Opioid Receptor

信号通路图

研究领域

  • 抑制剂选择性比较
  • 溶解性比较
目录号 产品目录 溶解度(25°C)
DMSO 酒精
S5701 Alvimopan dihydrate (LY246736 dihydrate) -1 mg/mL 92 mg/mL -1 mg/mL
S2503 Racecadotril <1 mg/mL 22 mg/mL 77 mg/mL
S3066 Naloxone HCl 72 mg/mL 72 mg/mL <1 mg/mL
S2722 JTC-801 <1 mg/mL 90 mg/mL 31 mg/mL
S2103 Naltrexone HCl 14 mg/mL 14 mg/mL <1 mg/mL
S2480 Loperamide HCl <1 mg/mL 22 mg/mL 4 mg/mL
S1139 ADL5859 HCl 5 mg/mL 86 mg/mL 1 mg/mL
S5507 Trimebutine maleate -1 mg/mL 100 mg/mL -1 mg/mL
S5087 Tianeptine -1 mg/mL 87 mg/mL -1 mg/mL
S2322 (+)-Matrine 11 mg/mL 49 mg/mL 49 mg/mL
S2085 Trimebutine <1 mg/mL 50 mg/mL <1 mg/mL
S4714 (-)-Menthol 16 mg/mL 31 mg/mL 31 mg/mL
S3204 Meptazinol HCl 53 mg/mL 53 mg/mL 53 mg/mL
S3972 Lobeline hydrochloride -1 mg/mL 74 mg/mL -1 mg/mL
S4588 Docusate Sodium 18 mg/mL 88 mg/mL 88 mg/mL

特异性亚型抑制剂

产品目录 产品描述 文献引用 实验数据
S5701New

Alvimopan dihydrate (LY246736 dihydrate)

Alvimopan (LY-246736) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors.

S2503

Racecadotril

Racecadotril 是一种外周性的脑啡肽酶抑制剂,IC50为4.5 μM。

S3066

Naloxone HCl

Naloxone HCl是阿片反向激动剂药物,用来中和过量阿片的效果。

S2722

JTC-801

JTC-801是一种选择性opioid receptor-like1 (ORL1) receptor(阿片受体样1受体)拮抗剂,IC50为94 nM,微弱抑制受体δ, κ和μ。

S2103

Naltrexone HCl

Naltrexone HCl是一种阿片受体拮抗剂,主要用于治疗酒精依赖和阿片类药物依赖。

S2480

Loperamide HCl

Loperamide HCl是一种阿片受体激动剂,ED50为0.15 mg/kg。

S1139

ADL5859 HCl

ADL5859 HCl是一种δ-opioid receptor激动剂,Ki为0.8 nM,选择性作用于opioid receptor κ,μ,对hERG通道具有微弱的抑制活性。Phase 2。

S5507New

Trimebutine maleate

Trimebutine maleate is the maleate salt form of trimebutine, which is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects.

S5087New

Tianeptine

Tianeptine is an antidepressant agent that act as an atypical agonist of the μ-opioid receptor with clinically negligible effects on the δ- and κ-opioid receptors.

S2322

(+)-Matrine

(+)-Matrine是一种在植物Sophora属中发现的生物碱,具有多种药理作用,包括抗癌作用,是κ阿片受体激动剂。

S2085

Trimebutine

Trimebutine是一种外周μ,κ和δ阿片受体激动剂,用作解痉剂用于治疗急性和慢性腹痛。

S4714

(-)-Menthol

(-)-Menthol是薄荷醇的左旋异构体,常被用作冷却剂,可激活TRPM8。

S3204

Meptazinol HCl

Meptazinol HCl是一种独特的中枢神经系统阿片类镇痛药,可以抑制[3H]二氢吗啡的结合,IC50为58nM。

S3972New

Lobeline hydrochloride

Lobeline hydrochloride is an alkaloid that acts on nicotinic cholinergic receptors but is less potent than nicotine. It is also a VMAT2 ligand and an antagonist of μ-opioid receptors.

S4588

Docusate Sodium

Docusate Sodium是一种用于治疗便秘的泻药。