MAP4K4 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S6499 PF-6260933

PF-6260933 (PF-06260933) is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity.

Selective MAP4K4, IC50: 3.7 nM
S0268 DMX-5084

DMX-5804 is a potent, orally active and selective inhibitor of MAP4K4 with IC50 of 3 nM. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.

Pan human MAP4K4, pIC50: 8.55; human MAP4K4, IC50: 3 nM