Tyrosinase

亚型特异性产品

Tyrosinase产品

• 所有产品(22)
• Tyrosinase抑制剂 (21)
• Tyrosinase激活剂 (1)
• 新Tyrosinase产品

目录号	产品名	产品描述	文献引用	实验数据
S4921	MNS (3,4-Methylenedioxy-β-nitrostyrene)	MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)是一种酪氨酸激酶抑制剂，抑制Syk， Src和p97， IC50分别为2.5 μM， 29.3 μM和1.7 μM。	Phytomedicine, 2019, 61:152859 J Biomol Struct Dyn, 2019, 10.1080/07391102.2019.1640133 Toxicol Res (Camb), 2016, 5(1):188-196
S2263	Arbutin	Arbutin (Uva, p-Arbutin, β-Arbutin) 是一种酪氨酸酶 tyrosinase 抑制剂，对Monophenolase和Diphenolase的IC50值分别为0.9 mM 和 0.7 mM。	Transl Oncol, 2023, 35:101712 G3 (Bethesda), 2020, 4;10(5):1585-1597 Int J Mol Sci, 2017, 18(9)
S6237	2-Ketoglutaric acid (alpha-ketoglutarate)	2-Ketoglutaric acid (alpha-ketoglutarate)是三羧酸循环中的关键分子，是该代谢过程的限速节点。在三羧酸循环中，2-Ketoglutaric acid脱羧基生成琥珀酰辅酶和二氧化碳。	Int J Biol Sci, 2021, 17(5):1250-1262 Front Cell Infect Microbiol, 2020, 10:599087
S3783	Echinacoside	Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions.	Antioxidants (Basel), 2023, 10.3390/antiox12111925 Naunyn Schmiedebergs Arch Pharmacol, 2020, 10.1007/s00210-020-02022-w
S1652	Monobenzone	Monobenzone(Benoquin)是一种外用药，用于治疗皮肤色素脱失。它能特异性地抑制tyrosinase。	Front Genet, 2020, 11:1000
S4739	Oxyresveratrol	Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene)是从Morus alba L.发现的天然化合物，对酪氨酸酶的多巴氧化酶活性具有有效抑制作用，能催化黑色素生物合成的限速步骤。	Int J Mol Sci, 2022, 23(23)15102
S5174	Kojic acid	Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.	Int J Mol Sci, 2017, 18(9)
S9111	Isorhamnetin	Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.	Anat Rec (Hoboken), 2020, 10.1002/ar.24506
S4132	Deoxyarbutin	DeoxyArbutin(D-arbutin,D-Arb) 是一种可逆的酪氨酸酶抑制剂,抑制酪氨酸酶活性，IC50为50 nM。
S4571	Hexylresorcinol	Hexylresorcinol (4-Hexylresorcinol)是一种具有局部麻醉效果、抗菌和驱虫剂特性的有机化合物。是酪氨酸酶的有效抑制剂。hexylresorcinol对单酚酶的IC50为1.24 μM，对二酚酶的IC50值为0.85 μM。
S6272	Glycolic acid	Glycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid)是一种果酸。由于它能很好地穿透皮肤，经常被用于护肤品中，用作美容换肤。
E2861	Kojic acid dipalmitate	Kojic acid是一种慢性结合抑制剂，能够抑制酪氨酸酶的儿茶酚酶活性，Ki为2.75 µm。
S2375	Aloin (Barbaloin)	Aloin (Barbaloin)是有效的酪氨酸酶抑制剂，作用于HeLaS3细胞，IC50为97 μM。	Nan Fang Yi Ke Da Xue Xue Bao, 2023, 43(5):702-709 Cell Cycle, 2021, 10.1080/15384101.2021.1988227 Drug Des Devel Ther, 2020, 14:145-155
S9284	Aloesin	Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.
S4997	4-Butylresorcinol	4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.
S3691	4-Chlorosalicylic acid	4-Chlorosalicylic acid (4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid) 被用于混合稀土中对铽放入灵敏性荧光法测定以及利用甲醛缩合制备poly(4-chlorosalicylic acid-formaldehyde)中。
E2908New	1-PHENYL-2-THIOUREA	1-PHENYL-2-THIOUREA(N-Phenylthiourea, PTU, Phenylthiocarbamide) 是酪氨酸酶 (tyrosinase, Tyr) 的抑制剂。 1-PHENYL-2-THIOUREA 可阻断斑马鱼 (Danio rerio) 胚胎的色素沉着并提高光学透明度。
S9089	Magnoflorine	Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.
E1509New	Bezuclastinib	Bezuclastinib(CGT9486; PLX 9486)是c-kit和c-kit D816V的有效抑制剂，IC50值<1 μM。Bezuclastinib也是酪氨酸激酶的抑制剂
S3166	Calcium 2-oxoglutarate	Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) 是2-oxoglutarate的钙盐形式。2-oxoglutarate 是自然存在于生物中的，是众所周知的在柠檬酸循环(Krebs cycle)中ATP或GTP产生的中间体。2-oxoglutarate 是 tyrosinase 的可逆抑制剂，其IC50值为15 mM。
S9376	Benzylacetone	Benzylacetone (4-Phenyl-2-butanone, Methyl 2-phenylethyl ketone) is an attractant compound in flowers.
S6221	Methyl cinnamate	Methyl cinnamate 是花椒(Zanthoxylum armatum)的活性成分，是一种广泛使用的具有抗菌和 tyrosinase 抑制剂活性的天然香料化合物。Methyl cinnamate 通过激活3T3-L1前脂肪细胞中的 CaMKK2--AMPK 信号通路来抑制脂肪细胞分化。
S4921	MNS (3,4-Methylenedioxy-β-nitrostyrene)	MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)是一种酪氨酸激酶抑制剂，抑制Syk， Src和p97， IC50分别为2.5 μM， 29.3 μM和1.7 μM。	Phytomedicine, 2019, 61:152859 J Biomol Struct Dyn, 2019, 10.1080/07391102.2019.1640133 Toxicol Res (Camb), 2016, 5(1):188-196
S2263	Arbutin	Arbutin (Uva, p-Arbutin, β-Arbutin) 是一种酪氨酸酶 tyrosinase 抑制剂，对Monophenolase和Diphenolase的IC50值分别为0.9 mM 和 0.7 mM。	Transl Oncol, 2023, 35:101712 G3 (Bethesda), 2020, 4;10(5):1585-1597 Int J Mol Sci, 2017, 18(9)
S6237	2-Ketoglutaric acid (alpha-ketoglutarate)	2-Ketoglutaric acid (alpha-ketoglutarate)是三羧酸循环中的关键分子，是该代谢过程的限速节点。在三羧酸循环中，2-Ketoglutaric acid脱羧基生成琥珀酰辅酶和二氧化碳。	Int J Biol Sci, 2021, 17(5):1250-1262 Front Cell Infect Microbiol, 2020, 10:599087
S1652	Monobenzone	Monobenzone(Benoquin)是一种外用药，用于治疗皮肤色素脱失。它能特异性地抑制tyrosinase。	Front Genet, 2020, 11:1000
S4739	Oxyresveratrol	Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene)是从Morus alba L.发现的天然化合物，对酪氨酸酶的多巴氧化酶活性具有有效抑制作用，能催化黑色素生物合成的限速步骤。	Int J Mol Sci, 2022, 23(23)15102
S5174	Kojic acid	Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.	Int J Mol Sci, 2017, 18(9)
S9111	Isorhamnetin	Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.	Anat Rec (Hoboken), 2020, 10.1002/ar.24506
S4132	Deoxyarbutin	DeoxyArbutin(D-arbutin,D-Arb) 是一种可逆的酪氨酸酶抑制剂,抑制酪氨酸酶活性，IC50为50 nM。
S4571	Hexylresorcinol	Hexylresorcinol (4-Hexylresorcinol)是一种具有局部麻醉效果、抗菌和驱虫剂特性的有机化合物。是酪氨酸酶的有效抑制剂。hexylresorcinol对单酚酶的IC50为1.24 μM，对二酚酶的IC50值为0.85 μM。
S6272	Glycolic acid	Glycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid)是一种果酸。由于它能很好地穿透皮肤，经常被用于护肤品中，用作美容换肤。
E2861	Kojic acid dipalmitate	Kojic acid是一种慢性结合抑制剂，能够抑制酪氨酸酶的儿茶酚酶活性，Ki为2.75 µm。
S2375	Aloin (Barbaloin)	Aloin (Barbaloin)是有效的酪氨酸酶抑制剂，作用于HeLaS3细胞，IC50为97 μM。	Nan Fang Yi Ke Da Xue Xue Bao, 2023, 43(5):702-709 Cell Cycle, 2021, 10.1080/15384101.2021.1988227 Drug Des Devel Ther, 2020, 14:145-155
S9284	Aloesin	Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.
S4997	4-Butylresorcinol	4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.
S3691	4-Chlorosalicylic acid	4-Chlorosalicylic acid (4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid) 被用于混合稀土中对铽放入灵敏性荧光法测定以及利用甲醛缩合制备poly(4-chlorosalicylic acid-formaldehyde)中。
E2908New	1-PHENYL-2-THIOUREA	1-PHENYL-2-THIOUREA(N-Phenylthiourea, PTU, Phenylthiocarbamide) 是酪氨酸酶 (tyrosinase, Tyr) 的抑制剂。 1-PHENYL-2-THIOUREA 可阻断斑马鱼 (Danio rerio) 胚胎的色素沉着并提高光学透明度。
S9089	Magnoflorine	Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.
E1509New	Bezuclastinib	Bezuclastinib(CGT9486; PLX 9486)是c-kit和c-kit D816V的有效抑制剂，IC50值<1 μM。Bezuclastinib也是酪氨酸激酶的抑制剂
S3166	Calcium 2-oxoglutarate	Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) 是2-oxoglutarate的钙盐形式。2-oxoglutarate 是自然存在于生物中的，是众所周知的在柠檬酸循环(Krebs cycle)中ATP或GTP产生的中间体。2-oxoglutarate 是 tyrosinase 的可逆抑制剂，其IC50值为15 mM。
S9376	Benzylacetone	Benzylacetone (4-Phenyl-2-butanone, Methyl 2-phenylethyl ketone) is an attractant compound in flowers.
S6221	Methyl cinnamate	Methyl cinnamate 是花椒(Zanthoxylum armatum)的活性成分，是一种广泛使用的具有抗菌和 tyrosinase 抑制剂活性的天然香料化合物。Methyl cinnamate 通过激活3T3-L1前脂肪细胞中的 CaMKK2--AMPK 信号通路来抑制脂肪细胞分化。
S3783	Echinacoside	Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions.	Antioxidants (Basel), 2023, 10.3390/antiox12111925 Naunyn Schmiedebergs Arch Pharmacol, 2020, 10.1007/s00210-020-02022-w
E2908New	1-PHENYL-2-THIOUREA	1-PHENYL-2-THIOUREA(N-Phenylthiourea, PTU, Phenylthiocarbamide) 是酪氨酸酶 (tyrosinase, Tyr) 的抑制剂。 1-PHENYL-2-THIOUREA 可阻断斑马鱼 (Danio rerio) 胚胎的色素沉着并提高光学透明度。
E1509New	Bezuclastinib	Bezuclastinib(CGT9486; PLX 9486)是c-kit和c-kit D816V的有效抑制剂，IC50值<1 μM。Bezuclastinib也是酪氨酸激酶的抑制剂