Fatty Acid Synthase
抑制剂选择性比较
Fatty Acid Synthase产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S2697 |
A-769662A-769662是一种有效的,可逆的AMPK激活剂,在无细胞试验中EC50为0.8 μM,对GPPase/FBPase活性几乎没有作用。 |
![]() ![]() Cells were treated with CP, DOXO, SRT1720 (100 nM), EX527 (100 nM), A769662 (10 μM) and Compound C (1 μM) under normoxic or hypoxic conditions for 48 hours, and then their viabilities were measured by MTT. |
|
S1629 |
Orlistat (Ro 18-0647)Orlistat (Ro 18-0647, Tetrahydrolipstatin) 是一种通用的脂肪酶 lipase 抑制剂,作用于人体十二指肠液的PL,IC50为122 ng/ml。Orlistat 处理可抑制细胞增殖、诱导凋亡并阻滞细胞周期。 |
||
S1937 |
IsoniazidIsoniazid是一种前体药物,通过与KatG 相互作用阻断了脂肪酸合成酶的作用,用于结核的预防和治疗。 |
||
S3300 |
DesoxyrhaponticinDesoxyrhaponticin (DC, DES) 是一种来自中国传统的营养食品 Rheum tanguticum Maxim. ex Balf. (rhubarb) 的对称二苯代乙烯配糖体,是 fatty acid synthase (FAS/FASN) 的抑制剂。Desoxyrhaponticin (DC, DES) 也是竞争性的 glucose 摄取的抑制剂,在兔肠膜囊泡和大鼠肠翻肠中的IC50值分别为148.3 μM和30.9 μM。Desoxyrhaponticin 对人癌细胞具有凋亡作用。 |
||
S6248New |
FasnallFasnall 是一种thiophenopyrimidine,是选择性的脂肪酸合成酶 fatty acid synthase (FASN) 的抑制剂,具有强大的抗肿瘤活性。 |
||
S8284 |
Fatostatin (125B11) HBrFatostatin HBr (Fatostatin A, 125B11)是固醇调节元件结合蛋白(SREBP)的抑制剂。它损害SREBP-1和SREBP-2的激活。 |
||
S6666 |
FT113FT113是一种fatty acid synthase (FAS/FASN)抑制剂,ic50为213 nM。 |
||
S2250 |
(-)-Epigallocatechin Gallate(-)-Epigallocatechin Gallate(EGCG) 是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase, 阻滞EGF受体和HER-2受体的激活,抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。 |
![]() ![]() |
|
S4754 |
BetulinBetulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity. |
||
S8915 |
C75 transC75 trans (trans-C75, (±)-C75) 是一种 fatty acid synthase (FAS/FASN) 的新型有效的合成抑制剂,在成株试验和球体生长测定中的IC50值分别为35 μM和50 μM。C75 可用作研究代谢紊乱和癌症中脂肪酸合成的工具。 |
||
S2314 |
Kaempferol (NSC 407289)Kaempferol (NSC 407289, Robigenin)是一种黄酮,是ERRα和ERRγ的反向激动剂。抑制topoisomerase I催化的DNA再连接和fatty acid synthase的活性。 |
![]() ![]() Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).
|
|
S3576 |
TVB-3166TVB-3166 是一种口服的、可逆的、有效的 fatty acid synthase (FASN) 的选择性抑制剂,在体外生化分析中,其IC50值为0.042 μM。TVB-3166 可诱导凋亡,并抑制体内异种移植肿瘤的生长。 |
||
S9392 |
Praeruptorin BPraeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities. |
||
S9785 |
FatostatinFatostatin (125B11) 是一种diarylthiazole的衍生物,是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein),并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡。 |
||
S8563 |
TVB-3664TVB-3664 是一种有效的、选择性的、口服活性 fatty acid synthase (FASN) 的可逆抑制剂,对于人和小鼠棕榈酸酯合成的IC50值分别为0.018 μM和0.012 μM。 |
||
S9714 |
TVB-2640TVB-2640 (ASC-40, FASN-IN-2) 是一种口服生物可利用的 fatty acid synthase (FAS/FASN) 的抑制剂,对NAFLD和非酒精性脂肪性肝炎具有治疗潜力。 |
||
S6466 |
Eicosapentaenoic acid ethyl esterEicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) 是omega-3 fatty acid 药剂,可显著地降低 triglyceride (TG) 的水平并改善其他脂质参数而不会显着增加低密度脂蛋白(LDL)胆固醇的水平。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S2697 |
A-769662A-769662是一种有效的,可逆的AMPK激活剂,在无细胞试验中EC50为0.8 μM,对GPPase/FBPase活性几乎没有作用。 |
![]() ![]() Cells were treated with CP, DOXO, SRT1720 (100 nM), EX527 (100 nM), A769662 (10 μM) and Compound C (1 μM) under normoxic or hypoxic conditions for 48 hours, and then their viabilities were measured by MTT. |
|
S1629 |
Orlistat (Ro 18-0647)Orlistat (Ro 18-0647, Tetrahydrolipstatin) 是一种通用的脂肪酶 lipase 抑制剂,作用于人体十二指肠液的PL,IC50为122 ng/ml。Orlistat 处理可抑制细胞增殖、诱导凋亡并阻滞细胞周期。 |
||
S1937 |
IsoniazidIsoniazid是一种前体药物,通过与KatG 相互作用阻断了脂肪酸合成酶的作用,用于结核的预防和治疗。 |
||
S3300 |
DesoxyrhaponticinDesoxyrhaponticin (DC, DES) 是一种来自中国传统的营养食品 Rheum tanguticum Maxim. ex Balf. (rhubarb) 的对称二苯代乙烯配糖体,是 fatty acid synthase (FAS/FASN) 的抑制剂。Desoxyrhaponticin (DC, DES) 也是竞争性的 glucose 摄取的抑制剂,在兔肠膜囊泡和大鼠肠翻肠中的IC50值分别为148.3 μM和30.9 μM。Desoxyrhaponticin 对人癌细胞具有凋亡作用。 |
||
S6248New |
FasnallFasnall 是一种thiophenopyrimidine,是选择性的脂肪酸合成酶 fatty acid synthase (FASN) 的抑制剂,具有强大的抗肿瘤活性。 |
||
S8284 |
Fatostatin (125B11) HBrFatostatin HBr (Fatostatin A, 125B11)是固醇调节元件结合蛋白(SREBP)的抑制剂。它损害SREBP-1和SREBP-2的激活。 |
||
S6666 |
FT113FT113是一种fatty acid synthase (FAS/FASN)抑制剂,ic50为213 nM。 |
||
S2250 |
(-)-Epigallocatechin Gallate(-)-Epigallocatechin Gallate(EGCG) 是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase, 阻滞EGF受体和HER-2受体的激活,抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。 |
![]() ![]() |
|
S4754 |
BetulinBetulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity. |
||
S8915 |
C75 transC75 trans (trans-C75, (±)-C75) 是一种 fatty acid synthase (FAS/FASN) 的新型有效的合成抑制剂,在成株试验和球体生长测定中的IC50值分别为35 μM和50 μM。C75 可用作研究代谢紊乱和癌症中脂肪酸合成的工具。 |
||
S2314 |
Kaempferol (NSC 407289)Kaempferol (NSC 407289, Robigenin)是一种黄酮,是ERRα和ERRγ的反向激动剂。抑制topoisomerase I催化的DNA再连接和fatty acid synthase的活性。 |
![]() ![]() Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).
|
|
S3576 |
TVB-3166TVB-3166 是一种口服的、可逆的、有效的 fatty acid synthase (FASN) 的选择性抑制剂,在体外生化分析中,其IC50值为0.042 μM。TVB-3166 可诱导凋亡,并抑制体内异种移植肿瘤的生长。 |
||
S9392 |
Praeruptorin BPraeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities. |
||
S9785 |
FatostatinFatostatin (125B11) 是一种diarylthiazole的衍生物,是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein),并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡。 |
||
S8563 |
TVB-3664TVB-3664 是一种有效的、选择性的、口服活性 fatty acid synthase (FASN) 的可逆抑制剂,对于人和小鼠棕榈酸酯合成的IC50值分别为0.018 μM和0.012 μM。 |
||
S9714 |
TVB-2640TVB-2640 (ASC-40, FASN-IN-2) 是一种口服生物可利用的 fatty acid synthase (FAS/FASN) 的抑制剂,对NAFLD和非酒精性脂肪性肝炎具有治疗潜力。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S6466 |
Eicosapentaenoic acid ethyl esterEicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) 是omega-3 fatty acid 药剂,可显著地降低 triglyceride (TG) 的水平并改善其他脂质参数而不会显着增加低密度脂蛋白(LDL)胆固醇的水平。 |