Chloroquine diphosphate

目录号:S4157 中文名称:二磷酸氯喹

仅限科研使用

Chloroquine diphosphate是一种4-氨基喹啉的抗疟疾和抗风湿药,也是一种ATM激活剂。Chloroquine 也是一种toll-like receptors (TLRs)的抑制剂。

Chloroquine diphosphate Chemical Structure

CAS: 50-63-5

规格 价格 库存 购买数量
RMB 797.66 现货
RMB 2211.3 现货
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客户使用Selleck生产的Chloroquine diphosphate发表文献182篇:

产品安全说明书

ATM/ATR抑制剂选择性比较

相关ATM/ATR产品

生物活性

产品描述 Chloroquine diphosphate是一种4-氨基喹啉的抗疟疾和抗风湿药,也是一种ATM激活剂。Chloroquine 也是一种toll-like receptors (TLRs)的抑制剂。
靶点
TLR3 [4] TLR7 [4] TLR8 [4] TLR9 [4] ATM [1]
(Cell-free assay)
体外研究

“Chloroquine是一种用于疟疾临床治疗的化疗剂。Chloroquine能够与DNA结合,并抑制DNA复制和RNA的合成从而导致细胞死亡。Chloroquine的作用可能也涉及到一种有毒的heme-Chloroquine复合物,通过提高液泡pH值,抑制液泡磷脂酶、液泡蛋白酶及亚铁血红素聚合酶的活性,Chloroquine抑制了滋养体血红蛋白的分解[1]。Chloroquine具有一定的抗风湿性。Chloroquine具有免疫调节作用,抑制肿瘤坏死因子和白细胞介素6的产生释放,并且,Chloroquine具有直接的抗病毒作用,抑制包括黄病毒,逆转录病毒,和冠状病毒的pH依赖阶段性复制。其最有价值的是对HIV复制的拮抗作用[2]。Chloroquine可以通过离子捕获积累内部的巨噬细胞吞噬溶酶体,进而通过不同的机制发挥对Histoplasma capsulatum Cryptococcus neoformans的强大抗真菌活性。Chloroquine可以通过pH依赖型铁剥夺抑制H. capsulatum的生长,而对C. neoformans具有直接毒性[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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MDA-MB-231 MVPDfZRwfG:6aXPpeJkh[XO|YYm= NYP4R5lCPDhiaILz MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSB{Mj61NkDPxE1w Mn3jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6MES5O|koRjF7OEC0PVc6RC:jPh?=
MDA-MB-231 MlWyRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVe0PEBpenN? NWjxeJlsSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDwOVMtKHCUQjDteZRidnRiYX7kJIV{fHKxZ3XuJJJm[2WydH;yJIRm\mmlaXXueEBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCyNk42OiEQvF2u NV2zZWpXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1OlE4OjBpPkKwOVYyPzJyPD;hQi=>
MDA-MB-231 NYeySmZwS3m2b4TvfIlkcXS7IHHzd4F6 M{DvU|Q5KGi{cx?= MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCyNk42OiEQvF2u NFjwTnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW4OlcyPid-Mki1PFY4OTZ:L3G+
CEM M2fL[GN6fG:2b4jpZ4l1gSCjc4PhfS=> M3rNT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNGVSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxicILvcIln\XKjdHnvckBjgSCFb4XseIVzKGOxdX70[ZIh[W6jbInzbZMtKEmFNUCgQUAzOyEQvF2u MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjFzNEixNUc,OjZzMUS4NVE9N2F-
CE81T M4DFOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVzMNHVvPDhiaILz MUXHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDDSVgyXCClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5JIlvKHC{ZYPlcoNmKG:oIEGwKUBHSlNic4XwdIxmdWWwdHXkJGROTU1ibXXkbZVuNCCJSUWwJF0hOjNwNDFOwG0v MlnXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5NEi3PFYoRjF7N{S4O|g3RC:jPh?=
MCF7 NFrubpFEgXSxdH;4bYNqfHliYYPzZZk> MonxO|IhcHK| M2q5e2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxiboXtZoVzKGmwY4XiZZRm\CCob4KgO|IhcHK|LDDJR|UxKD1iMkOuOFMh|ryPLh?= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|NUS3NUc,OjZzM{W0O|E9N2F-
HepG2 M4XYSGN6fG:2b4jpZ4l1gSCjc4PhfS=> MlT5O|IhcHK| M17XfGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IHnueJJi[2WubIXsZZIhSVSSIHzleoVtKGGodHXyJFczKGi{czDifUBE\WyudHn0[ZIuT2yxIHz1cYlv\XOlZX70JIF{e2G7LDDFR|UxKD1iMkWg{txONg>? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTlzMES2Okc,OjF7MUC0OlY9N2F-
HepG2 MYHDfZRwfG:6aXPpeJkh[XO|YYm= NWG1[mhiPzJiaILz MULDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCCwdX3i[ZIhcW6ldXLheIVlKG[xcjC3NkBpenNuIFnDOVAhRSB{NTFOwG0v NUfidWdoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|U1PzFpPkK2NVM2PDdzPD;hQi=>
BxPC3 M2XaTGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MmrxO|IhcHK| MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEK6UFOzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCVUlKgcYV1cG:mLDDJR|UxKD1iMkWg{txONg>? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ7OUG1O{c,OjV4OUmxOVc9N2F-
MDA-MB-468 MnniR5l1d3SxeHnjbZR6KGG|c3H5 NXmyb5ZzPDhiaILz NVPPWlZjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNlgvPThizszNMi=> MnHhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6MES5O|koRjF7OEC0PVc6RC:jPh?=
MDA-MB-468 NYXmR5o{S3m2b4TvfIlkcXS7IHHzd4F6 NGDFenE1QCCqcoO= MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNE[4JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSB{OD61PEDPxE1w MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODFyNk[2PEc,OjBzME[2Olg9N2F-
MDA-MB-468 NVvXPG12S3m2b4TvfIlkcXS7IHHzd4F6 NWr6TVVTPDhiaILz MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNE[4JINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCyPE42QCEQvF2u M1LN[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUi2O|E3Lz5{OEW4OlcyPjxxYU6=
K562 M2DMTGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4ntVmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkmuNFMh|ryPLh?= NV\QbWRXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlIzODJpPkG4OVYzOjB{PD;hQi=>
HeLa M3G4[mFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFK1PXM4OiCqcoO= M3;3U2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXMZUBk\WyuczDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iMkmuPVYh|ryPLh?= NUPjb|dDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2NFI5OjdpPkK2OlAzQDJ5PD;hQi=>
HepG2 NY\COmw3S3m2b4TvfIlkcXS7IHHzd4F6 Mk\ZO|IhcHK| NYrZdo83S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNyIN88UU4> NH;DSnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUS4NlQ4Pid-MUm0PFI1PzZ:L3G+
HepG2 MlLlR5l1d3SxeHnjbZR6KGG|c3H5 M3rMT|czKGi{cx?= MlvPR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMxKM7:TT6= NHHLSHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUmyOlE4Oyd-MUm5NlYyPzN:L3G+
HepG2 MkDhR5l1d3SxeHnjbZR6KGG|c3H5 Mn;BR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{Cg{txONg>? NWXDR5NmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5PFE1PjJpPkG3PVgyPDZ{PD;hQi=>
HepG2 NFn0ZYVEgXSxdH;4bYNqfHliYYPzZZk> MWi3NkBpenN? MnnyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhS0N3MDC9JFMxKM7:TT6= NXyzeoh1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3OFEyOzFpPkKxO|QyOTNzPD;hQi=>
HepG2 NUCxS|dwS3m2b4TvfIlkcXS7IHHzd4F6 MWi3NkBpenN? MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBESzVyIE2gN|Ah|ryPLh?= NUTaT5JpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4PFk2PTlpPkKyPFg6PTV7PD;hQi=>
HepG2 M2fGfmN6fG:2b4jpZ4l1gSCjc4PhfS=> MX23NkBpenN? M17N[2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEOFNUCgQUA{OCEQvF2u Ml;rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NE[yNVYoRjJ2OUS2NlE3RC:jPh?=
SH-SY5Y MWHDfZRwfG:6aXPpeJkh[XO|YYm= NUHPWIVpPzJiaILz NITBXnNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUUC2VWUXZJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFPDOVAhRSB|MDFOwG0v NYToTI1tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVkyQThpPkK5OVU6OTl6PD;hQi=>
HepG2 M4H1PGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2X3OlczKGi{cx?= M3LhT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEOFNUCgQUA{OCEQvF2u NFTzeYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi1PFU1Oyd-MkS4OVg2PDN:L3G+
HepG2 M{LkSGN6fG:2b4jpZ4l1gSCjc4PhfS=> NX:y[ZF7PzJiaILz M{jpcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KG2nYYP1doVlKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEOFNUCgQUA{OCEQvF2u NWrXO49qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexOVU1PjNpPkK3NVU2PDZ|PD;hQi=>
HepG2 NHTW[HlEgXSxdH;4bYNqfHliYYPzZZk> NFvaOpk4OiCqcoO= NXX1OVZES3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiQ1O1NEA:KDNyIN88UU4> NXjt[YtWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PVE3PzVpPkK1O|kyPjd3PD;hQi=>
HepG2 M4XhcmN6fG:2b4jpZ4l1gSCjc4PhfS=> MXy3NkBpenN? M1nQcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JG1VXCCjc4PhfUwhS0N3MDC9JFMxKM7:TT6= MnLWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{OEKyOlcoRjJ3MkiyNlY4RC:jPh?=
HepG2 M4fJVmN6fG:2b4jpZ4l1gSCjc4PhfS=> NHjPRnY4OiCqcoO= MnXOR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhS0N3MDC9JFMxKM7:TT6= M{jMTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEWyNVMzLz5{MUi1NlE{OjxxYU6=
HepG2 M4nqfWN6fG:2b4jpZ4l1gSCjc4PhfS=> M2j5blczKGi{cx?= MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBESzVyIE2gN|Ah|ryPLh?= NFq1dmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[wPFY4PSd-MkK2NFg3PzV:L3G+
HepG2 M2XYOGN6fG:2b4jpZ4l1gSCjc4PhfS=> MVe3NkBpenN? NUe0TJplS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGNEPTBiPTCzNEDPxE1w MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ3NEO5OUc,Ojd4NUSzPVU9N2F-
KB NV7C[nJ2S3m2b4TvfIlkcXS7IHHzd4F6 MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRkBk\WyuczDifUBUWkJiYYPzZZktKEWGNUCgQUA{OC56IN88UU4> NGDPSIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkW2Nlg{Oid-MU[1OlI5OzJ:L3G+
HepG2 NWThV2pQS3m2b4TvfIlkcXS7IHHzd4F6 M4HnblI1KGi{cx?= M3H1TmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFI1KGi{czDifUBv\XW2cnHsJJJm\CC3cIThb4Uh[XO|YYmsJHREPTBiPTCzNUDPxE1w M4q3fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUS1PFE3Lz5{M{G0OVgyPjxxYU6=
K562 NWXGOppGS3m2b4TvfIlkcXS7IHHzd4F6 NIrUNlU4OiCqcoO= NWS2WXZbS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA4OiCqcoOgZpkh\myxdzDjfZRwdWW2comsJGlEPTBiPTCzNkDPxE1w M3Hx[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NEiyOFc3Lz5zOUS4NlQ4PjxxYU6=
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RD M2LvOZFJXFNiYYPzZZk> M1j1XpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCURDDj[Yxtew>? Mn3aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
BT-37 Mn;FdWhVWyCjc4PhfS=> NF;VR4FyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiQmStN|ch[2WubIO= M{nkc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
BT-12 M{PafZFJXFNiYYPzZZk> Ml\odWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUGyJINmdGy| M3vkVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
MG 63 (6-TG R) MV3xTHRUKGG|c3H5 M{jsXZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCPRzC2N{ApPi2WRzDSLUBk\Wyucx?= M1T3bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB1643 NGDEfVVyUFSVIHHzd4F6 NHXPOnNyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKxOlQ{KGOnbHzz NF;STJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
OHS-50 Ml[ydWhVWyCjc4PhfS=> MYXxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhV0iVLUWwJINmdGy| MnrUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC MoK5dWhVWyCjc4PhfS=> MoXXdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO= NWXaeFZVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
LAN-5 MVLxTHRUKGG|c3H5 NYnEZ4JqeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IFzBUk02KGOnbHzz MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
HEK293 NWnncFJbSXW2b4DoZYd6KGG|c3H5 NHHsdmEyOCC3TR?= M121ZlghcHK| MUXJcoR2[3Srb36gc4Yh[XW2b4DoZYd6KGmwIFjFT|I6OyClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDwOlIhdGW4ZXygZZQhOTBidV2gZYZ1\XJiODDodpMh[nliaX3teY5w[myxdDDhcoFtgXOrcx?= Mm\DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2OEG1N|YoRjJ6NEixOVM3RC:jPh?=
HEK293 MlKxRZV1d3CqYXf5JIF{e2G7 NYLvOlV5OTBidV2= MmH5PEBpenN? Ml7pTY5lfWO2aX;uJI9nKGG3dH;wbIFogSCrbjDISWszQTNiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gUGM{NTJibHX2[Ywh[XRiMUCgeW0h[W[2ZYKgPEBpenNiYomgbY1ufW6xYnzveEBidmGueYPpdy=> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR6MUWzOkc,Ojh2OEG1N|Y9N2F-
LNCAP MUfGeY5kfGmxbjDhd5NigQ>? MU\S[YR2[3Srb36gbY4hT0[SIHX4dJJme3Orb36gbY4hcHWvYX6gUG5ESVBiY3XscJMhfHKjboPm[YN1\WRid3n0bEBxdGG|bXnkd{Bkdy2neIDy[ZN{cW6pIFfGVEBidmRic3jSUmF{KGGpYXnud5QhWkWYLVXSRoJmfGFiZn;scI94\WRiYomgZ49ueG:3bnSgeJJm[XSvZX70JFI1KGi{czDwc5N1NXS{YX7z[oVkfGmxbjDhcoQhdWWjc4Xy[YQhPDhiaILzJJBwe3RiZH;z[S=> MnrlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzM{W0O|EoRjJ4MUO1OFcyRC:jPh?=
SKBR3 MUHGeY5kfGmxbjDhd5NigQ>? MmnWVoVlfWO2aX;uJIlvKEeIUDDlfJBz\XO|aX;uJIlvKGi3bXHuJHNMSlJ|IHPlcIx{KHS{YX7z[oVkfGWmIIfpeIgheGyjc33p[JMh[29vZYjwdoV{e2mwZzDHSnAh[W6mIIPoVm5CeyCjZ3HpcpN1KFKHVj3FVmJj\XSjIH\vcIxwf2WmIHL5JINwdXCxdX7kJJRz\WG2bXXueEAzPCCqcoOgdI9{fC22cnHud4Zm[3Srb36gZY5lKG2nYYP1doVlKDR6IHjyd{Bxd3O2IHTvd4U> NUHF[ZI6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|U1PzFpPkK2NVM2PDdzPD;hQi=>
HepG2 NI[yV5RHfW6ldHnvckBie3OjeR?= MUjS[YR2[3Srb36gbY4hT0[SIHX4dJJme3Orb36gbY4hcHWvYX6gTIVxTzJiY3XscJMhfHKjboPm[YN1\WRid3n0bEBxdGG|bXnkd{Bkdy2neIDy[ZN{cW6pIFfGVEBidmRic3jSUmF{KGGpYXnud5QhWkWYLVXSRoJmfGFiZn;scI94\WRiYomgZ49ueG:3bnSgeJJm[XSvZX70JFI1KGi{czDwc5N1NXS{YX7z[oVkfGmxbjDhcoQhdWWjc4Xy[YQhPDhiaILzJJBwe3RiZH;z[S=> MlnpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzM{W0O|EoRjJ4MUO1OFcyRC:jPh?=
H460 NEG5SolCeG:ydH;zbZMh[XO|YYm= NEXnVWkzPSC2bzC3OUB2VQ>? NGX6VXozPCCqcoO= NGnXW|lKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIFi0OlAh[2WubIOgZZQhOjVidH:gO|UhfU1iYX\0[ZIhOjRiaILzJIJ6KGGwbnX4bY4uXiC|dHHpcolv\y2kYYPl[EBndG:5IHP5eI9u\XS{eR?= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ7OUG1O{c,OjV4OUmxOVc9N2F-
HepG2 M{LLemZ2dmO2aX;uJIF{e2G7 NH3vNZU2OCC3TR?= NYXqXnhGPiCqcoO= NI\a[GZT\WS3Y4Tpc44hcW5ibInzc5NwdWGuIHHjbYRq\mmlYYTpc44hcW5iaIXtZY4hUGWyR{KgZ4VtdHNiYYSgOVAhfU1iYX\0[ZIhPiCqcoOgZpkhTEGSST;sfZNwKHS{YXPr[ZIhemWmLXTveYJt\SC|dHHpcolv\yCkYYPl[EBkd26ob3PhcEBucWO{b4Pjc5Bq[yCjbnHsfZNqeyC{ZXzheIl3\SC2bzDjc451em:u M{SyZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUm3N|IxLz5{OEG5O|MzODxxYU6=
Assay
Methods Test Index PMID
Western blot ZEBRA / p-S824 KAP1 p62 / LC3 28249048 26677873
Immunofluorescence p-S824 KAP1 / ZEBRA CD1d-β2m / LAMP1 SQSTM1 / MAP1LC3B 28249048 20368272 29872540
Growth inhibition assay Cell viability 25521075

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度(25°C)

体外

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 515.86
化学式

C18H26ClN3.2H3O4P

CAS号 50-63-5
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04443270 Unknown status Drug: Chloroquine phosphate COVID-19 CMN 20 de Noviembre July 27 2020 Phase 1
NCT04462367 Active not recruiting -- COVID19|Coronavirus Infection|Pregnancy Disease|Severe Acute Respiratory Syndrome Instituto Materno Infantil Prof. Fernando Figueira July 1 2020 --
NCT04340544 Terminated Drug: Hydroxychloroquine|Drug: Placebo COVID-19 University Hospital Tuebingen|Robert Bosch Medical Center|Universitätsklinikum Hamburg-Eppendorf|Bernhard Nocht Institute for Tropical Medicine April 22 2020 Phase 2
NCT04334148 Completed Drug: Hydroxychloroquine|Drug: Placebo oral tablet COVID-19 Adrian Hernandez|Patient-Centered Outcomes Research Institute|Duke University April 22 2020 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-08-01)

技术支持

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操作手册

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