Tyrosinase
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S4921 | MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN) | <1 mg/mL | 39 mg/mL | <1 mg/mL |
| S1652 | Monobenzone | <1 mg/mL | 40 mg/mL | 40 mg/mL |
| S4132 | Deoxyarbutin | <1 mg/mL | 39 mg/mL | 39 mg/mL |
| S4571 | Hexylresorcinol | <1 mg/mL | 38 mg/mL | 38 mg/mL |
| S2375 | Aloin | 83 mg/mL | 83 mg/mL | 2 mg/mL |
| S4997 | 4-Butylresorcinol | -1 mg/mL | 34 mg/mL | -1 mg/mL |
| S9284 | Aloesin | -1 mg/mL | 78 mg/mL | -1 mg/mL |
| S9089 | Magnoflorine | -1 mg/mL | 93 mg/mL | -1 mg/mL |
| S9111 | Isorhamnetin | -1 mg/mL | 63 mg/mL | -1 mg/mL |
| S2263 | Arbutin | 55 mg/mL | 55 mg/mL | <1 mg/mL |
| S5174 | Kojic acid | -1 mg/mL | 28 mg/mL | -1 mg/mL |
Tyrosinase产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S4921 |
MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)是一种酪氨酸激酶抑制剂，抑制Syk， Src和p97， IC50分别为2.5 μM， 29.3 μM和1.7 μM。 |
WT mouse primary macrophages were untreated as control (lane 1) or treated with 0.1μg/ml E. coli LPS (lane 5-8), 10μM E-64 (lane 2 and 6), 250μM PMSF (lane 3 and 7), or 20μM MNS (lane 4 and 8). The cells were continuously cultured for 16 hrs. Extracts from whole cells or nuclei were separately purified and subjected to WB analysis with antibody against pERK2, LITAF, or actin/tubulin as control.
|
|
| S1652 |
MonobenzoneMonobenzone是一种外用药，用于治疗皮肤色素脱失。它能特异性地抑制tyrosinase。 |
||
| S4132 |
DeoxyarbutinDeoxyArbutin 是一种可逆的酪氨酸酶抑制剂,抑制酪氨酸酶活性，IC50为50 nM。 |
||
| S4571 |
HexylresorcinolHexylresorcinol是一种具有局部麻醉效果、抗菌和驱虫剂特性的有机化合物。是酪氨酸酶的有效抑制剂。hexylresorcinol对单酚酶的IC50为1.24 μM，对二酚酶的IC50值为0.85 μM。 |
||
| S2375 |
AloinAloin是有效的酪氨酸酶抑制剂，作用于HeLaS3细胞，IC50为97 μM。 |
||
| S4997New |
4-Butylresorcinol4-Butylresorcinol is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent. |
||
| S9284New |
AloesinAloesin is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro. |
||
| S9089New |
MagnoflorineMagnoflorine, an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase. |
||
| S9111New |
IsorhamnetinIsorhamnetin, a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity. |
||
| S2263 |
ArbutinArbutin是一种酪氨酸酶抑制剂，IC50为1.09 mM。 |
||
| S5174 |
Kojic acidKojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives. |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S4921 |
MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)是一种酪氨酸激酶抑制剂，抑制Syk， Src和p97， IC50分别为2.5 μM， 29.3 μM和1.7 μM。 |
WT mouse primary macrophages were untreated as control (lane 1) or treated with 0.1μg/ml E. coli LPS (lane 5-8), 10μM E-64 (lane 2 and 6), 250μM PMSF (lane 3 and 7), or 20μM MNS (lane 4 and 8). The cells were continuously cultured for 16 hrs. Extracts from whole cells or nuclei were separately purified and subjected to WB analysis with antibody against pERK2, LITAF, or actin/tubulin as control.
|
|
| S1652 |
MonobenzoneMonobenzone是一种外用药，用于治疗皮肤色素脱失。它能特异性地抑制tyrosinase。 |
||
| S4132 |
DeoxyarbutinDeoxyArbutin 是一种可逆的酪氨酸酶抑制剂,抑制酪氨酸酶活性，IC50为50 nM。 |
||
| S4571 |
HexylresorcinolHexylresorcinol是一种具有局部麻醉效果、抗菌和驱虫剂特性的有机化合物。是酪氨酸酶的有效抑制剂。hexylresorcinol对单酚酶的IC50为1.24 μM，对二酚酶的IC50值为0.85 μM。 |
||
| S2375 |
AloinAloin是有效的酪氨酸酶抑制剂，作用于HeLaS3细胞，IC50为97 μM。 |
||
| S4997New |
4-Butylresorcinol4-Butylresorcinol is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent. |
||
| S9284New |
AloesinAloesin is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro. |
||
| S9089New |
MagnoflorineMagnoflorine, an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase. |
||
| S9111New |
IsorhamnetinIsorhamnetin, a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity. |
||
| S2263 |
ArbutinArbutin是一种酪氨酸酶抑制剂，IC50为1.09 mM。 |
||
| S5174 |
Kojic acidKojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives. |
