RAD51

抑制剂选择性比较

RAD51产品

所有产品(4) RAD51抑制剂(3) RAD51激活剂(1)

目录号	产品描述	文献引用	实验数据
S1244	Amuvatinib (MP-470) Amuvatinib (MP-470, HPK 56) 是一种有效的，作用于c-Kit、PDGFα和Flt3的多靶点抑制剂，IC50分别为10 nM、40 nM和81 nM。Amuvatinib 可抑制c-MET和c-RET。Amuvatinib 还具有DNA修复蛋白Rad51抑制剂及抗肿瘤的活性。Phase 2。	Hum Cell, 2020, 10.1007/s13577-020-00420-z PLoS Genet, 2016, 12(9):e1006279 Oncotarget, 2016, 7(15):19620-30	Inactivation of AXL by MP470 reverses epithelial to mesenchymal transition. Immunoblot analyses of lysates from TGFβ/TNFα- treated MCF10A cells treated with varying amounts of MP470 for 72 hours.
S2871	T0070907 T0070907是一种有效的，选择性PPARγ抑制剂，无细胞试验中IC50为1 nM，比作用于PPARα和PPARδ选择性高800倍以上。T0070907 在ME-180和SiHa细胞中可显著降低 DNA-PKcs 和 RAD51 蛋白的表达水平。	Int Immunopharmacol, 2021, 92:107335 Sci Adv, 2020, 6(43)eaba9337 Cancer Lett, 2020, 476:34-47	Knocking down LKB1 reversed the PPARc antagonist T0070907-induced changes in the protein expression of the M1 markers (iNOS, green) and the M2 markers (CD206, red) by immunofluorescence staining. Scale bar = 20 μm.
S8077	RI-1 RI-1 (RAD51 inhibitor 1)是RAD51抑制剂，IC50为5至30 µM。	Mol Cancer Res, 2020, 10.1158/1541-7786.MCR-19-0507 Diagnostics (Basel), 2020, 10(2) FASEB J, 2019, 33(11):11668-11681	Inhibition of Rad51 sensitizes PTEN-WT BT549 cells to olaparib. A. Immunofluorescence showed the foci of γH2AX in PTEN-WT BT549 cells treated with 5 μM olaparib (OLA), 5 μM RI-1, and their combination. B. The quantification of immunofluorescenct results. p ≤ 0.05, * p ≤ 0.01, **p ≤ 0.001. C. MTT analysis of PTEN-WT BT549 treated with olaparib or olaparib in combining with RI-1. p ≤ 0.05, p ≤ 0.01, *p ≤ 0.001. D. MTT analysis of PTEN-WT BT549 treated with IR-1 for 48 h.
S8234	RS-1 RS-1是刺激RAD51的化合物。能够增加RAD51的DNA结合活性。在体内外兔胚胎实验中，RS-1可增强Cas9和TALEN介导的基因敲入效率。	Int J Biol Sci, 2021, 17(4): 1026-1040

目录号	产品描述	文献引用	实验数据
S1244	Amuvatinib (MP-470) Amuvatinib (MP-470, HPK 56) 是一种有效的，作用于c-Kit、PDGFα和Flt3的多靶点抑制剂，IC50分别为10 nM、40 nM和81 nM。Amuvatinib 可抑制c-MET和c-RET。Amuvatinib 还具有DNA修复蛋白Rad51抑制剂及抗肿瘤的活性。Phase 2。	Hum Cell,2020, 10.1007/s13577-020-00420-z PLoS Genet,2016, 12(9):e1006279 Oncotarget,2016, 7(15):19620-30	Inactivation of AXL by MP470 reverses epithelial to mesenchymal transition. Immunoblot analyses of lysates from TGFβ/TNFα- treated MCF10A cells treated with varying amounts of MP470 for 72 hours.
S2871	T0070907 T0070907是一种有效的，选择性PPARγ抑制剂，无细胞试验中IC50为1 nM，比作用于PPARα和PPARδ选择性高800倍以上。T0070907 在ME-180和SiHa细胞中可显著降低 DNA-PKcs 和 RAD51 蛋白的表达水平。	Int Immunopharmacol,2021, 92:107335 Sci Adv,2020, 6(43)eaba9337 Cancer Lett,2020, 476:34-47	Knocking down LKB1 reversed the PPARc antagonist T0070907-induced changes in the protein expression of the M1 markers (iNOS, green) and the M2 markers (CD206, red) by immunofluorescence staining. Scale bar = 20 μm.
S8077	RI-1 RI-1 (RAD51 inhibitor 1)是RAD51抑制剂，IC50为5至30 µM。	Mol Cancer Res,2020, 10.1158/1541-7786.MCR-19-0507 Diagnostics (Basel),2020, 10(2) FASEB J,2019, 33(11):11668-11681	Inhibition of Rad51 sensitizes PTEN-WT BT549 cells to olaparib. A. Immunofluorescence showed the foci of γH2AX in PTEN-WT BT549 cells treated with 5 μM olaparib (OLA), 5 μM RI-1, and their combination. B. The quantification of immunofluorescenct results. p ≤ 0.05, * p ≤ 0.01, **p ≤ 0.001. C. MTT analysis of PTEN-WT BT549 treated with olaparib or olaparib in combining with RI-1. p ≤ 0.05, p ≤ 0.01, *p ≤ 0.001. D. MTT analysis of PTEN-WT BT549 treated with IR-1 for 48 h.

目录号

产品描述

文献引用

实验数据

S1244

Amuvatinib (MP-470)

Amuvatinib (MP-470, HPK 56) 是一种有效的，作用于c-Kit、PDGFα和Flt3的多靶点抑制剂，IC50分别为10 nM、40 nM和81 nM。Amuvatinib 可抑制c-MET和c-RET。Amuvatinib 还具有DNA修复蛋白Rad51抑制剂及抗肿瘤的活性。Phase 2。

Hum Cell,2020, 10.1007/s13577-020-00420-z

PLoS Genet,2016, 12(9):e1006279

Oncotarget,2016, 7(15):19620-30

S2871

T0070907

T0070907是一种有效的，选择性PPARγ抑制剂，无细胞试验中IC50为1 nM，比作用于PPARα和PPARδ选择性高800倍以上。T0070907 在ME-180和SiHa细胞中可显著降低 DNA-PKcs 和 RAD51 蛋白的表达水平。

Int Immunopharmacol,2021, 92:107335

Sci Adv,2020, 6(43)eaba9337

Cancer Lett,2020, 476:34-47

S8077

RI-1

RI-1 (RAD51 inhibitor 1)是RAD51抑制剂，IC50为5至30 µM。

Mol Cancer Res,2020, 10.1158/1541-7786.MCR-19-0507

Diagnostics (Basel),2020, 10(2)

FASEB J,2019, 33(11):11668-11681

目录号	产品描述	文献引用	实验数据
S8234	RS-1 RS-1是刺激RAD51的化合物。能够增加RAD51的DNA结合活性。在体内外兔胚胎实验中，RS-1可增强Cas9和TALEN介导的基因敲入效率。	Int J Biol Sci, 2021, 17(4): 1026-1040

目录号

产品描述

文献引用

实验数据

S8234