Aromatase
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S1235 | Letrozole | <1 mg/mL | 57 mg/mL | <1 mg/mL |
| S1188 | Anastrozole | <1 mg/mL | 59 mg/mL | 59 mg/mL |
| S1196 | Exemestane | <1 mg/mL | 54 mg/mL | 15 mg/mL |
| S2208 | Formestane | <1 mg/mL | 61 mg/mL | <1 mg/mL |
| S1672 | Aminoglutethimide | <1 mg/mL | 20 mg/mL | 7 mg/mL |
| S5158 | alpha-Naphthoflavone | -1 mg/mL | 31 mg/mL | -1 mg/mL |
| S3784 | Obacunone | -1 mg/mL | 90 mg/mL | -1 mg/mL |
- Aromatase抑制剂（7）
- 新Aromatase产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1235 |
LetrozoleLetrozole是第三代aromatase抑制剂，无细胞试验中IC50为0.07-20 nM。在临床研究中，对17α-OH progesterone、TSH、促黄体激素、促卵泡激素或雄烯二酮的血浆浓度没有作用，不影响正常的尿电解质排泄或甲状腺功能。 |
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| S1188 |
AnastrozoleAnastrozole是第三代非甾体类选择性的aromatase抑制剂。相较于其他aromatase抑制剂，它具有更高的选择性，对内源性内分泌没有影响、对肾上腺类固醇也没有明显作用。 |
Cell viability analysis of BCSCs transduced as in A and treated with Anastrozole or Docetaxel, alone or in combination with BKM120 up to 72 hours. Data are mean ± SD of 3 independent experiments.
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| S1196 |
ExemestaneExemestane是一种Aromatase抑制剂，抑制人胎盘和大鼠卵巢芳香化酶，IC50分别为30 nM和40 nM。 |
Effect of exemestane on phosphatidylserine exposure. A. Original histogram of annexin-V-binding of erythrocytes following exposure for 48 hours to Ringer solution without (grey area) and with (black line) presence of 40 µg/ml exemestane. B. Arithmetic means ± SEM (n = 24) of erythrocyte annexin-V-binding following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) exemestane (10-40 µg/ml). For comparison, the effect of the solvent DMSO is shown (grey bar). **(p<0.01),***(p<0.001) indicates significant difference from the absence of exemestane (ANOVA).
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| S2208 |
FormestaneFormestane是第二代选择性芳香酶抑制剂，IC50为80 nM。 |
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| S1672 |
AminoglutethimideAminoglutethimide 是一种芳香化酶抑制剂，IC50为10 μM。 |
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| S5158New |
alpha-NaphthoflavoneAlpha-Naphthoflavone, a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM. |
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| S3784 |
ObacunoneObacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2. |
