Tyrosinase

特异性亚型抑制剂

• monophenolase
• diphenolase

Tyrosinase产品

目录号	产品描述	文献引用	实验数据
S4921	MNS (3,4-Methylenedioxy-β-nitrostyrene) MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)是一种酪氨酸激酶抑制剂，抑制Syk， Src和p97， IC50分别为2.5 μM， 29.3 μM和1.7 μM。	J Biomol Struct Dyn, 2019, 10.1080/07391102.2019.1640133 Phytomedicine, 2019, 61:152859 Toxicol Res (Camb), 2016, 5(1):188-196	WT mouse primary macrophages were untreated as control (lane 1) or treated with 0.1μg/ml E. coli LPS (lane 5-8), 10μM E-64 (lane 2 and 6), 250μM PMSF (lane 3 and 7), or 20μM MNS (lane 4 and 8). The cells were continuously cultured for 16 hrs. Extracts from whole cells or nuclei were separately purified and subjected to WB analysis with antibody against pERK2, LITAF, or actin/tubulin as control.
S1652	Monobenzone Monobenzone是一种外用药，用于治疗皮肤色素脱失。它能特异性地抑制tyrosinase。	Front Genet, 2020, 11:1000
S4132	Deoxyarbutin DeoxyArbutin 是一种可逆的酪氨酸酶抑制剂,抑制酪氨酸酶活性，IC50为50 nM。
S6237	2-Ketoglutaric acid 2-Ketoglutaric acid (AKG, alpha-ketoglutarate, alpha-ketoglutaric acid, 2-oxoglutaric acid)是三羧酸循环中的关键分子，是该代谢过程的限速节点。在三羧酸循环中，2-Ketoglutaric acid脱羧基生成琥珀酰辅酶和二氧化碳。	Int J Biol Sci, 2021, 17(5):1250-1262 Front Cell Infect Microbiol, 2020, 10:599087
S4571	Hexylresorcinol Hexylresorcinol (4-Hexylresorcinol)是一种具有局部麻醉效果、抗菌和驱虫剂特性的有机化合物。是酪氨酸酶的有效抑制剂。hexylresorcinol对单酚酶的IC50为1.24 μM，对二酚酶的IC50值为0.85 μM。
S3166New	Calcium 2-oxoglutarate Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) 是2-oxoglutarate的钙盐形式。2-oxoglutarate 是自然存在于生物中的，是众所周知的在柠檬酸循环(Krebs cycle)中ATP或GTP产生的中间体。2-oxoglutarate 是 tyrosinase 的可逆抑制剂，其IC50值为15 mM。
S6272	Glycolic acid Glycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid)是一种果酸。由于它能很好地穿透皮肤，经常被用于护肤品中，用作美容换肤。
S2375	Aloin Aloin (Barbaloin, Barbalin) 是有效的酪氨酸酶抑制剂，作用于HeLaS3细胞，IC50为97 μM。	Cell Cycle, 2021, 10.1080/15384101.2021.1988227 Drug Des Devel Ther, 2020, 14:145-155 J Sci Food Agric, 2020, 10.1002/jsfa.10650
S2263	Arbutin Arbutin (Uva, p-Arbutin, β-Arbutin) 是一种酪氨酸酶 tyrosinase 抑制剂，对Monophenolase和Diphenolase的IC50值分别为0.9 mM 和 0.7 mM。	G3 (Bethesda), 2020, 4;10(5):1585-1597 Int J Mol Sci, 2017, 18(9)
S4739	Oxyresveratrol Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene)是从Morus alba L.发现的天然化合物，对酪氨酸酶的多巴氧化酶活性具有有效抑制作用，能催化黑色素生物合成的限速步骤。
S9284	Aloesin Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.
S4997	4-Butylresorcinol 4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.
S3691	4-Chlorosalicylic acid 4-Chlorosalicylic acid (4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid) 被用于混合稀土中对铽放入灵敏性荧光法测定以及利用甲醛缩合制备poly(4-chlorosalicylic acid-formaldehyde)中。
S9089	Magnoflorine Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.
S5174	Kojic acid Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.	Int J Mol Sci, 2017, 18(9)
S9111	Isorhamnetin Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.	Anat Rec (Hoboken), 2020, 10.1002/ar.24506
S9376	Benzylacetone Benzylacetone (4-Phenyl-2-butanone, Methyl 2-phenylethyl ketone) is an attractant compound in flowers.
S6221	Methyl cinnamate Methyl cinnamate 是花椒(Zanthoxylum armatum)的活性成分，是一种广泛使用的具有抗菌和 tyrosinase 抑制剂活性的天然香料化合物。Methyl cinnamate 通过激活3T3-L1前脂肪细胞中的 CaMKK2--AMPK 信号通路来抑制脂肪细胞分化。
S3783	Echinacoside Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions.	Naunyn Schmiedebergs Arch Pharmacol, 2020, 10.1007/s00210-020-02022-w

目录号	产品描述	文献引用	实验数据
S4921	MNS (3,4-Methylenedioxy-β-nitrostyrene) MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)是一种酪氨酸激酶抑制剂，抑制Syk， Src和p97， IC50分别为2.5 μM， 29.3 μM和1.7 μM。	J Biomol Struct Dyn,2019, 10.1080/07391102.2019.1640133 Phytomedicine,2019, 61:152859 Toxicol Res (Camb),2016, 5(1):188-196	WT mouse primary macrophages were untreated as control (lane 1) or treated with 0.1μg/ml E. coli LPS (lane 5-8), 10μM E-64 (lane 2 and 6), 250μM PMSF (lane 3 and 7), or 20μM MNS (lane 4 and 8). The cells were continuously cultured for 16 hrs. Extracts from whole cells or nuclei were separately purified and subjected to WB analysis with antibody against pERK2, LITAF, or actin/tubulin as control.
S1652	Monobenzone Monobenzone是一种外用药，用于治疗皮肤色素脱失。它能特异性地抑制tyrosinase。	Front Genet,2020, 11:1000
S4132	Deoxyarbutin DeoxyArbutin 是一种可逆的酪氨酸酶抑制剂,抑制酪氨酸酶活性，IC50为50 nM。
S6237	2-Ketoglutaric acid 2-Ketoglutaric acid (AKG, alpha-ketoglutarate, alpha-ketoglutaric acid, 2-oxoglutaric acid)是三羧酸循环中的关键分子，是该代谢过程的限速节点。在三羧酸循环中，2-Ketoglutaric acid脱羧基生成琥珀酰辅酶和二氧化碳。	Int J Biol Sci,2021, 17(5):1250-1262 Front Cell Infect Microbiol,2020, 10:599087
S4571	Hexylresorcinol Hexylresorcinol (4-Hexylresorcinol)是一种具有局部麻醉效果、抗菌和驱虫剂特性的有机化合物。是酪氨酸酶的有效抑制剂。hexylresorcinol对单酚酶的IC50为1.24 μM，对二酚酶的IC50值为0.85 μM。
S3166New	Calcium 2-oxoglutarate Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) 是2-oxoglutarate的钙盐形式。2-oxoglutarate 是自然存在于生物中的，是众所周知的在柠檬酸循环(Krebs cycle)中ATP或GTP产生的中间体。2-oxoglutarate 是 tyrosinase 的可逆抑制剂，其IC50值为15 mM。
S6272	Glycolic acid Glycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid)是一种果酸。由于它能很好地穿透皮肤，经常被用于护肤品中，用作美容换肤。
S2375	Aloin Aloin (Barbaloin, Barbalin) 是有效的酪氨酸酶抑制剂，作用于HeLaS3细胞，IC50为97 μM。	Cell Cycle,2021, 10.1080/15384101.2021.1988227 Drug Des Devel Ther,2020, 14:145-155 J Sci Food Agric,2020, 10.1002/jsfa.10650
S2263	Arbutin Arbutin (Uva, p-Arbutin, β-Arbutin) 是一种酪氨酸酶 tyrosinase 抑制剂，对Monophenolase和Diphenolase的IC50值分别为0.9 mM 和 0.7 mM。	G3 (Bethesda),2020, 4;10(5):1585-1597 Int J Mol Sci,2017, 18(9)
S4739	Oxyresveratrol Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene)是从Morus alba L.发现的天然化合物，对酪氨酸酶的多巴氧化酶活性具有有效抑制作用，能催化黑色素生物合成的限速步骤。
S9284	Aloesin Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.
S4997	4-Butylresorcinol 4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.
S3691	4-Chlorosalicylic acid 4-Chlorosalicylic acid (4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid) 被用于混合稀土中对铽放入灵敏性荧光法测定以及利用甲醛缩合制备poly(4-chlorosalicylic acid-formaldehyde)中。
S9089	Magnoflorine Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.
S5174	Kojic acid Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.	Int J Mol Sci,2017, 18(9)
S9111	Isorhamnetin Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.	Anat Rec (Hoboken),2020, 10.1002/ar.24506
S9376	Benzylacetone Benzylacetone (4-Phenyl-2-butanone, Methyl 2-phenylethyl ketone) is an attractant compound in flowers.
S6221	Methyl cinnamate Methyl cinnamate 是花椒(Zanthoxylum armatum)的活性成分，是一种广泛使用的具有抗菌和 tyrosinase 抑制剂活性的天然香料化合物。Methyl cinnamate 通过激活3T3-L1前脂肪细胞中的 CaMKK2--AMPK 信号通路来抑制脂肪细胞分化。

目录号	产品描述	文献引用	实验数据
S3783	Echinacoside Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions.	Naunyn Schmiedebergs Arch Pharmacol, 2020, 10.1007/s00210-020-02022-w