Fatty Acid Synthase

Fatty Acid Synthase产品

目录号	产品描述	文献引用	实验数据
S2697	A-769662 A-769662是一种有效的，可逆的AMPK激活剂，在无细胞试验中EC50为0.8 μM，对GPPase/FBPase活性几乎没有作用。	Ecotoxicol Environ Saf, 2022, 236:113467 J Biol Chem, 2022, S0021-9258(22)00292-7 Cell Signal, 2022, S0898-6568(22)00031-6	Cells were treated with CP, DOXO, SRT1720 (100 nM), EX527 (100 nM), A769662 (10 μM) and Compound C (1 μM) under normoxic or hypoxic conditions for 48 hours, and then their viabilities were measured by MTT.
S1629	Orlistat (Ro 18-0647) Orlistat (Ro 18-0647, Tetrahydrolipstatin) 是一种通用的脂肪酶 lipase 抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。Orlistat 处理可抑制细胞增殖、诱导凋亡并阻滞细胞周期。	Nat Cell Biol, 2022, 24(3):364-372 Nat Commun, 2021, 12(1):3830 Cell Rep, 2021, 36(12):109742
S1937	Isoniazid Isoniazid是一种前体药物，通过与KatG 相互作用阻断了脂肪酸合成酶的作用，用于结核的预防和治疗。	Front Immunol, 2021, 12:712021 Nat Metab, 2021, 10.1038/s42255-021-00479-4 Molecules, 2019, 25(1)
S3300	Desoxyrhaponticin Desoxyrhaponticin (DC, DES) 是一种来自中国传统的营养食品 Rheum tanguticum Maxim. ex Balf. (rhubarb) 的对称二苯代乙烯配糖体，是 fatty acid synthase (FAS/FASN) 的抑制剂。Desoxyrhaponticin (DC, DES) 也是竞争性的 glucose 摄取的抑制剂，在兔肠膜囊泡和大鼠肠翻肠中的IC50值分别为148.3 μM和30.9 μM。Desoxyrhaponticin 对人癌细胞具有凋亡作用。	Nat Metab, 2021, 10.1038/s42255-021-00479-4
S6248New	Fasnall Fasnall 是一种thiophenopyrimidine，是选择性的脂肪酸合成酶 fatty acid synthase (FASN) 的抑制剂，具有强大的抗肿瘤活性。
S8284	Fatostatin (125B11) HBr Fatostatin HBr (Fatostatin A, 125B11)是固醇调节元件结合蛋白(SREBP)的抑制剂。它损害SREBP-1和SREBP-2的激活。	EMBO Rep, 2021, e52537 Nat Metab, 2021, 10.1038/s42255-021-00479-4 Cell, 2020, S0092-8674(20)31626-3
S6666	FT113 FT113是一种fatty acid synthase (FAS/FASN)抑制剂，ic50为213 nM。	Nat Metab, 2021, 10.1038/s42255-021-00479-4
S2250	(-)-Epigallocatechin Gallate (-)-Epigallocatechin Gallate(EGCG) 是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase， 阻滞EGF受体和HER-2受体的激活，抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。	Exp Cell Res, 2022, 411(1):113000 Int J Mol Med, 2022, 49(1)11 EMBO Rep, 2021, e53166
S4754	Betulin Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity.	Theranostics, 2021, 11(13):6560-6572 Front Oncol, 2021, 11:796152 Nat Metab, 2021, 10.1038/s42255-021-00479-4
S8915	C75 trans C75 trans (trans-C75, (±)-C75) 是一种 fatty acid synthase (FAS/FASN) 的新型有效的合成抑制剂，在成株试验和球体生长测定中的IC50值分别为35 μM和50 μM。C75 可用作研究代谢紊乱和癌症中脂肪酸合成的工具。	Signal Transduct Target Ther, 2022, 7(1):46 Nat Metab, 2021, 10.1038/s42255-021-00479-4
S2314	Kaempferol (NSC 407289) Kaempferol (NSC 407289, Robigenin)是一种黄酮，是ERRα和ERRγ的反向激动剂。抑制topoisomerase I催化的DNA再连接和fatty acid synthase的活性。	Molecules, 2021, 26(5)1210 Eur J Pharmacol, 2021, 907:174251 Nat Metab, 2021, 10.1038/s42255-021-00479-4	Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).
S3576	TVB-3166 TVB-3166 是一种口服的、可逆的、有效的 fatty acid synthase (FASN) 的选择性抑制剂，在体外生化分析中，其IC50值为0.042 μM。TVB-3166 可诱导凋亡，并抑制体内异种移植肿瘤的生长。
S9392	Praeruptorin B Praeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities.	Nat Metab, 2021, 10.1038/s42255-021-00479-4
S9785	Fatostatin Fatostatin (125B11) 是一种diarylthiazole的衍生物，是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein)，并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡。	EMBO Rep, 2021, e52537 Front Oncol, 2021, 11:796152 Reproduction, 2021, 162(6):397-410
S8563	TVB-3664 TVB-3664 是一种有效的、选择性的、口服活性 fatty acid synthase (FASN) 的可逆抑制剂，对于人和小鼠棕榈酸酯合成的IC50值分别为0.018 μM和0.012 μM。	EMBO J, 2022, e109463 Sci Rep, 2021, 11(1):22085 Nat Metab, 2021, 10.1038/s42255-021-00479-4
S9714	TVB-2640 TVB-2640 (ASC-40, FASN-IN-2) 是一种口服生物可利用的 fatty acid synthase (FAS/FASN) 的抑制剂，对NAFLD和非酒精性脂肪性肝炎具有治疗潜力。	Cancer Metab, 2021, 9(1):31 Nat Metab, 2021, 10.1038/s42255-021-00479-4 bioRxiv, 2021, 10.1101/2021.03.12.435005
S6466	Eicosapentaenoic acid ethyl ester Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) 是omega-3 fatty acid 药剂，可显著地降低 triglyceride (TG) 的水平并改善其他脂质参数而不会显着增加低密度脂蛋白(LDL)胆固醇的水平。

目录号	产品描述	文献引用	实验数据
S2697	A-769662 A-769662是一种有效的，可逆的AMPK激活剂，在无细胞试验中EC50为0.8 μM，对GPPase/FBPase活性几乎没有作用。	Ecotoxicol Environ Saf,2022, 236:113467 J Biol Chem,2022, S0021-9258(22)00292-7 Cell Signal,2022, S0898-6568(22)00031-6	Cells were treated with CP, DOXO, SRT1720 (100 nM), EX527 (100 nM), A769662 (10 μM) and Compound C (1 μM) under normoxic or hypoxic conditions for 48 hours, and then their viabilities were measured by MTT.
S1629	Orlistat (Ro 18-0647) Orlistat (Ro 18-0647, Tetrahydrolipstatin) 是一种通用的脂肪酶 lipase 抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。Orlistat 处理可抑制细胞增殖、诱导凋亡并阻滞细胞周期。	Nat Cell Biol,2022, 24(3):364-372 Nat Commun,2021, 12(1):3830 Cell Rep,2021, 36(12):109742
S1937	Isoniazid Isoniazid是一种前体药物，通过与KatG 相互作用阻断了脂肪酸合成酶的作用，用于结核的预防和治疗。	Front Immunol,2021, 12:712021 Nat Metab,2021, 10.1038/s42255-021-00479-4 Molecules,2019, 25(1)
S3300	Desoxyrhaponticin Desoxyrhaponticin (DC, DES) 是一种来自中国传统的营养食品 Rheum tanguticum Maxim. ex Balf. (rhubarb) 的对称二苯代乙烯配糖体，是 fatty acid synthase (FAS/FASN) 的抑制剂。Desoxyrhaponticin (DC, DES) 也是竞争性的 glucose 摄取的抑制剂，在兔肠膜囊泡和大鼠肠翻肠中的IC50值分别为148.3 μM和30.9 μM。Desoxyrhaponticin 对人癌细胞具有凋亡作用。	Nat Metab,2021, 10.1038/s42255-021-00479-4
S6248New	Fasnall Fasnall 是一种thiophenopyrimidine，是选择性的脂肪酸合成酶 fatty acid synthase (FASN) 的抑制剂，具有强大的抗肿瘤活性。
S8284	Fatostatin (125B11) HBr Fatostatin HBr (Fatostatin A, 125B11)是固醇调节元件结合蛋白(SREBP)的抑制剂。它损害SREBP-1和SREBP-2的激活。	EMBO Rep,2021, e52537 Nat Metab,2021, 10.1038/s42255-021-00479-4 Cell,2020, S0092-8674(20)31626-3
S6666	FT113 FT113是一种fatty acid synthase (FAS/FASN)抑制剂，ic50为213 nM。	Nat Metab,2021, 10.1038/s42255-021-00479-4
S2250	(-)-Epigallocatechin Gallate (-)-Epigallocatechin Gallate(EGCG) 是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase， 阻滞EGF受体和HER-2受体的激活，抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。	Exp Cell Res,2022, 411(1):113000 Int J Mol Med,2022, 49(1)11 EMBO Rep,2021, e53166
S4754	Betulin Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity.	Theranostics,2021, 11(13):6560-6572 Front Oncol,2021, 11:796152 Nat Metab,2021, 10.1038/s42255-021-00479-4
S8915	C75 trans C75 trans (trans-C75, (±)-C75) 是一种 fatty acid synthase (FAS/FASN) 的新型有效的合成抑制剂，在成株试验和球体生长测定中的IC50值分别为35 μM和50 μM。C75 可用作研究代谢紊乱和癌症中脂肪酸合成的工具。	Signal Transduct Target Ther,2022, 7(1):46 Nat Metab,2021, 10.1038/s42255-021-00479-4
S2314	Kaempferol (NSC 407289) Kaempferol (NSC 407289, Robigenin)是一种黄酮，是ERRα和ERRγ的反向激动剂。抑制topoisomerase I催化的DNA再连接和fatty acid synthase的活性。	Molecules,2021, 26(5)1210 Eur J Pharmacol,2021, 907:174251 Nat Metab,2021, 10.1038/s42255-021-00479-4	Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).
S3576	TVB-3166 TVB-3166 是一种口服的、可逆的、有效的 fatty acid synthase (FASN) 的选择性抑制剂，在体外生化分析中，其IC50值为0.042 μM。TVB-3166 可诱导凋亡，并抑制体内异种移植肿瘤的生长。
S9392	Praeruptorin B Praeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities.	Nat Metab,2021, 10.1038/s42255-021-00479-4
S9785	Fatostatin Fatostatin (125B11) 是一种diarylthiazole的衍生物，是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein)，并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡。	EMBO Rep,2021, e52537 Front Oncol,2021, 11:796152 Reproduction,2021, 162(6):397-410
S8563	TVB-3664 TVB-3664 是一种有效的、选择性的、口服活性 fatty acid synthase (FASN) 的可逆抑制剂，对于人和小鼠棕榈酸酯合成的IC50值分别为0.018 μM和0.012 μM。	EMBO J,2022, e109463 Sci Rep,2021, 11(1):22085 Nat Metab,2021, 10.1038/s42255-021-00479-4
S9714	TVB-2640 TVB-2640 (ASC-40, FASN-IN-2) 是一种口服生物可利用的 fatty acid synthase (FAS/FASN) 的抑制剂，对NAFLD和非酒精性脂肪性肝炎具有治疗潜力。	Cancer Metab,2021, 9(1):31 Nat Metab,2021, 10.1038/s42255-021-00479-4 bioRxiv,2021, 10.1101/2021.03.12.435005

目录号	产品描述	文献引用	实验数据
S6466	Eicosapentaenoic acid ethyl ester Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) 是omega-3 fatty acid 药剂，可显著地降低 triglyceride (TG) 的水平并改善其他脂质参数而不会显着增加低密度脂蛋白(LDL)胆固醇的水平。