Fatty Acid Synthase

抑制剂选择性比较

Fatty Acid Synthase产品

所有产品(15) Fatty Acid Synthase抑制剂(15)

目录号	产品描述	文献引用	实验数据
S2697	A-769662 A-769662是一种有效的，可逆的AMPK激活剂，在无细胞试验中EC50为0.8 μM，对GPPase/FBPase活性几乎没有作用。	Mol Cell, 2020, S1097-2765(20)30786-3 FASEB J, 2020, 34(3):4702-4717 J Lipid Res, 2020, 10.1194/jlr.RA119000542	Cells were treated with CP, DOXO, SRT1720 (100 nM), EX527 (100 nM), A769662 (10 μM) and Compound C (1 μM) under normoxic or hypoxic conditions for 48 hours, and then their viabilities were measured by MTT.
S1629	Orlistat Orlistat (Ro 18-0647, Tetrahydrolipstatin) 是一种通用的脂肪酶 lipase 抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。Orlistat 处理可抑制细胞增殖、诱导凋亡并阻滞细胞周期。	Nat Commun, 2019, 10(1):5151
S1937	Isoniazid Isoniazid是一种前体药物，通过与KatG 相互作用阻断了脂肪酸合成酶的作用，用于结核的预防和治疗。	Molecules, 2019, 25(1)
S3300^New	Desoxyrhaponticin Desoxyrhaponticin (DC, DES) 是一种来自中国传统的营养食品 Rheum tanguticum Maxim. ex Balf. (rhubarb) 的对称二苯代乙烯配糖体，是 fatty acid synthase (FAS/FASN) 的抑制剂。Desoxyrhaponticin (DC, DES) 也是竞争性的 glucose 摄取的抑制剂，在兔肠膜囊泡和大鼠肠翻肠中的IC50值分别为148.3 μM和30.9 μM。Desoxyrhaponticin 对人癌细胞具有凋亡作用。
S8284	Fatostatin HBr Fatostatin是固醇调节元件结合蛋白(SREBP)的抑制剂。它损害SREBP-1和SREBP-2的激活。	Cell, 2020, S0092-8674(20)31626-3 J Immunol, 2020, 205(8):2066-2076 Drug Des Devel Ther, 2020, 14:3535-3545
S9785^New	Fatostatin Fatostatin (125B11) 是一种diarylthiazole的衍生物，是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein)，并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡。
S9714^New	TVB-2640 TVB-2640 (ASC-40, FASN-IN-2) 是一种口服生物可利用的 fatty acid synthase (FAS/FASN) 的抑制剂，对NAFLD和非酒精性脂肪性肝炎具有治疗潜力。
S8915^New	C75 C75 是一种 fatty acid synthase (FAS/FASN) 的新型有效的合成抑制剂，在成株试验和球体生长测定中的IC50值分别为35 μM和50 μM。C75 可用作研究代谢紊乱和癌症中脂肪酸合成的工具。
S6666^New	FT113 FT113是一种fatty acid synthase (FAS/FASN)抑制剂，ic50为213 nM。
S2250	(-)-Epigallocatechin Gallate (-)-Epigallocatechin Gallate(EGCG) 是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase，阻滞EGF受体和HER-2受体的激活，抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。	PLoS Negl Trop Dis, 2020, 17;14(4):e0008224 Clin Sci (Lond), 2020, 10.1042/CS20190890 Sci Signal, 2020, 13(640):eaay1212
S4754	Betulin Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity.
S8588	ACSS2 inhibitor ACSS2 inhibitor 是有效的、特异性的乙酰辅酶A合成酶2 (ACSS2)抑制剂。ACSS2 inhibitor 还可抑制呼吸道合胞体病毒(RSV)。
S2314	Kaempferol Kaempferol (Robigenin) 是一种黄酮，是ERRα和ERRγ的反向激动剂。抑制topoisomerase I催化的DNA再连接和fatty acid synthase的活性。	Int J Mol Sci, 2020, 21(14):5025 Cell Rep, 2019, 26(8):2166-2177 J Med Virol, 2019, 91(8):1440-1447	Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).
S9392	Praeruptorin B Praeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities.
S8563	TVB-3664 TVB-3664 是一种有效的、选择性的、口服活性 fatty acid synthase (FASN) 的可逆抑制剂，对于人和小鼠棕榈酸酯合成的IC50值分别为0.018 μM和0.012 μM。

目录号	产品描述	文献引用	实验数据
S2697	A-769662 A-769662是一种有效的，可逆的AMPK激活剂，在无细胞试验中EC50为0.8 μM，对GPPase/FBPase活性几乎没有作用。	Mol Cell,2020, S1097-2765(20)30786-3 FASEB J,2020, 34(3):4702-4717 J Lipid Res,2020, 10.1194/jlr.RA119000542	Cells were treated with CP, DOXO, SRT1720 (100 nM), EX527 (100 nM), A769662 (10 μM) and Compound C (1 μM) under normoxic or hypoxic conditions for 48 hours, and then their viabilities were measured by MTT.
S1629	Orlistat Orlistat (Ro 18-0647, Tetrahydrolipstatin) 是一种通用的脂肪酶 lipase 抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。Orlistat 处理可抑制细胞增殖、诱导凋亡并阻滞细胞周期。	Nat Commun,2019, 10(1):5151
S1937	Isoniazid Isoniazid是一种前体药物，通过与KatG 相互作用阻断了脂肪酸合成酶的作用，用于结核的预防和治疗。	Molecules,2019, 25(1)
S3300^New	Desoxyrhaponticin Desoxyrhaponticin (DC, DES) 是一种来自中国传统的营养食品 Rheum tanguticum Maxim. ex Balf. (rhubarb) 的对称二苯代乙烯配糖体，是 fatty acid synthase (FAS/FASN) 的抑制剂。Desoxyrhaponticin (DC, DES) 也是竞争性的 glucose 摄取的抑制剂，在兔肠膜囊泡和大鼠肠翻肠中的IC50值分别为148.3 μM和30.9 μM。Desoxyrhaponticin 对人癌细胞具有凋亡作用。
S8284	Fatostatin HBr Fatostatin是固醇调节元件结合蛋白(SREBP)的抑制剂。它损害SREBP-1和SREBP-2的激活。	Cell,2020, S0092-8674(20)31626-3 J Immunol,2020, 205(8):2066-2076 Drug Des Devel Ther,2020, 14:3535-3545
S9785^New	Fatostatin Fatostatin (125B11) 是一种diarylthiazole的衍生物，是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein)，并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡。
S9714^New	TVB-2640 TVB-2640 (ASC-40, FASN-IN-2) 是一种口服生物可利用的 fatty acid synthase (FAS/FASN) 的抑制剂，对NAFLD和非酒精性脂肪性肝炎具有治疗潜力。
S8915^New	C75 C75 是一种 fatty acid synthase (FAS/FASN) 的新型有效的合成抑制剂，在成株试验和球体生长测定中的IC50值分别为35 μM和50 μM。C75 可用作研究代谢紊乱和癌症中脂肪酸合成的工具。
S6666^New	FT113 FT113是一种fatty acid synthase (FAS/FASN)抑制剂，ic50为213 nM。
S2250	(-)-Epigallocatechin Gallate (-)-Epigallocatechin Gallate(EGCG) 是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase，阻滞EGF受体和HER-2受体的激活，抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。	PLoS Negl Trop Dis,2020, 17;14(4):e0008224 Clin Sci (Lond),2020, 10.1042/CS20190890 Sci Signal,2020, 13(640):eaay1212
S4754	Betulin Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity.
S8588	ACSS2 inhibitor ACSS2 inhibitor 是有效的、特异性的乙酰辅酶A合成酶2 (ACSS2)抑制剂。ACSS2 inhibitor 还可抑制呼吸道合胞体病毒(RSV)。
S2314	Kaempferol Kaempferol (Robigenin) 是一种黄酮，是ERRα和ERRγ的反向激动剂。抑制topoisomerase I催化的DNA再连接和fatty acid synthase的活性。	Int J Mol Sci,2020, 21(14):5025 Cell Rep,2019, 26(8):2166-2177 J Med Virol,2019, 91(8):1440-1447	Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).
S9392	Praeruptorin B Praeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities.
S8563	TVB-3664 TVB-3664 是一种有效的、选择性的、口服活性 fatty acid synthase (FASN) 的可逆抑制剂，对于人和小鼠棕榈酸酯合成的IC50值分别为0.018 μM和0.012 μM。

Tags: FASN inhibition | FASN activation | FASN activity | FASN inhibitors in clinical trials | FASN inhibitor review