.
S3226^New	Dehydroabietic acid Dehydroabietic acid (DAA, DHAA) 是一种天然的二萜树脂酸，衍生自针叶植物（如 Pinus 和 Picea）通过抑制 Src、Syk 和 TAK1 介导的通路来产生抗炎活性。
S3295^New	Taxifolin 7-rhamnoside Taxifolin 7-rhamnoside (TR, Taxifolin 7-O-rhamnoside, Taxifolin 7-O-α-L-rhamnoside) 是一种从 Hypericum japonicum 中分离出的类黄酮，其具有对抗耐甲氧西林金黄色葡萄球菌 (MRSA).的临床分离株的抗菌活性。
S3307^New	Galangin 3-methyl ether Galangin 3-methyl ether (3-O-Methylgalangin, 3-Methylgalangin) 分离自 Lychnophora markgravii 的地上部分，具有很强的抗细菌和抗真菌作用。
S3308^New	Caftaric acid Caftaric acid (CA, Caffeoyl tartaric acid) 是一种具有抗氧化和抗炎作用的天然产物。
S3261^New	Myrislignan Myrislignan 是一种分离自Myristica fragrans Houtt的木脂素并具有抗炎活性。Myrislignan 可抑制 interleukin-6 (IL-6) 和 tumour necrosis factor-α (TNF-α)。Myrislignan 剂量依赖性地抑制LPS刺激的巨噬细胞中 inducible NO synthase (iNOS) 和 cyclooxygenase-2 (COX-2) 的表达。Myrislignan 可抑制 NF-κB 信号通路的激活。
S6867^New	Glyceryl monocaprate (Monocaprin) Monocaprin 是癸酸的1一甘油酯，对包膜病毒、某些细菌和白色念珠菌具有抗菌的活性。
S2764^New	DTNB DTNB 是一种非荧光探针，可用于定量样品中巯基的数量或浓度。DTNB 还是登革热病毒蛋白酶 protease (NS2B-NS3pro)和链霉菌蛋白酶的变构抑制剂。
S6801^New	AKOS B018304 AKOS B018304，是一种对位被极性取代的芳基亚烷基衍生物，一种有效的低微摩尔活性的 chikungunya virus 的抑制剂。
S6802^New	Etosalamide Etosalamide 是一种具有退烧和镇痛作用的抗炎药。
S8512^New	Cenicriviroc Cenicriviroc (CVC, TAK-652, TBR-652) 是一种有效的、口服活性的 CC chemokine receptor 2 (CCR2) 和 CCR5 的双效抑制剂。Cenicriviroc 还可抑制 HIV-1 和 HIV-2 并具有有效的抗炎和抗感染活性。
S6854^New	Triazavirin Triazavirin 是一种新型的抗病毒药物，一种核酸的 nucleoside analogue，可抑制 synthesis of viral RNA and DNA 以及基因组片段的复制。Triazavirin 对流感和许多其他病毒具有活性。Triazavirin 在流感传播阶段可作为有效的保护性药剂。
S6845^New	GRL0617 GRL0617 是一种有效的、选择性的、竞争性的重症急性呼吸综合征 (SARS-CoV) papain-like protease (PLPro)/deubiquitinase 的非共价抑制剂，其IC50值为0.6 μM、Ki值为0.49 μM。GRL0617 可抑制Vero E6细胞中的SARS-CoV病毒复制，对应的EC50值为15 microM，并且没有相关的细胞毒性。
S6848^New	3'-Fluoro-3'-deoxythymidine (Alovudine) 3'-Fluoro-3'-deoxythymidine (Alovudine) 是一种有效的 polymerase γ 和 reverse transcriptase 抑制剂，可用于治疗HIV感染。3'-Fluoro-3'-deoxythymidine (Alovudine) 也是一种 DNA synthesis 的标记，可以用作为胰腺癌化疗的早期反应生物标记物。
S4307^New	Auranofin Auranofin (Ridaura, SKF-39162) 是一种 thioredoxin reductase (TrxR) 的抑制剂，在无细胞分析中对纯化的幽门螺杆菌TrxR的IC50值为88 nM。Auranofin 具有抗癌活性，在1.2 μM浓度下可以完全抑制细菌的生长。Auranofin 是一种FDA批准的含金化合物，用于治疗类风湿关节炎。	Oncotarget, 2018,
S0833^New	EIDD-1931 EIDD-1931 (NHC) 是EIDD-2801的活性代谢产物，它是一种很有前途的 COVID-19 抑制剂。 EIDD-1931（NHC）对 SARS-CoV-2、MERS-CoV、SARS-CoV 和 related zoonotic group 2b或2c Bat-CoVs，对应的平均IC50值为0.15 μM，并且对带有对核苷类似物抑制剂remdesivir耐药性突变的冠状病毒的效力增强。
S8969^New	EIDD-2801 EIDD-2801 是一种口服生物活性的核糖核苷类似物β-d-N⁴-hydroxycytidine (NHC; EIDD-1931)的前药，具有广谱的抗病毒活性 antiviral activity 对抗 SARS-CoV-2、MERS-CoV、SARS-CoV 和 COVID-19的病原体。
S0436^New	Pleconaril Pleconaril 是一种 capsid 的抑制剂，之前用于治疗肠病毒感染。Pleconaril 可有效抑制病毒复制，其IC50值 <0.050 μM。
S0470^New	RSV604 RSV604 是一种新型苯二氮卓类药物，是 respiratory syncytial virus (RSV) 的抑制剂，其EC50值为0.86 μM。RSV604 具有潜在治疗RSV相关疾病的可能性。Phase 2。
S0491^New	Manogepix (E1210) Manogepix (E1210, MGX, APX001A) 是一种广谱的、口服活性的抗真菌剂，可抑制 Gwt1/Gwt1p (GPI锚定壁转移蛋白1)，该蛋白在真菌细胞壁完整性中起重要作用。
S0285^New	Bay 41-4109 racemate BAY 41-4109 racemate 是 BAY 41-4109的R-异构体和S-异构体的混合物。BAY 41-4109 是一种可抑制 human hepatitis B virus (HBV)的抗病毒化合物，其IC50值为53 nM。
S6814^New	GS-441524 GS-441524 是一种具有药理活性的三磷酸核苷分子的分子前体，是猫传染性腹膜炎病毒 feline infectious peritonitis virus (FIPV) 的有效抑制剂，其EC50值为0.78 μM。
S5183^New	PD 169316 PD 169316 是一种有效的、细胞可渗透的选择性 p38 MAP kinase 抑制剂，IC50值为89 nM。 PD169316 可消除 TGFbeta 和 Activin A 引发的信号传导。 PD169316对 Enterovirus71 具有抗病毒活性。
S0076^New	ABX464 ABX464 是一种新型的抗HIV的分子，可抑制 HIV-1 的复制，对来自5个不同供体的受刺激的外周血单个核细胞（PBMCs）中的IC50范围为0.1 μM至0.5 μM。
S0038^New	AB-423 AB-423 属于氨磺酰苯甲酰胺（SBA）类的一员，是一种 hepatitis B virus (HBV) capsid 的抑制剂，对于 HBV replication 具有抑制作用，在细胞中的EC50值为 0.08 μM - 0.27 μM，EC90值为 0.33 μM - 1.32 μM。Phase 1。
S6689^New	Merimepodib Merimepodib是一种有效、特异性和可逆的inosine monophosphate dehydrogenase(IMPDH)抑制剂，在体外对丙型肝炎病毒(HCV)和多种DNA和RNA病毒具有抗病毒活性。Merimepodib是一种免疫抑制剂。
S6771^New	MAC-545496 MAC-545496是一种纳摩尔浓度的glycopeptide-resistance-associated protein R(GraR)抑制剂，对全长GraR蛋白(Kd≤0.1 nM)具有很强的结合亲和力。 MAC-545496可以逆转耐甲氧西林菌株中的β-内酰胺耐药性，并与CAMP协同作用。 MAC-545496在巨噬细胞中显示出显着的活性，并减弱了苜蓿根瘤菌幼虫感染模型中的金黄色葡萄球菌毒力。
S8932^New	Remdesivir (GS-5734) Remdesivir是腺苷类似物的单磷酰胺酸盐前药，是一种研究性的广谱抗病毒剂，对多种RNA病毒（包括埃博拉病毒和CoV病毒）具有体外活性。	Antiviral Res, 2020, 181:104882 Antimicrob Agents Chemother, 2020, AAC.00825-20
S6676^New	Ebselen Ebselen是HIV-1复制的小分子衣壳抑制剂，在TR-FRET分析中的IC50为46.1 nM。
S4303^New	9-Aminoacridine 9-Aminoacridine是一种高荧光染料，在临床上用作局部防腐剂，在实验中用作诱变剂、细胞内pH指示剂和负模小分子MALDI基质。
S1230	Flavopiridol (Alvocidib) Flavopiridol (Alvocidib, NSC 649890, HMR-1275) 与ATP竞争性抑制CDKs，包括CDK1、CDK2、CDK4、CDK6和CDK9的IC50范围为20-100 nM。作用于CDK1、2、4、6、9比作用于CDK7更具有选择性。Flavopiridol最初被发现能抑制EGFR和PKA。Flavopiridol可诱导自噬和内质网应激反应。Flavopiridol可阻滞HIV-1的复制。Phase 1/2。	Nature, 2020, 580(7801):147-150 Mol Cell, 2020, 7;S1097-2765(20)30269-0 Nucleic Acids Res, 2020, 24;gkaa268	(C) In vivo treatment of Tg:Pomc-Pttg;Pomc-eGFP embryos with small-molecule CDK inhibitors (50 μM) or 0.2% DMSO as control from 18 to 40 hpf. One hundred to one hundred fifty embryos were treated with each compound. Representative images of live embryos are shown with gross morphology (Right) and pituitary Pomc-GFP-positive cells at higher magnification (Left) at 40 hpf. Embryos exposed to flavopiridol developed early developmental defect before pituitary POMC cell ontogeny occurs. (D) Relative expression of pituitary Pomc-eGFP fluorescence analyzed using Volocity 5.2 software (Improvision; mean ±SE of relative expression, n = 7). (E) R-roscovitine specifically suppresses expansion of pituitary POMC cells overexpressing zPttg from 18 to 48 hpf. Double transgenic Tg:Pomc-Pttg;Prl-RFP embryos were generated by breeding Tg:Pomc-Pttg fish with a previously generated PRL-RFP transgenic line, in which RFP was targeted to pituitary lactotrophs by a zebrafish Prolactin promoter (34). Representative fluorescent microscopy of pituitary POMC-eGFP (a and b) and PRL-RFP (c and d) expression in live Tg:Pomc-Pttg; Pomc-eGFP and Tg:Pomc-Pttg;Prl-RFP embryos treated with 0.2% DMSO (a and c) or 50 μM R-roscovitine (b and d). (F) Relative expression of pituitary POMC-eGFP or PRL-RFP fluorescence were analyzed (mean ±SE of relative expression; n = 10). Results represent one of three similar experiments;P < 0.02 and *P < 0.000005. (Scale bar, 50 μm.)
S2003	Maraviroc Maraviroc (UK-427857)是一种CCR5拮抗剂，作用于MIP-1α，MIP-1β和RANTES，无细胞试验中IC50分别为3.3 nM，7.2 nM和5.2 nM。Maraviroc可应用于治疗HIV感染。	Sci Adv, 2020, 22;6(21):eaaz8521 Mucosal Immunol, 2020, 28 Mol Cancer Ther, 2020, 13;molcanther11722019	CCR5 antagonists block FBS-induced breast cancer cell invasion. 3D reconstruction of FBS-induced invasion into collagen gels by Hs578T (A) or SUM-159 (C) breast cancer cells in presence of CCR5 antagonists (100 nmol/L). The corresponding quantifications (mean ±SEM, n = 3) and analysis (Bonferronit test) are displayed in B and D.
S2679	Flavopiridol HCl Flavopiridol HCl 与ATP竞争性抑制CDKs，作用于CDK1，CDK2，CDK4和CDK6，无细胞试验中IC50为~40 nM。作用于CDK1/2/4/6比作用于CDK7选择性高7.5倍。Flavopiridol最初被发现可抑制EGFR和PKA。Flavopiridol HCl 可诱导自噬和内质网应激反应。Flavopiridol HCl 可阻止HIV-1的复制。Phase 1/2。	Haematologica, 2019, 10.3324/haematol.2019.222935 Mol Cancer Ther, 2019, 18(9):1520-1532 Sci Rep, 2019, 9(1):17369	Comparative efficacy of anticancer therapies (Flavopiridol, vincristine, daunorubicin, et al.) in NMC vs non-NMC cell lines. Mean IC50 (± s.e.m.) of the indicated agents in three NMC (PER-403, PER-624, and PER-704) and two non-NMC cell lines (PER-535 and SAOS2), ***P<0.001, unpaired t-test, corrected for multiple testing.
S2728	AG-1478 (Tyrphostin AG-1478) AG-1478 (Tyrphostin AG-1478, NSC 693255) 是一种选择性EGFR抑制剂，在无细胞试验中IC50为3 nM，对HER2-Neu，PDGFR，Trk，Bcr-Abl和InsR几乎没有作用活性。AG-1478（Tyrphostin AG-1478）通过靶向 phosphatidylinositol 4-kinase IIIα (PI4KA) 抑制脑心肌炎病毒encephalomyocarditis virus (EMCV)和丙型肝炎病毒hepatitis c virus (HCV)。	Autophagy, 2020, 16(6):1061-1076 Mucosal Immunol, 2020, 4 Br J Pharmacol, 2020, 10.1111/bph.14998	A549 cells were treated with G15 (a specific antagonist of GPR30, 1 uM), AG1478 (a potent antagonist of EGFR, 10 uM), BPA (10^-5 M) alone for 15 min or BPA after a 90-min pretreatment with G15 or AG1478 for 15 min. Then the expression of p-ERK1/2 and total ERK1/2 were measured by western blot analysis.
S1209	Fluorouracil (5-Fluorouracil, 5-FU) Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) 是DNA/RNA合成抑制剂，在肿瘤细胞中通过抑制胸苷酸合成酶（TS）而干扰核苷酸合成。Fluorouracil 可诱导细胞凋亡并可用于治疗HIV。	Cancer Cell, 2020, 37(3):371-386 J Hematol Oncol, 2020, 1;13(1):40 mBio, 2020, 11(3):e01190-20	DNA-PKcs suppression mediated ROS production and GSH content in HepG2 cells exposed to CDDP and 5-Fu. a DNA-PKcs inhibition promoted ROS production in HepG2 cells treated with indicated concentrations of CDDP and 5-Fu. DCFH-DA fluorescent analysis was performed to assess the ROS level. Data presented were mean ?SD of three independent experiments.
S1537	DMXAA (Vadimezan) DMXAA (Vadimezan)是一种vascular disrupting agents (VDA)，也是一种DT-diaphorase的竞争性抑制剂，无细胞试验中Ki为20 μM ，IC50为62.5 μM。DMXAA (Vadimezan) 也是一种STING 激动剂，具有潜在的抗肿瘤活性。DMXAA (Vadimezan) 在体外可有效诱导 IFN-β 和 TNF-α 的表达，但对 TNF-α 影响相对较低。DMXAA (Vadimezan)具有抗病毒活性。Phase 3。	Immunity, 2020, 7 pii: S1074-7613(20)30129-1 J Ethnopharmacol, 2020, 113246 Cancer Discov, 2019, 9(6):722-737	(B and C) sh-scrambled or sh-ck2a–transducted L929 cells (B) and Raw cells (C) were stimulated by DMXAA (100 μg/ml) for various times. Cytosolic and nuclear extracts were prepared as described in Materials and Methods. Five percent of the cytosolic proteins and 20% of the nuclear proteins were resolved by 10% SDS-PAGE. Subsequently, immunoblotting was conducted by indicated Abs. The amounts of Tubulin and Lamin B1 in cytosol versus nuclei detected by respective Abs were used as internal control for fractionation.
S1117	Triciribine Triciribine (NSC 154020, VD-0002, vqd-002, API-2) 是一种DNA synthesis抑制剂，也抑制PC3细胞系中的Akt和CEM-SS，H9，H9IIIB，U1细胞中的HIV-1，IC50分别为130 nM和20 nM；对PI3K/PDK1没有抑制作用；作用于缺乏腺苷激酶的细胞，活性降低5000倍。Phase 1/2。	Cell Oncol (Dordr), 2020, 8 Int J Biol Sci, 2020, 16(13):2382-2391 Biol Pharm Bull, 2020, 10.1248	Effect of triciribine on the migration of (A) FaDu and (B) Hep2 cells. The cells were treated with 5 µM triciribine for different periods of time. *P<0.05 vs. control. Hpf, high-power field.
S1516	Cidofovir Cidofovir (HPMPC) 通过选择性抑制病毒DNA的合成而抑制病毒复制。	Nat Biotechnol, 2019, 37(3):303-313 J Virol, 2019, 93(4) Antiviral Res, 2019, 162:178-185	The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir.
S1228	Idarubicin HCl Idarubicin HCl (4-demethoxydaunorubicin, NSC256439, 4-DMDR) 是蒽环类抗生素Idarubicin的盐酸盐形式，抑制MCF-7细胞中的 DNA拓扑异构酶II (topo II)，无细胞试验中IC50为3.3 ng/mL。Idarubicin 可诱导mTOR依赖的细胞毒素的自噬。	Cancer Cell Int, 2020, 19;20:58 Toxicol In Vitro, 2020, 104928 Cell Stem Cell, 2019, 25(2):258-272	Sensitivity of AML cells to conventional induction treatment and small-molecule p53 activators. Cell viability in OCI-AML3 cells treated for 24 hours with cytarabin/idarubicin (CI) and Nultin-3A (Nut; A), CI and Leptomycin-B (LMB; B), or Nut and LMB (D), respectively. CI was tested at 0, 100, 200, and 300 nmol/L CI; Nutlin-3A at 0, 2.5, 5, 7.5; and LMB at 0, 2, 8, 32 ng/mL in dosages 0, 1, 2, and 3, respectively. Cell viability in normal and AML bone marrow cells.
S1442	Voriconazole Voriconazole (UK-109496) 是类似于氟康唑和伊曲康唑的新型三唑衍生物，其作用是通过抑制真菌 cytochrome P-450 依赖性的，14-alpha-sterol demethylase 介导的麦角固醇的合成。	Antimicrob Agents Chemother, 2020, 6 pii: AAC BMC Microbiol, 2020, 20(1):28 Med Mycol, 2018, 10.1093/mmy/myx150	Voriconazole increases the osteogenic activity of human osteoblasts in vitro. Osteoblasts were exposed to voriconazole (VCZ) or fluconazole (FCZ) at 15 or 200 μg/ml in osteoinductive medium (OS+) for up to 7 days. As a positive control, cells were also exposed to sodium fluoride (NaF) at 10 μM in nonosteoinductive medium (OS−). Osteoblastic differentiation was evaluated by measuring alkaline phosphatase (ALP) activity (A) and staining for calcium deposition with alazarin red S stain (B and C); calcium deposition was quantified by measuring the absorbance (A415) of extracted alazarin red S (B) and was assessed by the light microscopic appearance (white arrows) of stained osteoblast cultures (C). Values represent the means ± SD. *, P < 0.05, compared to osteoblasts grown under osteogenic conditions without treatment.
S7046	Brefeldin A Brefeldin A 作用于HCT 116细胞，抑制内酯抗生素和ATPase，作用于protein transport（蛋白转运），IC50为0.2 μM，诱导癌细胞分化和凋亡。它还能提高同源重组修复效率，是CRISPR-mediated HDR的增强剂。Brefeldin A 也是自噬和线粒体自噬的抑制剂。	Cell Host Microbe, 2020, 11;27(3):476-485 e7 Ann Transl Med, 2020, 8(8):532 Medicine (Baltimore), 2020, 99(31):e21491	Cells were treated with brefeldin A or manumycin A, and the resulting supernatant was collected after 48 h for exosomal preparation (lanes 1 and 2), or exosomes obtained from C81 cells were trypsin-treated or freeze/thawed (F/T) and then trypsin-treated (lanes 3 and 4). Lanes 5 and 6, input exosome controls from C81 or CEM cells, respectively. Resulting exosomes were assayed for the presence of Tax by Western blotting.
S1189	Aprepitant Aprepitant (MK-0869, L-754030)是一种有效的选择性 neurokinin-1 receptor 拮抗剂，IC50为0.1 nM。Aprepitant 可降低炎症因子的表达水平，包括 G-CSF、IL-6、IL-8 和 TNFα。Aprepitant 可抑制人巨噬细胞 HIV 的感染。	Nat Commun, 2020, 29;11(1):2673 Neuron, 2019, 103(3):432-444 Cell Syst, 2019, 8(2):97-108	HepT1, HepG2, and HuH6 cells were treated with increasing doses of aprepitant or SP [100 nM] and Western blot analysis was performed for the apoptotic markers PARP, Caspase-3, and BID.
S2713	Geldanamycin Geldanamycin (NSC 122750) 是一种天然的HSP90抑制剂，K_d为1.2 μM，特异性干扰糖皮质激素受体(GR)/HSP联合。Geldanamycin 通过减少宿主的炎症反应来减轻病毒感染引起的ALI(急性肺损伤)/ARDS(急性呼吸窘迫综合征)。	Cell Biol Toxicol, 2020, Proteomics, 2020, e1900372 Nat Commun, 2019, 10(1):2131	Phenotypic effect of Genetic or Pharmacologic Compromise of the 477 Hsp70-StiA-Hsp90 Complex. The impact of each genetic modification on radial growth, conidiation, and response to various stress conditions was assessed after inoculation of a suspension of 104 conidia on glucose minimal medium (GMM) agar plates and incubation at 37ºC for 5 days.
S1401	Tenofovir Tenofovir (GS-1278) 对reverse transcriptase（逆转录酶）和B型肝炎病毒感染具有抑制作用。	Cells, 2020, 17;9(4) pii: E1003 Antiviral Res, 2020, 175:104709 Sci Rep, 2020, 5;10(1):7604	The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; ** p<0.0001; * p<0.001 (unpaired t-test).
S7015	Birinapant Birinapant是一种SMAC模拟拮抗剂，对cIAP1最有效，无细胞试验中K_d为<1 nM，对XIAP作用较弱。Birinapant可帮助诱导HIV-1感染的细胞凋亡。Phase 2。	Cell Rep, 2020, 30(4):1260-1270 Cell Rep, 2020, 21;31(3):107547 Cell Death Differ, 2020, 26	Western blot analysis of XIAP and cIAP1 expression and PARP cleavage in H460, A549 and 34LU cells pre-treated with vorinostat or entinostat for 6h followed by the SMAC mimetic birinapant for 24h.
S1400	Tenofovir Disoproxil Fumarate Tenofovir (GS-1278) Disoproxil Fumarate 属于一类抗逆转录病毒药物，其通过与天然底物脱氧腺苷5’-三磷酸盐竞争以及整合到DNA后终止DNA链抑制HIV reverse transcriptase活性。	Antimicrob Agents Chemother, 2019, 64(1) Antimicrob Agents Chemother, 2018, 62(6) Antimicrob Agents Chemother, 2018, 62(9)	Human PBMCs containing indicated concentrations of Tenofovir disoproxil fumarate were inoculated with 5 ng mock-exposed or semen-exposed R5-HIV-luciferase, or 50 ng R5-HIV-luciferase as infectivity matched control. Infection rates were determined 3 days post inoculation.
S1704	Emtricitabine Emtricitabine (FTC)是一种新型的核苷剂，对人类免疫缺陷病毒HIV和HBV具有抑制活性。是逆转录酶抑制剂，在细胞中的半衰期为39 h。	JCI Insight, 2019, 4(12) Nat Med, 2018, 24(5):604-609 Antimicrob Agents Chemother, 2018, 62(9)
S2597	Oseltamivir Phosphate Oseltamivir Phosphate 是一种有效的和选择性的，甲型流感和乙型流感病毒复制必需的神经氨酸酶的抑制剂，用于治疗流行性感冒。	J Cell Mol Med, 2018, 22(3):1826-1839 Infect Immun, 2015, 10.1128/IAI.03118-14 Drug Metab Dispos, 2014, 42(9):1522-31	Nystatin, filipin III, and oseltamivir inhibit the labeling of trophozoites by CTXB and GM1 antibodies. (A) Trophozoites were treated with nystatin (27 μM), filipin III (7.6 μM), and oseltamivir (20 μM) for 30 min before labeling with Alexa Fluor-conjugated CTXB antibody (images a to d) and GM1 antibody (images a′ to d′). Myriocin (27 μM), a sphingolipid inhibitor, was used as a negative control (images e and e′). N, nucleus; PM, plasma membrane; F, flagella; VD, ventral disc. Bars, 5 μm. (B and C) Changes in intensity of control and inhibitor-treated trophozoites. For intensity measurements, cells were randomly selected from 10 to 15 fields from 3 to 5 separate experiments. Approximately 50 cells were considered for each condition and were analyzed using Zeiss Zen 2009 confocal software. One-way ANOVAs were performed to evaluate differences (means ± SDs) between the treatment and control groups. Mean intensities from 3 to 5 separate experiments are shown in panels B and C. Statistical significance was calculated using a one-way ANOVA test, followed by the Tukey (B) and Holm-Šídák (C) methods. , P < 0.05; , P < 0.01; **, P < 0.001; NS, not significant.
S3021	Rimonabant Rimonabant是一个大脑中心大麻素受体（CB1）特异性口服拮抗剂。在hCB1转染HEK293细胞中IC50浓度为13.6 nM，EC50浓度为17.3 nM。Rimonabant也是一种acyl CoA:cholesterol acyltransferases(ACAT) 1和2的双重抑制剂并且可抑制分支杆菌的MmpL3。	Microbiol Immunol, 2020, 10.1111/1348-0421.12777
S8030	Plerixafor (AMD3100) Plerixafor (AMD3100, JM 3100) 是一种趋化因子受体拮抗剂，作用于CXCR4和CXCL12介导的趋化性，无细胞试验中IC50分别为44 nM和5.7 nM。Plerixafor 可抑制human immunodeficiency virus (HIV)复制。	Cell Chem Biol, 2020, 10.1016/j.chembiol.2020.01.010 Mol Oncol, 2020, 14(4):779-794 J Biol Chem, 2020, 1 pii: jbc	BLI of NSG mice engrafted with BV173, treated with no therapy (control), plerixafor: 1 mg/kg IP daily, ESKM 100 ug twice weekly, and a combination of ESKM and plerixafor. (A) Logarithmic plot of BLI of leukemia growth measured weekly. Error bars are 5-95% confidence intervals. There was a small but not significant difference between ESKM and combination treated group. (B) End of therapy (day 34) BLI.
S1896	Hydroxyurea Hydroxyurea (nci-c04831, nsc32065) 是一种抗肿瘤药，通过抑制核苷二磷酸还原酶 ribonucleoside diphosphate reductase 而抑制DNA合成。 Hydroxyurea 可激活凋亡和自噬，并可用于治疗HIV感染。	Haematologica, 2020, 12;haematol.2019.233445 Cancer Cell Int, 2020, 19;20:58 Nat Commun, 2019, 10(1):5654	Lethally irradiated C57BL/6 recipient mice were injected with a 1:1 mixture of GFP+JAK2(V671F) and wild-type bone marrow cells. Five weeks later, mice were treated with vehicle (C), hydroxyurea (H; 30 mg/kg twice daily IP), ruxolitinib (R; 30 mg/kg twice daily oral gavage), BMN673 (B; 0.33 mg/kg IV), H+R, H+B, R+B, and H+R+B for 3 weeks. Percentage of GFP+JAK2(V617F) was measured in (panel B) bone marrow cells, (panel C) splenocytes, and (panel D) peripheral blood leukocytes; (panel E) number of GFP+JAK2(V617F) Lin−Sca1+c-Kit+ (LSK) cells per 106 bone marrow cells was calculated, too. P < .05, P < .05, and **P < .05 when compared with control, single treatment, and double treatment, respectively, from 6 to 7 mice using the Student t test.
S1386	Nafamostat Mesylate Nafamostat mesilate (FUT-175) 是合成的丝氨酸蛋白酶抑制剂，在血液透析中被用作是一种抗凝血剂。Nafamostat Mesylate可抑制SARS-CoV-2的激活，并用于COVID-19的治疗选择的研究中。Nafamostat Mesylate 可减弱炎症和凋亡。	Br J Pharmacol, 2018, 175(17):3516-3533 Cancer Lett, 2016, 380(1):87-97 Med Oncol, 2016, 33(5):53	Immunofluorescence of NF-κB/p65 in HCT 116 and SW 1116 cells exposed to TNFα (25 ng/ml) with or without nafamostat mesilate(FLU) (100 μM). Scale bars: 20 μm.
S1627	Nitazoxanide Nitazoxanide 是一种人工合成的nitrothiazolyl-salicylamide衍生物，是一种抗原虫剂（作用于犬流感病毒，IC50为0.17 到0.21 μM）。Nitazoxanide 可调节自噬并抑制 mTORC1 信号传递。	Biomed J, 2020, S2319-4170(20)30066-4 bioRxiv, 2020, 2020/9/20.4.7.30734 Nat Chem Biol, 2018, 14(1):94-101
S1623	Acetylcysteine(N-acetylcysteine) Acetylcysteine(N-acetyl-l-cysteine,NAC)是ROS抑制剂，拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂，主要用作祛痰剂，可通过维持或恢复肝脏中谷胱甘肽的浓度来处理扑热息痛(对乙酰氨基酚过量)。Acetylcysteine(N-acetyl-l-cysteine) 通过抑制IκB kinases抑制TNF诱导的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通过线粒体依赖性途径诱导凋亡并抑制铁死亡和病毒复制。现配现用。	Nat Immunol, 2020, 21(7):727-735 Cell Death Differ, 2020, 10.1038/s41418-020-0496-1 J Hazard Mater, 2020, 5;391:122203	(C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
S1384	Mizoribine Mizoribine (Bredinin, NSC 289637) 是一种咪唑核苷，是一种抑制 HCV RNA replication 的免疫抑制剂，其抗HCV活性的IC50约为 μM。 Mizoribine 是一种 inosine-5'-monophosphate dehydrogenase (IMPDH) 和 guanosine monophosphate synthetase 的选择性抑制剂。Mizoribine还可抑制SARS-CoV。	JCI Insight, 2020, 9;5(7):e135071 Cancer Cell, 2017, 32(5):624-638
S8047	Dynasore Dynasore 是一种细胞渗透性的，可逆的，非竞争性dynamin抑制剂，抑制dynamin 1/2的GTPase活性，无细胞试验中IC50为15 μM，也抑制线粒体dynamin Drp1，对其他小GTP酶没有作用效果。Dynasore 可抑制 mTORC1 活性并诱导自噬。Dynasore 抑制多种病毒的入侵，包括HSV。	Nat Cell Biol, 2020, 1 J Immunol, 2020, 204(5):1146-1157 Sci Rep, 2020, 26;10(1):8686	Immunocytochemistry demonstrates NR4A1 nuclear location at control (non-chymase treated) in HL-1 cells (a). Chymase (2.5 ug/ml) treatment for 2 h induces NR4A1 (red) cytoplasmic translocation in HL-1 cells as well as myosin (green) disruption (panel b). Active chymase enters HL-1 cells and is prevented by Dynasore (c and d). There marked entry into HL-1 cell nuclei and cytoplasm after treatment with chymase (5 ug/ml) for 2 h that is prevented by pre-treatment with Dynasore. Lack of co-staining with caveolin 3 (green) demonstrates that chymase is not transported via caveolae. Dynasore prevents transferrin uptake in HL-1 cells.
S1848	Curcumin Curcumin (Diferuloylmethane) 是流行的印度香料姜黄的主要姜黄色素，属于姜科（Zingiberaceae）。它是p300 histone acetylatransferase（IC50~25 μM）和Histone deacetylase (HDAC)的抑制剂，能够激活Nrf2 pathway并抑制NF-κB的激活。Curcumin 可诱导线粒体自噬、细胞自噬、凋亡和细胞周期阻滞，并具有抗肿瘤的活性。Curcumin 可通过减少铁死亡介导的细胞死亡来减少横纹肌溶解相关的肾衰竭。Curcumin 对各种人类病原体（如流感病毒，丙型肝炎病毒，HIV等）具有抗感染特性。	Front Microbiol, 2020, 15;10:3016 Protein Sci, 2020, 29(6):1366-1372 Pharm Biol, 2020, 58(1):25-34
S4157	Chloroquine diphosphate Chloroquine diphosphate是一种4-氨基喹啉的抗疟疾和抗风湿药，也是一种ATM激活剂。Chloroquine 也是一种toll-like receptors (TLRs)的抑制剂。	Autophagy, 2020, 10.1080/15548627.2020.1740529 Autophagy, 2020, 22:1-10 EMBO Rep, 2020, 6;21(5):e49232	NCI-H929 EV and miR-137 OE cells were treated with ATM activator Chloroquine Phosphate (CQ), specific ATM inhibitor KU-55933, and ATR inhibitor AZ20 for 12 hr. Immunoblotting showed the expression of p-ATM, p-Chk2, p-BRCA1, p-ATR and p-Chk1.
S2310	Honokiol Honokiol 是木兰的有效成分，抑制Akt磷酸化，且促进ERK1/2磷酸化。Honokiol 可造成 G0/G1 期阻滞，并可通过 ROS/ERK1/2 信号通路来诱导凋亡和自噬。Honokiol 可抑制 hepatitis C virus (HCV) 感染。Phase 3。	Cancers (Basel), 2020, 12(7):E1782 Int J Nanomedicine, 2020, 15:17-29 Radiat Environ Biophys, 2020,	(B) Cleaved PARP, Bax and Bcl2 protein expression was evaluated by immunoblotting of KRAS mutant cells lysates after 48 h of honokiol (10, 20, 40, and 60 μM) treatment. ∗∗P < 0.01 and ∗∗∗P < 0.001 for comparison between control group and honokiol-treated group.
S2239	Tubacin Tubacin 是一种高度有效的选择性的，可逆的，细胞渗透性HDAC6抑制剂，无细胞试验中IC50为4 nM，比作用于HDAC1的选择性高350倍。Tubacin 可通过减少病毒RNA合成来抑制乙型脑炎病毒的复制。	Toxicol Lett, 2020, 320:19-27 Theranostics, 2020, 10(16):7351-7368 Nat Commun, 2019, 10(1):5792	Verification of Hdac6 deletion in knockout MEFs. Expression of HDAC6 and acetylation of tubulin were analyzed by immunoblotting.
S1351	Ivermectin Ivermectin (MK-933, IVM) 是一种chloride channel激活剂，用作广谱抗寄生虫药。Ivermectin (MK-933, IVM) 是 P2X4 和 α7 nicotinic acetylcholine receptors (nAChRs) 的特异性正变构效应物。Ivermectin 对 HIV-1 和登革热dengue virus均具有有效的抗病毒活性。Ivermectin 可通过AKT/mTOR信号通路来诱导自噬，并诱导线粒体自噬。	Nat Cell Biol, 2020, Blood Cancer J, 2020, 10(6):72 J Cell Mol Med, 2020, 24(9):5387-5401
S2527	Methacycline HCl Methacycline HCl 是一种四环素类抗生素，同时也是表皮间质转换的抑制剂（IC50=5 μM），用于治疗各种感染。	Cancer Cell Int, 2020, 19;20:58 Sci Rep, 2018, 8(1):7653
S1677	Chloramphenicol Chloramphenicol (Chloromycetin)是通过抑制蛋白质的合成的抑菌剂。
S2716	Peramivir Trihydrate Peramivir三水合物是抗感染剂Peramivir（RWJ-270201，BCX-1812)的三水合物，这是一种过渡状态模拟和一个强有力的流感病毒神经氨酸酶特异抑制剂,IC50中位数为0.09 nM。	Emerg Microbes Infec, 2014, 3, e78 Emerg Microbes Infect, 2014, 3(11):e78	Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of peramivir (C) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice.
S1606	Clotrimazole Clotrimazole (BAY b 5097, FB 5097)是一种合成的抗真菌药物，是imidazole的广谱衍生物。	J Cell Physiol, 2020, 10.1002 J Biol Chem, 2018, 293(1):333-344
S1956	Miconazole Nitrate Miconazole (NSC 169434) Nitrate是一种咪唑类抗真菌剂，外用或静脉输液。	Biomol Ther (Seoul), 2020, 25 Cell Death Dis, 2019, 10(6):413 FASEB J, 2019, 10.1096/fj.201802603RR
S2557	Terbinafine HCl Terbinafine HCl 通过抑制角鲨烯环氧酶抑制了麦角固醇的合成，用作抗真菌药物。	J Cell Mol Med, 2020, 25
S2457	Clindamycin HCl Clindamycin HCl 是Clindamycin的水合盐酸盐，是一种半合成的抗生素。	Proc Natl Acad Sci U S A, 2016, 113(50):14408-14413
S1611	Cefoperazone Cefoperazone是一种头孢菌素类抗生素，能抑制rMrp2调节的17βG的吸收[³ H]E₂，其IC50是199 μM。
S3007	Zanamivir Zanamivir (GG167) 是神经氨酸酶抑制剂，用于治疗A型流感病毒和B型流感病毒引起的流感的治疗。	Emerg Microbes Infec, 2014, 3, e78 Emerg Microbes Infect, 2014, 3(11):e78	Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of oseltamivir zanamivir (B) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice.
S2908	Hygromycin B Hygromycin B是选择性抗生素，有效作用于大多数细菌，真菌，和更高等的真核生物，通过干扰易位，抑制蛋白合成，造成70S核糖体的错译。	Cell Res, 2020, Sci Rep, 2020, Cell Rep, 2020, 30(1):25-36
S1854	Bifonazole Bifonazole (Bay h 4502) 是一种抗真菌剂和前列腺芳香化酶抑制剂，IC50为1.6 μM。	Nature, 2018, 560(7718):372-376	Percentage of MBP+ oligodendrocytes generated from OPCs following treatment with azoles (c). n ≥ 4 wells per condition.
S1876	Valaciclovir HCl Valaciclovir HCl 是一种抗病毒药，用于治疗单纯疱疹，带状疱疹，疱疹B。
S1997	Liranaftate Liranaftate 是一种角鲨烯环氧酶抑制剂具有抗真菌活性。
S1791	Bacitracin Zinc Bacitracin是一种抗生素，能够干扰C55-isoprenyl pyrophosphate的去磷酸化，C55-isoprenyl pyrophosphate是一种膜载体分子，参与转运构成肽聚糖细菌细胞壁内膜外部成分。Bacitracin抑制甲硫啡肽中Tyr的裂解，IC50为10 μM。
S2572	Streptomycin sulfate Streptomycin sulfate是Streptomycin的硫酸盐形式，是一种蛋白质合成抑制剂。	Nutrients, 2020, 12(6):E1901 NPJ Precis Oncol, 2020, 4:21
S1685	Sulfanilamide Sulfanilamide是细菌酶中二氢喋呤合成的适度竞争性抑制剂，IC50为320 μM。
S8279	Shikonin Shikonin，是一种 Pyruvate kinase M2 (PKM2) 有效的、特异的抑制剂。它是紫草的主要成分，紫草是一种中草药，具有多种生物活性。在细胞荧光淬灭试验中，Shikonin也是TMEM16A氯离子通道的抑制剂。Shikonin 通过抑制 tumor necrosis factor-α (TNF-α) 发挥抗炎作用，并可通过抑制 proteasome 来阻止 nuclear factor-κB (NF-κB) 信号途径的激活。	Front Pharmacol, 2020, 11:861 Phytomedicine, 2020, 68:153189 Acta Biochim Biophys Sin (Shanghai), 2020, 52(1):9-17
S8750	NGI-1(ML414) NGI-1靶向寡糖转移酶，可能对虫媒病毒发挥抗病毒作用。
S5144	Neferine Neferine ((R)-1,2-Dimethoxyaporphine) 是 Nelumbo nucifera 的天然成分，具有抗肿瘤功效。Neferine 可诱导肾癌细胞凋亡。Neferine 通过激活肌肉细胞中的 Akt/mTOR 通路和 Nrf2 来防止自噬。Neferine 在抗凋亡的癌症中可诱导自噬依赖性的细胞死亡。Neferine具有多种治疗作用，例如抗糖尿病，抗衰老，抗微生物，抗血栓形成，抗心律不齐，抗炎甚至抗HIV。	Oncol Rep, 2020, 44(3):1116-1126
S2830	Clindamycin Clindamycin通过作用于50S ribosomal subunits（50S核糖体亚基）而抑制蛋白合成。
S7311	Q-VD-Oph Q-VD-OPh 是一种有效的pan-caspase抑制剂，作用于caspases 1， 3， 8和9，IC50范围在25到400 nM之间，有效抑制与细胞凋亡相关的末端caspase激活，底物裂解，及DNA梯状条带形成。Q-VD-OPh 可抑制HIV感染。	Nat Immunol, 2020, 21(5):546-554 Nat Commun, 2020, 24;11(1):1996 Cell Rep, 2020, 21;31(3):107547	UA and Q-VD-Oph attenuated TNF-α-induced unclear translocation of NF-κB (C) and P-STAT3(S727) (D) in BEAS-2B cells.
S5268	Solithromycin Solithromycin, belonging to the well-known class of macrolide antibiotics that also includes azithromycin, is a potent bacterial protein synthesis inhibitor.
S4970	Nerol Nerol是存在于多种香精油如柠檬草和槐花中的单萜化合物。
S7975	Favipiravir (T-705) Favipiravir (T-705)是一种有效的选择性RNA-dependent RNA polymerase抑制剂，用于治疗流感病毒感染。	Viruses, 2020, 22;12(3) pii: E351 Antiviral Res, 2020, 182:104902 Mol Ther Methods Clin Dev, 2019, 14:47-55	(A) BoDV-1 infection was measured by IFA. BoDV-1 P40 was detected with a primary monoclonal antibody (red), nuclei were stained with DAPI (blue), merged image (scale bars: 50 μm). Favipiravir: T-705
S4941	Farnesol Farnesol是一种天然的倍半萜烯醇，有效地治疗抗代谢障碍、具有抗炎、抗氧化、抗肿瘤和抗菌活性。
S7550	Erythromycin Cyclocarbonate Erythromycin Cyclocarbonate，红霉素的衍生物，通过结合于50S核糖体抑制细菌蛋白质合成。
S4599	Benzyl benzoate Benzyl benzoate (Ascabiol, Novoscabin, Scabitox, Benzoic acid benzyl ester) 是治疗疥疮的旧制剂之一。
S7784	Fumagillin Fumagillin是一种选择性且有效的甲硫氨酸胺基肽酶2(MetAP2)不可逆抑制剂，用作抗生素治疗微孢子虫病。
S4861	Oxindole Oxindole是芳香族杂环有机化合物，当剂量过量时，可引起镇静、肌无力、低血压和昏迷。
S8873	Letermovir（AIC246） Letermovir(AIC246, MK-8228)是新型的anti-CMV化合物，靶向病毒末端酶复合体，对DNA聚合酶抑制剂具有抗性的病毒也具有活性。
S4946	2,3-Dihydroxybenzoic acid 2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) 是一种天然酚类，存在于西印度醋栗和水生蕨类Salvinia molesta，也是人体中阿司匹林的代谢产物。它是一种潜在的铁螯合药物，具有抗菌特性。
S4647	Cefmenoxime hydrochloride Cefmenoxime (SCE-1365), 肠杆菌科的有效抑制剂，是一种头孢菌素抗生素，通常用于静脉注射或肌内注射。
S5499	Amantadine Amantadine is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is an M2 inhibitor which blocks the ion channel formed by the M2 protein that spans the viral membrane.
S4602	Acetohydroxamic acid Acetohydroxamic acid (N-Hydroxyacetamide, Methylhydroxamic acid, Acetic acid\|oxime, Lithostat) 是尿素酶抑制剂。在尿液中，它可作为细菌酶尿素酶的拮抗剂。
S8133	Resiquimod Resiquimod 是一种免疫反应调节剂，用作有效的TLR 7/TLR 8激动剂并可诱导如 TNF-α、IL-6 和 IFN-α 等细胞因子的上调。Resiquimod 可减少 hepatitis C virus (HCV)感染。Phase 2。	Vaccines (Basel), 2020, 15;8(2):E186 Nat Commun, 2020, 11(1):3521 Cancer Lett, 2020, 469:173-185
S8588	ACSS2 inhibitor ACSS2 inhibitor 是有效的、特异性的乙酰辅酶A合成酶2 (ACSS2)抑制剂。ACSS2 inhibitor 还可抑制呼吸道合胞体病毒(RSV)。
S6549	PBTZ169 PBTZ169是DprE1的不可逆性抑制剂，是一种抗生素。	Cell Death Dis, 2019, 10(4):319
S9303	Saikosaponin B2 Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.	Phytomedicine, 2019, 67:153163
S9018	Luteoloside Luteoloside is a member of the flavonoids family that exhibits several bioactivities including anti-microbial and anti-cancer activities. It is an inhibitor of 3C Protease of Enterovirus 71 with an IC50 value of 0.36 mM.
S5345	Nerolidol Nerolidol (Peruviol) is a naturally occurring sesquiterpene found in the essential oils of many types of plants and flowers. It has diverse range of pharmacological and biological activities including antioxidant, anti-microbial, anti-biofilm, anti-parasitic, insecticidal, anti-ulcer, skin penetration enhancer, anti-tumor, anti-nociceptive and anti-inflammatory properties.	Int Immunopharmacol, 2020, 80:106118
S7775	Emricasan Emricasan 是有效的、不可逆的泛半胱天冬酶（pan-caspase）抑制剂。Emricasan 也是寨卡病毒感染的抑制剂。	Nature, 2020, 580(7803):391-395 Nat Immunol, 2020, 21(5):546-554 Immunity, 2020, 22 pii: S1074-7613(20)30160-6
S7273	SC75741 SC75741 是强效的NF-κB抑制剂，其EC50为200 nM。SC75741 可有效地阻断流感病毒的传播。	J Neurochem, 2020, 10.1111/jnc.14963 J Invest Surg, 2020, 10.1080/08941939.2019.1705941 Elife, 2020, 9:e53367	Immunofluorescence of NF-κB (p65) (200×). SK-OV-3 and A2780S cells were treated with different compounds (vehicle, 5 μM JSH-23, 5 μM SC75741, 5 μM CAPE, 4 μM MIL, 4 μM MIL combined with pre-treated 5 μM JSH-23, 4 μM MIL combined with pre-treated 5 μM SC75741, 4 μM MIL combined with pre-treated 5 μM CAPE) for 48 h. NF-κB(p65) was detected by a fluorescence microscopy. The nuclei were stained with Hoechst 33258.
S8068	Chaetocin Chaetocin，一类来自毛壳菌属的天然产物，是一类 histone methyltransferase 抑制剂，其对dSU(VAR)3-9，小鼠G9a和粗糙链孢霉 DIM5的IC50分别为0.8 μM, 2.5 μM和3 μM。Chaetocin是一种抗癌药物并是 thioredoxin reductase (TrxR) 的抑制剂。	Front Endocrinol (Lausanne), 2020, 11:323 Nat Commun, 2019, 10(1):273 Cell Death Dis, 2019, 10(12):894
S9063	Harringtonine Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.
S4430	Hydroxychloroquine Sulfate Hydroxychloroquine Sulfate (HCQ) 是一种抗疟疾药，用于治疗系统性红斑狼疮，类风湿关节炎等自身免疫病，炎症以及皮肤病。它也是autophagy和toll-like receptor (TLR) 7/9的抑制剂。	Nat Commun, 2020, 24;11(1):1985 Geroscience, 2020, 10.1007/s11357-020-00166-4 J Cell Physiol, 2020, 10.1002/jcp.29433	C, SA-beta gal staining results of A549-LKB1 cells treated by trametinib (30 nmol/L), radiotherapy (2 Gy), and HCQ (50 μmol/L). Cells were treated by HCQ and/or trametinib 4 hours prior to radiotherapy. Drugs were washed out 24 hours after radiotherapy. Cells were incubated for additional 48 hours before staining. D, Clonogenic survival assay of A549-LKB1 cells treated with trametinib (30 nmol/L) and HCQ (50 μmol/L).
S9064	Trilobatin Trilobatin, a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect.
S5704	Myclobutanil Myclobutanil is a widely used triazole fungicide and also a steroid demethylation inhibitor.
S4983	Sorbic acid
S9070	Isoxanthohumol Isoxanthohumol is one of the most important prenylflavonoids found in hops. It exhibits an antiproliferative activity against human breast cancer cell lines, ovarian cancer, prostate cancer, and colon cancer cells. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV).
S4198	Aminothiazole Aminothiazole作为甲状腺抑制剂，具有抗菌活性。
S9072	Sweroside Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects.
S5927	Proguanil Proguanil是预防性抗疟药。它能抑制疟原虫的二氢叶酸还原酶，阻止嘌呤和嘧啶的合成。
S3710	Fosfomycin calcium Fosfomycin (phosphomycin, phosphonomycin) 是一种杀菌剂，可通过使UDP-N-acetylglucosamine-3-enolpyruvyltransferase失活而一直细菌细胞壁形成。Fosfomycin可通过甘油磷酸盐转运蛋白进入细胞壁。
S5166	Benzoyleneurea Benzoyleneurea (2,4-Dihydroxyquinazoline, Quinazolinedione, Quinazoline-2,4-diol) scaffold is used in the synthesis of novel protein geranylgeranyltransferase-I inhibitors.
S5025	Efinaconazole Efinaconazole (KP-103) 是14 alpha-demethylase的抑制剂。14 alpha-demethylase参与ergosterol的生物合成，ergosterol是真菌细胞膜的成分之一。
S4104	Diminazene Aceturate Diminazene是一种二脒，也称4,4-（1-三氮烯-1,3-二取代基）双（苯甲脒)，用作有效的杀锥虫剂。	Am J Physiol Lung Cell Mol Physiol, 2020, 10.1152/ajplung.00025.2020
S4105	Closantel Sodium Closantel Sodium是革兰氏阳性的抗菌活性抑制剂，抑制KinA/Spo0F系统，IC50为3.8 μM。
S4106	Closantel Closantel (R-31520) 是革兰氏阳性的抗菌活性抑制剂，抑制KinA/Spo0F系统，IC50为3.8 μM。
S3711	Carbasalate Calcium Carbasalate calcium (Iromin, Alcacyl, Omegin, Rheomin, Solupsan) 是一种止痛剂、退热剂，是一种抗炎药物以及血小板聚集的抑制剂。
S4701	2-Deoxy-D-glucose (2-DG) 2-Deoxy-D-glucose (2-DG, 2-deoxyglucose, NSC 15193), 一种葡萄糖类似物，是具有抗病毒活性的糖酵解抑制剂。2-Deoxy-D-glucose 可诱导凋亡并抑制 Herpes Simplex Virus type-1 (HSV-1) receptor 的表达。	Cancer Cell, 2020, 13;37(4):599-617 e7 PLoS Pathog, 2020, 9;16(6):e1008568 Metabolism, 2020, 13;107:154231	(B) 2-DG activates AMPK and suppresses H3K27me3, PRC2 of ovarian cancer cells in normoglycemic condition.
S9341	3,4-Dimethoxycinnamic acid 3,4-Dimethoxycinnamic acid is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.
S4515	Ademetionine disulfate tosylate Ademetionine Disulfate Tosylate是腺苷蛋氨酸离子的非对映异构体的硫酸氢盐-甲苯磺酸盐混合盐形式。Ademetionine（腺苷蛋氨酸）具有抗炎活性，被用于治疗慢性肝疾病。
S3028	Geneticin (G418 Sulfate) Geneticin (G418 Sulfate), 一种氨基糖苷类抗生素, 是80 S ribosomes延伸的抑制剂，在原核和真核细胞中均能通过抑制延伸步骤来阻断多肽合成。	Mol Ther Oncolytics, 2020, 29;17:21-30 G3 (Bethesda), 2020, 4;10(5):1585-1597 Redox Biol, 2020, 36:101652
S7417	Puromycin 2HCl Puromycin 2HCl 是一种氨基核苷抗菌素，其可作为蛋白质合成的抑制剂。	Autophagy, 2020, 15:1-13 Cell Rep, 2020, 30(2):497-509 Oncogene, 2020, 39(21):4212-4226
S4780	7-Methoxy-4-methylcoumarin 7-Methoxy-4-methylcoumarin is a coumarin derivative and fluorescent label.
S4783	Benzyl isothiocyanate Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.	Biomolecules, 2019, 9(12)
S7867	Oleuropein Oleuropein 是一种从橄榄叶中分离出的抗氧化多酚。Oleuropein 具有抗氧化、抗炎和抗动脉粥样硬化的作用，并在体外抑制脂肪细胞的分化。Oleuropein 抑制 PPARγ 活性。Oleuropein 通过直接抑制PPARγ转录活性发挥抗脂肪形成作用。Oleuropein 还可抑制aromatase。Oleuropein 可诱导凋亡。Phase 2。
S4549	Antimonyl potassium tartrate trihydrate Antimonyl potassium tartrate trihydrate (Tartar emetic) 是一种有效的催吐剂，同样也用于治疗血吸虫病和利什曼病。
S7889	Xanthohumol Xanthohumol，来自啤酒花的一种异戊烯化查耳酮，抑制COX-1和COX-2活性，并表现出化学预防作用。Xanthohumol 可抑制 diacylglycerol acyltransferase 1 (DGAT1) 和 DGAT2，对应的IC50值均为40 μM。Xanthohumol 也是一种有效的针对一系列DNA和RNA病毒的抗病毒药剂。Xanthohumol 在肿瘤细胞中可诱导生长阻滞和凋亡。Phase 1。	J-Cancer, 2020, 6;11-14-:4047-4058 Int J Biol Sci, 2019, 15(11):2497-2508 PLoS One, 2019, 14(3):e0213776
S4286	Anidulafungin (LY303366) Anidulafungin (LY303366), 一种echinocandin的衍生物, 抑制glucan synthase的活性, 用作抗真菌药。	Antimicrob Agents Chemother, 2020, 64(2) BMC Infect Dis, 2020, 19;20(1):287 Front Microbiol, 2020, 10:2936	Effect of Anidulafungin on hemolysis. Arithmetic means ± SEM (n = 8) of the percentage of hemolytic erythrocytes following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Anidulafungin (1.5-6 μg/ml). ***(p<0.001) indicates significant difference from the absence of Anidulafungin (ANOVA).
S5952	Baloxavir marboxil Baloxavir marboxil是一种抗病毒药物，是限制内切核酸酶抑制剂。
S7419	Blasticidin S HCl Blasticidin S HCl是一种从Stretomyces girseochromogenes中分离得到的核苷antibiotic，也是DNA和蛋白质合成的抑制剂，用于筛选携带brs或BSD抗性基因的转染细胞。	Cells, 2020, 9(1) Nat Chem Biol, 2019, 15(11):1110-1119 Cell, 2018, 174(6):1477-1491
S7465	FTI 277 HCl FTI 277 HCl是FTI 277的甲酯，是一种有效的选择性farnesyltransferase (FTase)抑制剂，IC50为500 pM，选择性比密切相关的GGTase I 高100倍。FTI 277 HCl可抑制细胞生长并诱导凋亡。FTI 277 HCl可有效清除HDV病毒血症。	Nat Commun, 2019, 10(1):273 Cancer Lett, 2018, 442:202-212 Oncol Rep, 2018, 40(4):2171-2182	(A) HCT 116 cells were treated with Tram (0, 30, or 60 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD. (B) SW480 and MDA-MB-231 cells were treated with Tram (0, 80, 160 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD.
S4854	Bedaquiline fumarate Bedaquiline fumarate (TMC-207), an oral diarylquinoline, is a bactericidal antimycobacterial drug. It is a proton-translocating ATP synthetase inhibitor.
S1958	Sulbactam Sulbactam 是β-内酰胺酶抑制剂，IC50为0.8 μM。
S4564	Diethylcarbamazine citrate Diethylcarbamazine citrate是丝虫微丝蚴中花生四烯酸代谢的抑制剂，对几种寄生虫高度特异，不含任何有毒金属元素。
S3251^New	Goitrin Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) 是板蓝根 Radix isatidis 的主要成分之一，广泛用于治疗发烧、清热的传统中药。Goitrin 具有抗病毒和抗内毒素活性。
S3269^New	Acetylcorynoline Acetylcorynoline 是衍生自中草药 Corydalis bungeana 的主要生物碱成分，具有抗炎特性。Acetylcorynoline 可能通过降低 egl-1 的表达来抑制细胞凋亡通路，并增加 rpn5 的表达来增强 proteasomes 的活性。
S3270^New	Genipin 1-O-beta-D-gentiobioside Genipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) 是从栀子 Gardenia jasminoides Ellis 中分离到的一种生物活性类环烷苷，具有保肝、抗炎、抗氧化和抗血栓形成的功能。
S3279^New	Polyphyllin B (Formosanin C) Polyphyllin B (Formosanin C, FC) 是一种从Paris formosana分离得到的薯蓣皂苷，也是一种具有抗肿瘤活性的免疫调节剂。Polyphyllin B (Formosanin C, FC) 可诱导凋亡。
S1208	Doxorubicin (Adriamycin) HCl Doxorubicin (Adriamycin, NSC 123127, DOX) HCl是一种抗生素类试剂，可抑制DNA topoisomerase II，并在肿瘤细胞中诱导DNA损伤、线粒体自噬和凋亡。Doxorubicin 可降低 AMPK的基础磷酸化。Doxorubicin 可应用于HIV感染病人的联合治疗，但是在免疫治疗中有将HBV重活化的风险。	Nat Commun, 2020, 24;11(1):1972 PLoS Biol, 2020, 23;18(3):e3000666 Cancer Res, 2020, 10.1158/0008-5472.CAN-19-2069	Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.
S3288^New	Absinthin Absinthin (Absynthine) 是一种来自 Artemisia absinthium 的天然三萜内酯，具有抗炎特性。Absinthin (Absynthine) 可显著地增强 matrix metalloproteinase-8 (MMP-8) 的表达，并且是潜在的急性肺损伤(ALI)的候选治疗药物。
S3220^New	Trigonelline Trigonelline (Trigenolline) 是一种植物生物碱，是咖啡和葫芦巴的主要成分，具有抗脱粒、抗糖尿病、抗氧化、抗炎和神经保护的作用。 Trigonelline 可抑制FcεRI介导的细胞内信号通路，例如 PLCγ1、PI3K 和 Akt 的磷酸化。Trigonelline (Trigenolline) 还可抑制RBL-2H3细胞中 microtubule 的形成。
S3280^New	Linderene Linderene (Lindenenol) 是从Lindera pulcherrima中分离出来的呋喃倍半萜类，具有抗菌和抗氧化活性。
S3210^New	3'-Hydroxy-4'-methoxyacetophenone 3'-Hydroxy-4'-methoxyacetophenone (Acetoisovanillone, Isoacetovanillone, Diosmin EP Impurity A) 是一种具有消炎潜能的活性多刺疟原虫提取物。
S0917^New	Allosecurinin Allosecurinine (Phyllochrysine) 是一种从 M.indica 和 M.discoidea 分离的具有抗真菌活性的Securinega生物碱。
S0906^New	6-Methoxydihydrosanguinarine 6-Methoxydihydrosanguinarine (6-Methoxy Dihydrosanguinarine) 是一种从红景天的果实中分离得到的生物碱，具有抗菌、杀虫和抗肿瘤的作用。6-Methoxydihydrosanguinarine 对MCF-7和SF-268细胞系表现出强烈的细胞毒性，对应的IC50值分别为0.61 μM和0.54 μM。
S4389^New	Bephenium Hydroxynaphthoate Bephenium 是一种 B-type Acetylcholine receptor (AChR) 的激活剂。Bephenium 可选择性地激活由Hco-UNC-29.1，Hco-UNC-38，Hco-UNC-63，Hco-ACR-8亚基组成的Hco-L-AChR1亚型。Bephenium hydroxynaphthoate 是一种驱虫药，以前用于治疗钩虫感染和蛔虫病。
S4408^New	Procodazole Procodazole 可用作增效剂，对病毒和细菌感染具有非特异性活性免疫保护作用。
S0443^New	Desciclovir Desciclovir（DCV）是一种抗疱疹antiherpetic 药物无环鸟苷acyclovir (ACV)的前药，在人体内通过黄嘌呤氧化酶转化为ACV。
S6761^New	Dalfopristin Dalfopristin is a semi-synthetic analogue of ostreogyrcin A, Quinupristin/dalfopristin is a new combination streptogramin product with a selective spectrum of antibacterial activity, mainly against gram-positive aerobic bacteria.
S9466^New	Methenamine Hippurate Methenamine Hippurate是methenamine的马草酸盐形式，是一种前药和惰性弱碱，在酸性尿液中会水解成甲醛。Methenamine Hippurate是Hiprex药物的成分，具有抗菌活性。
S4393^New	Cephapirin Sodium Cephapirin Sodium是cephapirin的钠盐形式，是一种半合成的第一代头孢菌素抗生素，对革兰氏阴性细菌和革兰氏阳性细菌都有效。
S4404^New	Pasiniazid Pasiniazid，由isoniazid和4-aminosalicylic acid组成，用于治疗肺结核患者。
S6729^New	Besifovir Besifovir是新型有效的无环核苷膦酸酯，用于治疗HBV感染。
S3013	Plerixafor 8HCl (AMD3100 8HCl) Plerixafor 8HCl (AMD3100, JM 3100) 是Plerixafor的盐酸盐，是CXCR4趋化因子受体拮抗剂，作用于CXCR4和CXCL12介导调节的趋化性，IC50分别为44 nM和5.7 nM。Plerixafor 可应用为抗HIV的药物。	Mol Oncol, 2020, 14(4):779-794 Biol Reprod, 2019, 101(1):102-111 Gastroenterology, 2018, 155(3):880-891.e8	BLI of NSG mice engrafted with BV173, treated with no therapy (control), plerixafor: 1 mg/kg IP daily, ESKM 100 ug twice weekly, and a combination of ESKM and plerixafor. (A) Logarithmic plot of BLI of leukemia growth measured weekly. Error bars are 5-95% confidence intervals. There was a small but not significant difference between ESKM and combination treated group. (B) End of therapy (day 34) BLI.
S1373	Daptomycin Daptomycin (LY146032)是一种新型抗生素，在体外对革兰氏阳性菌具有快速的杀菌活性。	Front Microbiol, 2020, 21;11:646 PLoS One, 2020, 15(2):e0228509 ACS Infect Dis, 2019, 5(4):539-549	Same experiment as in Figure 2 with fluorescent daptomycin shown as confocal images. A 7/3 DOPC/DOPG GUV (including 1% Rh-PE) was introduced at time zero into a solution containing 1 uM daptomycin with 0.5 uM BODIPY-daptomycin and 1 mM Ca2+. To show colocalization of lipid and peptide in aggregates, confocal images were taken: red for RH-PE and green for BODIPY-daptomycin. As the protrusion length decreased, aggregates appeared on the GUV surface containing both lipid and peptide. The scale bar is 10 um.
S1408	Linezolid Linezolid (PNU-100766) 是一种合成的抗生素，用于治疗严重感染。	Front Microbiol, 2020, 11:265 J Mol Cell Biol, 2019, pii: mjz020 PLoS One, 2019, 14(10):e0222970
S1097	BTZ043 Racemate BTZ043 Racemate是一种decaprenylphosphoryl-β-D-ribose 2’-epimerase的抑制剂，是一个可以杀死结核杆菌的新的抗分支杆菌的药物。	J Med Chem, 2020, 28;63(10):5367-5386 Biochem Pharmacol, 2019, 162:41-54 Blood Adv, 2019, 3(5):797-812
S1517	Natamycin Natamycin (Pimaricin) 是一种天然存在的三唑类抗真菌药物。具有极少或无味道干扰。	Expert Opin Drug Deliv, 2020, 17(3):407-421
S1403	Tigecycline Tigecycline (GAR-936) 是一种甘氨酰环素类抗生素，具有抑菌作用，是一种蛋白质合成的抑制剂，通过与细菌的 30S核糖体亚基结合，从而在原核翻译过程中阻止氨酰tRNA进入核糖体的A位点。Tigecycline 可通过下调PI3K-AKT-mTOR途径诱导自噬。	Aging (Albany NY), 2020, 12(12):11364-11385 Sci Rep, 2018, 8(1):11747 BMC Infect Dis, 2017, 17(1):197	CHX blocked Pim-1 AUG isoform translocation from the cytosol to mitochondria and led to reduced pBADS112. Cox-2 was examined to assess the effect of tigecycline on mitochondrial translation. Cy-Cox-2: cytoplasmic Cox-2; Mt-Cox-2: mitochondrial Cox-2.
S1878	Ganciclovir Ganciclovir 是一种抗病毒药，作用于猫科动物1型疱疹病毒，无细胞试验中IC50为5.2 μM。	Mol Cancer Ther, 2020, 19(3):966-971 Neuroendocrinology, 2019, PLoS One, 2019, 14(6):e0218471	Effect of ganciclovir on viral DNA accumulation (A,B) and induction of TGF-β1 production after human cytomegalovirus infection in human trabecular meshwork cells (C). Cells were harvested at 5 day post-infection at a high multiplicity of infection (MOI 1) under the treatment with different concentrations of ganciclovir (GAN). Treatment with 10 μmol of ganciclovir significantly decreased the viral DNA accumulation (p < 0.001) (A,B). However, treatment with ganciclovir did not affect the TGF-β production using a TGF-β1 luciferase bioassay. Results are expressed as the mean +/− standard deviation of three different experiments.
S2504	Ribavirin Ribavirin 是一种抗病毒剂，用于治疗重症RSV感染，丙型肝炎病毒感染和其他病毒感染。	Toxicology, 2020, 15;435:152422 bioRxiv, 2020, 2020/9/20.4.7.30734 PLoS Negl Trop Dis, 2019, 13(7):e0007595	(E) Left panel, Western blot showed that 20 μM Ribavirin effectively inhibits elevated Sox2 expression in irradiated SW1990 cells. Right panel, qPCR analysis showed that Sox2 mRNA level in irradiated SW1990 cells at 48 hours was lower than that in non-irradiated SW1990 cells, *p < 0.05. (F) Left panel, Western blot showed 20 μM Ribavirin inhibits elevated Sox2 expression in irradiated BxPc-3 cells. Right panel, qPCR analysis showed that there is no significant fluctuation of Sox2 mRNA in irradiated BxPc-3 cells and Ribavirin did not influence sox2 mRNA level in irradiated BxPc-3 cells.
S1807	Aciclovir Acyclovir (Acyclovir, Acycloguanosine, Zovirax) 是一种合成的核苷类似物，有效作用于疱疹病毒。Acyclovir 可在Jurkat白血病细胞中诱导细胞周期紊乱和凋亡。	Antimicrob Agents Chemother, 2020, AAC.00245-20 Sci Adv, 2019, 5(8):eaax0780 Nat Immunol, 2019, 20(12):1681-1691	(A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.
S1374	Doripenem Hydrate Doripenem Hydrate (S-4661) 是一种超广谱的，注射用的抗生素。	ACS Chem Biol, 2018, 13(8):2020-2026
S1381	Meropenem Meropenem (SM 7338)是一种超广谱的，注射用的抗生素。
S1162	Pretomanid (PA-824) PA-824是一种抗肺结核药，作用于tuberculosis，MIC为<1 μg/mL。Phase 2。
S1934	Nystatin (Fungicidin) Nystatin (Fungicidin) 是一种多烯类抗真菌剂，常常被用作oropharyngeal candidosis的局部治疗剂。	Biochim Biophys Acta Mol Cell Res, 2020, 1867(5):118676 Neoplasia, 2020, 22(10):470-483 Fish Shellfish Immunol, 2019, 84:138-147
S1741	Rifabutin Rifabutin (LM427, Ansamycin) 是一种半合成的Ansamycin 抗生素，具有有效的抗分枝杆菌特性。	Antibiotics (Basel), 2020, 9(2) Antimicrob Agents Chemother, 2020, AAC.00363-20
S1370	Biapenem Biapenem (L-627, LJC10627) 是一种碳青霉烯类抗生素，抑制了革兰氏阳性菌以及革兰氏阴性菌的活性。
S1371	Cefoselis Sulfate Cefoselis (FK 037) 是一种抗生素。
S2159	Tebipenem Pivoxil Tebipenem pivoxil (L-084, ME1211) 是一种新型口服的 Carbapenem抗生素，用于治疗鼻咽喉及呼吸道感染。
S1636	Amphotericin B Amphotericin B (AMB, NSC 527017) 是两亲多烯抗生素，使含有麦角固醇-膜具有渗透性。	J Antimicrob Chemother, 2019, 74(10):2950-2958 J Antimicrob Chemother, 2019, 74(10):2943-2949 Sci Rep, 2019, 9(1):9482
S1282	Artemisinin Artemisinin (Qinghaosu, Artemisinine)青蒿素用于治疗耐多药的恶性疟疾菌株。	Antiviral Res, 2020, 29:104810 ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00522 Biomed Pharmacother, 2019, 117:109181
S1399	Teicoplanin Teicoplanin (Teichomycin) 是一种预防用的抗生素。	ACS Appl Mater Interfaces, 2020, 12(14):16150-16158 Clin Exp Dent Res, 2016, 2(1):35-43
S2468	Fenbendazole Fenbendazole 是一种广谱苯并咪唑类驱虫药，作用于胃肠道寄生虫，IC50为0.01 μg/ml。
S1505	Aztreonam Aztreonam (SQ 26776) 是一种合成的单环β-内酰胺类抗生素。	Expert Opinion on Orphan Drugs, 2013, 1(7):549-556
S1725	Terbinafine Terbinafine (SF 86-327) 用于治疗真菌感染，可以杀死真菌或防止其生长。	J Cell Mol Med, 2020, 25 Eur J Pharm Sci, 2019, 136:104945 BMC Microbiol, 2018, 18(1):203
S2510	Spectinomycin 2HCl Spectinomycin 2HCl是由Streptomyces spectabilis中制备的一种新型的肠道外抗生素。	Cell Rep, 2020, 32(2):107897
S1768	Cefditoren Pivoxil Cefditoren Pivoxil (ME-1207) 是一种广谱的抗生素，用于治疗格兰仕阳性菌和阴性菌感染。
S1450	Nanchangmycin Nanchangmycin是一种聚醚抗生素，与Dianemycin结构相似，非常有效地防治广谱的有害线虫和昆虫，而对哺乳动物和植物没有作用效果。	Antimicrob Agents Chemother, 2020, 1;AAC.00289-20 J Virol, 2017, 91(23) Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2015, 32(5):686-701
S1839	Chloroxine Chloroxine是一种人工合成的抗菌化合物，加入洗发液中，有效治疗头皮屑和脂溢性皮炎。	Front Microbiol, 2020, 10:2936
S2264	Artemether Artemether (SM-224, CGP 56696) 是一种抗疟药，用于治疗恶性疟疾的耐药菌株。	Cancer Cell Int, 2020, 19;20:58 ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00522 PLoS Negl Trop Dis, 2015, 9(3):e0003593	Schistosomicidal effects of PZQ, ART(Artemether) and OXA on 14-day schistosomula. Magnification of the in vitro-cultured schistosomula treated with PZQ, ART, and OXA at 10 μM. Drugs were added at day 14 and schistosomula were analyzed at day 21 (late treatment). 0.1% DMSO in medium (solvent of the drugs; used as negative control) had no effect on schistosomula development.
S1666	Flucytosine Flucytosine是氟嘧啶类似物, 是抗菌药，作用于人白色念珠菌（C. albicans）时 IC50 为0.12 μg/mL。
S1998	D-Cycloserine D-cycloserine (RO-1-9213) 是氨基酸D-丙氨酸的类似物。
S2479	Lincomycin HCl Lincomycin hydrochloride (Lincocin, NSC 70731) 是Lincomycin的一水盐, 是Lincolnensis链霉菌属的成员生长所产生的物质。	Cancer Cell Int, 2020, 19;20:58 Proc Natl Acad Sci U S A, 2016, 113(50):14408-14413
S1605	Cefdinir Cefdinir (FK 482, PD 134393, CI-983) 是一种杀菌抗生素。
S3073	Caspofungin Acetate Caspofungin acetate (MK-0991) 是一种脂肽类抗真菌β-1,3-glucan synthase抑制剂。	Antimicrob Agents Chemother, 2020, 64(2) Biotechnol Adv, 2019, 37(6):107352 J Antimicrob Chemother, 2019, 74(10):2950-2958
S2528	Ciclopirox Ciclopirox 是一种合成的抗真菌药物。
S2152	Sitafloxacin Hydrate Sitafloxacin Hydrate (DU-6859a)是新一代口服的广谱喹诺酮类抗生素。	Interact Cardiovasc Thorac Surg, 2018, 10.1093/icvts/ivy209 mSphere, 2018, 3(5)
S1502	Cephalexin Cephalexin (Cefalexin)是可以治疗许多细菌感染的抗生素。	Clin Cancer Res, 2018, 24(3):659-673 Theranostics, 2017, 7(7):2092-2107 Blood Cancer J, 2017, 10.1038/bcj.2017.61
S1835	Azithromycin Azithromycin是一种抑制蛋白合成的抗生素，用于细菌感染的治疗。	Cancer Cell Int, 2020, 19;20:58 Clin Transl Med, 2020, 9(1):22 mBio, 2018, 9(5)
S1773	Oxytetracycline (Terramycin) Oxytetracycline(Terramycin) 是第二个被发现的广谱四环素类抗生素。	Sci Rep, 2018, 8(1):7653 Front Microbiol, 2016, 7: 1765	Effect of FDA approved drugs on EBOV transfected donor and recipient immune cells. (A) Varying concentrations of Cambinol and Esomepraole (1 nM, 1 μM, 10 μM), Oxytetracycline (1 nM, 10 nM, 10 μM), and DMSO (0.00001, 0.0001, 0.001%) treatments were administered to VP40-transfected 293T cells, followed by incubation for 3 days. Supernatant was centrifuged to remove cellular material and subsequently incubated for 72 h at 4°C with 20 μL of 30% slurry of NT80/82 beads. The NT pellet was washed twice with PBS and resuspended in SDS Laemmli buffer, followed by Western blot analysis for levels of exosomal markers CD63 and Alix. Actin levels were also analyzed. Mid-log phase EVTR2C cells (containing VP40) were treated with either low (0.1 μM), medium (1 μM), or high (10 μM) concentrations of Oxytetracycline and incubated for 5 days along with untreated 293T cells. Cell-free supernatants were harvested, filtered, and used to treat CEM (B), Jurkat (C), and U937 (D) cells. Cells were incubated for 5 days and assayed with CellTiter-Glo for viability. Statistical significance was determined using two-tailed student’s t-test with all groups compared to the untreated 293T cell control groups. RLU, Relative Luminescent Units. ∗p < 0.05, ∗∗∗p < 0.001.
S1637	Docosanol Docosanol是一种饱和脂肪酸，在化妆品领域，作为一种润肤剂，乳化剂，和增稠剂，也是营养补充剂，抑制病毒产生，ED50为1.7 mg/ml。
S2535	Econazole nitrate Econazole Nitrate (NSC 243115) 是一种咪唑类抗真菌药物。	Biomol Ther (Seoul), 2020, 25
S2568	Neomycin sulfate Neomycin sulfate属于氨基糖苷类抗生素。	Mol Cell, 2020, 22 pii: S1097-2765(20)30231-8
S1777	Ethionamide Ethionamide (Bayer 5312)是一种抗生素，用于治疗肺结核。
S1635	Erythromycin Erythromycin (E-Mycin)是一种大环内酯类抗生素，具有与青霉素类似的或略宽于青霉素的抗菌谱(IC50为1.5 μg/ml)。	J Med Chem, 2018, 61(9):4189-4202
S2420	Aloperine Aloperine是提取自苦参植物，如Sophora alopecuroides L的生物碱，具有抗炎，抗菌，抗病毒,和抗肿瘤的特性。	J Cancer Res Clin Oncol, 2020, 10.1007/s00432-020-03157-2 PeerJ, 2019, 7:e7652 Onco Targets Ther, 2018, 11:2735-2743
S4226	Minocycline HCl Minocycline HCl 是脂溶性的最活跃的四环素类抗生素，结合到30S核糖体亚基，抑制tRNA结合到核糖体mRNA复合物，干扰蛋白质合成。	J Neurosci, 2020, 40(2):297-310 Antimicrob Agents Chemother, 2020, 6 pii: AAC Neuropharmacology, 2020, 11:108132
S2486	Moroxydine HCl Moroxydine HCl 是一种合成的抗病毒化合物，属于杂环双胍系列。	Cancer Cell Int, 2020, 19;20:58
S1644	Nitrofural Nitrofural (Nitrofurazone) 是外用的抗感染剂，IC50为22.83±1.2 μM，作用于大鼠，LD50为590 mg/kg。
S3079	Atovaquone Atovaquone 用于治疗或预防肺孢子菌肺炎，弓形虫病, 疟疾和巴贝西虫。	Sci Transl Med, 2015, 7(290):290ra89
S4050	Valganciclovir HCl Valganciclovir HCl是一种ganciclovir 的前体药物，具有抗病毒活性，用于治疗巨细胞病毒感染。	Transl Res, 2016, 177:113-126
S4052	Netilmicin Sulfate Netilmicin Sulfate 是一种氨基糖苷类抗生素家族成员。	J Cancer Res Clin Oncol, 2019, 145(6):1495-1507
S4082	Spiramycin Spiramycin (Formacidine) 是16元环大环内酯（抗生素）。	Chemistry, 2020, 10.1002/chem.201905599
S2565	Amoxicillin Sodium Amoxicillin Sodium (Clavulanate) 是一种中等谱，溶菌，β-内酰胺类抗生素。	Toxicol Appl Pharmacol, 2015, 285(1):51-60
S2544	Cefprozil hydrate Cefprozil hydrate 是第二代头孢菌素类抗生素。
S2563	Oxacillin sodium monohydrate Oxacillin sodium monohydrate是一种抗菌剂，是一种窄谱，青霉素类的β-内酰胺类抗生素。
S3129	Trimethoprim Trimethoprim (BW 56-72, NIH 204, NSC-106568) 是一种抑制细菌的抗生素，主要用于预防和治疗尿路感染。
S2028	Diclazuril Diclazuril 是一种抗球虫药。
S3161	Sertaconazole nitrate Sertaconazole nitrate是一种外用广谱抗真菌药，是用来治疗表面皮肤和粘膜感染的辅助用药
S1499	Cefaclor Cefaclor (Cefachlor, Cefaclorum) 是一种头孢菌素类抗生素。
S1915	Sulfamethoxazole Sulfamethoxazole 是磺胺类抑制细菌的抗生素，IC50为2.7 μM。
S2120	Arbidol HCl Arbidol HCl是一种抗病毒药，用于治疗流感病毒感染。
S2467	Famciclovir Famciclovir 是一种鸟嘌呤类似物抗病毒药物，用于治疗各种疱疹病毒感染。	Cancer Cell Int, 2020, 19;20:58
S2031	Fenticonazole Nitrate Fenticonazole Nitrate 是一种唑类抗真菌药物。
S2574	Tetracycline HCl Tetracycline HCl是Tetracycline的盐酸盐，是一种广谱的聚酮类抗生素。	PLoS Pathog, 2020, 16;16(3):e1008341 Sci Rep, 2018, 8(1):7653
S2575	Vancomycin HCl Vancomycin HCl 是Vancomycin的盐酸盐，是一种窄谱的糖肽类抗菌剂。
S1851	Oxibendazole Oxibendazole是一种广谱驱虫药。	Oncol Lett, 2018, 15(2):2218-2226
S2501	Pyrantel Pamoate Pyrantel pamoate是一种广谱驱虫剂，用于治疗一些寄生虫感染。
S4030	Gentamicin Sulfate Gentamycin Sulfate (NSC-82261, SCH9724) 是一种广谱的氨基糖苷类抗生素，用于细胞培养，抑制蛋白合成。
S2514	Tobramycin Tobramycin (NSC 180514) 是一种氨基糖苷类抗生素，IC50为9.7 μM。
S1762	Pyrazinamide Pyrazinamide (Pyrazinoic Acid Amide) 是一种治疗肺结核的药物。
S1676	Amorolfine HCl Amorolfine HCl是一种抗真菌药物。	Cell Chem Biol, 2019, 26(4):593-599 Nature, 2018, 560(7718):372-376	b, GC–MS-based quantification of three metabolite levels in human glioma cells (GBM528) treated for 24 h with the indicated small molecules at the following concentrations: tamoxifen, 100 nM; clemastine, 2 μM; ifenprodil, 2 μM; ketoconazole, 2.5 μM; amorolfine, 100 nM. Left, lanosterol; centre, zymostenol; right, 14-dehydrozymostenol. n = 2 wells per condition.
S4075	Zinc Pyrithione Zinc Pyrithione是一种抗真菌和抗细菌药物，可以通过阻断质子泵破坏膜转运。	Biol Reprod, 2019, 100(2):468-478 Cell Syst, 2017, 4(6-:600-610
S2530	7-Aminocephalosporanic acid 7-Aminocephalosporanic acid 是一种中间体，用于合成头孢菌素类抗生素。
S2536	Miconazole Miconazole 是一种咪唑类抗真菌药物。	Biomol Ther (Seoul), 2020, 25
S2543	Ceftiofur HCl Ceftiofur HCl 是Ceftiofur的盐酸盐，是一种广谱头孢菌素。
S1691	Praziquantel Praziquantel是一种驱虫药，有效作用于扁形虫。	Parasitology, 2020, 1-11 PLoS Negl Trop Dis, 2015, 9(3):e0003593	Schistosomicidal effects of PZQ, ART and OXA on 14-day-schistosomula. Magnification of the in vitro-cultured schistosomula treated with PZQ, ART, and OXA at 10 μM. Drugs were added at day 14 and schistosomula were analyzed at day 21 (late treatment). 0.1% DMSO in medium (solvent of the drugs; used as negative control) had no effect on schistosomula development.
S4237	Primaquine Diphosphate Primaquine Diphosphate是一种临床有效的阻断传播的抗疟疾药，对人类疟疾的的配子体具有明显的抵抗活性。	Cell Syst, 2019, 8(2):97-108
S1964	Rimantadine Rimantadine 是一种抗流感病毒药物，作用于T. brucei，IC50为7 μM。	J Virol Methods, 2019, 274:113714
S1883	Idoxuridine Idoxuridine (NSC 39661, SKF 14287) 是一种抗病毒药，作用一猫疱疹病毒1型，IC50为4.3 μM。
S3162	Tylosin tartrate Tylosin tartrate是一种大环内酯类抗菌素，用于控制家禽的支原体病。
S1916	Sulfisoxazole Sulfisoxazole (NU-445) 是一种磺胺类抗菌药，具有一个恶唑取代基。
S1770	Sulfadiazine Sulfadiazine 是一种磺胺类抗生素。
S3195	Azlocillin sodium salt Azlocillin sodium salt是一种酰基氨苄青霉素，具有广谱抗菌作用。
S4004	Ethambutol 2HCl Ethambutol是一种抗分枝杆菌抑菌剂, 通过抑制阿拉伯糖基转移酶来干扰细胞壁形成。	Molecules, 2019, 25(1)
S2469	Fleroxacin Fleroxacin 是一种新型广谱喹诺酮类。
S3116	Sulfathiazole Sulfathiazole是一种有机硫化合物，已被用来作为一种短效的磺胺类药物。
S1910	Tioconazole Tioconazole (UK-20349) 是一种抗真菌药物，IC50为1.7 μM。	Chem Biol Drug Des, 2016, 10.1111/cbdd.12872
S2506	Roxithromycin Roxithromycin 是一种半合成的大环内酯类抗生素，用于治疗呼吸道，泌尿及软组织感染。	Chemistry, 2020, 10.1002/chem.201905599 J Med Chem, 2018, 61(9):4189-4202
S2048	Clindamycin Phosphate Clindamycin Phosphate是一种林可酰胺类抗生素，作用于 Plasmodium falciparum，IC50为12 nM。
S3055	Besifloxacin HCl Besifloxacin HCl是一种第四代氟喹诺酮类抗生素。
S4120	Sulconazole Nitrate Sulconazole Nitrate 是一种咪唑衍生物，具有广谱抗真菌活性。
S2511	Sulfadoxine Sulfadoxine (Sulphadoxine) 是一种超长效磺胺类药物，作用于P. Vivax，IC50为249 μg/ml。
S3067	Chlorhexidine 2HCl Chlorhexidine hydrochloride (NSC-185) 是一种防腐剂，可以有效抵抗大多数革兰氏阴性和阳性有机体。
S3059	Enrofloxacin Enrofloxacin是一种氟喹诺酮类抗生素。
S4141	Dinitolmide Dinitolmide (Zoalene) 是一种广谱抗球虫的药物。
S1977	Sarafloxacin HCl Sarafloxacin HCl (A-56620) 是Sarafloxacin的盐酸盐形式，是一种喹诺酮类抗生素IC50为0.96 μg/L。
S4146	Bacitracin Bacitracin是由Bacillus subtilis var生物体产生的相关环状多肽组成的混合物，通过干扰细胞壁肽聚糖的合成，从而破坏革兰氏阳性和革兰氏阴性细菌。	Chem Res Toxicol, 2017, 30(10):1804-1814
S4147	Azithromycin Dihydrate Azithromycin Dihydrate 是对酸稳定的，口服的，大环内酯类抗菌药物，结构与红霉素相关。
S4044	Toltrazuril Toltrazuril 是一种抗原生动物药剂，对球虫寄生虫有活性。
S4254	Apramycin Sulfate Apramycin是一种氨基糖苷类抗生素，与RNA的深槽结合。
S4056	Retapamulin Retapamulin (SB-275833) 是一种局部抗生素,可以结合大肠杆菌和金黄色葡萄球菌核糖体，效果类似，K_d值为3 nM.
S3015	Amoxicillin Amoxicillin (Amoxycillin) 是一种温和β-内酰胺抗生素，用于治疗敏感菌引起的微生物细菌感染。	Toxicol Appl Pharmacol, 2015, 285(1):51-60
S4184	Penciclovir Penciclovir (BRL-39123, VSA 671) 是一种嘌呤的无环核苷类似物，具有强大的抗病毒活性。	Proc Natl Acad Sci U S A, 2020, 14;202002392 bioRxiv, 2020, 2020/9/20.4.7.30734
S4191	Betamipron Betamipron是一种化学化合物，与Panipenem一起使用，抑制Panipenem吸收进肾小管，防止肾毒性。
S1957	Sulfamethizole Sulfamethizole 是一种磺胺类抗菌剂。
S2537	Secnidazole Secnidazole (Flagentyl, PM 185184, RP 14539) 是一种硝基咪唑类抗感染剂。
S4195	Broxyquinoline Broxyquinoline是一种抗原虫剂，作用于粘膜，可以从水中释放氧自由基。
S4196	Ethacridine lactate monohydrate Ethacridine lactate monohydrate是一种芳香族有机化合物，用作防腐剂。	Carcinogenesis, 2014, 35(12):2822-30
S4093	Bismuth Subcitrate Potassium Bismuth Subcitrate是一种抗生素，用于治疗感染幽门螺旋杆菌的胃溃疡。	J Clin Invest, 2020, 130(7):3901-3918
S4094	Tetramisole HCl Tetramisole是右旋和左旋异构体的混合物，用作驱虫剂。
S2539	Lomefloxacin HCl Lomefloxacin HCl 是Lomefloxacin 的盐酸盐，是一种喹诺酮类抗生素。	Front Microbiol, 2020, 10:2936
S2612	Ribitol Ribitol (Adonitol) 是一种戊糖醇结晶，通过核糖还原形成，在Adonis vernalis植物中自然发生。
S3122	Amikacin hydrate Amikacin hydrate 是一种氨基糖甙类抗生素，用于治疗不同类型的细菌感染。	Molecules, 2019, 25(1)
S3105	Nadifloxacin Nadifloxacin 是一种有效的具有广谱作用的喹诺酮类外用药物，主要针对痤疮及其它皮肤感染。Nadifloxacin可以抑制参与细菌DNA 合成和复制的DNA促旋酶活性，从而抑制细菌增殖。体外研究表明nadifloxacin具有广谱抗菌作用对好氧的革兰氏阳性菌，革兰氏阴性菌以及厌氧细菌都有效果。此外，研究表明nadifloxacin对于炎症性痤疮病变也有效果，这可能与它对炎症前细胞因子的抑制效果有关，如白细胞介素 (IL)-1α, IL-6以及IL-8 ，这些因子在痤疮发病过程中起到重要作用。
S4234	Capreomycin Sulfate Capreomycin Sulfate是一种环状多肽类抗生素，通过与70S核糖体结合，从而抑制蛋白合成。	Mol Cell Proteomics, 2019, 18(2):231-244
S3133	Sulfamethazine Sulfamethazine是一种磺胺类抗菌药,是一种用来治疗支气管炎，前列腺炎以及尿道感染的抗生素。Sulfamethazine 通过抑制二氢叶酸合成酶活性来阻断二氢叶酸合成。此外， sulfamethazine 是一种对氨基苯甲酸(PABA)的结构类似物和竞争性拮抗剂，可以抑制正常的细菌利用PABA 来合成叶酸，而叶酸是一种重要的DNA合成代谢物。
S1855	Pefloxacin Mesylate Pefloxacin Mesylate是一种合成的化疗药物和抗菌剂，IC50为6.7 nM。	J Biol Chem, 2019, 294(49):18624-18638
S3154	Butenafine HCl Butenafine HCl是一种合成的苄胺类抗真菌药物，通过抑制甾醇合成，通过抑制角鲨烯环氧酶，而发挥作用。
S3156	Naftifine HCl Naftifine HCl是一种烯丙基胺类抗真菌药，外用治疗足癣，股癣，体癣，通过抑制角鲨烯2,3-环氧酶选择性抑制甾醇的生物合成。
S1833	Butoconazole nitrate Butoconazole nitrate 是一种抗真菌剂，抑制PHA刺激下人外周血淋巴细胞中细胞因子（如IL-2, TNFα, IFN 和 GM-CSF）的分泌，IC50分别为7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL 和 7.6 μg/mL。
S3179	Carbenicillin disodium Carbenicillin (BRL-2064) 是一种半合成的青霉素抗生素，可以干扰革兰氏阴性菌细胞壁的合成，具有低毒性。
S3193	Ticarcillin sodium Ticarcillin (AB 2288, BRL 2288) 是一种半合成的抗生素，对多种革兰氏阳性和阴性需氧以及厌氧菌具有广谱杀菌活性。
S1881	Protionamide Protionamide (Prothionamide, 1321-TH) 用于治疗肺结核的一种药。
S1830	Oxfendazole Oxfendazole 是Fenbendazole的亚砜形式，是一种广谱的苯并咪唑类驱虫药。	Mol Med Rep, 2019, 19(4):2921-2926
S4726	Lauric Acid Lauric Acid（月桂酸）是饱和中链脂肪酸，在多种植物、动物油脂中都天然存在，是椰子油和棕榈仁油的主要成分。
S5227	Erythromycin thiocyanate Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits and inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
S3941	Pinocembrin Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone)是制药工业中多功能黄酮类分子，它具有很多药学活性，如抗菌、消炎、抗氧化和抗癌活性。
S5352	Cefminox Sodium Cefminox Sodium is the sodium salt form of cefminox, a semi-synthetic, second-generation, beta-lactamase-stable cephalosporin with antibacterial activity.
S6235	Sodium dehydroacetate Sodium dehydroacetate是无水醋酸的钠盐形式。无水醋酸是一种杀菌剂，通常被用作食品防腐剂。
S8071	UNC0638 UNC0638 是一种有效的选择性的组蛋白赖氨酸甲基转移酶（HMTase）抑制剂，作用于G9a和GLP，IC50分别为< 15 nM和19 nM，有效且选择性地作用于多种表观遗传和非表观遗传靶点。UNC0638 具有抗病毒的活性。	Nat Commun, 2020, 11(1):604 Clin Epigenetics, 2019, 11(1):165 Biochim Biophys Acta Gene Regul Mech, 2019, 1862(2):173-183
S3621	Pazufloxacin mesylate Pazufloxacin Mesylate，也被称作是Pazucross和T-3762，是一种喹诺酮类抗菌剂，用于多种感染的治疗。
S5560	Midecamycin Midecamycin is a naturally occuring macrolide antibiotic that acts by inhibiting bacterial protein synthesis.
S3999	α-santonin α-santonin, a naturally occurring sesquiterpene lactone, is a potent antiparasitic agent.
S5406	Sultamicillin Tosylate Sultamicillin Tosylate is the tosylate salt of the double ester of sulbactam plus ampicillin. Sulbactam is a semisynthetic beta-lactamase inhibitor which, in combination with ampicillin, extends the antibacterial activity of the latter to include some beta-lactamase-producing strains of bacteria that would otherwise be resistant.
S5048	Fosfomycin Disodium Fosfomycin (Phosphonemycin)是一种具有杀菌活性的，低分子量、广谱抗生素，通过抑制细胞壁合成的早期阶段，对一些细菌具有潜在活性，如多药耐药的革兰氏阴性细菌。
S9200	Pneumocandin B0 Pneumocandin B0 is a natural product and a key intermediate in the synthesis of the antifungal agent.
S5051	Pipemidic acid Pipemidic acid是一类吡啶并嘧啶类抗生素，是piromidic acid的衍生物，对革兰氏阴性和某些革兰氏阳性细菌具有活性。
S5328	Gamithromycin Gamithromycin is a new macrolide antibiotic that is only registered for use in cattle to treat respiratory disorders such as bovine respiratory disease.
S4576	Sulfabenzamide Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) 是一种抗菌剂，它通过多种途径也可以发挥抗肿瘤效果。
S5353	Cefpiramide sodium Cefpiramide sodium (CPMS, SM-1652,wy-44635) is an anionic β-lactam antibiotic. It exhibits antibacterial activity against gram-positive and gram-negative bacteria, in particular, to Pseudomonas aeruginosa, which can result in achronic life-threatening infection in the lungs of cystic fibrosis patients.
S4848	Dalbavancin Dalbavancin是一种脂糖肽类抗生素，对革兰氏阳性菌，如多种葡萄状球菌，具有杀菌活性。
S5081	Ceforanide Ceforanide是一种新型头孢菌素，具有抗细菌活性，具有较长的消除半衰期。
S5951	Cefoxitin Cefoxitin是一种β-内酰胺、头孢菌素抗生素，具有杀菌活性。
S5035	6-Aminopenicillanic acid 6-Aminopenicillanic acid (6-APA)是一种青霉素β-内酰胺抗生素的核心组分。它被用作抗菌化合物ampicillin和amoxicillin的前体。
S5356	Ceftiofur Ceftiofur is a semisynthetic, beta-lactamase-stable, broad-spectrum cephalosporin with antibacterial activity.	Vet J, 2018, 234:24-26
S9564	p-Hydroxy-cinnamic Acid p-Hydroxy-cinnamic Acid在体外具有抗疟活性和体内抗骨质疏松活性。
S4581	Triacetin Triacetin (Glycerol triacetate, Glyceryl triacetate, Glycerin triacetate, 1,2,3-Triacetoxypropane) 是一种甘油三酸酯，具有杀真菌作用。
S5012	Octenidine Dihydrochloride Octenidine是一种阳离子型表面活性剂，对革兰氏阳性和阴性的细菌具有活性。
S2583	Thiamphenicol Thiamphenicol (Thiophenicol) 是一种抗菌的抗生素，是Chloramphenicol的甲磺酰基类似物。
S3741	Benznidazole Benznidazole是一种硝基咪唑衍生物，能够干扰寄生虫蛋白质的生物合成、影响其细胞因子的产生、刺激宿主的吞噬作用，因而具有抗原虫活性。
S5213	Piroctone Olamine Piroctone Olamine (piroctone ethanolamine) is a wide spectrum antibacterial and antifungal agent used in the treatment of dandruff,fungal infections.
S3623	Ceftibuten dihydrate Ceftibuten Dihydrate is the dihydrate form of ceftibuten, a semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity.
S6288	Chlorhexidine diacetate Chlorhexidine diacetate是一种消毒剂和局部抗感染剂，也用于漱口水中防止口腔菌斑。
S4850	Flucloxacillin sodium Flucloxacillin sodium (Floxacillin sodium) is the sodium salt of flucloxacillin, a penicillin antibiotic used to treat bacterial infections.
S5553	Kasugamycin hydrochloride Kasugamycin is an aminoglycosidic antibiotic isolated from Streptomyces kasugaensis, showing broad-spectrum anti-fungal activity against yeast and various fungus species.
S9224	Dehydroandrographolide Succinate Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects.
S5944	Butenafine Butenafine是合成的苄胺抗真菌剂。
S4846	Meropenem Trihydrate Meropenem is a broad-spectrum antibacterial agent of the carbapenem family with a broad spectrum of in vitro activity against Gram-positive and Gram-negative pathogens.
S5533	Tobramycin sulfate Tobramycin sulfate is the sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity.
S9226	Steviolbioside Steviolbioside, a natural sweetener, exhibits moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro.
S4594	Cephalothin Cephalothin是一种半合成的β-内酰胺类抗生素，第一代头孢菌素抗生素，具有杀菌活性。Cephalothin与位于细菌细胞壁内膜的青霉素结合蛋白（PBP）结合并使之失活。
S4865	Cefetamet pivoxil hydrochloride Cefetamet pivoxil hydrochloride is the hydrochloride salt form of cefetamet pivoxil, which is an oral third-generation cephalosporin antibiotic.
S5359	Butoconazole Ethyl chrysanthemate is an allelochemical compound used as an attractant.	Nature, 2018, 560(7718):372-376	Percentage of MBP+ oligodendrocytes generated from OPCs following treatment with azoles (c). n ≥ 4 wells per condition.
S5941	Besifloxacin Besifloxacin是第四代氟喹诺酮类眼部抗生素，用于治疗细菌性结膜炎。
S4866	Nicarbazin Nicarbazin是一种有效的抗球虫试剂，是一种广谱的寄生虫药物。
S5366	Fipronil Fipronil (Fluocyanobenpyrazole, Termidor) is a recalcitrant phenylpyrazole-based pesticide used for flea/tick treatment and termite control that is distributed in urban aquatic environments via stormwater and contributes to stream toxicity.
S9094	Pogostone Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity.
S4420	Mefloquine HCl Mefloquine HCl是一种血液裂殖体杀灭剂，抑制疟原虫色素的形成，用作抗疟疾药物。	bioRxiv, 2020, 2020/9/20.4.7.30734 Int J Parasitol Drugs Drug Resist, 2018, 8(2):331-340 PLoS Negl Trop Dis, 2017, 11(9):e0005942	BALB/c mice, orally infected with E. multilocularis eggs, were treated by either mefloquine (100 mg/kg twice per week, n = 9), ABZ (200 mg/kg, 5 times per week, n = 8) or control-treated (placebo, n = 9). After 12 weeks of treatment, parasite lesion numbers in the liver were assessed microscopically (A).
S3966	Nifuratel Nifuratel is a nitrofuran derivative with local antiprotozoal and antifungal activity and a broad spectrum of antibacterial action.
S4880	Cefathiamidine Cefathiamidine is the first generation of cephalosporin antibacterial used for the treatment of respiratory, liver, five senses, urinary tract infections, endocarditis and sepsis.
S5531	Doripenem Doripenem is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens.	Biomed Chromatogr, 2017, 31(5)
S9158	Atractylon Atractylon, the sesquiterpenoid oxide isolated from the rhizomes of Atractylodes japonica and its related plants (Compositae), shows significant antiviral activities for influenza A virus.
S3971	Fusidine Fusidine (Fusidic Acid), isolated from Fusidium coccineum, is a steroidal antibiotic that inhibits protein synthesis.
S1617	Sulfapyridine Sulfapyridine 是一种磺胺类抗菌药。
S5332	Cefquinome sulfate Cefquinome sulphate is a veterinary, parenteral, and fourth-generation cephalosporin. Its antimicrobial potency and extensive antibacterial spectrum result from the introduction of a methoxyimino-aminothiazolyl moiety into the acyl side chain.
S5278	Tedizolid (TR-700) Tedizolid is an oxazolidinone-class antibiotic prodrug used for the treatment of acute bacterial skin and skin structure infections caused by susceptible isolates of several Gram-positive bacteria.
S4029	Colistin Sulfate Colistin是一种环状阳离子十肽，链接到脂肪酸侧链，属于一组结构类似的细菌抗微生物肽。	Biogerontology, 2016, 17(5-6):907-920
S4122	Tilmicosin Tilmicosin (EL 870) 是一种大环内酯类抗菌素。
S2052	Oxytetracycline Dihydrate Oxytetracycline Dihydrate 是一种处方抗生素，干扰细菌产生必需蛋白质的能力。
S5532	Erythromycin estolate Erythromycin (Lubomycine B), a naturally occurring macrolide, is derived from Streptomyces erythrus. It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits.
S5535	Moxifloxacin Moxifloxacin is an antibiotic used to treat a number of bacterial infections, active against Mycobacterium tuberculosis in vitro.	Transl Vis Sci Technol, 2018, 7(2):11 Circ Arrhythm Electrophysiol, 2016, 9(4):e003655 Invest Ophthalmol Vis Sci, 2015, 56(4):2234-42
S5684	Lapachol Lapachol, a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity.
S4876	Robenidine Hydrochloride Robenidine Hydrochloride (Dexium, Nugatex, Rasexinium, Toraxine) 是一种应用于家禽中的抗球虫剂。
S5625	Ammonium lactate Ammonium lactate is the ammonium salt of lactic acid with mild anti-bacterial properties.
S4869	Sulfamethoxazole sodium Sulfamethoxazole sodium是一种用于治疗细菌感染的抗生素。
S5719	Ceftizoxime sodium Ceftizoxime sodium is a semisynthetic cephalosporin antibiotic that is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms.
S2058	Tolnaftate Tolnaftate 是一种合成的硫代氨基甲酸酯，用作抗真菌剂。	Cancer Cell Int, 2020, 19;20:58
S5054	Rifamycin sodium salt Rifamycin sodium is an antibacterial drug used for treatment of mycobacterium infections.
S4584	Butylparaben Butylparaben (Butyl parahydroxybenzoate, Butyl 4-hydroxybenzoate) 是一种常在化妆品中被用作抗菌防腐剂的化合物。	Environ Toxicol, 2018, 33(4):436-445
S5207	Cephalexin Monohydrate Cephalexin is a semisynthetic cephalosporin antibiotic with antimicrobial activity.
S4585	Succinylsulfathiazole Succinylsulfathiazole是一种磺胺类抗生素。
S5491	Lomefloxacin Lomefloxacin is a fluoroquinolone antibiotic used to treat bacterial infections.
S4142	Clopidol Clopidol是一种抗原虫药剂。
S4592	Captisol (SBE-β-CD) Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) 是一种新型的、化学修饰过的环糊精，具有比较好的稳定性和溶解性。	Theranostics, 2019, 9(3):796-810 J Exp Clin Cancer Res, 2019, 38(1):264 Cell Death Dis, 2017, 8(5):e2776
S5331	Ceftezole sodium Ceftezole Sodium (Celoslin sodium, Falomesin sodium) is the sodium salt form of ceftezole, a semi-synthetic first-generation cephalosporin with antibacterial activity.
S4595	Cefazolin Sodium Cefazolin Sodium 是一种半合成的头孢菌素类似物，具有广谱抗菌作用，抑制细菌细胞壁的合成。它能达到较高的血清水平，通过尿液排泄出去。
S5333	Sulbenicillin Sodium Sulbenicillin Sodium is the sodium salt of sulbenicillin, which is a penicillin antibiotic.
S5936	Cefazolin Cefazolin是一种半合成的头孢菌素，具有广谱的抗菌作用，抑制细菌细胞壁的合成。它可达到高血清水平，通过尿液快速排泄。
S4145	Decoquinate Decoquinate是一种球虫抑制药。
S4596	Cefixime Cefixime (Cefixima, Cefiximum, Cephoral, Cefspan, FR-17027, FK-027, CL-284635) 是一种对于治疗许多细菌感染疾病有用的抗生素。
S5700	Phthalylsulfathiazole Phthalylsulfathiazole is a broad-spectrum antimicrobial that can treat different types of infections including intestinal.
S6118	Terpinen-4-ol Terpinen-4-ol是一种天然存在的单萜，是茶树油的主要活性成分，具有多种生物活性如抗真菌活性。
S4148	Ampicillin Trihydrate Ampicillin Trihydrate是β-内酰胺类抗生素，通过使细菌细胞膜内表面上的转肽酶失活而抑制细菌细胞壁合成（肽聚糖的交联）。	Bone Joint Res, 2020, 16;9(4):152-161
S4996	Tavaborole (AN-2690) Tavaborole (AN-2690) is a boron-containing small molecule with broad spectrum antifungal activity.
S2259	Aloe-emodin Aloe-emodin (NSC 38628, Rhabarberone) 是一种干扰素诱导剂，作用于JEV，IC50为1 μg/mL，作用于EV71，IC50为0.33 μg/mL。	PLoS One, 2019, 14(4):e0215664 J Tradit Complement Med, 2015, 5(2):96-9	Flow cytometry result. Promastigotes were stained with Annexin V and propidium iodide 48 hours after treatment with aloe-emodin
S4041	Olsalazine Sodium Olsalazine Sodium 是一种抗炎症前体药，包含2个5-ASA部分，通过偶氮键相连。	Oncotarget, 2017, 8(1):228-237	Values represent the average scores for each group ± S.E. (N = 10 per group). The differences between individual experimental groups and 17 days DSS only group were statistically significant (p < 0.05) for all groups.
S4150	Orbifloxacin Orbifloxacin是一种人工合成的广谱fluoroquinolone抗生素。
S4875	Cephapirin Benzathine Cephapirin Benzathine是cephapirin的苄星青霉素盐形式。Cephapirin是半合成的、广谱的、第一代头孢菌素，具有抗菌活性。
S6136	(±)-α-Bisabolol α-bisabolol是一种植物来源的油性倍半萜烯醇，具有抗炎和抗菌活性。
S4421	Josamycin Josamycin是一种来源于那波链霉菌的大环内脂类抗菌素，对一系列的病原体具有广泛的抗菌活性。
S4885	Taurolidine Taurolidine (Taurolin, Tauroline, Tauroflex) 是一种合成的、广谱的抗生素，具有抗细菌、抗凝的和潜在的抗血管新生的活性。
S5757	Isoeugenol Isoeugenol, an essential oil constituent of nutmeg, clove, and cinnamon, shows antimicrobial activity.
S4250	Sulfamethoxypyridazine Sulfamethoxypyridazine是长效磺胺类药物，用于治疗疱疹样皮炎。
S9278	Saikosaponin C Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities.
S5397	Chlorhexidine Chlorhexidine is a disinfectant and topical anti-infective agent that is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes, and yeasts.
S4156	Chlortetracycline HCl Chlortetracycline HCl是首批确定的四环素类抗生素。
S4158	Ceftriaxone disodium salt hemi(heptahydrate) Ceftriaxone disodium salt hemi(heptahydrate)是第三代头孢菌素类抗生素。
S6173	Amylmetacresol Amylmetacresol是一种防腐杀菌剂，用于治疗口腔和喉咙的感染。
S6185	Arachidonic acid Arachidonic acid是非饱和必需脂肪酸，在动物和人类肝脏、脑部和腺器官脂肪中都有发现。它是前列腺素、凝血噁烷和白细胞三烯的生物合成的前体化合物。
S4160	Penicillin G Sodium Benzylpenicillin sodium 是由Penicillin spp产生的β-内酰胺类抗生素。
S2271	Berberine chloride Berberine chloride 是异喹啉类生物碱的季铵盐。Berberine chloride 可激活 caspase 3 和 caspase 8，分裂 poly ADP-ribose polymerase (PARP) 和释放 cytochrome c。Berberine chloride 可降低 c-IAP1，Bcl-2 和 Bcl-XL 的表达。Berberine chloride 可通过 JNK 和 p38 MAPK 的持续磷酸化以及产生 ROS 来诱导凋亡。Berberine chloride 是一个 topoisomerase I 和 II 的双效抑制剂。Berberine chloride 也是一个潜在的自噬调节剂。	Oncol Rep, 2018, 40(3):1525-1532 Shandong University, 2014, Haoran Cui
S4942	4-Hydroxy-3,5-dimethoxybenzyl alcohol 4-Hydroxy-3,5-dimethoxybenzyl alcohol，也被称作Syringic alcohol，是一种酚类，具有抗病毒活性。
S5492	Econazole Econazole is a broad spectrum antimycotic with some action against Gram positive bacteria.	Am J Cancer Res, 2020, 10(1):263-274 Biomol Ther (Seoul), 2020, 25
S4874	Cefazedone Cefazedone (Refosporen, Cefazedonum) 是一种半合成的一代头孢菌素，具有抗细菌活性。
S2282	Cinchonidine Cinchonidine是一种生物碱，在有机化学中用于不对称合成。
S5475	Novaluron Novaluron belongs to the class of insecticides called insect growth regulators with pesticide properties.
S9292	Dictamnine Dictamnine, a natural plant product, has been reported to have antimicrobial activity against bacteria and fungi.
S5296	Cephradine monohydrate Cefradine is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.
S5290	Ormetoprim Ormetoprim (OMP) is an antibiotic to prevent the spread of disease in freshwater aquaculture.
S5487	Cefoperazone sodium Cefoperazone Sodium is the sodium salt form of cefoperazone, which is a semi-synthetic, broad-spectrum, beta-lactamase resistant antibiotic with bactericidal activity.
S4610	Mebendazole Mebendazole (Vermox, Telmin, Pantelmin, Mebenvet) 是一种合成的苯并咪唑衍生物，还是一种驱虫药物。它能通过抑制寄生虫的胞质微管的形成，干扰它们的生殖和生存，有选择性的、不可逆的抑制糖吸收。	J Biol Chem, 2019, 10.1074/jbc.RA119.010144
S4822	Silver Sulfadiazine Silver sulfadiazine是一种杀菌剂，对很多革兰氏阴性和阳性的细菌以及酵母都十分有效。
S5294	Cephalotin acid Cephalotin acid is a cephalosporin antibiotic.
S5736	Benzathine penicilline Benzathine penicilline is an antibiotic useful for the treatment of a number of bacterial infections.
S4167	Cyromazine Cyromazine是一种三嗪类昆虫生长调节剂，作为杀虫剂和杀螨剂。
S4612	Dapson Dapsone是一种抗生素，常与利福平及氯法齐明结合使用，用于治疗麻疯病。
S1884	Sparfloxacin Sparfloxacin 是一种喹诺酮类抗生素，具有广谱有效的抗菌活性。
S5722	Oxantel Pamoate Oxantel Pamoate is the pamoate salt form of oxantel, a tetrahydropyrimidine anthelmintic used against intesitnal worms, particularly in a veterinary setting.
S1395	Polymyxin B sulphate Polymyxin B (Aerosporin, PMB, Poly-RX) 是一种抗生素，用于抵抗革兰阴性菌感染。	Free Radic Biol Med, 2019, 137:24-36
S2385	Hordenine Hordenine是一种苯乙胺生物碱具有抗菌特性。
S4634	Sodium sulfadiazine Sodium Sulfadiazine是sulfadiazine的钠盐形式，一种具有中效抑菌作用的合成sulfanilamide衍生物。
S4959	Skatole Skatole (3-Methylindole)是一种具有轻度毒性的白色结晶有机化合物，天然存在于排泄物中，具有相当广泛的抑菌作用。
S5601	Balofloxacin Dihydrate Balofloxacin Dihydrate is an orally active fluoroquinolone antibiotic.
S4172	Cetylpyridinium Chloride Cetylpyridinium chloride是一种阳离子季铵化合物，作为口咽消毒剂。
S4641	Tedizolid Phosphate Tedizolid (TR-701FA) 是一种恶唑烷酮类的抗生素。Tedizolid phosphate是活性化合物tedizolid的磷酯前体药物。	Sci Transl Med, 2019, 11(516)
S6243	Ethyl pyruvate Ethyl pyruvate是丙酮酸一种简单的脂肪族酯，通过发挥消炎、抗氧化和抗凋亡活性而具有神经保护作用。
S3695	Cystamine dihydrochloride Cystamine dihydrochloride acts as an anti-infective agent, which is used in the treatment of urinary tract infections and also as a radiation-protective agent that interferes with sulfhydryl enzymes.
S5291	sulfaisodimidine Sulfaisodimidine (Sulfamethin) is a sulfonamide antibacterial.
S4175	Sulfaguanidine Sulfaguanidine是一种磺胺药物，作为抗感染剂。
S2395	Rheochrysidin Rheochrysidin 是大承气汤的主要成分之一，用于治疗炎症。	ACS Chem Biol, 2015, 10.1021/cb5009487	AmpC β-lactamase and MDH inhibition dose-response curves in the absence (black circles) and presence (red triangles) of DTT for (C and D) physcion.
S3787	Picroside I Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.
S3645	Kitasamycin Kitasamycin is a macrolide antibiotic. It has antimicrobial activity against a wide spectrum of pathogens.
S6562	KKL-35 KKL-35抑制trans-translation tagging reaction，IC50为0.9 μM。它具有广谱抗生素活性。
S4178	Climbazole Climbazole是一种广谱的咪唑类抗真菌药剂，具有抗头皮屑的效果。
S3644	Sulfamonomethoxine
S9016	Dipsacoside B Dipsacoside B, extracted from the flowerbuds of Lonicera confusa DC, shows strong antimicrobial activity.
S3646	Thimerosal Thimerosal is a well-established antiseptic and antifungal agent and usually used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks.
S5298	Amoxicillin trihydrate Amoxicillin (Amoxil, Amoxipen, Moxaline) is a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity.
S5546	Sulfacetamide Sulfacetamide is a synthetic sulfanylacetamide derivative with bacteriostatic activity. It is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.
S5908	Garenoxacin Garenoxacin (T-3811ME, BMS-284756)是一种新型的des-F(6)喹诺酮，在体外对许多病原体具有有效作用，包括gram-positive和gram-negative的需氧菌和厌氧菌。
S4179	Mezlocillin Sodium Mezlocillin Sodium是青霉素的beta-内酰胺类抗生素，通常用于治疗革兰氏阳性菌引起的感染。
S4060	Erythromycin Ethylsuccinate Erythromycin Ethylsuccinate, 是一种口服的大环内酯类抗菌素，由链霉菌产生, 可以可逆的结合细菌50S 核糖体并抑制蛋白合成。
S5515	Penicillin G Procaine Procaine benzylpenicillin (Procaine benzylpenicillin), also known as Procaine benzylpenicillin, is an antibiotic useful for the treatment of a number of bacterial infections.
S3649	Ceftazidime Ceftazidime is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa.
S5289	Ceftezole Ceftezole is a semi-synthetic first-generation cephalosporin with antibacterial activity.
S4062	Ronidazole Ronidazole 是一种抗原生动物药剂。
S4183	Paromomycin Sulfate Paromomycin Sulfate是氨基糖甙类抗生素，作用于非抗性细胞，通过与16S核糖体RNA结合，从而抑制蛋白合成。
S3655	Cefepime Dihydrochloride Monohydrate Cefepime is a cephalosporin antibacterial drug used to treat pneumonia, urinary tract, skin, and intra-abdominal infections.
S5020	Tilorone dihydrochloride Tilorone dihydrochloride是一种广谱的、具有口服活性的抗病毒试剂，可激活干扰素的生成。它具有抗肿瘤和抗炎活性。
S5637	Cefotiam Hexetil Hydrochloride Cefotiam Hexetil Hydrochloride is the hydrochloride salt of cefotiam hexetil. Cefotiam is a semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity.
S4541	Triclosan Triclosan (Irgasan, Cloxifenolum) 是在化妆品和香皂中被用作防腐剂的二苯醚衍生物。它具有抑菌作用。	FASEB J, 2019, 10.1096/fj.201802603RR Onco Targets Ther, 2018, 11:2945-2954
S4971	Buparvaquone Buparvaquone是第二代羟基萘醌化合物，有希望治疗和预防泰勒虫病。
S5638	Cefozopran hydrochloride Cefozopran Hydrochloride is the hydrochloride salt form of cefozopran, a semi-synthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity.
S4187	Salicylanilide Salicylanilides是一组具有广泛的生物活性的化合物，具有抗病毒效力，抗菌（包括抗分枝杆菌），和抗真菌活性。
S5299	Tosufloxacin p-Toluenesulfonate Hydrate Tosufloxacin (T-3262) is a fluoroquinolone antibiotic that is used to treat susceptible infections.
S5644	Ceftriaxone Sodium Ceftriaxone Sodium is the sodium salt form of ceftriaxone, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity.
S4720	Cefotaxime Cefotaxime是第三代头孢菌素抗生素，对革兰氏阴性菌和阳性菌具有广谱活性。
S4898	Sulfalozine sodium Sulfalozine sodium (Sulfaclozine sodium, Sulfachlopryrazine sodium) 是一种抗原生动物药，用于球虫病的研究。
S5295	Lincomycin Hydrochloride Monohydrate Lincomycin hydrochloride monohydrate is a narrow-spectrum antibiotic used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.
S8871	Omadacycline tosylate Omadacycline tosylate 是氨甲环素类抗生素，对革兰氏阳性和阴性的需氧菌以及一些厌氧菌具有抗菌活性。
S4068	Tinidazole Tinidazole是抗寄生药。
S3676	Carbendazim Carbendazim (Mercarzole, Carbendazole) is a broad-spectrum systemic antimycotic and can be used to control a broad range of diseases on field crops, fruits, and vegetables, including sclerotinia rot of canola, wheat head blight, peanut leaf spot, and SB on rice. Its mode of action is to inhibit the formation of mitotic microtubules in of fungi.
S2315	Kanamycin sulfate Kanamycin sulfate (Kanamycin monosulfate, Ophtalmokalixan)是一种氨基糖苷类化合物，口服有效，可静脉注射，肌肉注射，广泛应用于感染。
S4192	Chlorquinaldol Chlorquinaldol是一种抗微生物药剂。
S4258	Luliconazole Luliconazole是一种广谱抗真菌药物。
S5420	Clindamycin alcoholate Clindamycin alcoholate is a crystallizable compound of Clindamycin with alcohol. Clindamycin is a semisynthetic lincosamide antibiotic that inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits.
S5816	pyrvinium Pyrvinium是一种驱虫剂，对蛲虫有效。	bioRxiv, 2020, 2020/9/20.4.7.30734 Antimicrob Agents Chemother, 2018, 62(4)
S4882	Resorantel Resorantel是一种安全的抗绦虫药，对莫尼茨绦虫和Thysaniezia spp.十分有效，对Paramphistomum spp.有一定效力。
S5421	Fluoroquinolonic Acid Fluoroquinolonic Acid is an antibiotic and antimicrobial agent.
S5292	Diazolidinyl urea Diazolidinyl urea (Germall II) is an antimicrobial preservative used in cosmetics.
S6423	Tildipirosin Tildipirosin是一种半合成的大环内脂类抗菌素。	Nat Cell Biol, 2017, 19(10):1274-1285
S4750	Sulfacetamide sodium salt hydrate Sulfacetamide是一种磺胺类抗生素，通过抑制dihydropteroate synthase(DHPS)阻滞二氢叶酸的合成。Sulfacetamide是细菌para-aminobenzoic acid (PABA)的竞争性抑制剂，PABA是细菌合成叶酸所必需的。
S5017	Oxyclozanide Oxyclozanide是N-水杨酰苯胺驱虫剂，也是线粒体解偶联驱虫剂。兽用。
S9046	Berberine Berberine, an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic.	Front Pharmacol, 2020, 11:185 Int J Mol Sci, 2018, 19(12) J Biol Chem, 2018, 293(29):11341-11357
S6582	Ozenoxacin Ozenoxacin是一种喹诺酮药物，用于治疗脓疱病。
S8627	OSS_128167 OSS_128167 (SIRT6-IN-1)是一种特异性的 SIRT6 抑制剂，对SIRT6, SIRT1和SIRT2的IC50分别为89, 1578和751 μM。OSS_128167 在HBV的转录和复制中起到抗病毒的作用。	J Exp Clin Cancer Res, 2020, 39(1):142 J Neuroinflammation, 2019, 16(1):47 Arthritis Res Ther, 2019, 21(1):220
S4870	Cefodizime Sodium Cefodizime Sodium是第三代头孢菌素类抗生素，具有广谱活性，对多数beta-lactamases稳定。
S9057	Sinigrin Sinigrin is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects.	J Invest Dermatol, 2018, 138(12):2644-2652
S5887	Khellin Khellin分离自阿密茴（伞形科）种子，被用于治疗多种疾病。
S4081	Sulfacetamide Sodium Sulfacetamide Sodium是一种抗生素。	G3 (Bethesda), 2020, 4;10(5):1585-1597
S3636	Cefadroxil hydrate Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections.
S3637	Cefpirome sulfate Cefpirome is a fourth-generation cephalosporin and is considered highly active against Gram-negative bacteria.
S4759	p-Coumaric Acid p-Coumaric acid是肉桂酸的羟基衍生物。肉桂酸存在于多种可食用植物，具有抗氧化、消炎和抗菌活性。	J Nutr Biochem, 2015, 26(11):1379-84
S3638	Cefamandole nafate Cefamandole Nafate is the sodium salt form of cefamandole formyl ester. Cefamandole binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall, interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
S5440	Berberine Sulfate Berberine sulfate, an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa.
S5948	Amodiaquine Amodiaquine是一种合成的氨基喹啉，通过与原生动物或寄生DNA结合、阻止DNA和RNA的生成以及后续蛋白质的合成。它被用于治疗疟疾。	bioRxiv, 2020, 2020/9/20.4.7.30734 F1000Res, 2016, 5:150
S5016	Isoprinosine Isoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) 是一种免疫药理试剂，具有抗病毒活性。
S2534	Isoconazole nitrate Isoconazole nitrate 是一种唑类抗真菌药物。
S4978	Azathramycin Azathramycin (Azaerythromycin)是一种含红霉支糖的大环内酯抗生素。
S3713	Moxidectin
S7411	Ascomycin (FK520) Ascomycin (FK520, FR 900520, Immunomycin), FK-506的一种类似物, 是中性的大环内酯类 immunosuppressant, 能够防止器官移植后的排斥反应。	Melanoma Res, 2020, 30(4):325-335
S5784	Vancomycin Vancomycin是一种抗生素，用于治疗各种细菌感染。
S3705	Chlorobutanol Chlorobutanol (trichloro-2-methyl-2-propanol)是一种防腐剂、镇静剂、催眠剂和弱的局部麻醉剂，具有抗菌抑菌作用。
S3860	Allicin Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.
S9387	Maackiain Maackiain is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects.
S3707	Ethopabate Ethopabate (ETP)是一种球虫抑制剂，常被用于治疗鸡类球虫病。
S3708	Sulfachloropyridazine Sulfachloropyridazine是一种抗生素，用于治疗多种细菌感染。
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