PRMT3 选择性抑制剂 | 化学产品

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S7832 SGC707

SGC707是一种有效的,选择性的,且具有细胞活性的蛋白精氨酸甲基转移酶 3 (PRMT3)变构抑制剂,IC50Kd分别为31 nM 和 53 nM。

Selective PRMT3, Kd: 53 nM; PRMT3, IC50: 31 nM
S0184 XY1

XY1, a close analog of SGC707, is completely inactive against PRMT3 at concentrations as high as 100 µM. It is intended to be used as a negative control for SGC707 in studies involving PRMT3 action.

Selective PRMT3, Kd: 53 nM; PRMT3, IC50: 31 nM
S8112 MS023

MS023是一类高效选择性并且有细胞活性的I型PRMT抑制剂,其对PRMT1, PRMT3, PRMT4, PRMT6和PRMT8的IC50分别为30 nM, 119 nM, 83 nM, 4 nM, 和5 nM。

Pan PRMT3, IC50: 119 nM
S8858 GSK3368715 (EPZ019997) 3HCl

GSK3368715 is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM.

Pan