CRM1
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S7252 | Selinexor (KPT-330) | <1 mg/mL | 88 mg/mL | 40 mg/mL |
| S7125 | KPT-185 | <1 mg/mL | 71 mg/mL | 71 mg/mL |
| S7251 | KPT-276 | <1 mg/mL | 20 mg/mL | <1 mg/mL |
| S8397 | Eltanexor (KPT-8602) | <1 mg/mL | 85 mg/mL | 1 mg/mL |
| S7707 | Verdinexor (KPT-335) | <1 mg/mL | 88 mg/mL | 11 mg/mL |
| S7551 | Piperlongumine | <1 mg/mL | 16 mg/mL | 6 mg/mL |
- CRM1抑制剂（6）
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7252 |
Selinexor (KPT-330)Selinexor (KPT-330)是一种口服生物有效的选择性CRM1抑制剂。Phase 2。 |
Bortezomib and KPT330 enhance apoptosis in HCT116 and RKO cells. A, HCT116 and RKO cells were treated with bortezomib, KPT330, or their combination for 48 hours at the indicated concentrations. The cells were subsequently stained with Annexin V, apoptotic cells were distinguished by flow cytometric analysis. B, Measurement of caspase-3 and -7 by means of a luminometric assay was performed in cells receiving the same treatment. |
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| S7125 |
KPT-185KPT-185是一种有效的、具有选择性的CRM1抑制剂，可抑制一些NHL细胞的生长并诱导凋亡，IC50约为25 nM。 |
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| S7251 |
KPT-276KPT-276是一种口服生物有效的CRM1选择性抑制剂 |
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| S8397 |
Eltanexor (KPT-8602)Eltanexor(KPT-8602)是具有口服生物活性的XPO1 (CRM1)抑制剂。在AML细胞系，IC50范围为20-211 nM。 |
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| S7707 |
Verdinexor (KPT-335)Verdinexor（KPT-335）是一种口服生物可利用的，选择性XPO1/CRM1抑制剂。 |
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| S7551 |
PiperlonguminePiperlongumine，存在于胡椒科植物荜茇中的一种天然生物碱，能够增加reactive oxygen species (ROS)水平，并选择性杀死癌细胞。它还是TrxR1的直接抑制剂，对胃癌具有抑制活性；一种新型的CRM1抑制剂；在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。 |
a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. *P < 0.05; **P < 0.01; ***P < 0.001.
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