Aromatase

信号通路图

研究领域

抑制剂选择性比较

Aromatase产品

产品目录 产品描述 文献引用 实验数据
S1235

Letrozole

Letrozole是第三代aromatase抑制剂,无细胞试验中IC50为0.07-20 nM。在临床研究中,对17α-OH progesterone、TSH、促黄体激素、促卵泡激素或雄烯二酮的血浆浓度没有作用,不影响正常的尿电解质排泄或甲状腺功能。

S1188

Anastrozole

Anastrozole是第三代非甾体类选择性的aromatase抑制剂。相较于其他aromatase抑制剂,它具有更高的选择性,对内源性内分泌没有影响、对肾上腺类固醇也没有明显作用。

S1196

Exemestane

Exemestane是一种Aromatase抑制剂,抑制人胎盘和大鼠卵巢芳香化酶,IC50分别为30 nM和40 nM。

S2208

Formestane

Formestane是第二代选择性芳香酶抑制剂,IC50为80 nM。

S1672

Aminoglutethimide

Aminoglutethimide 是一种芳香化酶抑制剂,IC50为10 μM。

S5158

alpha-Naphthoflavone

Alpha-Naphthoflavone, a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.

S3784

Obacunone

Obacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.

产品目录 产品描述 文献引用 实验数据
S1235

Letrozole

Letrozole是第三代aromatase抑制剂,无细胞试验中IC50为0.07-20 nM。在临床研究中,对17α-OH progesterone、TSH、促黄体激素、促卵泡激素或雄烯二酮的血浆浓度没有作用,不影响正常的尿电解质排泄或甲状腺功能。

S1188

Anastrozole

Anastrozole是第三代非甾体类选择性的aromatase抑制剂。相较于其他aromatase抑制剂,它具有更高的选择性,对内源性内分泌没有影响、对肾上腺类固醇也没有明显作用。

S1196

Exemestane

Exemestane是一种Aromatase抑制剂,抑制人胎盘和大鼠卵巢芳香化酶,IC50分别为30 nM和40 nM。

S2208

Formestane

Formestane是第二代选择性芳香酶抑制剂,IC50为80 nM。

S1672

Aminoglutethimide

Aminoglutethimide 是一种芳香化酶抑制剂,IC50为10 μM。

S5158

alpha-Naphthoflavone

Alpha-Naphthoflavone, a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.

S3784

Obacunone

Obacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.

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