Fatty Acid Synthase
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S2697 | A-769662 | <1 mg/mL | 72 mg/mL | <1 mg/mL |
| S1629 | Orlistat | <1 mg/mL | 99 mg/mL | 99 mg/mL |
| S1937 | Isoniazid | 27 mg/mL | 27 mg/mL | 27 mg/mL |
| S2250 | (-)-Epigallocatechin Gallate | 23 mg/mL | 72 mg/mL | 83 mg/mL |
| S8588 | ACSS2 inhibitor | <1 mg/mL | 30 mg/mL | 2 mg/mL |
| S2314 | Kaempferol | <1 mg/mL | 57 mg/mL | 3 mg/mL |
- Fatty Acid Synthase抑制剂（6）
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S2697 |
A-769662A-769662是一种有效的，可逆的AMPK激活剂，在无细胞试验中EC50为0.8 μM，对GPPase/FBPase活性几乎没有作用。 |
Cells were treated with CP, DOXO, SRT1720 (100 nM), EX527 (100 nM), A769662 (10 μM) and Compound C (1 μM) under normoxic or hypoxic conditions for 48 hours, and then their viabilities were measured by MTT. |
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| S1629 |
OrlistatOrlistat是一种通用的脂肪酶抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。 |
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| S1937 |
IsoniazidIsoniazid是一种前体药物，通过与KatG 相互作用阻断了脂肪酸合成酶的作用，用于结核的预防和治疗。 |
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| S2250 |
(-)-Epigallocatechin Gallate(-)-Epigallocatechin Gallate是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase， 阻滞EGF受体和HER-2受体的激活，抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。 |
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-Epigallocatechin-Gallate-S225001Y0120170210.gif)
(a) Huh7 cells were incubated with HCVcc of JFH-1 for 2 h before overlaying with 1% agarose dissolved in culture medium or with AR3A anti-E2 neutralizing antibodies, in the presence of 20 μg/ml SZA. EGCG (50 μM) was introduced as a positive control. At 48 h post-infection, infected cells were quantified by IF. Nuclei were stained with DAPI. (b) Numbers of cells per positive colony were determined in 15 foci.
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| S8588 |
ACSS2 inhibitorACSS2 inhibitor是有效的、特异性的乙酰辅酶A合成酶2 (ACSS2)抑制剂。 |
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| S2314 |
KaempferolKaempferol是一种黄酮，是ERRα和ERRγ的反向激动剂。抑制topoisomerase I催化的DNA再连接和fatty acid synthase的活性。 |
Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).
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