Fatty Acid Synthase

抑制剂选择性比较

Fatty Acid Synthase产品

所有产品 Fatty Acid Synthase抑制剂(8) 新Fatty Acid Synthase产品

目录号	产品描述	文献引用	实验数据
S2697	A-769662 A-769662是一种有效的，可逆的AMPK激活剂，在无细胞试验中EC50为0.8 μM，对GPPase/FBPase活性几乎没有作用。	cell, 2019, 178(5):1102-1114 Cell Metab, 2019, 30(3):508-524 Cell Metab, 2019, 29(6):1350-1362	Cells were treated with CP, DOXO, SRT1720 (100 nM), EX527 (100 nM), A769662 (10 μM) and Compound C (1 μM) under normoxic or hypoxic conditions for 48 hours, and then their viabilities were measured by MTT.
S1629	Orlistat Orlistat是一种通用的脂肪酶抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。	Nat Commun, 2019, 10(1):5151
S1937	Isoniazid Isoniazid是一种前体药物，通过与KatG 相互作用阻断了脂肪酸合成酶的作用，用于结核的预防和治疗。	Molecules, 2019, 25(1)
S6666^New	FT113 FT113是一种fatty acid synthase(FASN)抑制剂，ic50为213 nM。
S2250	(-)-Epigallocatechin Gallate (-)-Epigallocatechin Gallate是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase，阻滞EGF受体和HER-2受体的激活，抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。	Clin Sci (Lond), 2020, 10.1042/CS20190890 Oncogene, 2019, 38(15):2690-2705 Onco Targets Ther, 2019, 12:6033-6043
S8563^New	TVB-3664 TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor.
S8588	ACSS2 inhibitor ACSS2 inhibitor是有效的、特异性的乙酰辅酶A合成酶2 (ACSS2)抑制剂。
S2314	Kaempferol Kaempferol是一种黄酮，是ERRα和ERRγ的反向激动剂。抑制topoisomerase I催化的DNA再连接和fatty acid synthase的活性。	Cell Rep, 2019, 26(8):2166-2177 Biochem Biophys Res Commun, 2017, 494(3-4):706-713 Nat Commun, 2016, 7:12702	Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).

目录号	产品描述	文献引用	实验数据
S2697	A-769662 A-769662是一种有效的，可逆的AMPK激活剂，在无细胞试验中EC50为0.8 μM，对GPPase/FBPase活性几乎没有作用。	cell,2019, 178(5):1102-1114 Cell Metab,2019, 30(3):508-524 Cell Metab,2019, 29(6):1350-1362	Cells were treated with CP, DOXO, SRT1720 (100 nM), EX527 (100 nM), A769662 (10 μM) and Compound C (1 μM) under normoxic or hypoxic conditions for 48 hours, and then their viabilities were measured by MTT.
S1629	Orlistat Orlistat是一种通用的脂肪酶抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。	Nat Commun,2019, 10(1):5151
S1937	Isoniazid Isoniazid是一种前体药物，通过与KatG 相互作用阻断了脂肪酸合成酶的作用，用于结核的预防和治疗。	Molecules,2019, 25(1)
S6666^New	FT113 FT113是一种fatty acid synthase(FASN)抑制剂，ic50为213 nM。
S2250	(-)-Epigallocatechin Gallate (-)-Epigallocatechin Gallate是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase，阻滞EGF受体和HER-2受体的激活，抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。	Clin Sci (Lond),2020, 10.1042/CS20190890 Oncogene,2019, 38(15):2690-2705 Onco Targets Ther,2019, 12:6033-6043
S8563^New	TVB-3664 TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor.
S8588	ACSS2 inhibitor ACSS2 inhibitor是有效的、特异性的乙酰辅酶A合成酶2 (ACSS2)抑制剂。
S2314	Kaempferol Kaempferol是一种黄酮，是ERRα和ERRγ的反向激动剂。抑制topoisomerase I催化的DNA再连接和fatty acid synthase的活性。	Cell Rep,2019, 26(8):2166-2177 Biochem Biophys Res Commun,2017, 494(3-4):706-713 Nat Commun,2016, 7:12702	Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).

Tags: FASN inhibition | FASN activation | FASN activity | FASN inhibitors in clinical trials | FASN inhibitor review