PDE3 选择性抑制剂 | 激活剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S9229 Linderane

Linderane, isolated from Lindera strychnifolia vill., is an indirect PDE3 activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache.

Selective
S5806 Cilostamide

Cilostamide (OPC 3689) is an inhibitor of type III phosphodiesterases with IC50 values of 27 nM and 50 nM for PDE3A and PDE3B, respectively.

Selective PDE3B, IC50: 50 nM; PDE3A, IC50: 27 nM
S1294 Cilostazol (OPC-13013)

Cilostazol是一种环核苷酸磷酸二酯酶3型(PDE3)抑制剂,IC50为0.2 μM,也抑制腺苷酸的摄取。

Selective PDE3, IC50: 0.2 μM
S1550 Pimobendan

Pimobendan是一种磷酸二酯酶III(PDE III)选择性抑制剂,IC50为0.32 μM。

Selective PDE3, IC50: 0.32 μM
S5539 Olprinone

Olprinone is a phosphodiesterase III (PDE3) inhibitor with IC50 values of 0.35 mM, 150 mM and 100 mM for human cardiac PDE III, PDE I and PDE II, respectively.

Selective PDE3, IC50: 0.35 mM
S6433 Udenafil

Udenafil is a potent antagonist of human PDE5 with an IC50 of 8.25 nM and a comparable selectivity profile as sildenafil for the other PDEs.

Pan PDE3, IC50: 52 nM
S2484 Milrinone

Milrinone是一种有效的,选择性的磷酸二酯酶-3抑制剂,抑制FIII PDE,IC50为0.42 μM。

Pan PDE3, IC50: 2.1 μM
S5836 IBMX

IBMX (Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine) is a nonspecific inhibitor of phosphodiesterase (PDE) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. It may enhance the intracellular cAMP levels and also acts as an adenosine (A1) receptor antagonist.

Pan PDE3, IC50: 6.5 μM
S2320 Luteolin

Luteolin是一种非选择性的PDE抑制剂,作用于PDE1-5Ki分别为15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM和9.5 μM。Phase 2.

Pan PDE3, Ki: 13.9 μM
S4090 Fenspiride HCl

Fenspiride是一种支气管扩张剂,具有抗炎特性,作用于人离体的支气管,抑制磷酸二酯酶4和磷酸二酯酶3活性,logIC50值分别为4.16和3.44。

Pan PDE3, pIC50: 3.44