TpoR

TpoR产品

目录号	产品描述	文献引用	实验数据
S4502	Eltrombopag Eltrombopag (SB-497115),属于biarylhydrazone小分子，是一种thrombopoietin receptor (TpoR)的非肽类激动剂，用于治疗慢性丙型肝炎相关的血小板减少和慢性免疫性(自发的)血小板减少(ITP)。	Biochem Pharmacol, 2021, 186:114436 Blood Adv, 2021, bloodadvances.2021004207 Cells, 2019, 9(1)	32D‐MPL cells were treated with hetrombopag (10 nmol/L), eltrombopag (100 nmol/L) or rhTPO (10 ng/mL) for the indicated time. Whole‐cell lysates were analysed by Western blotting using the indicated antibodies.
S2229	Eltrombopag (SB497115) Olamine Eltrombopag Olamine (SB-497115-GR, SB497115) 是小分子，c-mpl (TpoR)受体激动剂，抑制 hERG K+通道尾电流，IC50为0.69 μM。	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918 Hum Cell, 2021, 10.1007/s13577-021-00639-4
S6624	Avatrombopag Avatrombopag是一种可口服的血小板生成素受体（c-Mpl）激动剂，可增加血小板数量，但不激活血小板。
S6988	Lusutrombopag Lusutrombopag (Mulpleta, S-888711) 是口服生物可利用的 thrombopoietin (TPO) receptor 激动剂，正用于慢性肝病(CLD)治疗的研究。

目录号	产品描述	文献引用	实验数据
S4502	Eltrombopag Eltrombopag (SB-497115),属于biarylhydrazone小分子，是一种thrombopoietin receptor (TpoR)的非肽类激动剂，用于治疗慢性丙型肝炎相关的血小板减少和慢性免疫性(自发的)血小板减少(ITP)。	Biochem Pharmacol, 2021, 186:114436 Blood Adv, 2021, bloodadvances.2021004207 Cells, 2019, 9(1)	32D‐MPL cells were treated with hetrombopag (10 nmol/L), eltrombopag (100 nmol/L) or rhTPO (10 ng/mL) for the indicated time. Whole‐cell lysates were analysed by Western blotting using the indicated antibodies.

目录号	产品描述	文献引用	实验数据
S2229	Eltrombopag (SB497115) Olamine Eltrombopag Olamine (SB-497115-GR, SB497115) 是小分子，c-mpl (TpoR)受体激动剂，抑制 hERG K+通道尾电流，IC50为0.69 μM。	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918 Hum Cell, 2021, 10.1007/s13577-021-00639-4
S6624	Avatrombopag Avatrombopag是一种可口服的血小板生成素受体（c-Mpl）激动剂，可增加血小板数量，但不激活血小板。
S6988	Lusutrombopag Lusutrombopag (Mulpleta, S-888711) 是口服生物可利用的 thrombopoietin (TPO) receptor 激动剂，正用于慢性肝病(CLD)治疗的研究。