| S0184 |
XY1 |
XY1 is an inactive, close analog of SGC707 that can be used as the negative control for SGC707. SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively. |
Selective |
PRMT3, IC50: 31 nM; PRMT3, Kd: 53 nM |
| S7832 |
SGC707 |
SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively.
|
Selective |
PRMT3, IC50: 31 nM; PRMT3, Kd: 53 nM |
| S8112 |
MS023 |
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.
|
Pan |
PRMT3, IC50: 119 nM |
| S8858 |
GSK3368715 3HCl |
GSK3368715 3HCl is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM. |
Pan |
|
