Fatty Acid Synthase

抑制剂选择性比较

Fatty Acid Synthase产品

所有产品 Fatty Acid Synthase抑制剂(7) 新Fatty Acid Synthase产品

产品目录	产品描述	文献引用	实验数据
S2697	A-769662 A-769662是一种有效的，可逆的AMPK激活剂，在无细胞试验中EC50为0.8 μM，对GPPase/FBPase活性几乎没有作用。	cell, 2019, 178(5):1102-1114 J Exp Clin Cancer Res, 2019, 38(1):192 Cell Signal, 2019, 57:45-57	Cells were treated with CP, DOXO, SRT1720 (100 nM), EX527 (100 nM), A769662 (10 μM) and Compound C (1 μM) under normoxic or hypoxic conditions for 48 hours, and then their viabilities were measured by MTT.
S1629	Orlistat Orlistat是一种通用的脂肪酶抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。
S1937	Isoniazid Isoniazid是一种前体药物，通过与KatG 相互作用阻断了脂肪酸合成酶的作用，用于结核的预防和治疗。
S2250	(-)-Epigallocatechin Gallate (-)-Epigallocatechin Gallate是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase，阻滞EGF受体和HER-2受体的激活，抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。	Exp Ther Med, 2018, 15(5):4284-4290 J Cell Mol Med, 2017, 10.1111/jcmm.13169 Front Pharmacol, 2017, 8:325
S8588	ACSS2 inhibitor ACSS2 inhibitor是有效的、特异性的乙酰辅酶A合成酶2 (ACSS2)抑制剂。
S8563^New	TVB-3664 TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor.
S2314	Kaempferol Kaempferol是一种黄酮，是ERRα和ERRγ的反向激动剂。抑制topoisomerase I催化的DNA再连接和fatty acid synthase的活性。	Cytotechnology, 2016, 68(4):1633-40 Food Funct, 2015, 6(8):2824-33	Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).

产品目录	产品描述	文献引用	实验数据
S2697	A-769662 A-769662是一种有效的，可逆的AMPK激活剂，在无细胞试验中EC50为0.8 μM，对GPPase/FBPase活性几乎没有作用。	cell,2019, 178(5):1102-1114 J Exp Clin Cancer Res,2019, 38(1):192 Cell Signal,2019, 57:45-57	Cells were treated with CP, DOXO, SRT1720 (100 nM), EX527 (100 nM), A769662 (10 μM) and Compound C (1 μM) under normoxic or hypoxic conditions for 48 hours, and then their viabilities were measured by MTT.
S1629	Orlistat Orlistat是一种通用的脂肪酶抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。
S1937	Isoniazid Isoniazid是一种前体药物，通过与KatG 相互作用阻断了脂肪酸合成酶的作用，用于结核的预防和治疗。
S2250	(-)-Epigallocatechin Gallate (-)-Epigallocatechin Gallate是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase，阻滞EGF受体和HER-2受体的激活，抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。	Exp Ther Med,2018, 15(5):4284-4290 J Cell Mol Med,2017, 10.1111/jcmm.13169 Front Pharmacol,2017, 8:325
S8588	ACSS2 inhibitor ACSS2 inhibitor是有效的、特异性的乙酰辅酶A合成酶2 (ACSS2)抑制剂。
S8563^New	TVB-3664 TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor.
S2314	Kaempferol Kaempferol是一种黄酮，是ERRα和ERRγ的反向激动剂。抑制topoisomerase I催化的DNA再连接和fatty acid synthase的活性。	Cytotechnology,2016, 68(4):1633-40 Food Funct,2015, 6(8):2824-33	Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).

Tags: FASN inhibition | FASN activation | FASN activity | FASN inhibitors in clinical trials | FASN inhibitor review