RAD51
抑制剂选择性比较
RAD51产品
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1244 |
Amuvatinib (MP-470)Amuvatinib (MP-470, HPK 56) 是一种有效的，作用于c-Kit、PDGFα和Flt3的多靶点抑制剂，IC50分别为10 nM、40 nM和81 nM。Amuvatinib 可抑制c-MET和c-RET。Amuvatinib 还具有DNA修复蛋白Rad51抑制剂及抗肿瘤的活性。Phase 2。 |
Inactivation of AXL by MP470 reverses epithelial to mesenchymal transition. Immunoblot analyses of lysates from TGFβ/TNFα- treated MCF10A cells treated with varying amounts of MP470 for 72 hours.
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| S2871 |
T0070907T0070907是一种有效的，选择性PPARγ抑制剂，无细胞试验中IC50为1 nM，比作用于PPARα和PPARδ选择性高800倍以上。T0070907 在ME-180和SiHa细胞中可显著降低 DNA-PKcs 和 RAD51 蛋白的表达水平。 |
Knocking down LKB1 reversed the PPARc antagonist T0070907-induced changes in the protein expression of the M1 markers (iNOS, green) and the M2 markers (CD206, red) by immunofluorescence staining. Scale bar = 20 μm.
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| S8077 |
RI-1RI-1 (RAD51 inhibitor 1)是RAD51抑制剂，IC50为5至30 µM。 |
Inhibition of Rad51 sensitizes PTEN-WT BT549 cells to olaparib. A. Immunofluorescence showed the foci of γH2AX in PTEN-WT BT549 cells treated with 5 μM olaparib (OLA), 5 μM RI-1, and their combination. B. The quantification of immunofluorescenct results. *p ≤ 0.05, ** p ≤ 0.01, ***p ≤ 0.001. C. MTT analysis of PTEN-WT BT549 treated with olaparib or olaparib in combining with RI-1. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. D. MTT analysis of PTEN-WT BT549 treated with IR-1 for 48 h.
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| S8234 |
RS-1RS-1是刺激RAD51的化合物。能够增加RAD51的DNA结合活性。在体内外兔胚胎实验中，RS-1可增强Cas9和TALEN介导的基因敲入效率。 |
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1244 |
Amuvatinib (MP-470)Amuvatinib (MP-470, HPK 56) 是一种有效的，作用于c-Kit、PDGFα和Flt3的多靶点抑制剂，IC50分别为10 nM、40 nM和81 nM。Amuvatinib 可抑制c-MET和c-RET。Amuvatinib 还具有DNA修复蛋白Rad51抑制剂及抗肿瘤的活性。Phase 2。 |
Inactivation of AXL by MP470 reverses epithelial to mesenchymal transition. Immunoblot analyses of lysates from TGFβ/TNFα- treated MCF10A cells treated with varying amounts of MP470 for 72 hours.
|
|
| S2871 |
T0070907T0070907是一种有效的，选择性PPARγ抑制剂，无细胞试验中IC50为1 nM，比作用于PPARα和PPARδ选择性高800倍以上。T0070907 在ME-180和SiHa细胞中可显著降低 DNA-PKcs 和 RAD51 蛋白的表达水平。 |
Knocking down LKB1 reversed the PPARc antagonist T0070907-induced changes in the protein expression of the M1 markers (iNOS, green) and the M2 markers (CD206, red) by immunofluorescence staining. Scale bar = 20 μm.
|
|
| S8077 |
RI-1RI-1 (RAD51 inhibitor 1)是RAD51抑制剂，IC50为5至30 µM。 |
Inhibition of Rad51 sensitizes PTEN-WT BT549 cells to olaparib. A. Immunofluorescence showed the foci of γH2AX in PTEN-WT BT549 cells treated with 5 μM olaparib (OLA), 5 μM RI-1, and their combination. B. The quantification of immunofluorescenct results. *p ≤ 0.05, ** p ≤ 0.01, ***p ≤ 0.001. C. MTT analysis of PTEN-WT BT549 treated with olaparib or olaparib in combining with RI-1. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. D. MTT analysis of PTEN-WT BT549 treated with IR-1 for 48 h.
|
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S8234 |
RS-1RS-1是刺激RAD51的化合物。能够增加RAD51的DNA结合活性。在体内外兔胚胎实验中，RS-1可增强Cas9和TALEN介导的基因敲入效率。 |
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