MAP4K

抑制剂选择性比较

MAP4K产品

目录号 产品描述 文献引用 实验数据
S0268New

DMX-5084

DMX-5804 is a potent, orally active and selective inhibitor of MAP4K4 with IC50 of 3 nM. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.

S6499

PF-6260933

PF-6260933是MAP4K4抑制剂,IC50为3.7 nM,具有良好的激酶组选择性。

S8868New

NG25

NG25是一种新型的TAK1抑制剂,对TAK1和MAP4K2的IC50分别为149 nM和21.7 nM。

目录号 产品描述 文献引用 实验数据
S0268New

DMX-5084

DMX-5804 is a potent, orally active and selective inhibitor of MAP4K4 with IC50 of 3 nM. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.

S6499

PF-6260933

PF-6260933是MAP4K4抑制剂,IC50为3.7 nM,具有良好的激酶组选择性。

S8868New

NG25

NG25是一种新型的TAK1抑制剂,对TAK1和MAP4K2的IC50分别为149 nM和21.7 nM。