Chloroquine diphosphate

For research use only. Not for use in humans.

目录号:S4157 中文名称:二磷酸氯喹

Chloroquine diphosphate Chemical Structure

CAS No. 50-63-5

Chloroquine diphosphate是一种4-氨基喹啉的抗疟疾和抗风湿药,也是一种ATM激活剂。Chloroquine 也是一种toll-like receptors (TLRs)的抑制剂。

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客户使用Selleck生产的Chloroquine diphosphate发表文献157篇:

产品安全说明书

ATM/ATR抑制剂选择性比较

生物活性

产品描述 Chloroquine diphosphate是一种4-氨基喹啉的抗疟疾和抗风湿药,也是一种ATM激活剂。Chloroquine 也是一种toll-like receptors (TLRs)的抑制剂。
靶点
TLR3 [4]
()
TLR7 [4]
()
TLR8 [4]
()
TLR9 [4]
()
ATM [1]
(Cell-free assay)
体外研究

“Chloroquine是一种用于疟疾临床治疗的化疗剂。Chloroquine能够与DNA结合,并抑制DNA复制和RNA的合成从而导致细胞死亡。Chloroquine的作用可能也涉及到一种有毒的heme-Chloroquine复合物,通过提高液泡pH值,抑制液泡磷脂酶、液泡蛋白酶及亚铁血红素聚合酶的活性,Chloroquine抑制了滋养体血红蛋白的分解[1]。Chloroquine具有一定的抗风湿性。Chloroquine具有免疫调节作用,抑制肿瘤坏死因子和白细胞介素6的产生释放,并且,Chloroquine具有直接的抗病毒作用,抑制包括黄病毒,逆转录病毒,和冠状病毒的pH依赖阶段性复制。其最有价值的是对HIV复制的拮抗作用[2]。Chloroquine可以通过离子捕获积累内部的巨噬细胞吞噬溶酶体,进而通过不同的机制发挥对Histoplasma capsulatum Cryptococcus neoformans的强大抗真菌活性。Chloroquine可以通过pH依赖型铁剥夺抑制H. capsulatum的生长,而对C. neoformans具有直接毒性[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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MDA-MB-231 MkOyR5l1d3SxeHnjbZR6KGG|c3H5 NXLVNJliPDhiaILz MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSB{Mj61NkDPxE1w NVPnTotVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4NFQ6PzlpPkG5PFA1QTd7PD;hQi=>
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MDA-MB-231 MoTUR5l1d3SxeHnjbZR6KGG|c3H5 M1fDPFQ5KGi{cx?= Mon4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNlIvPTJizszNMi=> M1f4e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUi2O|E3Lz5{OEW4OlcyPjxxYU6=
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MCF7 MW\DfZRwfG:6aXPpeJkh[XO|YYm= MkXrO|IhcHK| MX;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKG63bXLldkBqdmO3YnH0[YQh\m:{IEeyJIhzeyxiSVO1NEA:KDJ|LkSzJO69VS5? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|NUS3NUc,OjZzM{W0O|E9N2F-
HepG2 MWLDfZRwfG:6aXPpeJkh[XO|YYm= MmPVO|IhcHK| MYjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCrboTyZYNmdGy3bHHyJGFVWCCuZY\lcEBi\nSncjC3NkBpenNiYomgR4VtdHSrdHXyMWdtdyCudX3pcoV{[2WwdDDhd5NigSxiRVO1NEA:KDJ3IN88UU4> M2DPO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUGwOFY3Lz5{MUmxNFQ3PjxxYU6=
HepG2 M3PoUWN6fG:2b4jpZ4l1gSCjc4PhfS=> MUK3NkBpenN? MkjxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxiboXtZoVzKGmwY4XiZZRm\CCob4KgO|IhcHK|LDDJR|UxKD1iMkWg{txONg>? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|NUS3NUc,OjZzM{W0O|E9N2F-
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MDA-MB-468 MXXDfZRwfG:6aXPpeJkh[XO|YYm= M2nsW|Q5KGi{cx?= NIrLU4JEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtOFY5KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCyPE42QCEQvF2u NUDX[XJ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4NFQ6PzlpPkG5PFA1QTd7PD;hQi=>
MDA-MB-468 MUDDfZRwfG:6aXPpeJkh[XO|YYm= MknTOFghcHK| MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNE[4JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSB{OD61PEDPxE1w NXPsdmh4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxNFY3PjhpPkKwNVA3PjZ6PD;hQi=>
MDA-MB-468 MmfTR5l1d3SxeHnjbZR6KGG|c3H5 NEHsZ|I1QCCqcoO= M2PC[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20Olgh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFI5NjV6IN88UU4> M1TITFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUi2O|E3Lz5{OEW4OlcyPjxxYU6=
K562 M{GyZWN6fG:2b4jpZ4l1gSCjc4PhfS=> MlrsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{OT6wN{DPxE1w Mo\KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3NkKyNFIoRjF6NU[yNlAzRC:jPh?=
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HepG2 NVHGW|BSS3m2b4TvfIlkcXS7IHHzd4F6 NHjhTGM4OiCqcoO= NGDDO2tEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzBizszNMi=> NYC1Sm5VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0PFI1PzZpPkG5OFgzPDd4PD;hQi=>
HepG2 M1i0XGN6fG:2b4jpZ4l1gSCjc4PhfS=> MXy3NkBpenN? M2Di[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{OCEQvF2u MmTiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7Mk[xO|MoRjF7OUK2NVc{RC:jPh?=
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HepG2 MmO2R5l1d3SxeHnjbZR6KGG|c3H5 NXv6UGFnPzJiaILz M1T6SWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEOFNUCgQUA{OCEQvF2u MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh6OUW1PUc,OjJ6OEm1OVk9N2F-
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HepG2 NYf2RpFTS3m2b4TvfIlkcXS7IHHzd4F6 NUnLT3NHPzJiaILz M{Xrc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JG1VXCCjc4PhfUwhS0N3MDC9JFMxKM7:TT6= NFOyWWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK4NlI3Pyd-MkWyPFIzPjd:L3G+
HepG2 MoezR5l1d3SxeHnjbZR6KGG|c3H5 MkC1O|IhcHK| MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBESzVyIE2gN|Ah|ryPLh?= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh3MkGzNkc,OjF6NUKxN|I9N2F-
HepG2 NXfRcGRuS3m2b4TvfIlkcXS7IHHzd4F6 MnfZO|IhcHK| NYnYcXg3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiQ1O1NEA:KDNyIN88UU4> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZyOE[3OUc,OjJ4MEi2O|U9N2F-
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MG 63 (6-TG R) NUT6OYVpeUiWUzDhd5NigQ>? MWjxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN? NUT4cnM1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
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OHS-50 M3mxN5FJXFNiYYPzZZk> MXLxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhV0iVLUWwJINmdGy| MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
SK-N-MC M2PxWZFJXFNiYYPzZZk> MVnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?= NHS1WIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
LAN-5 NFqw[ZlyUFSVIHHzd4F6 MVrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVEGQLUWgZ4VtdHN? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
HEK293 MU\BeZRweGijZ4mgZZN{[Xl? M4HGbVExKHWP Mn;iPEBpenN? M3;udWlv\HWldHnvckBw\iCjdYTvdIhi\3liaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJA3OiCuZY\lcEBifCBzMDD1UUBi\nSncjC4JIhzeyCkeTDpcY12dm:kbH;0JIFv[Wy7c3nz M{W4b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEixOVM3Lz5{OES4NVU{PjxxYU6=
HEK293 NFKyZlhCfXSxcHjh[5kh[XO|YYm= NYPXd285OTBidV2= NE\oUIs5KGi{cx?= MXTJcoR2[3Srb36gc4Yh[XW2b4DoZYd6KGmwIFjFT|I6OyClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDMR|MuOiCuZY\lcEBifCBzMDD1UUBi\nSncjC4JIhzeyCkeTDpcY12dm:kbH;0JIFv[Wy7c3nz NELMfJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES4NVU{Pid-Mki0PFE2OzZ:L3G+
LNCAP NV\OSZBtTnWwY4Tpc44h[XO|YYm= MXnS[YR2[3Srb36gbY4hT0[SIHX4dJJme3Orb36gbY4hcHWvYX6gUG5ESVBiY3XscJMhfHKjboPm[YN1\WRid3n0bEBxdGG|bXnkd{Bkdy2neIDy[ZN{cW6pIFfGVEBidmRic3jSUmF{KGGpYXnud5QhWkWYLVXSRoJmfGFiZn;scI94\WRiYomgZ49ueG:3bnSgeJJm[XSvZX70JFI1KGi{czDwc5N1NXS{YX7z[oVkfGmxbjDhcoQhdWWjc4Xy[YQhPDhiaILzJJBwe3RiZH;z[S=> M2HPcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUO1OFcyLz5{NkGzOVQ4OTxxYU6=
SKBR3 MWLGeY5kfGmxbjDhd5NigQ>? NWrjWlg4WmWmdXP0bY9vKGmwIFfGVEBmgHC{ZYPzbY9vKGmwIHj1cYFvKFONQmKzJINmdGy|IITyZY5{\mWldHXkJJdqfGhicHzhd41q\HNiY3:t[ZhxemW|c3nu[{BITlBiYX7kJJNpWk6DczDh[4FqdnO2IGLFWk1GWkKkZYThJIZwdGyxd3XkJIJ6KGOxbYDveY5lKHS{ZXH0cYVvfCB{NDDodpMheG:|dD30doFve2[nY4Tpc44h[W6mIH3lZZN2emWmIES4JIhzeyCyb4P0JIRwe2V? NUGxOJU2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|U1PzFpPkK2NVM2PDdzPD;hQi=>
HepG2 NXXQXIRETnWwY4Tpc44h[XO|YYm= M4Hpd3Jm\HWldHnvckBqdiCJRmCg[ZhxemW|c3nvckBqdiCqdX3hckBJ\XCJMjDj[YxteyC2cnHud4Zm[3SnZDD3bZRpKHCuYYPtbYR{KGOxLXX4dJJme3OrbnegS2ZRKGGwZDDzbHJPSXNiYXfhbY5{fCCURW[tSXJD[mW2YTDmc4xtd3enZDDifUBkd22yb4Xu[EB1emWjdH3lcpQhOjRiaILzJJBwe3RvdILhcpNn\WO2aX;uJIFv\CCvZXHzeZJm\CB2ODDodpMheG:|dDDkc5Nm MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|NUS3NUc,OjZzM{W0O|E9N2F-
H460 M1n2ZmFxd3C2b4Ppd{Bie3OjeR?= MmLtNlUhfG9iN{WgeW0> MUKyOEBpenN? M2n3RWlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iSES2NEBk\WyuczDheEAzPSC2bzC3OUB2VSCjZoTldkAzPCCqcoOgZpkh[W6wZYjpck1XKHO2YXnubY5oNWKjc3XkJIZtd3diY4n0c41mfHK7 MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ7OUG1O{c,OjV4OUmxOVc9N2F-
HepG2 M3TsdmZ2dmO2aX;uJIF{e2G7 M2n5flUxKHWP M4jaTlYhcHK| NVzQOFRTWmWmdXP0bY9vKGmwIHz5d49{d22jbDDhZ4llcW[rY3H0bY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFUxKHWPIHHmeIVzKDZiaILzJIJ6KESDUFmvcJl{dyC2cnHjb4VzKHKnZD3kc5VjdGVic4ThbY5qdmdiYnHz[YQh[2:wZn;jZYwhdWmlcn;zZ49xcWNiYX7hcJl{cXNicnXsZZRqfmVidH:gZ49vfHKxbB?= Mo\hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzOUezNlAoRjJ6MUm3N|IxRC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
ZEBRA / p-S824 KAP1 ; 

PubMed: 28249048     


HH514-16 BL cells were treated with chloroquine and harvested at different times post-treatment for immunoblotting with antibodies as indicated. 

p62 / LC3 ; 

PubMed: 26677873     


Antiautophagic activity of Lys01. Panc 10.05 cells were treated for 24 h with the indicated doses of chloroquine or Lys01 and were probed by Western blot.

28249048 26677873
Immunofluorescence
p-S824 KAP1 / ZEBRA ; 

PubMed: 28249048     


HH514-16 BL cells were treated with chloroquine (CQ) or chloroquine plus KU-55933 (CQ+KU) and harvested at 24 hours followed by staining with anti-phospho KAP1 (S824) plus anti-ZEBRA antibodies and visualized at 1000X magnification.

CD1d-β2m / LAMP1 ; 

PubMed: 20368272     


HEK293-CD1d WT cells were treated overnight with 20 μM of chloroquine (or vehicle). The cells were then fixed, permeabilized and stained with the anti-CD1d-β2m mAb (red), anti-LAMP-1 (green) and Hoechst (blue). The stained cells were then analyzed by confocal microscopy. 

SQSTM1 / MAP1LC3B ; 

PubMed: 29872540     


Immunofluorescent images of astrocytoma SNB-19 cells treated with DMSO, emetine or chloroquine for 24 h, then stained with SQSTM1 protein (green), MAP1LC3B protein (red) and nuclei (blue). 

28249048 20368272 29872540
Growth inhibition assay
Cell viability ; 

PubMed: 25521075     


A549 cells were treated with serial concentrations of chloroquine for 72 h, and Huh7 cells were treated with the same concentrations for 48 h. Tumour cell viability was determined by cell viability assay. Data represent means from at least three independent experiments ± SD. 

25521075

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 Water 100 mg/mL (193.85 mM)
DMSO Insoluble
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 515.86
化学式

C18H26ClN3.2H3O4P

CAS号 50-63-5
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04443270 Not yet recruiting Drug: Chloroquine phosphate COVID-19 CMN 20 de Noviembre July 27 2020 Phase 1
NCT04462367 Recruiting -- COVID19|Coronavirus Infection|Pregnancy Disease|Severe Acute Respiratory Syndrome Instituto Materno Infantil Prof. Fernando Figueira July 1 2020 --
NCT04340544 Terminated Drug: Hydroxychloroquine|Drug: Placebo COVID-19 University Hospital Tuebingen|Robert Bosch Medical Center|Universitätsklinikum Hamburg-Eppendorf|Bernhard Nocht Institute for Tropical Medicine April 22 2020 Phase 2
NCT02378532 Completed Drug: Chloroquine|Radiation: Radiotherapy|Drug: Temozolomide Glioblastoma Multiforme Maastricht Radiation Oncology August 2016 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

ATM/ATR Signaling Pathway Map

相关ATM/ATR产品

Tags: 购买Chloroquine diphosphate | Chloroquine diphosphate ic50 | Chloroquine diphosphate价格 | Chloroquine diphosphate DMSO溶解度 | 采购Chloroquine diphosphate | Chloroquine diphosphate生产 | Chloroquine diphosphate 小鼠 | Chloroquine diphosphate化学结构 | Chloroquine diphosphate分子量 | Chloroquine diphosphate molecular weight | Chloroquine diphosphate说明书 | Chloroquine diphosphate供应商 | Chloroquine diphosphate体内 | Chloroquine diphosphate细胞系 | Chloroquine diphosphate浓度 | Chloroquine diphosphate nmr | Chloroquine diphosphate核磁 | Chloroquine diphosphate半数抑制浓度 | Chloroquine diphosphate体外
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID