• PDE1
  • PDE2
  • PDE3
  • PDE4
  • PDE5
  • PDE6
  • PDE10A
  • PDE9
  • PDE4B

PDE3 选择性抑制剂 | 激活剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S9229 Linderane Linderane, isolated from Lindera strychnifolia vill., is an indirect PDE3 activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache. Selective
S5806 Cilostamide Cilostamide (OPC 3689) is an inhibitor of type III phosphodiesterases with IC50 values of 27 nM and 50 nM for PDE3A and PDE3B, respectively. Selective PDE3A, IC50: 27 nM; PDE3B, IC50: 50 nM
S1294 Cilostazol (OPC-13013) Cilostazol (Pletal,OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake. Selective PDE3, IC50: 0.2 μM
S1550 Pimobendan Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 with IC50 of 0.32 μM. Selective PDE3, IC50: 0.32 μM
S5539 Olprinone Olprinone is a phosphodiesterase III (PDE3) inhibitor with IC50 values of 0.35 mM, 150 mM and 100 mM for human cardiac PDE III, PDE I and PDE II, respectively. Selective PDE3, IC50: 0.35 mM
S6433 Udenafil Udenafil is a potent antagonist of human PDE5 with an IC50 of 8.25 nM and a comparable selectivity profile as sildenafil for the other PDEs. Pan PDE3, IC50: 52 nM
S2484 Milrinone Milrinone (Win 47203,Primacor) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility. Pan PDE3, IC50: 2.1 μM
S5836 IBMX IBMX (Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine) is a nonspecific inhibitor of phosphodiesterase (PDE) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. It may enhance the intracellular cAMP levels and also acts as an adenosine (A1) receptor antagonist. Pan PDE3, IC50: 6.5 μM
S2320 Luteolin Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Pan PDE3, Ki: 13.9 μM
S4090 Fenspiride HCl Fenspiride(Decaspiride) is a bronchodilator with anti-inflammatory properties, inhibiting phosphodiesterase 4 and phosphodiesterase 3 activities with logIC50 values of 4.16 and 3.44, respectively, in human isolated bronchi. Pan PDE3, pIC50: 3.44
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