MAO

信号通路图

研究领域

抑制剂选择性比较

特异性亚型抑制剂

MAO产品

新MAO产品
产品目录 产品描述 文献引用 实验数据
S1472

Safinamide Mesylate

Safinamide Mesylate是Safinamide的甲磺酸盐,是一种选择性的且可逆的MAO-B抑制剂,IC50为98 nM,比作用于MAO-A选择性高5918倍。Phase 3。

S2102

Rasagiline Mesylate

Rasagiline Mesylate是一种新型MAO-B抑制剂,用于治疗突发性帕金森病。

S4246

Tranylcypromine (2-PCPA) HCl

Tranylcypromine (2-PCPA) HCl是一种非选择性的不可逆的单胺氧化酶(MAO)抑制剂,用作抗抑郁药和抗焦虑药。

S3212

Moclobemide (Ro 111163)

Moclobemide (Ro 111163)是一种MAO-A (5-HT)抑制剂,IC50为6.1 μM。

S4856

Iproniazid

Iproniazid是一种非选择性的、不可逆的MAO抑制剂,具有抗抑郁活性。

S6602New

TB5

TB5是一种有效的、选择性MAO-B抑制剂,对MAO-B和MAO-A的Ki值分别为110 nM和1450 nM。

S6462New

Amezinium (methylsulfate)

Amezinium是一种拟交感药物,在治疗低血压中具有给血管加压的作用。它是一种MAO抑制剂,拮抗对酪胺的反应活性、阻止神经元对去甲肾上腺素的摄取。

S6422New

Lazabemide

Lazabemide是可逆性、选择性MAO-B抑制剂,Ki值为7.9 nM。

S5795New

Rasagiline

Rasagiline是一种选择性的、不可逆的MAO-B炔丙胺抑制剂,对MAO-B和MAO-A的IC50分别为4.43 nM和412 nM。

S9464New

Tranylcypromine Sulfate

Tranylcypromine是不可逆型单胺氧化酶 (MAO)抑制剂。

S5663New

Minaprine dihydrochloride

Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.

S5357

Safinamide

Safinamide is an orally active, selective, reversible monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. The IC50 value of safinamide for MAO-B is 98 nM.

S4033

Sennoside A

Sennoside A,一种从大黄根茎中分离得到的刺激性泻药,在肠道中引起通便作用。

S2302

Glycyrrhizin (Glycyrrhizic Acid)

Glycyrrhizin (Glycyrrhizic Acid)是一种直接的高迁移率族蛋白1(HMGB1)的抑制剂,抑制依赖于HMGB1的炎症分子表达和氧化应激反应。调节p38和p-JNK信号通路,而不影响p-ERK信号通路。同时也能抑制11 beta-hydroxysteroid dehydrogenase

S3690

Pargyline hydrochloride

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.

S2339

Paeonol

Paeonol是从中草药牡丹皮和Cynanchum paniculatum中提取的主要成分。

S3868

Harmine

Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression through inhibition of the Wnt signaling pathway. It also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but not the variant MAO-B.

S4717

Isatin

Isatin是一种有效的、内源性的MAO抑制剂,IC50为15 μM。它对MAO-B比对MAO-A更有活性。

产品目录 产品描述 文献引用 实验数据
S1472

Safinamide Mesylate

Safinamide Mesylate是Safinamide的甲磺酸盐,是一种选择性的且可逆的MAO-B抑制剂,IC50为98 nM,比作用于MAO-A选择性高5918倍。Phase 3。

S2102

Rasagiline Mesylate

Rasagiline Mesylate是一种新型MAO-B抑制剂,用于治疗突发性帕金森病。

S4246

Tranylcypromine (2-PCPA) HCl

Tranylcypromine (2-PCPA) HCl是一种非选择性的不可逆的单胺氧化酶(MAO)抑制剂,用作抗抑郁药和抗焦虑药。

S3212

Moclobemide (Ro 111163)

Moclobemide (Ro 111163)是一种MAO-A (5-HT)抑制剂,IC50为6.1 μM。

S4856

Iproniazid

Iproniazid是一种非选择性的、不可逆的MAO抑制剂,具有抗抑郁活性。

S6602New

TB5

TB5是一种有效的、选择性MAO-B抑制剂,对MAO-B和MAO-A的Ki值分别为110 nM和1450 nM。

S6462New

Amezinium (methylsulfate)

Amezinium是一种拟交感药物,在治疗低血压中具有给血管加压的作用。它是一种MAO抑制剂,拮抗对酪胺的反应活性、阻止神经元对去甲肾上腺素的摄取。

S6422New

Lazabemide

Lazabemide是可逆性、选择性MAO-B抑制剂,Ki值为7.9 nM。

S5795New

Rasagiline

Rasagiline是一种选择性的、不可逆的MAO-B炔丙胺抑制剂,对MAO-B和MAO-A的IC50分别为4.43 nM和412 nM。

S9464New

Tranylcypromine Sulfate

Tranylcypromine是不可逆型单胺氧化酶 (MAO)抑制剂。

S5663New

Minaprine dihydrochloride

Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.

S5357

Safinamide

Safinamide is an orally active, selective, reversible monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. The IC50 value of safinamide for MAO-B is 98 nM.

S4033

Sennoside A

Sennoside A,一种从大黄根茎中分离得到的刺激性泻药,在肠道中引起通便作用。

S2302

Glycyrrhizin (Glycyrrhizic Acid)

Glycyrrhizin (Glycyrrhizic Acid)是一种直接的高迁移率族蛋白1(HMGB1)的抑制剂,抑制依赖于HMGB1的炎症分子表达和氧化应激反应。调节p38和p-JNK信号通路,而不影响p-ERK信号通路。同时也能抑制11 beta-hydroxysteroid dehydrogenase

S3690

Pargyline hydrochloride

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.

S2339

Paeonol

Paeonol是从中草药牡丹皮和Cynanchum paniculatum中提取的主要成分。

S3868

Harmine

Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression through inhibition of the Wnt signaling pathway. It also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but not the variant MAO-B.

S4717

Isatin

Isatin是一种有效的、内源性的MAO抑制剂,IC50为15 μM。它对MAO-B比对MAO-A更有活性。