LDL

抑制剂选择性比较

LDL产品

所有产品 LDL调节剂(5) 新LDL产品

产品目录	产品描述	文献引用	实验数据
S1655	Ezetimibe Ezetimibe 是一种有效的、选择性的胆固醇吸收抑制剂，用来降低胆固醇。	Nature, 2016, 535(7611):303-7 Antiviral Res, 2015, 120:140-6 J Radioanal Nucl Chem, 2015, 10.1007/s10967-015-3996-6	Caco-2 cells grown in transwell inserts were transfected with scrambled siRNA, or siRNA specific for CCK1R, CCK2R, or both CCK1 and CCK2R and then incubated with 0.002 uCi of [³H]cholesterol micelles in the apical compartment and with culture medium alone (Control) or 10 nm [Thr28,Nle31]CCK with or without 50 uM ezetimibe (EZ) in the basolateral compartment. Absorbed [³H]cholesterol was determined by radioactivity counting of the basolateral medium. Values represent the mean ± S.E. (error bars) of 4-5 independent experiments. *, p < 0.05 versus control; †, p < 0.05 versus cells treated with CCK alone; ‡, p < 0.05 versus cells transfected with scrambled siRNA alone; $, p < 0.05 versus cells treated with scrambled siRNA and CCK.
S2748	Anacetrapib (MK-0859) Anacetrapib (MK-0859)是一种有效的，选择性，可逆的rhCETP和突变CETP(C13S)抑制剂，IC50分别为7.9 nM和11.8 nM，提高HDL-C，降低LDL-C，不提高醛固酮和血压。Phase 3。
S7953	ETC-1002 ETC-1002是一种可用于口服、降低LDL-C的小分子，是肝脏AMPK的激活剂。
S2119	Probucol Probucol 是一种抗高血脂药，通过促进LDL分解代谢率，而降低血液中胆固醇水平。
S9187^New	Phillygenin Phillygenin, a bioactive intergradient in Osmanthus fragrans, has anti-inflammatory, anti-obesity and antipyretic activities. It could reduce blood lipid levels and low density lipoprotein.

产品目录	产品描述	文献引用	实验数据
S1655	Ezetimibe Ezetimibe 是一种有效的、选择性的胆固醇吸收抑制剂，用来降低胆固醇。	Nature, 2016, 535(7611):303-7 Antiviral Res, 2015, 120:140-6 J Radioanal Nucl Chem, 2015, 10.1007/s10967-015-3996-6	Caco-2 cells grown in transwell inserts were transfected with scrambled siRNA, or siRNA specific for CCK1R, CCK2R, or both CCK1 and CCK2R and then incubated with 0.002 uCi of [³H]cholesterol micelles in the apical compartment and with culture medium alone (Control) or 10 nm [Thr28,Nle31]CCK with or without 50 uM ezetimibe (EZ) in the basolateral compartment. Absorbed [³H]cholesterol was determined by radioactivity counting of the basolateral medium. Values represent the mean ± S.E. (error bars) of 4-5 independent experiments. *, p < 0.05 versus control; †, p < 0.05 versus cells treated with CCK alone; ‡, p < 0.05 versus cells transfected with scrambled siRNA alone; $, p < 0.05 versus cells treated with scrambled siRNA and CCK.
S2748	Anacetrapib (MK-0859) Anacetrapib (MK-0859)是一种有效的，选择性，可逆的rhCETP和突变CETP(C13S)抑制剂，IC50分别为7.9 nM和11.8 nM，提高HDL-C，降低LDL-C，不提高醛固酮和血压。Phase 3。
S7953	ETC-1002 ETC-1002是一种可用于口服、降低LDL-C的小分子，是肝脏AMPK的激活剂。
S2119	Probucol Probucol 是一种抗高血脂药，通过促进LDL分解代谢率，而降低血液中胆固醇水平。
S9187^New	Phillygenin Phillygenin, a bioactive intergradient in Osmanthus fragrans, has anti-inflammatory, anti-obesity and antipyretic activities. It could reduce blood lipid levels and low density lipoprotein.

Tags: LDL modulation | LDL modulator | LDL regulation| LDL review