RIP3-kinase 选择性抑制剂 | 激活剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S8465 GSK'872 (GSK2399872A)

GSK'872 (GSK2399872A)是一种有效的、特异性的RIP3 kinase抑制剂,与RIP3激酶区域以高亲和力结合(IC50为1.8 nM),抑制酶活性的IC50为1.3 nM。仅具微弱交叉反应。

Selective RIP3K, IC50: 1.3 nM
S8775 HS-1371

HS-1371 is a potent RIP3 kinase inhibitor with an IC50 of 20.8 nM. It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro.

Selective RIP3 kinase, IC50: 20.8 nM
S3238 Resibufogenin

Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 exp

S8261 GSK583

GSK583是一种高度有效的、选择性的RIP2激酶抑制剂,IC50为5 nM。

Pan RIP3, IC50: 16 nM
S5584 Citronellol

Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells.