RAD51

抑制剂选择性比较

RAD51产品

所有产品(4) RAD51抑制剂(3) RAD51激活剂(1)

目录号	产品描述	文献引用	实验数据
S1244	Amuvatinib (MP-470) Amuvatinib (MP-470, HPK 56) 是一种有效的，作用于c-Kit、PDGFα和Flt3的多靶点抑制剂，IC50分别为10 nM、40 nM和81 nM。Amuvatinib 可抑制c-MET和c-RET。Amuvatinib 还具有DNA修复蛋白Rad51抑制剂及抗肿瘤的活性。Phase 2。	Hum Cell, 2022, 10.1007/s13577-022-00671-y mBio, 2021, 12(6):e0322821 Hum Cell, 2021, 34(6):1911-1918	Inactivation of AXL by MP470 reverses epithelial to mesenchymal transition. Immunoblot analyses of lysates from TGFβ/TNFα- treated MCF10A cells treated with varying amounts of MP470 for 72 hours.
S2871	T0070907 T0070907是一种有效的，选择性PPARγ抑制剂，无细胞试验中IC50为1 nM，比作用于PPARα和PPARδ选择性高800倍以上。T0070907 在ME-180和SiHa细胞中可显著降低 DNA-PKcs 和 RAD51 蛋白的表达水平。	Redox Biol, 2022, 50:102256 Front Cell Dev Biol, 2021, 9:745554 J Inflamm Res, 2021, 14:395-411	Knocking down LKB1 reversed the PPARc antagonist T0070907-induced changes in the protein expression of the M1 markers (iNOS, green) and the M2 markers (CD206, red) by immunofluorescence staining. Scale bar = 20 μm.
S8077	RI-1 RI-1 (RAD51 inhibitor 1)是RAD51抑制剂，IC50为5至30 µM。	Elife, 2021, 10e65234 Oncogene, 2021, 10.1038/s41388-021-01932-0 Front Oncol, 2021, 11:646256	Inhibition of Rad51 sensitizes PTEN-WT BT549 cells to olaparib. A. Immunofluorescence showed the foci of γH2AX in PTEN-WT BT549 cells treated with 5 μM olaparib (OLA), 5 μM RI-1, and their combination. B. The quantification of immunofluorescenct results. p ≤ 0.05, * p ≤ 0.01, **p ≤ 0.001. C. MTT analysis of PTEN-WT BT549 treated with olaparib or olaparib in combining with RI-1. p ≤ 0.05, p ≤ 0.01, *p ≤ 0.001. D. MTT analysis of PTEN-WT BT549 treated with IR-1 for 48 h.
S8234	RS-1 RS-1是刺激RAD51的化合物。能够增加RAD51的DNA结合活性。在体内外兔胚胎实验中，RS-1可增强Cas9和TALEN介导的基因敲入效率。	Int J Biol Sci, 2021, 17(4):1026-1040 Chembiochem, 2021, 22(20):2957-2965

目录号	产品描述	文献引用	实验数据
S1244	Amuvatinib (MP-470) Amuvatinib (MP-470, HPK 56) 是一种有效的，作用于c-Kit、PDGFα和Flt3的多靶点抑制剂，IC50分别为10 nM、40 nM和81 nM。Amuvatinib 可抑制c-MET和c-RET。Amuvatinib 还具有DNA修复蛋白Rad51抑制剂及抗肿瘤的活性。Phase 2。	Hum Cell,2022, 10.1007/s13577-022-00671-y mBio,2021, 12(6):e0322821 Hum Cell,2021, 34(6):1911-1918	Inactivation of AXL by MP470 reverses epithelial to mesenchymal transition. Immunoblot analyses of lysates from TGFβ/TNFα- treated MCF10A cells treated with varying amounts of MP470 for 72 hours.
S2871	T0070907 T0070907是一种有效的，选择性PPARγ抑制剂，无细胞试验中IC50为1 nM，比作用于PPARα和PPARδ选择性高800倍以上。T0070907 在ME-180和SiHa细胞中可显著降低 DNA-PKcs 和 RAD51 蛋白的表达水平。	Redox Biol,2022, 50:102256 Front Cell Dev Biol,2021, 9:745554 J Inflamm Res,2021, 14:395-411	Knocking down LKB1 reversed the PPARc antagonist T0070907-induced changes in the protein expression of the M1 markers (iNOS, green) and the M2 markers (CD206, red) by immunofluorescence staining. Scale bar = 20 μm.
S8077	RI-1 RI-1 (RAD51 inhibitor 1)是RAD51抑制剂，IC50为5至30 µM。	Elife,2021, 10e65234 Oncogene,2021, 10.1038/s41388-021-01932-0 Front Oncol,2021, 11:646256	Inhibition of Rad51 sensitizes PTEN-WT BT549 cells to olaparib. A. Immunofluorescence showed the foci of γH2AX in PTEN-WT BT549 cells treated with 5 μM olaparib (OLA), 5 μM RI-1, and their combination. B. The quantification of immunofluorescenct results. p ≤ 0.05, * p ≤ 0.01, **p ≤ 0.001. C. MTT analysis of PTEN-WT BT549 treated with olaparib or olaparib in combining with RI-1. p ≤ 0.05, p ≤ 0.01, *p ≤ 0.001. D. MTT analysis of PTEN-WT BT549 treated with IR-1 for 48 h.

目录号

产品描述

文献引用

实验数据

S1244

Amuvatinib (MP-470)

Amuvatinib (MP-470, HPK 56) 是一种有效的，作用于c-Kit、PDGFα和Flt3的多靶点抑制剂，IC50分别为10 nM、40 nM和81 nM。Amuvatinib 可抑制c-MET和c-RET。Amuvatinib 还具有DNA修复蛋白Rad51抑制剂及抗肿瘤的活性。Phase 2。

Hum Cell,2022, 10.1007/s13577-022-00671-y

mBio,2021, 12(6):e0322821

Hum Cell,2021, 34(6):1911-1918

S2871

T0070907

T0070907是一种有效的，选择性PPARγ抑制剂，无细胞试验中IC50为1 nM，比作用于PPARα和PPARδ选择性高800倍以上。T0070907 在ME-180和SiHa细胞中可显著降低 DNA-PKcs 和 RAD51 蛋白的表达水平。

Redox Biol,2022, 50:102256

Front Cell Dev Biol,2021, 9:745554

J Inflamm Res,2021, 14:395-411

S8077

RI-1

RI-1 (RAD51 inhibitor 1)是RAD51抑制剂，IC50为5至30 µM。

Elife,2021, 10e65234

Oncogene,2021, 10.1038/s41388-021-01932-0

Front Oncol,2021, 11:646256

目录号	产品描述	文献引用	实验数据
S8234	RS-1 RS-1是刺激RAD51的化合物。能够增加RAD51的DNA结合活性。在体内外兔胚胎实验中，RS-1可增强Cas9和TALEN介导的基因敲入效率。	Int J Biol Sci, 2021, 17(4):1026-1040 Chembiochem, 2021, 22(20):2957-2965

目录号

产品描述

文献引用

实验数据

S8234