LDL
抑制剂选择性比较
LDL产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S1655 |
Ezetimibe (SCH-58235)Ezetimibe (SCH-58235) 是一种有效的、选择性的胆固醇吸收抑制剂,用来降低胆固醇。 |
![]() ![]() Caco-2 cells grown in transwell inserts were transfected with scrambled siRNA, or siRNA specific for CCK1R, CCK2R, or both CCK1 and CCK2R and then incubated with 0.002 uCi of [3H]cholesterol micelles in the apical compartment and with culture medium alone (Control) or 10 nm [Thr28,Nle31]CCK with or without 50 uM ezetimibe (EZ) in the basolateral compartment. Absorbed [3H]cholesterol was determined by radioactivity counting of the basolateral medium. Values represent the mean ± S.E. (error bars) of 4-5 independent experiments. *, p < 0.05 versus control; †, p < 0.05 versus cells treated with CCK alone; ‡, p < 0.05 versus cells transfected with scrambled siRNA alone; $, p < 0.05 versus cells treated with scrambled siRNA and CCK.
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S2748 |
Anacetrapib (MK-0859)Anacetrapib (MK-0859)是一种有效的,选择性,可逆的rhCETP和突变CETP(C13S)抑制剂,IC50分别为7.9 nM和11.8 nM,提高HDL-C,降低LDL-C,不提高醛固酮和血压。Phase 3。 |
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S7953 |
ETC-1002ETC-1002 (Bempedoic acid, ESP-55016)是一种可用于口服、降低LDL-C的小分子,是肝脏AMPK的激活剂。ETC-1002 对肝ATP-citrate lyase具有有效的抑制作用(IC50 = 29 uM)。 |
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S2119 |
ProbucolProbucol (DH-581) 是一种抗高血脂药,通过促进LDL分解代谢率,而降低血液中胆固醇水平。 |
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S9187 |
PhillygeninPhillygenin (Sylvatesmin), a bioactive intergradient in Osmanthus fragrans, has anti-inflammatory, anti-obesity and antipyretic activities. It could reduce blood lipid levels and low density lipoprotein. |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1655 |
Ezetimibe (SCH-58235)Ezetimibe (SCH-58235) 是一种有效的、选择性的胆固醇吸收抑制剂,用来降低胆固醇。 |
![]() ![]() Caco-2 cells grown in transwell inserts were transfected with scrambled siRNA, or siRNA specific for CCK1R, CCK2R, or both CCK1 and CCK2R and then incubated with 0.002 uCi of [3H]cholesterol micelles in the apical compartment and with culture medium alone (Control) or 10 nm [Thr28,Nle31]CCK with or without 50 uM ezetimibe (EZ) in the basolateral compartment. Absorbed [3H]cholesterol was determined by radioactivity counting of the basolateral medium. Values represent the mean ± S.E. (error bars) of 4-5 independent experiments. *, p < 0.05 versus control; †, p < 0.05 versus cells treated with CCK alone; ‡, p < 0.05 versus cells transfected with scrambled siRNA alone; $, p < 0.05 versus cells treated with scrambled siRNA and CCK.
|
|
S2748 |
Anacetrapib (MK-0859)Anacetrapib (MK-0859)是一种有效的,选择性,可逆的rhCETP和突变CETP(C13S)抑制剂,IC50分别为7.9 nM和11.8 nM,提高HDL-C,降低LDL-C,不提高醛固酮和血压。Phase 3。 |
||
S7953 |
ETC-1002ETC-1002 (Bempedoic acid, ESP-55016)是一种可用于口服、降低LDL-C的小分子,是肝脏AMPK的激活剂。ETC-1002 对肝ATP-citrate lyase具有有效的抑制作用(IC50 = 29 uM)。 |
||
S2119 |
ProbucolProbucol (DH-581) 是一种抗高血脂药,通过促进LDL分解代谢率,而降低血液中胆固醇水平。 |
||
S9187 |
PhillygeninPhillygenin (Sylvatesmin), a bioactive intergradient in Osmanthus fragrans, has anti-inflammatory, anti-obesity and antipyretic activities. It could reduce blood lipid levels and low density lipoprotein. |