Lamivudine (BCH-189)

For research use only. Not for use in humans.

目录号:S1706 别名: GR109714X 中文名称:拉米夫定, 拉美呋定, 拉米呋啶

Lamivudine (BCH-189) Chemical Structure

CAS No. 134678-17-4

Lamivudine (BCH-189, GR109714X)是一种有效的核苷类似物逆转录酶抑制剂,用于治疗慢性乙肝和艾滋病。它主要是通过阻滞HIV逆转录酶乙肝病毒聚合酶发挥其作用。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1054.87 现货
RMB 647.01 现货
RMB 1521.26 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Lamivudine (BCH-189)发表文献9篇:

客户使用该产品的1个实验数据:

  • The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.

    Oncotarget, 2017, 8(15):24694-24705. Lamivudine (BCH-189) purchased from Selleck.

产品安全说明书

Reverse Transcriptase抑制剂选择性比较

生物活性

产品描述 Lamivudine (BCH-189, GR109714X)是一种有效的核苷类似物逆转录酶抑制剂,用于治疗慢性乙肝和艾滋病。它主要是通过阻滞HIV逆转录酶乙肝病毒聚合酶发挥其作用。
靶点
Reverse transcriptase [1]
体外研究

Lamivudine具有特异的抗脱氧胞苷激酶的活性,HBV聚合酶的非天然的L-构型的dNTP的不寻常的底物,而PCV的抗HBV活性似乎取决于几个因素,包括最佳磷酸(足够抗病毒活性,但不杀伤)由密钥细胞酶,PCV-TP的细胞内半衰期和PCV-TP的能力,抑制乙肝病毒的RT吸反应以及RT和DNA聚合酶活性。[1] Lamivudine和Penciclovir抑制鸭乙型肝炎病毒(DHBV)的复制,与单独使用时的效果类似,两个核苷类似物在很宽的范围内的临床相关浓度具有协同作用。Lamivudine和Penciclovir联用比单独两种药物更有效地减少DHBV的常顽固病毒共价闭合环状(CCC)DNA的形式。[2]在PBMC 中,Lamivudine抑制HIV-I产生的p24抗原产量,ED50s从0.07 μM到0.2 μM。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MT-4 NYiyPVhTTnWwY4Tpc44h[XO|YYm= M2jlVWNwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDzfY51cWOjIH\vdo1ifGmxbjDifUA2OCViaX6gTGlXNTFiaX7m[YN1\WRiTWStOEBk\WyuczygTWM2OD1yLkJOwG0> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85ODN3NEK5K|45ODN3NEK5QE9iRg>?
PBMC M3LCRWZ2dmO2aX;uJIF{e2G7 NXuyToNSS2:wY3XueJJifGmxbjDy[ZF2cXKnZDDmc5Ih[W62aY\pdoFtKGGldHn2bZR6KGmwIGDCUWMhMGi3bXHuJJBmemmyaHXyZYwh[myxb3SgcY9vd263Y3zlZZIh[2WubIOpJIlv\mWldHXkJJdqfGhiSFnWMVEhe3S{YXnuJGxCXixiRVO1NF0xNjByMUlOwG0> MmT3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDRzMEm3OUc,QDRzMEm3OVww[T5?
PBMC NEH2NmpHfW6ldHnvckBie3OjeR?= NH\yZ5FEd26lZX70doF1cW:wIILldZVqemWmIH\vdkBidnSrdnnyZYwh[WO2aY\peJkhcW5iUFLNR{ApcHWvYX6gdIVzcXCqZYLhcEBjdG:xZDDtc45wdnWlbHXhdkBk\WyuczmgbY5n\WO2ZXSge4l1cCCKSW[tNUB{fHKjaX6gUGFXNCCHQ{WwQVAvOjIQvF2= NUXhWGszRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOESxNFk4PSd-OESxNFk4PTxxYU6=
PBMC NGGzOXVCdnSrLVjJWk0yKGG|c3H5 MUjBcpRqNUiLVj2xJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjCoVGJOMSClZXzsd{Bqdm[nY4Tl[EB4cXSqIFjJWk0yKHO2cnHpckBNSVZuIFXDOVA:OC5yMEG4{txO M1y5dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh2MkO1PVEoRjh2MkO1PVE9N2F-
PBMC NE\3e5hCdnSrLVjJWk0yKGG|c3H5 M1LNN2FvfGlvSFnWMVEh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJEhRSk1rIHPlcIx{KGmwZnXjeIVlKHerdHigTGlXNTFic4TyZYlvKEyDVjygSWM2OD1yLkC2{txO NVf3XYVPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOESyN|U6OSd-OESyN|U6OTxxYU6=
PBMC M2LQb2FvfGlvSFnWMVEh[XO|YYm= MULBcpRqNUiLVj2xJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjCoVGJOMSClZXzsd{Bqdm[nY4Tl[EB4cXSqIFjJWk0yKHO2cnHpckBNSVZuIFXDOVA:OC5{Md88US=> NHnRW4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96NEKzOVkyLz56NEKzOVkyRC:jPh?=
PBMC MmSzRY51cS2KSW[tNUBie3OjeR?= NFfy[JJCdnSrLVjJWk0yKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gdIVzcXCqZYLhcEBjdG:xZDDtc45wdnWlbHXhdkApWEKPKTDj[YxteyCrbn\lZ5Rm\CC5aYToJGhKXi1zIIP0doFqdiCOQW[sJGVEPTB;MUCuNe69VQ>? NYXncoFORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOESyN|U6OSd-OESyN|U6OTxxYU6=
2.2.15 M{HteGZ2dmO2aX;uJIF{e2G7 MoXiTY4hfmm2cn:g[YZn\WO2aY\lJINwdmOnboTyZZRqd25iYXfhbY5{fCCqZYDheIl1cXNiQjD2bZJ2eyC5YYOg[IV1\XKvaX7l[EBqdiB{LkKuNVUh[2WubIOsJGVEPTB;MD6wNFjPxE1? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86OzBzNkW5K|46OzBzNkW5QE9iRg>?
PBMC MnizRY51cS2KSW[tNUBie3OjeR?= M{\QUmlvKH[rdILvJIFvfGlvSFnWJIFkfGm4aYT5JIlvKHCncnnwbIVz[WxiYnzvc4QhdW:wb371Z4xm[XJiY3XscJMtKEWFNUC9NE4xP87:TR?= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86OzBzNkW5K|46OzBzNkW5QE9iRg>?
2.2.15 NInjSWVCdnSrdnnyZYwh[XO|YYm= M2H2Z2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmeGG2aYTpd{BDKH[rcoXzJEhJSlZrIHnuJFIvOi5zNTDj[YxteyxiRVO1NF0xNjByON88US=> M4O1O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEWyO|k2Lz5zMUC1Nlc6PTxxYU6=
PBMC MlvJRY51cX[rcnHsJIF{e2G7 M4mzdmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGludXWwb3Tl[olkcWWwY4mgeolzfXNidInw[U0yKCiKSW[tNUkhcW5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjDj[YxteyxiRVO1NF0xNjB5zszN M3LWTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEWyO|k2Lz5zMUC1Nlc6PTxxYU6=
H9 NUnEOWhJSW62aY\pdoFtKGG|c3H5 NV;yTVhYSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTCzRkBqdiCqdX3hckBJQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYomg[o9zdWG8YX6tZoF{\WRiY3;ueoVvfGmxbnHsJINwdG:{aX3leJJq[yC2ZXPocolyfWVuIFXDOVA:OC5yNt88US=> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTR|MECxPUc,OTF2M{CwNVk9N2F-
H9 MkLBRY51cX[rcnHsJIF{e2G7 MkDTRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSCURjDpckBpfW2jbjDIPUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[nliZn;ycYF7[W5vYnHz[YQh[2:wdnXueIlwdmGuIHPvcI9zcW2ndILpZ{B1\WOqbnnxeYUtKEWFNUC9NE4xPs7:TR?= M3PERlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNEOwNFE6Lz5zMUSzNFAyQTxxYU6=
PBMC MmrvRY51cX[rcnHsJIF{e2G7 NUHid|FISW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYLUH4fGJTXSCvdYThcpQhe3S{YXnuJIlvKGi3bXHuJHBDVSClZXzsd{whTUN7ME2wMlA5|ryP NEGwVIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkO4N|AyPCd-MUKzPFMxOTR:L3G+
PBMC NVPCbVlJTnWwY4Tpc44h[XO|YYm= NVnmOHV1SWO2aY\peJkh[WejaX7zeEBN[W2rdoXkbY5mNXKnc3nzeIFvfCC4aYL1d{ApUEmYLUHYXGJTXSliaX6gbJVu[W5iUFLNJINmdGy|LDDlfJBz\XO|ZXSgZZMhTUN3MDygSWM2OD1yLkCzOe69VQ>? NXHOb5c5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK4OVI4PTVpPkGyPFUzPzV3PD;hQi=>
PBMC MWrGeY5kfGmxbjDhd5NigQ>? Mn7nTY4hfmm2cn:gZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDpcohq[mm2IITo[UBJUVZvMTDMRVEhemWybHnjZZRqd25ib36gVGJOS3NiY3XscEApeGW{aYDo[ZJidCCkbH;v[EBud26xboXjcIVieiClZXzsd{ktKEWFNUC9NE4xOc7:TR?= NFnwVJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMki1Nlk1Oyd-MUK4OVI6PDN:L3G+
PBMC MV3GeY5kfGmxbjDhd5NigQ>? MnnOSYZn\WO2aY\lJINwdmOnboTyZZRqd25idH:gbY5pcWKrdDDITXYuOSCOQVmgZ5l1d3CjdHjpZ4l1gSCrbjDQRm1EKGOnbHzzJJdieyCmZYTldo1qdmWmIHnuJJZqfHKxLDDFR|UxRTBwMEGxOu69VQ>? MofwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR7N{G4PVgoRjF2OUexPFk5RC:jPh?=
HepG2.2.15 M1S4XmZ2dmO2aX;uJIF{e2G7 NXKyWXh2TW[oZXP0bZZmKGOxbnPlcpRz[XSrb36geI8hcW6qaXLpeEBp\XCjdHn0bZMhSiC4aYL1d{BkgXSxcHH0bIlkcXS7IHnuJGhmeEd{LkKuNVUh[2WubIOge4F{KGSndHXycYlv\WRiaX6geol1em9uIFXDOVA:OC5{zszN NVfqeGhORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS5O|E5QThpPkG0PVcyQDl6PD;hQi=>
MT-4 MlnjSpVv[3Srb36gZZN{[Xl? M1zoVGVn\mWldHn2[UBkd26lZX70doF1cW:wIITvJIlvcGmkaYSgTGlXNTFiSVnJRkBkgXSxcHH0bIlkcXS7IHnuJG1VNTRiY3XscJMhf2G|IHTleIVzdWmwZXSgbY4hfmm2cn:sJGVEPTB;MD61{txO NHHQc2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEm3NVg6QCd-MUS5O|E5QTh:L3G+
PBMC MUXBcpRqfmm{YXygZZN{[Xl? M375VWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJUVZidnnyeZMpgHiEUmWpJIlvKEi3bXHuJJBmemmyaHXyZYwh[myxb3SgcY9vd263Y3zlZZIhMFCETTmgZ4VtdHNuIFXDPVA:OC5yON88US=> M{PMT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MEK3PFU1Lz5zNUCyO|g2PDxxYU6=
PBMC MoX6SpVv[3Srb36gZZN{[Xl? M1n6OmVn\mWldHn2[UBkd26lZX70doF1cW:wIHHnZYlve3RiV3ns[EBVgXCnIFjJWk0yKH[rcoXzJIlvKGi3bXHuJJBmemmyaHXyZYwh[myxb3SgcY9vd263Y3zlZZIh[2WubIOsJGVEPTB;MD6wOFHPxE1? MoHpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVzOEmwN|YoRjF3MUi5NFM3RC:jPh?=
CEM-SS NITH[VlCdnSrdnnyZYwh[XO|YYm= MnzrOkBl[Xm| MWnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKDOEIHnu[oVkfGWmIHnuJIh2dWGwIFPFUU1UWyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhPiCmYYnzJIJ6KE2WUzDhd5NigSxiRVS1NF0xNjN4zszN M3;YR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MkG3NlgyLz5zNUKxO|I5OTxxYU6=
HOG.R5 MlznRY51cX[rcnHsJIF{e2G7 NVGxXFFwPCCmYYnz M{DnVWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiM1KgbY5n\WO2ZXSgbY4hcHWvYX6gTG9INlJ3IHPlcIx{KGGodHXyJFQh\GG7czygTWM2OD1zLkNOwG0> NWDl[XBWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWyNVczQDFpPkG1NlE4OjhzPD;hQi=>
2.2.15 M1myUmZ2dmO2aX;uJIF{e2G7 MWXJcohq[mm2aX;uJI9nKEiEVjDy[ZBtcWOjdHnvckBqdiB{LkKuNVUh[2WubIOgZpkhTE6DIHj5ZpJq\Gm8YYTpc44h[XO|YYmsJGVEPTB;MD6wNu69VQ>? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZzNUW0OUc,OTV4MUW1OFU9N2F-
2.2.15 NG\VboNHfW6ldHnvckBie3OjeR?= MkX2SYZn\WO2aY\lJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDo[ZBifGm2aYOgRkB3cXK3czDy[ZBtcWOjdHnvckBqdiB{LkKuNVUh[2WubIOgbY4hTE6DIHj5ZpJq\Gm8YYTpc44h[XO|YYmsJGVEPTB;MD6wOe69VQ>? M3fwWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkO0NFA{Lz5zNU[zOFAxOzxxYU6=
PBMC MlfOSpVv[3Srb36gZZN{[Xl? MUHJckB3cXS{bzDl[oZm[3SrdnWgZ49v[2WwdILheIlwdiCjZ3HpcpN1KEyjbXn2eYRqdmVicnXzbZN1[W62IIfpcIQhfHmyZTDITXYuOSCrbjDoeY1idiCyZYLpdIhmemGuIHLsc49lKG2xbn;ueYNt\WG{IHPlcIx{NCCHQ{WwQVAvODJ5zszN NULPeGFCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW5NVY1OjVpPkG1PVE3PDJ3PD;hQi=>
PBMC MofrSpVv[3Srb36gZZN{[Xl? NWnMbGFIUW5idnn0do8h\W[oZXP0bZZmKGOxbnPlcpRz[XSrb36gZYdicW6|dDDMZY1qfnWmaX7lJJJme2m|dHHueEB4cWymIIT5dIUhUEmYLUGgbY4hcHWvYX6gdIVzcXCqZYLhcEBjdG:xZDDtc45wdnWlbHXhdkBk\WyuczygSWM6OD1yLkK1{txO MlPYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV7MU[0NlUoRjF3OUG2OFI2RC:jPh?=
2.2.15 Mn;nSpVv[3Srb36gZZN{[Xl? MlPSSYZn\WO2aY\lJINwdmOnboTyZZRqd26|IHH0JJdpcWOqIEKt[o9t\CCmZYDy[ZN{cW:wIH;mJIV5fHKjY3XscJVt[XJidnnybY9vKESQQTCoTGJXMSC5YYOgc4J{\XK4ZXSgbY4hOi5{LkG1JGNmdGy|LDDFR|UxRTBwMEdOwG0> MmjEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZyM{OyPFMoRjF4MEOzNlg{RC:jPh?=
2.2.15 NYTVeotZTnWwY4Tpc44h[XO|YYm= MlWwSYZn\WO2aY\lJINwdmOnboTyZZRqd26|IHH0JJdpcWOqIEKt[o9t\CCmZYDy[ZN{cW:wIH;mJIV5fHKjY3XscJVt[XJidnnybY9vKESQQTCoTGJXMSC5YYOgc4J{\XK4ZXSgbY4hOi5{LkG1JGNmdGy|LDDFR|kxRTBwMUhOwG0> M{KyNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MEOzNlg{Lz5zNkCzN|I5OzxxYU6=
2.2.15 MlftSpVv[3Srb36gZZN{[Xl? NV\sbJNjTW[oZXP0bZZmKGOxbnPlcpRz[XSrb37zJIF1KHeqaXPoJFExNW[xbHSg[IVxemW|c3nvckBw\iCrboTyZYNmdGy3bHHyJIlvfGW{bXXkbYF1\XNib3[gTGJXKESQQTD3ZZMhd2K|ZYL2[YQhcW5iMj6yMlE2KEOnbHzzMEBGSzVyPUCuNlPPxE1? MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjB|M{K4N{c,OTZyM{OyPFM9N2F-
2.2.15 Mm\SSpVv[3Srb36gZZN{[Xl? M3q2S2Vn\mWldHn2[UBkd26lZX70doF1cW:wczDheEB4cGmlaDCxNE1nd2ymIHTldJJme3Orb36gc4YhcW62cnHj[YxtfWyjcjDpcpRmem2nZHnheIV{KG:oIFjCWkBFVkFid3HzJI9je2W{dnXkJIlvKDJwMj6xOUBE\WyuczygSWM6OD1yLk[5{txO NWHZTFVNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[wN|MzQDNpPkG2NFM{Ojh|PD;hQi=>
2.2.15 MnfISpVv[3Srb36gZZN{[Xl? M3jrVGlvcGmkaYTpc44hd2Zic4nueIhme2m|IH;mJIV5fHKjY3XscJVt[XJidnnybY9vKESQQTDy[Yxm[XOnIHnuJIN2dHS3cnXkJIh2dWGwIHjldIF1d2KuYYP0c41iKDJwMj6xOUBk\WyuczygSWM2OD1yLkC0PO69VQ>? NX3oWFRNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[yNVM4OTNpPkG2NlE{PzF|PD;hQi=>
2.2.15 NYDQWY9ZTnWwY4Tpc44h[XO|YYm= NUDXVXN[UW6qaXLpeIlwdiCxZjDzfY51cGW|aYOgc4Yh\Xi2cnHj[YxtfWyjcjD2bZJqd25iRF7BJJJmdGWjc3WgbY4h[3WudIXy[YQhcHWvYX6gbIVx[XSxYnzhd5RwdWFiMj6yMlE2KGOnbHzzMEBGSzlyPUCuNVUy|ryP MoWxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ{MUO3NVMoRjF4MkGzO|E{RC:jPh?=
2.2.15 MkHhSpVv[3Srb36gZZN{[Xl? NIrZclFKdmirYnn0bY9vKG:oIIP5cpRp\XOrczDv[kBqdnS{YXPlcIx2dGG{IFjCWkBFVkFicnXwcIlk[XSrdnWgbY51\XKvZXTpZZRmeyCrbjDjeYx1fXKnZDDoeY1idiCqZYDheI9jdGG|dH;tZUAzNjJwMUWgZ4VtdHNuIFXDOVA:OC5{NUJOwG0> M2jEXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MkGzO|E{Lz5zNkKxN|cyOzxxYU6=
2.2.15 Ml;ISpVv[3Srb36gZZN{[Xl? NEH5bVlKdmirYnn0bY9vKG:oIIP5cpRp\XOrczDv[kBqdnS{YXPlcIx2dGG{IFjCWkBFVkFicnXwcIlk[XSrdnWgbY51\XKvZXTpZZRmeyCrbjDjeYx1fXKnZDDoeY1idiCqZYDheI9jdGG|dH;tZUAzNjJwMUWgZ4VtdHNuIFXDPVA:OC54NElOwG0> NV\WfnlVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[yNVM4OTNpPkG2NlE{PzF|PD;hQi=>
2.2.15 NHL4WplHfW6ldHnvckBie3OjeR?= M1T6N2lvcGmkaYTpc44hd2Zid3ns[EB1gXCnIFjCWkB1emGwc3\lZ5Rm\CCrbjDoeY1idiCqZYDheI9jdGG|dH;tZUAzNjJwMUWgZ4VtdHNuIFXDOVA:Oi5zzszN MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO5N{c,OTZ3M{mzPVM9N2F-
hepatoma 2.2.15 MnPDRY51cX[rcnHsJIF{e2G7 M{HtUGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJSlZiaX6gbJVu[W5iaHXwZZRwdWFiMj6yMlE2KGOnbHzzMEBGSzVyPUKuNe69VQ>? NI[5XYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNke1PVEyOid-MU[3OVkyOTJ:L3G+
2.2.15 NX6wdXp1TnWwY4Tpc44h[XO|YYm= NX7Oc4l[UW6qaXLpeIlwdiCxZjDIRnYhemWybHnjZZRqd25iaX6gNk4zNjF3IHPlcIx{KGK7IFTORUBpgWK{aXTpfoF1cW:wIHHzd4F6NCCHQ{WwQVAvODMQvF2= NG\jXVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{CwOFczPid-MUewNFQ4OjZ:L3G+
MDCK2 MlrESpVv[3Srb36gZZN{[Xl? NWLtN|liOTBidV2= NFWwS2tKdmirYnn0bY9vKG:oIHj1cYFvKE2UUEKg[ZhxemW|c3XkJIlvKE2GQ1uyJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGmwdILhZ4VtdHWuYYKgR21HKG[udX;y[ZNk\W6lZTDheEAyOCC3TTDifUBEVU[GQTDhd5NigQ>? M16zVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUeyN|EyLz5zN{G3NlMyOTxxYU6=
MDCK2 NWjnbHhpTnWwY4Tpc44h[XO|YYm= M4DvcVExKHWP Ml7QTY5pcWKrdHnvckBw\iCqdX3hckBOWlB|IHX4dJJme3OnZDDpckBOTEONMjDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBqdnS{YXPlcIx2dGG{IFPNSkBndHWxcnXzZ4Vv[2ViYYSgNVAhfU1iYomgR21HTEFiYYPzZZk> M4H6TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUeyN|EyLz5zN{G3NlMyOTxxYU6=
MDCK2 MX7GeY5kfGmxbjDhd5NigQ>? MUSxNEB2VQ>? NVnQb3lTUW6qaXLpeIlwdiCxZjDoeY1idiCPUmCxJIV5eHKnc4Pl[EBqdiCPRFPLNkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJGNOTiCobIXvdoV{[2WwY3WgZZQhOTBidV2gZpkhS02IRFGgZZN{[Xl? Ml3zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzN{KzNVEoRjF5MUeyN|EyRC:jPh?=
Huh7 MYDGeY5kfGmxbjDhd5NigQ>? NX3TbVlYUW6qaXLpeIlwdiCxZjD3bYxlKHS7cHWgTGJXKHKncHzpZ4F1cW:wIHnuJGh2cDdiY3XscJMtKEWFNUC9Ne69VQ>? Ml;nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|N{G4NlcoRjF5M{exPFI4RC:jPh?=
PBMC NH3OZ4dCdnSrdnnyZYwh[XO|YYm= M{SzVWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiTFHJJIlvKGi3bXHuJHBDVSClZXzsd{whTUN3ME2wMlAzPs7:TR?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRyM{m5Okc,OTd2MEO5PVY9N2F-
PBMC M373cmFvfGm4aYLhcEBie3OjeR?= NYrYRXNwSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDMRWkhcW5iaIXtZY4hWEKPIHPlcIx{NCCHQ{mwQVAvOTMQvF2= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRyM{m5Okc,OTd2MEO5PVY9N2F-
HepG2.2.15 M4rPc2FvfGm4aYLhcEBie3OjeR?= Mm[4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwIFjldGczNjJwMUWgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h\Xi2cnHj[YxtfWyjcjD2bZJidCCGTlGgcIV3\WxiYomgVnQuWEOULDDFR|UxRTBwMd88US=> M1X0bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEC0NFA3Lz5zN{SwOFAxPjxxYU6=
Huh7 M3vuNGFvfGm4aYLhcEBie3OjeR?= NGXITFU2KGSjeYO= NGnD[JdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiZ3Xuc5R6eGViRDD3bZRpKHKndnXyd4UhfHKjboPjdolxfGG|ZTDMPFBKKG23dHH0bY9vKGmwIHj1cYFvKEi3aEegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjZoTldkA2KGSjeYOsJGVEPTB;MD6wN:69VQ>? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR|OEC0O{c,OTd2M{iwOFc9N2F-
Huh7 NHW0epJCdnSrdnnyZYwh[XO|YYm= NUX4S3g1PSCmYYnz M3jxc2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhD\UGpLXTl[olkcWWwdDDIRnYh\2Wwb4T5dIUhTCC5aYToJJBz\WOxcnWgS|E5QT[DIH31eIF1cW:wIHHu[EBz\X[ncoPlJJRz[W6|Y4LpdJRie2ViTEiwTUBufXSjdHnvckBqdiCqdX3hckBJfWh5IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[W[2ZYKgOUBl[Xm|LDDFR|UxRTBwMEROwG0> M{OycVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEO4NFQ4Lz5zN{SzPFA1PzxxYU6=
Huh7 NI[0fWhCdnSrdnnyZYwh[XO|YYm= MlHBOUBl[Xm| MoTtRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGenbn;0fZBmKERiaX6gbJVu[W5iSIXoO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDViZHH5d{whTUN3ME2wMlQy|ryP MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR|OEC0O{c,OTd2M{iwOFc9N2F-
Huh7 M1rVeGFvfGm4aYLhcEBie3OjeR?= NELNZpQ2KGSjeYO= MUXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRoVC\y2mZX\pZ4lmdnRiSFLWJIdmdm:2eYDlJGQhf2m2aDDwdoVkd3KnIFexPFk3SSCvdYTheIlwdiCrbjDoeY1idiCKdXi3JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhPSCmYYnzMEBGSzVyPUCuOFbPxE1? NHiwPYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SzPFA1Pyd-MUe0N|gxPDd:L3G+
HepG2(2.2.15) NXqyWpB4SW62aY\pdoFtKGG|c3H5 MmfuRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwIHH5e{B4cWymIIT5dIUhUGWyR{KoNk4zNjF3KTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJGRPSSC{ZYDsbYNifGmxbjygTWM2OD1yLkC1{txO MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR6OEixO{c,OTd2OEi4NVc9N2F-
HepG2(2.2.15) NWD2dldjTnWwY4Tpc44h[XO|YYm= MYHJcohq[mm2aX;uJI9nKEiEVjDwdo9ud3SncjDpckBpfW2jbjDI[ZBIOih{LkKuNVUqKGOnbHzzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OD1yLkC4{txO NYfsSGJyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PFg5OTdpPkG3OFg5QDF5PD;hQi=>
HepW10 NHTiVXRCdnSrdnnyZYwh[XO|YYm= MYrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW5iYXTybYFugWOrbj3y[ZNqe3SjboSge4lt\CC2eYDlJGhmeFdzMDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJGRPSSC{ZYDsbYNifGmxbjygTWM2OD1yLkJOwG0> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR6OEixO{c,OTd2OEi4NVc9N2F-
HBV-Met NFjvdJhCdnSrdnnyZYwh[XO|YYm= M3zUN2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbjDtc5V{\SCjeYege4lt\CC2eYDlJGhDXi2PZYSgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBFVkFicnXwcIlk[XSrb36sJGlEPTB;MD6y{txO MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR6OEixO{c,OTd2OEi4NVc9N2F-
HepG2.2.15 MojkSpVv[3Srb36gZZN{[Xl? NX;sWFdxQCCmYYnz M4rk[WlvcGmkaYTpc44hd2ZiY4n0c5Bt[XOvaXOgTGJXKESQQTDzfY51cGW|aYOgbY4hUGWyR{KuNk4yPSClZXzsd{Bi\nSncjC4JIRigXNuIFnDOVA:OC5|ON88US=> NGLPOIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S5PVg5QSd-MUe0PVk5QDl:L3G+
PBMC NUnKcXBlTnWwY4Tpc44h[XO|YYm= NXLqR|BJOzByIH3n M2Lod|ch\GG7cx?= MULDcYF5KGmwIFjJWk1qdm[nY4Tl[EBpfW2jbjDhd5Nme3OnZDDhd{BN[W2rdoXkbY5mKG2xbn;wbI9{eGijdHWgcIV3\WxiaX6gVGJOSyCjdDCzNFAhdWdiUVSg[o9zKDdiZHH5d{Bu\WG|dYLl[EBx\XJiMUCnOkBk\WyuczDpckBxemW|ZX7j[UBw\iC8aXTvepVlcW6nLDDDcYF5RTBwMECwNFAxQM7:TR?= NEDWXXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[2OFMzQCd-MUe2OlQ{Ojh:L3G+
PBMC M2fwfGZ2dmO2aX;uJIF{e2G7 NITRNVg{ODBibXe= NGrU[Xo4KGSjeYO= NYryOVd1S22jeDDpckBJUVZvaX7m[YN1\WRiaIXtZY4h[XO|ZYPz[YQh[XNiTHHtbZZ2\GmwZTDkbZBpd3OyaHH0[UBt\X[nbDDpckBRSk2FIHH0JFMxOCCvZzDRSEBnd3JiNzDkZZl{KG2nYYP1doVlKHCncjCxNEc3KGOnbHzzJIlvKHC{ZYPlcoNmKG:oIIrp[I93fWSrbnWsJGNu[Xh;MD6wNFAxODR2zszN MkjtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4NkSzNlgoRjF5Nk[0N|I5RC:jPh?=
PBMC MXXGeY5kfGmxbjDhd5NigQ>? NH\zZYI{ODBibXe= NVjYT29nPyCmYYnz MoTQR41igCCrbjDITXYucW6oZXP0[YQhcHWvYX6gZZN{\XO|ZXSgZZMhVGGvaY\1[Ilv\SC2cnnwbI9{eGijdHWgcIV3\WxiaX6gVGJOSyCjdDCzNFAhdWdiUVSg[o9zKDdiZHH5d{Bu\WG|dYLl[EBx\XJiMUCnOkBk\WyuczDpckBxemW|ZX7j[UBw\iC8aXTvepVlcW6nLDDDcYF5RTBwMECwNFA1QM7:TR?= NXXVNlZYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2OlQ{OjhpPkG3OlY1OzJ6PD;hQi=>
MAGIC-5A M1HTWGFvfGm4aYLhcEBie3OjeR?= MUS0NEBpenN? MYjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGlXOSCQTEStN{Bxem:mdXPl[EBnem:vIH\1cIwhdGWwZ4ToJJBTQWSnbIThRZBiKGmwZnXjeIVlKGmwIHj1cYFvKE2DR1nDMVVCKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gUIFkMyCob3PpJIV5eHKnc4Ppc44h[W[2ZYKgOFAhcHK|LDDFR|UxRTBwOElOwG0> MlnHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7Nke5NVMoRjF5OU[3PVE{RC:jPh?=
MAGIC-5A NITnSZFCdnSrdnnyZYwh[XO|YYm= M3\5clQxKGi{cx?= NXr1bJlXSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiLVkKgVm9FKHC{b3T1Z4VlKG[{b32g[pVtdCCuZX7neIgheFKRREmgbY5n\WO2ZXSgbY4hcHWvYX6gUWFIUUNvNVGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCOYXOrJIZw[2liZYjwdoV{e2mxbjDh[pRmeiB2MDDodpMtKEWFNUC9Nu69VQ>? M1\0VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OU[3PVE{Lz5zN{m2O|kyOzxxYU6=
MAGIC-5A MnG4RY51cX[rcnHsJIF{e2G7 NH;DU4k1OCCqcoO= MX7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDteYx1cW63Y3zlc5Nq\GVvcnXzbZN1[W62IFjJWlEhVkx2LUOgbIFz[m:{aX7nJGE3OlZuIG[3OWktKEZ5N1ysJGYyOT[\LDDRNVUyVSCvdYTheIlwdiCrbjD2bZJidCC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgbY5n\WO2ZXSgbY4hcHWvYX6gUWFIUUNvNVGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCOYXOrJIZw[2liZYjwdoV{e2mxbjDh[pRmeiB2MDDodpMtKEWFNUC9N{44|ryP NILIT4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m2O|kyOyd-MUe5Olc6OTN:L3G+
PBMC Ml\SRY51cX[rcnHsJIF{e2G7 MoG5NUBpeg>? MnjwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSC|dXL0fZBmKEJvQWPNJFA1PCCrbn\lZ5Rm\CCrbjCxJIhzNXC{ZYTy[YF1\WRiUFLNR{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIICyOEBidnSrZ3XuJJBzd2S3Y4Tpc44hdWWjc4Xy[YQhd25iZHH5JFUheG:|dHnu[oVkfGmxbjDifUBGVEmVQTygSWM2OD1yLkC0{txO MmXEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|MU[1NlEoRjF6M{G2OVIyRC:jPh?=
MT2 NGfiSVVCdnSrdnnyZYwh[XO|YYm= NYLY[VE6PSCmYYnz M376O2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JFAvODB3IF3PTUB4cWymIIT5dIUhUEmYMTDOUFQuOyCrbn\lZ5Rm\CCrbjDoeY1idiCPVEKgZ4VtdHNibXXhd5Vz\WRiYX\0[ZIhPSCmYYnzJIJ6KFKWIGPQRUwhTUN3ME2wMlA1|ryP NIPadVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOxOlUzOSd-MUizNVY2OjF:L3G+
MT2 NF;tNVlCdnSrdnnyZYwh[XO|YYm= NFrYWZRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEAxNjByNTDNU2khUEmYMTDOUFQuOyCqYYLic5Jqdmdid3ns[EB1gXCnIGLUJIlv\mWldHXkJIlvKGi3bXHuJG1VOiClZXzsd{whTUN3ME2wMlA1|ryP M2rFT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{G2OVIyLz5zOEOxOlUzOTxxYU6=
MT2 NIfQT2dCdnSrdnnyZYwh[XO|YYm= MVLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKHO3YoT5dIUhSi1|QjDpcoZm[3SnZDDpckAyKGi{LYDy[ZRz\WG2ZXSgbJVu[W5iTWSyJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZibYXseIlkgWOuZTDy[ZBtcWOjdHnvckBu\WG|dYLl[EBwdiCmYYmgOUBxd3O2aX7m[YN1cW:wIHL5JHJVKFOSQTygSWM2OD1yLkC0O:69VQ>? M2WwZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{G2OVIyLz5zOEOxOlUzOTxxYU6=
MT2 M{nBO2FvfGm4aYLhcEBie3OjeR?= MlntOUBl[Xm| NWrW[pJYSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhOC5yMTDNU2khf2muZDD0fZBmKEiLVkGgUmw1NTNiaX7m[YN1\WRiaX6gbJVu[W5iTWSyJINmdGy|IH3lZZN2emWmIHHmeIVzKDViZHH5d{BjgSCUVDDTVGEtKEWFNUC9NE4xPjQQvF2= MorWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|MU[1NlEoRjF6M{G2OVIyRC:jPh?=
PBMC NVLweGM2SW62aY\pdoFtKGG|c3H5 NGPDR2pCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIIP1ZpR6eGViQj3BV20hODN2IHnu[oVkfGWmIHnuJFEhcHJvcILleJJm[XSnZDDQRm1EKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdFI1KGGwdHnn[Y4heHKxZIXjeIlwdiCvZXHzeZJm\CCxbjDkZZkhPSCyb4P0bY5n\WO2aX;uJIJ6KEWOSWPBMEBGSzVyPUCuNFcy|ryP MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNzNkWyNUc,OTh|MU[1NlE9N2F-
PBMC Ml[zRY51cX[rcnHsJIF{e2G7 MUnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKHO3YoT5dIUhSi17MmXTNFc3KGmwZnXjeIVlKGmwIEGgbJIueHKndILlZZRm\CCSQl3DJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicEK0JIFvfGmpZX6gdJJw\HWldHnvckBu\WG|dYLl[EBwdiCmYYmgOUBxd3O2aX7m[YN1cW:wIHL5JGVNUVODLDDFR|UxRTBwMEix{txO MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNzNkWyNUc,OTh|MU[1NlE9N2F-
MT2 Mkf5RY51cX[rcnHsJIF{e2G7 NF\vcZo2KGSjeYO= NGXPeotCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEAxNjB{IF3PTUB4cWymIIT5dIUhUEmYMTDOUFQuOyCrbn\lZ5Rm\CCrbjDoeY1idiCPVEKgZ4VtdHNibXXhd5Vz\WRiYX\0[ZIhPSCmYYnzJIJ6KFKWIGPQRUwhTUN3ME2wMlA5Ps7:TR?= NG\mW2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOxOlUzOSd-MUizNVY2OjF:L3G+
MT2 M{e0dWFvfGm4aYLhcEBie3OjeR?= MoC2NUBpeg>? MofERY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSC|dXL0fZBmKEJvUl[gbY5n\WO2ZXSgbY4hOSCqcj3wdoV1emWjdHXkJIh2dWGwIF3UNkBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIH31cJRq[3mlbHWgdoVxdGmlYYTpc44hdWWjc4Xy[YQhd25iZHH5JFUheG:|dHnu[oVkfGmxbjDifUBTXCCVUFGsJGVEPTB;MD6xNFXPxE1? NIXZT|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOxOlUzOSd-MUizNVY2OjF:L3G+
MT2 M2nIUGFvfGm4aYLhcEBie3OjeR?= MVyxJIhz NU\nenFUSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDzeYJ1gXCnIFKtUmw1NTNiaX7m[YN1\WRiaX6gNUBpei2ycnX0doVifGWmIHj1cYFvKE2WMjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKG23bITpZ5lkdGVicnXwcIlk[XSrb36gcYVie3W{ZXSgc44h\GG7IEWgdI9{fGmwZnXjeIlwdiCkeTDSWEBUWEFuIFXDOVA:OC5zN{JOwG0> NYLRR5QxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVY2OjFpPkG4N|E3PTJzPD;hQi=>
MT2 MUDBcpRqfmm{YXygZZN{[Xl? M2naTlEhcHJ? Mmq3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSC|dXL0fZBmKEJvTFHJJIlv\mWldHXkJIlvKDFiaIKtdJJmfHKnYYTl[EBpfW2jbjDNWFIh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDteYx1cWO7Y3zlJJJmeGyrY3H0bY9vKG2nYYP1doVlKG:wIHThfUA2KHCxc4TpcoZm[3Srb36gZpkhWlRiU2DBMEBGSzVyPUCuNVgz|ryP NGrsO5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOxOlUzOSd-MUizNVY2OjF:L3G+
MT2 MmnkRY51cX[rcnHsJIF{e2G7 M3vlTlEhcHJ? Ml75RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSC|dXL0fZBmKEJvU1[tNkBqdm[nY4Tl[EBqdiBzIHjyMZBz\XS{ZXH0[YQhcHWvYX6gUXQzKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gcZVtfGmleXPs[UBz\XCuaXPheIlwdiCvZXHzeZJm\CCxbjDkZZkhPSCyb4P0bY5n\WO2aX;uJIJ6KFKWIGPQRUwhTUN3ME2wMlE5O87:TR?= NFr1VYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOxOlUzOSd-MUizNVY2OjF:L3G+
MT2 Mk[wRY51cX[rcnHsJIF{e2G7 M13wZ|EhcHJ? MW\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKHO3YoT5dIUhSi2KWFKyJIlv\mWldHXkJIlvKDFiaIKtdJJmfHKnYYTl[EBpfW2jbjDNWFIh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDteYx1cWO7Y3zlJJJmeGyrY3H0bY9vKG2nYYP1doVlKG:wIHThfUA2KHCxc4TpcoZm[3Srb36gZpkhWlRiU2DBMEBGSzVyPUCuNlAz|ryP Mn\SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|MU[1NlEoRjF6M{G2OVIyRC:jPh?=
MT2 NEnhcJpCdnSrdnnyZYwh[XO|YYm= NXjjZVhIPSCmYYnz NUnoOGRPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhOC5yMEWgUW9KKHerbHSgeJlx\SCKSW[xJG5NPC1|IHnu[oVkfGWmIHnuJIh2dWGwIF3UNkBk\WyuczDt[YF{fXKnZDDh[pRmeiB3IHThfZMh[nliTWTTJIF{e2G7LDDFR|UxRTBwMkG5{txO NY[yXo46RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVY2OjFpPkG4N|E3PTJzPD;hQi=>
MT2 NX3Sb5VwSW62aY\pdoFtKGG|c3H5 NEXaXnY2KGSjeYO= MXLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDCwMlA2KE2RSTD3bYxlKHS7cHWgTGlXOSCQTEStN{Bqdm[nY4Tl[EBqdiCqdX3hckBOXDJiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgOUBl[Xm|IHL5JHJVKFOSQTygSWM2OD1yLkO3Nu69VQ>? NXu5e2lrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVY2OjFpPkG4N|E3PTJzPD;hQi=>
MT2 MWPBcpRqfmm{YXygZZN{[Xl? NVvBOmRyPSCmYYnz MXLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDCwMlAxPSCPT1mge4lt\CC2eYDlJGhKXjFiTly0MVMhcW6oZXP0[YQhcW5iMjDodk1xemW2cnXheIVlKGi3bXHuJG1VOiClZXzsd{Bu\WG|dYLl[EBi\nSncjC1JIRigXNiYomgVnQhW1CDLDDFR|UxRTBwNE[y{txO NIPhPIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOxOlUzOSd-MUizNVY2OjF:L3G+
MT2 M1\DRWFvfGm4aYLhcEBie3OjeR?= MmDrOUBl[Xm| M2rN[2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JFAvODFiTV;JJJdqdGRidInw[UBJUVZzIF7MOE0{KGmwZnXjeIVlKGmwIHj1cYFvKE2WMjDj[YxteyCvZXHzeZJm\CCjZoTldkA2KGSjeYOgZpkhVVSVIHHzd4F6NCCHQ{WwQVAvPTV2zszN MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNzNkWyNUc,OTh|MU[1NlE9N2F-
MT2 MX;BcpRqfmm{YXygZZN{[Xl? M{HoN|Uh\GG7cx?= NX7Xdol[SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhOC5yMTDNU2khf2muZDD0fZBmKEiLVkGgUmw1NTNiaX7m[YN1\WRiaX6gNkBpei2ycnX0doVifGWmIHj1cYFvKE2WMjDj[YxteyCvZXHzeZJm\CCjZoTldkA2KGSjeYOgZpkhWlRiU2DBMEBGSzVyPUCuOlY4|ryP NEHXWpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOxOlUzOSd-MUizNVY2OjF:L3G+
PBMC M1rmXWFvfGm4aYLhcEBie3OjeR?= MXGxJIhz Moj0RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSC|dXL0fZBmKEJvOUPVV|E1OyCrbn\lZ5Rm\CCrbjCxJIhzNXC{ZYTy[YF1\WRiUFLNR{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIICyOEBidnSrZ3XuJJBzd2S3Y4Tpc44hdWWjc4Xy[YQhd25iZHH5JFUheG:|dHnu[oVkfGmxbjDifUBGVEmVQTygSWM2OD1yLki1{txO MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNzNkWyNUc,OTh|MU[1NlE9N2F-
MT2 MonPRY51cX[rcnHsJIF{e2G7 MoL4OUBl[Xm| Mo\yRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgNE4xPSCPT1mge4lt\CC2eYDlJGhKXjFiTly0MVMhcW6oZXP0[YQhcW5iaIXtZY4hVVR{IHPlcIx{KG2nYYP1doVlKGGodHXyJFUh\GG7czDifUBOXFNiYYPzZZktKEWFNUC9NE46OjgQvF2= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNzNkWyNUc,OTh|MU[1NlE9N2F-
MT2 MXPBcpRqfmm{YXygZZN{[Xl? NF[5VHo2KGSjeYO= NVTXO2o5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhOC5yMjDNU2khf2muZDD0fZBmKEiLVkGgUmw1NTNiaX7m[YN1\WRiaX6gbJVu[W5iTWSyJINmdGy|IH3lZZN2emWmIHHmeIVzKDViZHH5d{BjgSCPVGOgZZN{[XluIFXDOVA:OC57NkpOwG0> M{TZflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{G2OVIyLz5zOEOxOlUzOTxxYU6=
MT2 M3Tp[WFvfGm4aYLhcEBie3OjeR?= MVO1JIRigXN? M{mydGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJB{\XWmb4T5dIUhUEmYMTDOUE1TVHWlIHnu[oVkfGWmIHnuJIh2dWGwIF3UNkBk\WyuczDt[YF{fXKnZDDvckBl[XliNTDwc5N1cW6oZXP0bY9vKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2xMlE1|ryP MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNzNkWyNUc,OTh|MU[1NlE9N2F-
MT2 M3LROGFvfGm4aYLhcEBie3OjeR?= M4q1T|Uh\GG7cx?= NGPtfZVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEAxNjByNTDNU2khf2muZDD0fZBmKEiLVkGgUmw1NTNiaX7m[YN1\WRiaX6gNkBpei2ycnX0doVifGWmIHj1cYFvKE2WMjDj[YxteyCvZXHzeZJm\CCjZoTldkA2KGSjeYOgZpkhVVSVIHHzd4F6NCCHQ{WwQVEvOjV7zszN NV;jW5dRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVY2OjFpPkG4N|E3PTJzPD;hQi=>
MT2 NXvqS5hISW62aY\pdoFtKGG|c3H5 NGG1RYE2KGSjeYO= M4Lw[WFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JFAvODFiTV;JJJdqdGRidInw[UBJUVZzIF7MOE0{KGmwZnXjeIVlKGmwIEKgbJIueHKndILlZZRm\CCqdX3hckBOXDJiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgOUBl[Xm|IHL5JG1VWyCjc4PhfUwhTUN3ME2xMlY5O87:TR?= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNzNkWyNUc,OTh|MU[1NlE9N2F-
MT2 NG\wSGJCdnSrdnnyZYwh[XO|YYm= MmKzOUBl[Xm| NXzRd4Z[SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhOC5yMjDNU2khf2muZDD0fZBmKEiLVkGgUmw1NTNiaX7m[YN1\WRiaX6gNkBpei2ycnX0doVifGWmIHj1cYFvKE2WMjDj[YxteyCvZXHzeZJm\CCjZoTldkA2KGSjeYOgZpkhWlRiU2DBMEBGSzVyPUGuPVg2|ryP NXnwSYI5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVY2OjFpPkG4N|E3PTJzPD;hQi=>
MT2 MXHBcpRqfmm{YXygZZN{[Xl? MVi1JIRigXN? MoDSRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgNE4xOiCPT1mge4lt\CC2eYDlJGhKXjFiTly0MVMhcW6oZXP0[YQhcW5iMjDodk1xemW2cnXheIVlKGi3bXHuJG1VOiClZXzsd{Bu\WG|dYLl[EBi\nSncjC1JIRigXNiYomgUXRUKGG|c3H5MEBGSzVyPUKuOFQ2|ryP NVrIWpUxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVY2OjFpPkG4N|E3PTJzPD;hQi=>
MT2 MVLBcpRqfmm{YXygZZN{[Xl? MnP5OUBl[Xm| MWrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDCwMlA2KE2RSTD3bYxlKHS7cHWgTGlXOSCQTEStN{Bqdm[nY4Tl[EBqdiB{IHjyMZBz\XS{ZXH0[YQhcHWvYX6gUXQzKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEWg[IF6eyCkeTDSWEBUWEFuIFXDOVA:Oi52N988US=> NXvMVJd{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVY2OjFpPkG4N|E3PTJzPD;hQi=>
MT2 MkizRY51cX[rcnHsJIF{e2G7 NHmxd5M2KGSjeYO= NYnVSWU2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhOC5yNTDNU2khf2muZDD0fZBmKEiLVkGgUmw1NTNiaX7m[YN1\WRiaX6gNkBpei2ycnX0doVifGWmIHj1cYFvKE2WMjDj[YxteyCvZXHzeZJm\CCjZoTldkA2KGSjeYOgZpkhVVSVIHHzd4F6NCCHQ{WwQVMvOjR5zszN MorGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|MU[1NlEoRjF6M{G2OVIyRC:jPh?=
HepG2(2.2.15) MnjKRY51cX[rcnHsJIF{e2G7 MXGyOEBpenN? M1nIfGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbjDoeY1idiCKZYDHNkgzNjJwMUWpJINmdGy|IHHzd4V{e2WmIHHzJIV5fHKjY3XscJVt[XJiSFLWJJZqemmxbjDEUmEhdGW4ZXygZYZ1\XJiMkSgbJJ{NCCHQ{WwQVAvODR6zszN MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB5Mk[5OEc,OTlyN{K2PVQ9N2F-
HepG2(2.2.15) MojWRY51cX[rcnHsJIF{e2G7 NUL3cWlwOjRiaILz MlPpRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwIHj1cYFvKEincFeyLFIvOi5zNTmgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVxdGmlYYTpc44hcW62ZYLt[YRq[XSnczDh[pRmeiB{NDDodpMtKEWFNUC9NE4yPc7:TR?= M3;yRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyOlk1Lz5zOUC3NlY6PDxxYU6=
Huh7 NVzWS|JJSW62aY\pdoFtKGG|c3H5 NWrwe4ZiPCCmYYnz NHH1PFZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBt[W2rdoXkbY5mNXKnc3nzeIFvfCC5aXzkJJR6eGViSFLWJIlvKGi3bXHuJGh2cDdiY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JIlvfHKjY3XscJVt[XJiSFLWJGRPSSC{ZYDsbYNifGmxbjDhd5NigSxiRVO1NF0xNjMQvF2= NGLwUZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
Huh7 MkLIRY51cX[rcnHsJIF{e2G7 MWG0JIRigXN? NXfq[5FLSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhdGGvaY\1[Ilv\S2{ZYPpd5RidnRiSFLWJJJmfmW{c3WgeJJidnOlcnnweIF{\SB{M{\UJI12fGGwdDDpckBpfW2jbjDIeYg4KGOnbHzzJIFnfGW{IESg[IF6eyCkeTDpcpRz[WOnbHz1cIFzKEiEVjDEUmEhemWybHnjZZRqd25iYYPzZZktKEWFNUC9NE4{|ryP MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB5Mk[5OEc,OTlyN{K2PVQ9N2F-
Huh7 MWXBcpRqfmm{YXygZZN{[Xl? NEX0RZA1KGSjeYO= NF3UNm1CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GWob4\pdk1z\XOrc4ThcpQhf2muZDD0fZBmKEiEVjDpckBpfW2jbjDIeYg4KGOnbHzzJIFnfGW{IESg[IF6eyCkeTDpcpRz[WOnbHz1cIFzKEiEVjDEUmEhemWybHnjZZRqd25iYYPzZZktKEWFNUC9NU4{|ryP NHG3S5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
Huh7 NGO4UGJCdnSrdnnyZYwh[XO|YYm= MlHMOEBl[Xm| M3u2OmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl\W[xdnnyMZJme2m|dHHueEBJSlZicnX2[ZJ{\SC2cnHud4NzcXC2YYPlJG0zODSYIH31eIFvfCCrbjDoeY1idiCKdXi3JINmdGy|IHHmeIVzKDRiZHH5d{BjgSCrboTyZYNmdGy3bHHyJGhDXiCGTlGgdoVxdGmlYYTpc44h[XO|YYmsJGVEPTB;MT61{txO NFTFbpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
Huh7 NE\4ZoVCdnSrdnnyZYwh[XO|YYm= M2jBcFQh\GG7cx?= MnjoRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRm\m:4aYKtdoV{cXO2YX70JGhDXiC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgUFE5OE1ibYX0ZY51KGmwIHj1cYFvKEi3aEegZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KGmwdILhZ4VtdHWuYYKgTGJXKESQQTDy[ZBtcWOjdHnvckBie3OjeTygSWM2OD1zLkdOwG0> NHTCXVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
Huh7 M1PBcGFvfGm4aYLhcEBie3OjeR?= M4jp[|Qh\GG7cx?= MWrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IVnd3[rcj3y[ZNqe3SjboSgTGJXKHKndnXyd4UhfHKjboPjdolxfGG|ZTDMUU9z\X[ncoPlJJRz[W6|Y4LpdJRie2ViTW[g[I92[mynIH31eIFvfCCrbjDoeY1idiCKdXi3JINmdGy|IHHmeIVzKDRiZHH5d{BjgSCrboTyZYNmdGy3bHHyJGhDXiCGTlGgdoVxdGmlYYTpc44h[XO|YYmsJGVEPTB;MT62{txO NI\ydHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
Huh7 NIP5XXJCdnSrdnnyZYwh[XO|YYm= M2P1Z|Qh\GG7cx?= MX3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IVnd3[rcj3y[ZNqe3SjboSgTGJXKHKndnXyd4UhfHKjboPjdolxfGG|ZTDNNlA1USCvdYThcpQhcW5iaIXtZY4hUHWqNzDj[YxteyCjZoTldkA1KGSjeYOgZpkhcW62cnHj[YxtfWyjcjDIRnYhTE6DIILldIxq[2G2aX;uJIF{e2G7LDDFR|UxRTFwON88US=> M3fiSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyOlk1Lz5zOUC3NlY6PDxxYU6=
Huh7 MV\BcpRqfmm{YXygZZN{[Xl? NVPQdGZPPCCmYYnz MkOzRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRm\m:4aYKtdoV{cXO2YX70JGhDXiC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgNlM3XCCvdYThcpQhcW5iaIXtZY4hUHWqNzDj[YxteyCjZoTldkA1KGSjeYOgZpkhcW62cnHj[YxtfWyjcjDIRnYhTE6DIILldIxq[2G2aX;uJIF{e2G7LDDFR|UxRTdwN988US=> MlTsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
Huh7 MlO2RY51cX[rcnHsJIF{e2G7 NGXXPVI1KGSjeYO= NYPjNY5LSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhdGGvaY\1[Ilv\S2{ZYPpd5RidnRiSFLWJJJmfmW{c3WgeJJidnOlcnnweIF{\SCOMUiwUUBufXSjboSgbY4hcHWvYX6gTJVpPyClZXzsd{Bi\nSncjC0JIRigXNiYomgbY51emGlZXzseYxieiCKQm[gSG5CKHKncHzpZ4F1cW:wIHHzd4F6NCCHQ{WwQVEx|ryP MknYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
HuH7 NYLhc5FGSW62aY\pdoFtKGG|c3H5 NGXtNnAzPCCqcoO= MYjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEi3SEegZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hfmm{YXygeJJidnOrZX70JJRz[W6|ZnXjeIlwdiCjZoTldkAzPCCqcoOsJGVEPTB;MD6y{txO MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN7OE[0PEc,OTl|OUi2OFg9N2F-
HuH7 MkjvRY51cX[rcnHsJIF{e2G7 NU\U[od1OjRiaILz NUSxNVF{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHjhdoJwemmwZzDSUmEheG:ueX3ldoF{\SCQMkO2WEBufXSjboSg[4Vv\SCrbn\lZ5Rm\CCrbjDoeY1idiCKdVi3JINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKH[rcnHsJJRz[W6|aXXueEB1emGwc3\lZ5Rqd25iYX\0[ZIhOjRiaILzMEBGSzVyPUCuN:69VQ>? NEfFV4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5PFY1QCd-MUmzPVg3PDh:L3G+
HuH7 NV[0[otrSW62aY\pdoFtKGG|c3H5 MWCyOEBpenN? NV3uUpVlSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHjhdoJwemmwZzDSUmEheG:ueX3ldoF{\SCQMkO2WEBufXSjboSg[4Vv\SCrbn\lZ5Rm\CCrbjDoeY1idiCKdVi3JINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKH[rcnHsJJRz[W6|aXXueEB1emGwc3\lZ5Rqd25iYX\0[ZIhOjRiaILzMEBGSzlyPUGuOe69VQ>? NWH6bZBERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzPVg3PDhpPkG5N|k5PjR6PD;hQi=>
HuH7 M3\DTWFvfGm4aYLhcEBie3OjeR?= MVeyOEBpenN? M2nNUWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSIXIO{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiC4aYLhcEB1emGwc3nlcpQhfHKjboPm[YN1cW:wIHHmeIVzKDJ2IHjyd{whTUN7ME2z{txO NFXqepg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5PFY1QCd-MUmzPVg3PDh:L3G+
HuH7 NYWzNWdISW62aY\pdoFtKGG|c3H5 M1;RT|I1KGi{cx?= M1LlOmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCqYYLic5JqdmdiUl7BJJBwdHmvZYLhd4UhVDF6MF2gcZV1[W62IHflcoUhcW6oZXP0[YQhcW5iaIXtZY4hUHWKNzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckB3cXKjbDD0doFve2mnboSgeJJidnOoZXP0bY9vKGGodHXyJFI1KGi{czygSWM2OD1zNt88US=> NX7VNWJsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzPVg3PDhpPkG5N|k5PjR6PD;hQi=>
HuH7 NGS2PHpCdnSrdnnyZYwh[XO|YYm= M1PpcFI1KGi{cx?= MkPLRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGijcnLvdolv\yCUTlGgdI9tgW2ncnHz[UBNOThyTTDteZRidnRiZ3Xu[UBqdm[nY4Tl[EBqdiCqdX3hckBJfUh5IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJZqemGuIITyZY5{cWWwdDD0doFve2[nY4Tpc44h[W[2ZYKgNlQhcHK|LDDFR|kxRTRzzszN NYrpdpBxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzPVg3PDhpPkG5N|k5PjR6PD;hQi=>
MT2 NUKwOnc4SW62aY\pdoFtKGG|c3H5 M3;xZmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiaX7m[YN1\WRiaX6gbJVu[W5iTWSyJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25uIFnDOVA:OC54zszN NFrv[W09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUW5Olg5PSd-MUm1PVY5QDV:L3G+
HeLa P4/R5 M2S0W2FvfGm4aYLhcEBie3OjeR?= MknsRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSCrbn\lZ5Rm\CCrbjDoeY1idiCKZVzhJHA1N1J3IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44tKEmFNUC9NE44QM7:TR?= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV7Nki4OUc,OTl3OU[4PFU9N2F-
TZM-bl M1TkNmFvfGm4aYLhcEBie3OjeR?= MoDvO|IhcHK| M{HSSmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFicF7MOE0{KGijcnLvdolv\yCUZY\ldpNmKHS{YX7zZ5JqeHSjc3WgVFEyQVNibYX0ZY51KGenbnWgbY5n\WO2ZXSgbY4hXFqPLXLsJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCudXPp[oVz[XOnIHHzd4F6NCCHQ{WwQVAvPDgQvF2= NFq3OpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUewOFE{OSd-MUm3NFQyOzF:L3G+
TZM-bl M1zaTGFvfGm4aYLhcEBie3OjeR?= NEmyN5VCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB4cWymLYT5dIUhUEmYMTDwUmw1NTNiaX7m[YN1\WRiaX6gWHpONWKuIHPlcIx{KGK7IHz1Z4ln\XKjc3WgZZN{[XluIFXDOVA:OC54Nd88US=> MnHBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5MESxN|EoRjF7N{C0NVMyRC:jPh?=
TZM-bl MkPERY51cX[rcnHsJIF{e2G7 MkfRO|IhcHK| MVnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKHCQTEStN{Bp[XKkb4LpcochWmW4ZYLz[UB1emGwc3PybZB1[XOnIGSxOlVCKG23dHHueEBo\W6nIHnu[oVkfGWmIHnuJHRbVS2kbDDj[YxteyCjZoTldkA4OiCqcoOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhTUN3ME2xMlA5|ryP MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTdyNEGzNUc,OTl5MESxN|E9N2F-
TZM-bl NH[5NolCdnSrdnnyZYwh[XO|YYm= NXn3WZY4PzJiaILz NIDLTlVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIIDOUFQuOyCqYYLic5JqdmdiUnX2[ZJ{\SC2cnHud4NzcXC2YYPlJHAyOTmVL2SxOlVCKG23dHHueEBo\W6nIHnu[oVkfGWmIHnuJHRbVS2kbDDj[YxteyCjZoTldkA4OiCqcoOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhTUN3ME2yMlHPxE1? NYDHeoNmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3NFQyOzFpPkG5O|A1OTNzPD;hQi=>
HepG2.2.15 M2O0SmFvfGm4aYLhcEBie3OjeR?= NYj6eWdGSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHnu[oVkfGWmIHnuJIh2dWGwIFjldGczNjJwMUWgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBFVkFicnXwcIlk[XSrb36sJGlEPTB;MD6yNu69VQ>? M{fK[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OEm3N|Y{Lz5zOUi5O|M3OzxxYU6=
1.3ES2 MnTXRY51cX[rcnHsJIF{e2G7 MYC2JIRigXN? MYPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZBifGm2aYOgRkB3cXK3czDhfZchcW5iaIXtZY4hOS5|RWOyJINmdGy|IIP0ZYJtgSC2cnHud4Zm[3SnZDD3bZRpKDFwMzDmc4xlKHerbHSgeJlx\SCKQm[gZZl4KHO2cnHpckBo\W6xbXWgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcnHsJGRPSSCuZY\lcEBi\nSncjC2JIRigXNiYomgVnQuWEOU MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB4MUG1PEc,OjByNkGxOVg9N2F-
HepG2.2.15 MUTBcpRqfmm{YXygZZN{[Xl? NELwcI46KGSjeYO= NEDlV21CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB4cWymIIT5dIUhUEKYIHnu[oVkfGWmIHnuJGhmeEd{LkKuNVUh[2WubIOgZZN{\XO|ZXSgZZMhdnWlbHXpZ{Bi[2mmIHHu[EBxem:2ZXnuJIxmfmWuczDkc5Nm\CCmYXnsfUBnd3JiOTDkZZl{KGGwZDDt[YF{fXKnZDCyOEBpenNiYX\0[ZIhdGG|dDD0doVifG2nboSgZpkhW2:3dHjldo4h[myxdDDofYJzcWSrenH0bY9vNCCHQ{WwQVAvOs7:TR?= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODFzN{mzNEc,OjBzMUe5N|A9N2F-
HepG2.2.15 MoGwRY51cX[rcnHsJIF{e2G7 MUS5JIRigXN? MkXGRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgRWRXNXKnc3nzeIFvfCCKQm[gUlI{PlRibYX0ZZRqd25iaX7m[YN1\WRiaX6gTIVxTzJwMj6xOUBk\WyuczDhd5Nme3OnZDDhd{BvfWOuZXnjJIFkcWRiYX7kJJBzd3SnaX6gcIV3\Wy|IHTvd4VlKGSjaXz5JIZweiB7IHThfZMh[W6mIH3lZZN2emWmIEK0JIhzeyCjZoTldkBt[XO2IITy[YF1dWWwdDDifUBUd3W2aHXyckBjdG:2IHj5ZpJq\Gm8YYTpc44tKEWFNUC9NE4z|ryP MlrGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMUe5N|AoRjJyMUG3PVMxRC:jPh?=
HepG2.2.15 Mn3MRY51cX[rcnHsJIF{e2G7 NGOyWVA6KGSjeYO= MVzBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGJXKGmwZnXjeIVlKGmwIFjldGczNjJwMUWgZ4VtdHNiYYPz[ZN{\WRiYYOgcpVkdGWrYzDhZ4llKGGwZDDwdo91\WmwIHzleoVteyCmb4Pl[EBl[WmueTDmc5IhQSCmYYnzJIFv\CCvZXHzeZJm\CB{NDDodpMh[W[2ZYKgcIF{fCC2cnXheI1mdnRiYomgV492fGincn6gZoxwfCCqeXLybYRqgmG2aX;uMEBGSzlyPUCuO:69VQ>? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODFzN{mzNEc,OjBzMUe5N|A9N2F-
HepG2.2.15 Mmf5RY51cX[rcnHsJIF{e2G7 NIq4TZU6KGSjeYO= NHPLc2tCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBCTFZvcnXzbZN1[W62IFjCWkBPOjN4VDDteZRifGmxbjDpcoZm[3SnZDDpckBJ\XCJMj6yMlE2KGOnbHzzJIF{e2W|c3XkJIF{KG63Y3zlbYMh[WOrZDDhcoQheHKxdHXpckBt\X[nbIOg[I9{\WRiZHHpcJkh\m:{IEmg[IF6eyCjbnSgcYVie3W{ZXSgNlQhcHK|IHHmeIVzKGyjc4SgeJJm[XSvZX70JIJ6KFOxdYTo[ZJvKGKub4SgbJljemmmaYrheIlwdixiRVO5NF0xNjkQvF2= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODFzN{mzNEc,OjBzMUe5N|A9N2F-
HepG2.2.15 NYHu[m93SW62aY\pdoFtKGG|c3H5 NUPRS2tEQSCmYYnz M3\qXmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JFNVSy2{ZYPpd5RidnRiSFLWJJdqfGhicH;sfY1memG|ZTDMNVgxVSCvdYTheIlwdiCrbn\lZ5Rm\CCrbjDI[ZBIOi5{LkG1JINmdGy|IHHzd4V{e2WmIHHzJI52[2ynaXOgZYNq\CCjbnSgdJJwfGWrbjDs[ZZmdHNiZH;z[YQh\GGrbImg[o9zKDliZHH5d{BidmRibXXhd5Vz\WRiMkSgbJJ{KGGodHXyJIxie3RidILlZZRu\W62IHL5JHNwfXSqZYLuJIJtd3RiaInidollcXqjdHnvckwhTUN3ME21MlPPxE1? NXXGfZFLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxNVc6OzBpPkKwNVE4QTNyPD;hQi=>
HepG2.2.15 MYHBcpRqfmm{YXygZZN{[Xl? M3ntWFkh\GG7cx?= NWTOXpprSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhO1SFLYLld4l{fGGwdDDIRnYhf2m2aDDwc4x6dWW{YYPlJGwyQDCPIH31eIF1cW:wIHnu[oVkfGWmIHnuJGhmeEd{LkKuNVUh[2WubIOgZZN{\XO|ZXSgZZMhdnWlbHXpZ{Bi[2mmIHHu[EBxem:2ZXnuJIxmfmWuczDkc5Nm\CCmYXnsfUBnd3JiOTDkZZl{KGGwZDDt[YF{fXKnZDCyOEBpenNiYX\0[ZIhdGG|dDD0doVifG2nboSgZpkhW2:3dHjldo4h[myxdDDofYJzcWSrenH0bY9vNCCHQ{mwQVIx|ryP MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODFzN{mzNEc,OjBzMUe5N|A9N2F-
HepG2(2.2.15) M1vFbGFvfGm4aYLhcEBie3OjeR?= NXLMT2pxOTNidV2= MojhO|IhcHK| NHHxcnRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XCjdHn0bZMhSiC4aYL1d{Bqdm[nY4Tl[EBqdiCqdX3hckBJ\XCJMjiyMlIvOTVrIHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJIlvfHKjY3XscJVt[XJidnnyZYwhTE6DIHzleoVtKGG2IEGzJJVOKGGodHXyJFczKGi{czDifUBTXC2SQ2KgZY5idHm|aYO= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF5Nki5N{c,OjBzN{[4PVM9N2F-
HEK293 MX;BcpRqfmm{YXygZZN{[Xl? MVG3NkBpenN? M{XNO2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFic4XieJlx\SCGIHnzc4xifGViODDpcoZm[3SnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{Bz\XCuaXPheIlwdiCjZoTldkA4OiCqcoOsJGVEPTB;Mz6yOe69VQ>? NYPTWJgxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzNFg{PzdpPkKwN|A5Ozd5PD;hQi=>
HEK293 MWnBcpRqfmm{YXygZZN{[Xl? NIHBZWo4OiCqcoO= NFXRWlhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIIP1ZpR6eGViQTDpd49t[XSnIEGgbY5n\WO2ZXSgbY4hUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMhemWybHnjZZRqd25iYX\0[ZIhPzJiaILzMEBGSzVyPUOuOVTPxE1? NF;sZYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEOwPFM4Pyd-MkCzNFg{Pzd:L3G+
HEK293 M2\OZWFvfGm4aYLhcEBie3OjeR?= Mm\wO|IhcHK| MYjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKHO3YoT5dIUhSyCrc3;sZZRmKDZiaX7m[YN1\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgdoVxdGmlYYTpc44h[W[2ZYKgO|IhcHK|LDDFR|UxRTNwOd88US=> NUHaT5luRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzNFg{PzdpPkKwN|A5Ozd5PD;hQi=>
HEK293 MV;BcpRqfmm{YXygZZN{[Xl? M4rSNVczKGi{cx?= M3TScGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFic4XieJlx\SCFIHnzc4xifGViNzDpcoZm[3SnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{Bz\XCuaXPheIlwdiCjZoTldkA4OiCqcoOsJGVEPTB;ND6wOu69VQ>? NY\TV2hwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzNFg{PzdpPkKwN|A5Ozd5PD;hQi=>
HEK293 NVXvNHMySW62aY\pdoFtKGG|c3H5 NXXC[pgzPzJiaILz NG\pTpBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIIP1ZpR6eGViQl[gbZNwdGG2ZTC1JIlv\mWldHXkJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{KHKncHzpZ4F1cW:wIHHmeIVzKDd{IHjyd{whTUN3ME20MlI1|ryP MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODNyOEO3O{c,OjB|MEizO|c9N2F-
HEK293 NGfneJFCdnSrdnnyZYwh[XO|YYm= MkXQO|IhcHK| MVHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKHO3YoT5dIUhSSCrc3;sZZRmKDJiaX7m[YN1\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgdoVxdGmlYYTpc44h[W[2ZYKgO|IhcHK|LDDFR|UxRTRwNElOwG0> NXmweYhKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzNFg{PzdpPkKwN|A5Ozd5PD;hQi=>
HEK293 NUTF[YNCSW62aY\pdoFtKGG|c3H5 NWXzfpp1PzJiaILz MXTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKE6OND2zJIlv\mWldHXkJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{KHKncHzpZ4F1cW:wIHHmeIVzKDd{IHjyd{whTUN3ME20MlY5|ryP MknBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|MEizO|coRjJyM{C4N|c4RC:jPh?=
HEK293 MlvERY51cX[rcnHsJIF{e2G7 NHzCeYY4OiCqcoO= NH3DTINCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIIP1ZpR6eGViQjDpd49t[XSnIEOgbY5n\WO2ZXSgbY4hUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMhemWybHnjZZRqd25iYX\0[ZIhPzJiaILzMEBGSzVyPUSuO|jPxE1? M2W1bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{C4N|c4Lz5{MEOwPFM4PzxxYU6=
HEK293 NF7tOGRCdnSrdnnyZYwh[XO|YYm= MkO5O|IhcHK| MlrnRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSC|dXL0fZBmKEJiaYPvcIF1\SB2IHnu[oVkfGWmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzJJJmeGyrY3H0bY9vKGGodHXyJFczKGi{czygSWM2OD13LkSz{txO NX;xdYZpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzNFg{PzdpPkKwN|A5Ozd5PD;hQi=>
HEK293 M4PkOmFvfGm4aYLhcEBie3OjeR?= NInYfpM4OiCqcoO= NH75SVRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIHX4dJJme3OrbnegdoV3\XK|ZTD0doFve2O{aYD0ZZNmKEtzMEPOM3kyQDGFL1exPVBCKG23dHHueEBqdm[nY4Tl[EBqdiCKRVuyPVMh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2eyC{ZYDsbYNifGmxbjDh[pRmeiB5MjDodpMtKEWFNUC9O{4yPs7:TR?= MoDaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|MEizO|coRjJyM{C4N|c4RC:jPh?=
HepG2(2.2.15) MkPJRY51cX[rcnHsJIF{e2G7 NITIOJY5KGSjeYO= Mm\wRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVx[XSrdHnzJGIhfmm{dYOgbY5n\WO2ZXSgbY4hcHWvYX6gTIVxTzJqMj6yMlE2MSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIHP5eI9xdGG|bXnjJGRPSSC|eX70bIV{cXNiYX\0[ZIhQCCmYYnzJIJ6KFKWLWDDVkBidmGueYPpd{whUUN3ME2wMlE3|ryP M2Hs[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkO5NVExLz5{ME[zPVEyODxxYU6=
HepG2(2.2.15) MmXkR5l1d3SxeHnjbZR6KGG|c3H5 NV3RTGlPQCCmYYnz MoLjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJqMj6yMlE2MSClZXzsd{Bi\nSncjC4JIRigXNiYomgUXRVKGG|c3H5MEBESzVyPUZOwG0> NYTic3p5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2N|kyOTBpPkKwOlM6OTFyPD;hQi=>
MT2 M4jVR2FvfGm4aYLhcEBie3OjeR?= M1HPd|IhfG9iMzDkZZl{ NVS4NGl2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gbY1ufW6xZHXmbYNq\W6leTD2bZJ2eyBzIEPCJIlv\mWldHXkJIlvKGi3bXHuJG1VOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|IHnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RibXXhd5Vz\WRiYX\0[ZIhOiC2bzCzJIRigXNiYomgVGNTNCCHQ{WwQVAvQM7:TR?= M1LTV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUG1O|k1Lz5{MUGxOVc6PDxxYU6=
MT2 NVfX[mFFSW62aY\pdoFtKGG|c3H5 M4fReWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHntcZVvd2SnZnnjbYVv[3lidnnyeZMhOSB|QjDoZZJjd3KrbnegdoV3\XK|ZTD0doFve2O{aYD0ZZNmKE1zOETWMEBOOTh2STDteZRidnRiaX7m[YN1\WRiaX6gbJVu[W5iTWSyJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMhcW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEB{\WynY4Tl[EBwdiCmYYmgNVQh[W[2ZYKgOEBx[XO|YXfld{BjgSCSQ2KgZY5idHm|aYOsJGVEPTB;MD64{txO MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTFzNUe5OEc,OjFzMUW3PVQ9N2F-
MT2 M1Sye2FvfGm4aYLhcEBie3OjeR?= NUDnWnl3SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gbY1ufW6xZHXmbYNq\W6leTD2bZJ2eyBzIEPCJIhiemKxcnnu[{Bz\X[ncoPlJJRz[W6|Y4LpdJRie2ViTUG4OHYhdXW2YX70JIlv\mWldHXkJIlvKGi3bXHuJG1VOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|IHnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3Ric3Xs[YN1\WRib36g[IF6KDF2IHHmeIVzKDRicHHzd4Fo\XNiYomgVGNTKGGwYXz5d4l{NCCHQ{WwQVAvQM7:TR?= NEWzTYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGxOVc6PCd-MkGxNVU4QTR:L3G+
MT2 MWfBcpRqfmm{YXygZZN{[Xl? MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCrbX31co9l\W[rY3nlcoN6KH[rcoXzJFEhO0JiaHHyZo9zcW6pIILleoVze2VidILhcpNkemmydHHz[UBOOTh2VjygUVE5PEluIFu4Nm4hdXW2YX70JIlv\mWldHXkJIlvKGi3bXHuJG1VOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|IHnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3Ric3Xs[YN1\WRib36g[IF6KDF2IHHmeIVzKDRicHHzd4Fo\XNiYomgVGNTKGGwYXz5d4ktKEWFNUC9NE45|ryP MnLSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzMUW3PVQoRjJzMUG1O|k1RC:jPh?=
HepG2(2.2.15) MoPYRY51cX[rcnHsJIF{e2G7 NFLqdYxCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XCjdHn0bZMhSiC4aYL1d{Bqdm[nY4Tl[EBqdiCqdX3hckBJ\XCJMjiyMlIvOTVrIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXKjbDDEUmEh[nliU3;1eIhmem5iYnzveJRqdmduIFXDOVA:OC5yNt88US=> NGPpUYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzN|U{PSd-MkGzN|M2OzV:L3G+
Huh7 NYjObmZISW62aY\pdoFtKGG|c3H5 M1XJcVEh\GG7 MnnURY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVx[XSrdHnzJGIhfmm{dYOgbY5n\WO2ZXSgbY4hcHWvYX6gTJVpPyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxiRF7BJIFnfGW{IEGg[IF6KGK7IGPveZRp\XKwIHLsc5R1cW6pLDDFR|UxRTBwMd88US=> NULOS41FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN|M2OzVpPkKxN|M{PTN3PD;hQi=>
HuH7 MWXDfZRwfG:6aXPpeJkh[XO|YYm= M4jDS|Qh\GG7cx?= MX;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIeWg4KGOnbHzzJIFnfGW{IESg[IF6eyCkeTDu[ZV1emGuIILl[EBlgWVidYD0ZYtmKGG|c3H5MEBESzVyPUCuNe69VQ>? NFnOU289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzN|U{PSd-MkGzN|M2OzV:L3G+
HepG2(2.2.15) MVPBcpRqfmm{YXygZZN{[Xl? MmriOEBl[Xm| NFzMU4tCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XCjdHn0bZMhSiC4aYL1d{Bqdm[nY4Tl[EBqdiCqdX3hckBJ\XCJMjiyMlIvOTVrIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygSG5CKHKncHzpZ4F1cW:wIHHmeIVzKDRiZHH5d{BjgSCUVD3QR3Ih[W6jbInzbZMtKEmFNUC9NE4{O87:TR?= NV62SXlyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1NlQ2QDhpPkKxOVI1PTh6PD;hQi=>
HepG2(2.2.15) MXTBcpRqfmm{YXygZZN{[Xl? NGP3SFk6KGSjeYO= M1r1N2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJ\XCjdHn0bZMhSiC4aYL1d{Bqdm[nY4Tl[EBqdiCqdX3hckBJ\XCJMjiyMlIvOTVrIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgdoVxdGmlYYTpc44hfHKnYYTl[EBl[WmueTDmc5IhQSCmYYnzJIJ6KHG3YX70bZRifGm4ZTDicI91KGi7YoLp[Il7[XSrb36gcYV1cG:mLDDFR|UxRTBwMt88US=> NX[0cYRZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5N|A{PzdpPkKxPVMxOzd5PD;hQi=>
HepG2(2.2.15) MUnBcpRqfmm{YXygZZN{[Xl? NV\UZllbQSCmYYnz MYjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IVnd3[rcj3y[ZNqe3SjboSgTIVx[XSrdHnzJGIhfmm{dYOgbIFz[m:{aX7nJJJmfmW{c3WgeJJidnOlcnnweIF{\SCQMkO2WEBufXSjboSgbY5n\WO2ZXSgbY4hcHWvYX6gTIVxTzJqMj6yMlE2MSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|IILldIxq[2G2aX;uJJRz\WG2ZXSg[IFqdHliZn;yJFkh\GG7czDifUByfWGwdHn0ZZRqfmViYnzveEBpgWK{aXTpfoF1cW:wIH3leIgtKEWFNUC9NE4z|ryP NHXLN5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUmzNFM4Pyd-MkG5N|A{Pzd:L3G+
HepG2(2.2.15) NEnxdpdCdnSrdnnyZYwh[XO|YYm= M{[0Nlkh\GG7cx?= NXnaeY1HSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEincHH0bZRqeyCEII\pdpV{KGmwZnXjeIVlKGmwIHj1cYFvKEincFeyLFIvOi5zNTmgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKGmwZnXjeIlwfXNidnnyeZMhfGm2ZYKgeJJm[XSnZDDkZYltgSCob4KgPUBl[Xm|IHL5JJF2[W62aYTheIl3\SCVb4X0bIVzdiCkbH;0JIh6[nKrZHn6ZZRqd25iYYPzZZktKEWFOUC9NE43|ryP MlLYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7M{CzO|coRjJzOUOwN|c4RC:jPh?=
HepG2(2.2.15) NYLid2Y4SW62aY\pdoFtKGG|c3H5 NYC0RoJ2QSCmYYnz M{DsN2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl\W[xdnnyMZJme2m|dHHueEBJ\XCjdHn0bZMhSiC4aYL1d{Bp[XKkb4LpcochemW4ZYLz[UB1emGwc3PybZB1[XOnIF6yN|ZVKG23dHHueEBqdm[nY4Tl[EBqdiCqdX3hckBJ\XCJMjiyMlIvOTVrIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kBqdm[nY4Tpc5V{KH[rcoXzJJRqfGW{IITy[YF1\WRiZHHpcJkh\m:{IEmg[IF6eyCkeTDxeYFvfGm2YYTpeoUhW2:3dHjldo4h[myxdDDofYJzcSxiRVO5NF0xNjoQvF2= NEjmWFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUmzNFM4Pyd-MkG5N|A{Pzd:L3G+
HepG2(2.2.15) M{X2R2FvfGm4aYLhcEBie3OjeR?= MlfBPUBl[Xm| MnP2RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgcIFucX[3ZHnu[U1z\XOrc4ThcpQhUGWyYYTpeIl{KEJidnnyeZMhcGG{Yn;ybY5oKHKndnXyd4UhfHKjboPjdolxfGG|ZTDMNVgxVSCvdYThcpQhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzJJJmeGyrY3H0bY9vKHS{ZXH0[YQh\GGrbImg[o9zKDliZHH5d{BjgSCzdXHueIl1[XSrdnWgZoxwfCCqeXLybYRqgmG2aX;uJI1mNCCHQ{WwQVEvPc7:TR?= MmXpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7M{CzO|coRjJzOUOwN|c4RC:jPh?=
HepG2(2.2.15) NX;kbo97SW62aY\pdoFtKGG|c3H5 MljPPUBl[Xm| M2TqOmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIxidWm4dXTpcoUuemW|aYP0ZY51KEincHH0bZRqeyCEII\pdpV{KGijcnLvdolv\yC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgUFE5OE1ibYX0ZY51KGmwZnXjeIVlKGmwIHj1cYFvKEincFeyLFIvOi5zNTmgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKGmwZnXjeIlwfXNidnnyeZMhfGm2ZYKgeJJm[XSnZDDkZYltgSCob4KgPUBl[Xm|IHL5JJF2[W62aYTheIl3\SCVb4X0bIVzdiCkbH;0JIh6[ixiRVO5NF0zOs7:TR?= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl|MEO3O{c,OjF7M{CzO|c9N2F-
HeLa P4/R5 M4PNRmFvfGm4aYLhcEBie3OjeR?= MUKyJIhzew>? MXrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKEKjTDDpcoZm[3SnZDDpckBJ\UyjIGC0M3I2KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJidCCrbn\lZ5Rqd25iaX7jeYJifGWmIH\vdkAzKGi{czDmc4xtd3enZDDifUBqdmO3YnH0[YQhcW5iZIL1[{1nemWnIH3l[Il2dSCob4KgOFYhcHK|IHL5JJNqdmeuZTDyc5Vv\CCrbn\lZ5Rqd25iYnX0ZU1o[WyjY4Tvd4ll[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MUGuN:69VQ>? M1HGSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{WyPFA6Lz5{MkO1NlgxQTxxYU6=
HeLa P4/R5 MVnBcpRqfmm{YXygZZN{[Xl? NVf0OHBnOiCqcoO= NIGy[2xCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIEPCJIlv\mWldHXkJIlvKEinTHGgVFQwWjViY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqemGuIHnu[oVkfGmxbjDpcoN2[mG2ZXSg[o9zKDJiaILzJIZwdGyxd3XkJIJ6KGmwY4XiZZRm\CCrbjDkdpVoNW[{ZXWgcYVlcXWvIH\vdkA1PiCqcoOgZpkhe2mwZ3zlJJJwfW6mIHnu[oVkfGmxbjDi[ZRiNWejbHHjeI9{cWSjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2zNk44|ryP MoGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|NUK4NFkoRjJ{M{WyPFA6RC:jPh?=
HeLa P4/R5 NGPISHZCdnSrdnnyZYwh[XO|YYm= M4rJOVIhcHK| MVHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKEKjTDDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHnu[oVkfGmxbjDpckBJ\UyjIGC0M3I2KGOnbHzzJIV5eHKnc4PpcochS0R2IILlZ4VxfG:{IHHu[EBj\XSjLXfhcEBqdmO3YnH0[YQh\m:{IEKgbJJ{KG[xbHzve4VlKGK7IHPvcZBwfW6mLYfhd4ghd3W2IH3lZZN2emWmIHHmeIVzKDR4IHjyd{BjgSC|aX7ncIUhem:3bnSgbY5n\WO2aX;uJG1CT0liYYPzZZktKEWFNUC9NVEvPM7:TR?= MnjlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3M{O4OVAoRjJ{NUOzPFUxRC:jPh?=
HeLa P4/R5 NIjnXnBCdnSrdnnyZYwh[XO|YYm= MXyyJIhzew>? NF;TdIVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIEPCJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gbY5n\WO2aX;uJIlvKEinTHGgVFQwWjViY3XscJMh\XiycnXzd4lv\yCFRESgdoVk\XC2b4KgZY5lKGKndHGt[4FtKGmwY4XiZZRm\CCob4KgNkBpenNiZn;scI94\WRiYomgZ49ueG:3bnSte4F{cCCxdYSgcYVie3W{ZXSgZYZ1\XJiNE[gbJJ{KGK7IIPpcodt\SC{b4Xu[EBqdm[nY4Tpc44hVUGJSTDhd5NigSxiRVO1NF0{Oi55zszN MnrJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3M{O4OVAoRjJ{NUOzPFUxRC:jPh?=
CEM-SS MV3BcpRqfmm{YXygZZN{[Xl? MmrOOkBl[Xm| NV;CNoxlSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYLUGgd5VjfHmyZTCzRkBqdm[nY4Tl[EBqdiCFRV2tV3Mh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB4IHThfZMh[nliWGTUJIF{e2G7LDDFR|UxRTBwMt88US=> NYjvbo5DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OVgxQTdpPkKyPFU5ODl5PD;hQi=>
HuH7 NGTzSZdCdnSrdnnyZYwh[XO|YYm= MUTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTIVx[XSrdHnzJGIhfmm{dYOgbY5n\WO2ZXSgbY4hcHWvYX6gTJVJPyClZXzsd{whTUN3ME2wMlA2Ps7:TR?= M3zEdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkO3PFQyLz5{M{KzO|g1OTxxYU6=
HuH7 NUWzVmpRSW62aY\pdoFtKGG|c3H5 M3LKRWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJ\XCjdHn0bZMhSiC4aYL1d{Bqdm[nY4Tl[EBqdiCqdX3hckBJfUh5IHPlcIx{NCCHQ{mwQVAvOTR{zszN NXLGeVRnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyN|c5PDFpPkKzNlM4QDRzPD;hQi=>
MT4 M{XhTGFvfGm4aYLhcEBie3OjeR?= M{XZb|Uh\GG7cx?= MYDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKDOEIHnu[oVkfGWmIHnuJIh2dWGwIF3UOEBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qhfmm{YXytbY5lfWOnZDDjfZRwfG:6aXPpeJkh[W[2ZYKgOUBl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME2xMljPxE1? NEX3cHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGxPVQ1QCd-MkSxNVk1PDh:L3G+
MT4 MnfwRY51cX[rcnHsJIF{e2G7 MVm1JIRigXN? NWnTWXV4SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMjDSU2QhcW6oZXP0[YQhcW5iaIXtZY4hVVR2IHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5Rm[3Srb36gZYdicW6|dDD2bZJidC2rbnT1Z4VlKGO7dH;0c5hq[2m2eTDh[pRmeiB3IHThfZMh[nliTWTUJIF{e2G7LDDFR|UxRTVwOd88US=> NFrFTpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGxPVQ1QCd-MkSxNVk1PDh:L3G+
CEM NV3vOm9PSW62aY\pdoFtKGG|c3H5 NXrzb2VRPCCmYYnz NHnWSVZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIEPCJIlv\mWldHXkJIlvKGi3bXHuJGNGVSClZXzsd{Bie3Onc4Pl[EBieyC4aYL1d{1qdmS3Y3XkJIdq[W62IHPlcIwh\m:{bXH0bY9vKGGodHXyJFQh\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB7Od88US=> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF5N{O1PUc,OjRzN{ezOVk9N2F-
CEM MnnSRY51cX[rcnHsJIF{e2G7 MWi0JIRigXN? MYDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYzKFKRRDDpcoZm[3SnZDDpckBpfW2jbjDDSW0h[2WubIOgZZN{\XO|ZXSgZZMhfmm{dYOtbY5lfWOnZDDnbYFvfCClZXzsJIZwem2jdHnvckBi\nSncjC0JIRigXNiYomgcYlkem:|Y3;wbYMh[W6jbInzbZMtKEWFNUC9NE4yQM7:TR?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF5N{O1PUc,OjRzN{ezOVk9N2F-
HOG.R5 NGfyOGdCdnSrdnnyZYwh[XO|YYm= MXnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYuOSB|Qj;IPUBqdm[nY4Tl[EBqdiCqdX3hckBJV0dwUkWgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCCKSW[xJGxVWi2JRmCgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDifUBndHWxcnXzZ4Vv[2ViYX7hcJl{cXNuIFnDOVA:OS5{zszN NWPYfm04RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0NFQ4PTdpPkK0OFA1PzV5PD;hQi=>
MT4 M{ToWWFvfGm4aYLhcEBie3OjeR?= M2fQT2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiM1KgbY5n\WO2ZXSgbY4hcHWvYX6gUXQ1KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JI1m[XO3cnXkJFUh\GG7czDwc5N1KH[rcnHsJIlv\mWldHnvckBjgSCPVGSgZZN{[XluIFXDOVA:Oi52NENOwG0> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd7NEe1NUc,OjR5OUS3OVE9N2F-
MT4 MYnBcpRqfmm{YXygZZN{[Xl? NFP6Zm1CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZ{IGLPSEBqdm[nY4Tl[EBqdiCqdX3hckBOXDRiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJkhdWWjc4Xy[YQhPSCmYYnzJJBwe3RidnnyZYwhcW6oZXP0bY9vKGK7IF3UWEBie3OjeTygSWM2OD15LkNOwG0> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd7NEe1NUc,OjR5OUS3OVE9N2F-
MT4 NF;4Z3dCdnSrdnnyZYwh[XO|YYm= NV7oXm9IPSCmYYnz NEH0Z|lCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDpcY12dm:mZX\pZ4lmdmO7II\pdpV{KDFiM3KgbY5n\WO2ZXSgbY4hcHWvYX6gUXQ1KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNicnXwcIlk[XSrb36gZYZ1\XJiNTDkZZl{KGK7IF3UWEBie3OjeTygTWM2OD1|LkpOwG0> NWnFTIdFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NlY5ODdpPkK0PVI3QDB5PD;hQi=>
MT4 M1LmWmFvfGm4aYLhcEBie3OjeR?= NIT5R3U2KGSjeYO= M13JXmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHntcZVvd2SnZnnjbYVv[3lidnnyeZMhfHmyZTCyJHJQTCCrbn\lZ5Rm\CCrbjDoeY1idiCPVESgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{Bz\XCuaXPheIlwdiCjZoTldkA2KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVE2NjYQvF2= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl{NkiwO{c,OjR7Mk[4NFc9N2F-
MT4 Mm[5RY51cX[rcnHsJIF{e2G7 NV\BOIV3PSCmYYnz MknpRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\CC2eYDlJGhKXjFiM1KgbY5n\WO2ZXSgbY4hcHWvYX6gUXQ1KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCjZoTldkA2KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVMvQDoQvF2= NF\5epE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1NlMxPSd-MkS5OVI{ODV:L3G+
MT4 Ml\2RY51cX[rcnHsJIF{e2G7 Mm\zOUBl[Xm| M{L4cGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjJiUl;EJIlv\mWldHXkJIlvKGi3bXHuJG1VPCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliYX\0[ZIhPSCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NF0yPS53M988US=> NHnYZo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1NlMxPSd-MkS5OVI{ODV:L3G+
HepG2.2.15 M4DlO2FvfGm4aYLhcEBie3OjeR?= NXL3UHFRSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcGWyYYTpeIl{KEJidnnyeZMhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KuNk4yPSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uMEBKSzVyPUG0MlE4|ryP NWXRfI5GRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWxNlcyODRpPkK1NVI4OTB2PD;hQi=>
MT4 M{C3SWFvfGm4aYLhcEBie3OjeR?= NGLqSm42KGSjeYO= MX;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKDOEIHnu[oVkfGWmIHnuJIh2dWGwIF3UOEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQhe3mwY4n0bZVuKG[xcn3heIlwdiCjZoTldkA2KGSjeYOgZpkhVVSWIHHzd4F6NCCHQ{WwQVIvOjMQvF2= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ2MEC5OUc,OjV{NECwPVU9N2F-
MT4 MWrBcpRqfmm{YXygZZN{[Xl? M3PDclUh\GG7cx?= MWDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYzKFKRRDDpcoZm[3SnZDDpckBpfW2jbjDNWFQh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKHO7bnP5eIl2dSCob4LtZZRqd25iYX\0[ZIhPSCmYYnzJIJ6KE2WVDDhd5NigSxiRVO1NF05NjhzzszN NFW0eYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK0NFA6PSd-MkWyOFAxQTV:L3G+
HepG2(2.2.15) MlvySpVv[3Srb36gZZN{[Xl? M2nuU|AvPzVidH:gN{B2VQ>? NYrTOopGPzJiaILz M1XUOWRm[3KnYYPlJIlvKEiEVjD2bZJidCCGTlGgdoVxdGmlYYTpc44hcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjdDCwMlc2KHSxIEOgeW0h[W[2ZYKgO|IhcHK|IHL5JJJm[WxvdHnt[UBRS1JiYX7hcJl{cXNuIFnDOVA:Py54M988US=> NWDKVFZsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0OlE5QTFpPkK1OFYyQDlzPD;hQi=>
MT4 MknMRY51cX[rcnHsJIF{e2G7 NInYboQ2KGSjeYO= MVrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGlXNTFiM1KgbY5n\WO2ZXSgbY4hcHWvYX6gUXQ1KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFUh\GG7czDifUBOXFRiYYPzZZktKEWFNUC9Nk4zPM7:TR?= M1roPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUO3OVMzLz5{NUWzO|U{OjxxYU6=
MT4 NHGyOZVCdnSrdnnyZYwh[XO|YYm= MnLqOUBl[Xm| MYnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGlXNTJiUl;EJIlv\mWldHXkJIlvKGi3bXHuJG1VPCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA2KGSjeYOgZpkhVVSWIHHzd4F6NCCHQ{WwQVgvPzoQvF2= M4TUcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUO3OVMzLz5{NUWzO|U{OjxxYU6=
MT4 Mnz5RY51cX[rcnHsJIF{e2G7 MWC1JIRigXN? MoDMRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSB|QjDpcoZm[3SnZDDpckBpfW2jbjDNWFQh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgOUBl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME2yMlI{Qc7:TR?= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ{NkG0OUc,OjV4Mk[xOFU9N2F-
MT4 NHnE[YlCdnSrdnnyZYwh[XO|YYm= MWm1JIRigXN? Mne2RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSB|QjDpcoZm[3SnZDDpcoZm[3SnZDDpckBpfW2jbjDNWFQh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KH[rcoXzMYlv\HWlZXSgZ5l1d3SxeHnjbZR6KGGodHXyJFUh\GG7czDifUBOXFRiYYPzZZktKEWFNUC9NE45Qc7:TR?= Mn7DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEK1OlIoRjJ3NkiyOVYzRC:jPh?=
MT4 MkjoRY51cX[rcnHsJIF{e2G7 NVzsRnJYPSCmYYnz MUjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYzKFKRRDDpcoZm[3SnZDDpckBpfW2jbjDNWFQh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KH[rcoXzMYlv\HWlZXSgZ5l1d3SxeHnjbZR6KGGodHXyJFUh\GG7czDifUBOXFRiYYPzZZktKEWFNUC9N{42Ps7:TR?= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6MkW2Nkc,OjV4OEK1OlI9N2F-
MT4 NVHQXHZuSW62aY\pdoFtKGG|c3H5 NWe4cGZTPSCmYYnz NFnO[3FCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIEPCJIlv\mWldHXkJIlvKGi3bXHuJG1VPCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA2KGSjeYOgZpkhVVSWIHHzd4F6NCCHQ{WwQVIvOs7:TR?= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTdyN{CxN{c,OjV5MEewNVM9N2F-
HepG2.2.15 MnvoRY51cX[rcnHsJIF{e2G7 NEfXbI1CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XCjdHn0bZMhSiC4aYL1d{Bqdm[nY4Tl[EBqdiCqdX3hckBJ\XCJMj6yMlE2KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gTGJXKESQQTDy[ZBtcWOjdHnvckBjgSC{ZXHsMZRqdWViZnz1c5Jme2OnbnPlJJF2[W62aYTheIl3\SCSQ2KgZY5idHm|aYOsJGlEPTB;Nj64Ou69VQ>? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh2N{e2OUc,OjV6NEe3OlU9N2F-
MT4 MY\BcpRqfmm{YXygZZN{[Xl? NETTWHA2KGSjeYO= MliyRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOS1|QjDpcoZm[3SnZDDpckBpfW2jbjDNWFQh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2eyCrbnT1Z4VlKGOnbHyg[IVifGhibXXhd5Vz\WRiYX\0[ZIhPSCmYYnzJI9nKGmwZnXjeIlwdiCkeTDNWHQh[XO|YYmsJGVEPTB;Mz65{txO MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl2NkGxOkc,OjV7NE[xNVY9N2F-
MT4 MX;BcpRqfmm{YXygZZN{[Xl? MX21JIRigXN? MlHqRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOi2UT1SgbY5n\WO2ZXSgbY4hcHWvYX6gUXQ1KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNiaX7keYNm\CClZXzsJIRm[XSqIH3lZZN2emWmIHHmeIVzKDViZHH5d{Bw\iCrbn\lZ5Rqd25iYomgUXRVKGG|c3H5MEBGSzVyPUG1MlXPxE1? M3z5dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUS2NVE3Lz5{NUm0OlEyPjxxYU6=
HepG22.2.15 MV3BcpRqfmm{YXygZZN{[Xl? NF\wbWo{KGSjeYO= MX7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KyMlIvOTViY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JI5mfXS{YXygdoVlKGS7ZT3iZZNm\CCybHHxeYUhemWmdXP0bY9vKGG|c3H5MEBKSzVyPUCuNFM6|ryP NHPvRZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK2NFM{Pid-Mk[yOlA{OzZ:L3G+
U87 MkP0RY51cX[rcnHsJIF{e2G7 NH7WSWQyOCC3TR?= M13oTFQh\GG7cx?= Mn\1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXNTFiTly0MVMhcW6oZXP0[YQhcW5iaIXtZY4hXTh5IHPlcIx{KGW6cILld5NqdmdiQ1S0MmNZS1J2IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicEK0JJBzd2S3Y4Tpc44h[XRiMUCgeW0hdWWjc4Xy[YQh[W[2ZYKgOEBl[Xm|IHL5JJAzPCCHTFnTRS=> M1LLWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEmxNFcxLz5{N{C5NVA4ODxxYU6=
U87 M{j3OGFvfGm4aYLhcEBie3OjeR?= NHWzZpAyODBidV2= M2DnXlQh\GG7cx?= MUnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYuOSCQTEStN{Bqdm[nY4Tl[EBqdiCqdX3hckBWQDdiY3XscJMh\XiycnXzd4lv\yCFRESuR3hEWjRiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCyMkSgdJJw\HWldHnvckBifCBzMECgeW0hdWWjc4Xy[YQh[W[2ZYKgOEBl[Xm|IHL5JJAzPCCHTFnTRS=> NUfIcFVJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewPVExPzBpPkK3NFkyODdyPD;hQi=>
MT4 MX;BcpRqfmm{YXygZZN{[Xl? MXi1JIRigXN? MnzyRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSB|QjDlfJBz\XO|aX7nJJdqdGRidInw[UBz\X[ncoPlJJRz[W6|Y4LpdJRie2ViaX7m[YN1\WRiaX6gbJVu[W5iTWS0JINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h[WejaX7zeEB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHHmeIVzKDViZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:Oy5zzszN M3\1WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Mk[3NFA2Lz5{N{K2O|AxPTxxYU6=
HepG2.2.15.7 MVXBcpRqfmm{YXygZZN{[Xl? MXq5JIRigXN? NVHC[WlUSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHnu[oVkfGWmIHnuJIh2dWGwIFjldGczNjJwMUWuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKESQQTDs[ZZmdCCjZoTldkA6KGSjeYOgZpkhemWjbDD0bY1mKFCFUjDt[ZRpd2RuIFXDOVA:OC5yM988US=> NILHR5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{SyOlMxOyd-Mke0NlY{ODN:L3G+
MT4 M4WwUmFvfGm4aYLhcEBie3OjeR?= NFj2SZk2KGSjeYO= NUi1WlNzSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiLVkGgN2IhcGG{Yn;ybY5oKHKndnXyd4UhfHKjboPjdolxfGG|ZTDpcoZm[3SnZDDpckBpfW2jbjDNWFQh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KH[rcoXzJIlv\HWlZXSgZ5l1d3SxeHnjbZR6KGGodHXyJFUh\GG7czDifUBOXFRiYYPzZZktKEWFNUC9Nk4zPM7:TR?= NHnsZ3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W0NVU4QCd-Mke1OFE2Pzh:L3G+
MT4 NH\m[41CdnSrdnnyZYwh[XO|YYm= M2KwWVUh\GG7cx?= NELqTXVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZ{IGLPSEBp[XKkb4LpcochemW4ZYLz[UB1emGwc3PybZB1[XOnIHnu[oVkfGWmIHnuJIh2dWGwIF3UOEBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qhfmm{dYOgbY5lfWOnZDDjfZRwfG:6aXPpeJkh[W[2ZYKgOUBl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME24Mlc6|ryP M4fnNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUSxOVc5Lz5{N{W0NVU4QDxxYU6=
HepG2(2.2.15) MnLaRY51cX[rcnHsJIF{e2G7 NUPPTIcxPiCmYYnz NHKwb2lCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiYYn3NUBqdm[nY4Tl[EBqdiCqdX3hckBJ\XCJMjiyMlIvOTVrIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXKjbDDy[ZBtcWOjdHnvckBjgSCvZXHzeZJqdmdiaX70doFk\WyudXzhdkB3cXKjbDDEUmEh[2:yeTDueY1j\XJiYX\0[ZIhPiCmYYnzJIJ6KHKnYXyteIlu\SCzUFPSJI1mfGixZDygSWM2ODxyLkCx{txO M1[5WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{S4OVkxLz5{N{e0PFU6ODxxYU6=
HepG2(2.2.15) MoD6RY51cX[rcnHsJIF{e2G7 NV3MfndvPiCmYYnz MmDPRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGG7d{GgbY5n\WO2ZXSgbY4hcHWvYX6gTIVxTzJqMj6yMlE2MSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxicnXwcIlk[XSrb36gZpkhdWWjc4XybY5oKGW6dILhZ4VtdHWuYYKgeolz[WxiRF7BJINweHliboXtZoVzKGGodHXyJFYh\GG7czDifUBz\WGuLYTpcYUheVCFUjDt[ZRpd2RuIFXDOVA:OC5yMd88US=> M3S3fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{S4OVkxLz5{N{e0PFU6ODxxYU6=
MT4 MXTBcpRqfmm{YXygZZN{[Xl? NFPKdGQ2KGSjeYO= MVTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKDOEIHnu[oVkfGWmIHnuJIh2dWGwIF3UOEBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB3IHThfZMh[nliTWTUJIF{e2G7LDDFR|UxRTJwMkNOwG0> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd2OEW5NEc,Ojd5NEi1PVA9N2F-
MT4 NHrOTXdCdnSrdnnyZYwh[XO|YYm= MVi1JIRigXN? NETWSnRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZ{IGLPSEBqdm[nY4Tl[EBqdiCqdX3hckBOXDRiY3XscJMh[XO|ZYPz[YQh[XNicILveIVkfGmxbjDh[4FqdnO2II\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgOUBl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME24Mlgy|ryP MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd2OEW5NEc,Ojd5NEi1PVA9N2F-
Huh7 M3vt[WFvfGm4aYLhcEBie3OjeR?= MofNRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgcIFucX[3ZHnu[U1z\XOrc4ThcpQhf2muZDD0fZBmKGincHH0bZRqeyCEII\pdpV{KGmwZnXjeIVlKGmwIHj1cYFvKEi3aEegZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKHOnY4LleIVlKESQQTDs[ZZmdHNibXXhd5Vz\WRib36g[IF6KDdiYomgdoVidC22aX3lJHBEWiCjbnHsfZNqeyxiRVO1NF0xNjB3Nd88US=> MoX5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEKwOlgoRjJ6MEiyNFY5RC:jPh?=
HepG2.215 NE\C[HRCdnSrdnnyZYwh[XO|YYm= MUnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDo[ZBifGm2aYOgRkB3cXK3czDpcoZm[3SnZDDpckBpfW2jbjDI[ZBIOi5{MUWgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcnHsJGRPSSC{ZYDsbYNifGmxbjDt[YF{fXKnZDDvckBl[XliNzDifUBz\WGuIITpcYUhWEOUIHHuZYx6e2m|LDDFR|UxRTBwMd88US=> NXi2fZNURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFIxPjhpPkK4NFgzODZ6PD;hQi=>
Huh7 MmPoRY51cX[rcnHsJIF{e2G7 NFTkdnhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBt[W2rdoXkbY5mNXKnc3nzeIFvfCC5aXzkJJR6eGViaHXwZZRqfGm|IFKgeolzfXNiaX7m[YN1\WRiaX6gbJVu[W5iSIXoO{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iaX70doFk\WyudXzhdkBFVkFibHX2[Yx{KG2nYYP1doVlKG:wIHThfUA4KGK7IILlZYwufGmvZTDQR3Ih[W6jbInzbZMtKEWFNUC9NE4zOzgQvF2= NUDQdYZ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFIxPjhpPkK4NFgzODZ6PD;hQi=>
HepG2.215 MVPBcpRqfmm{YXygZZN{[Xl? M1nISGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIhmeGG2aYTpd{BDKH[rcoXzJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{LkKxOUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwhTE6DIILldIxq[2G2aX;uJI1m[XO3cnXkJI9vKGSjeTC3JIJ6KHKnYXygeIlu\SCSQ2KgZY5idHm|aYOsJGVEQTB;Mt88US=> MoTmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEKwOlgoRjJ6MEiyNFY5RC:jPh?=
HepAD38 MoS4RY51cX[rcnHsJIF{e2G7 NX;0XoNZPSCmYYnz M{Hn[mFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbn\lZ5Rm\CCrbjDoeY1idiCKZYDBSFM5KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gSG5CKHKncHzpZ4F1cW:wIHHmeIVzKDViZHH5d{BjgSCUVD3QR3IhdWW2aH;kMEBGSzVyPUCuNFTPxE1? NGDv[JE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC5OFE4QSd-MkiwPVQyPzl:L3G+
P4R5 MAGI MWTGeY5kfGmxbjDhd5NigQ>? MUCyJIhzew>? M1\WdmlvcGmkaYTpc44hd2ZiSFnWNUBD[UxiZHnueYNt\W:|aXTlJJJmfmW{c3WgeJJidnOlcnnweIF{\SCrbn\lZ5Rm\CCrbjDoeY1idiCSNGK1JG1CT0liY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqemGuIHnu[oVkfGmxbjDh[pRmeiB{IHjyd{BjgSCJYXzhZ5RwNVO2YYKgZoV1[S2pYXzhZ5Rwe2mmYYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NVEvO87:TR?= MnHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|NUG1PFgoRjJ6M{WxOVg5RC:jPh?=
P4R5 MAGI NEXrTHJHfW6ldHnvckBie3OjeR?= NEL0V4MzKGi{cx?= NGnL[5FKdmirYnn0bY9vKG:oIFjJWlEhO0JiZHnueYNt\W:|aXTlJJJmfmW{c3WgeJJidnOlcnnweIF{\SCrbn\lZ5Rm\CCrbjDoeY1idiCSNGK1JG1CT0liY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqemGuIHnu[oVkfGmxbjDh[pRmeiB{IHjyd{BjgSCJYXzhZ5RwNVO2YYKgZoV1[S2pYXzhZ5Rwe2mmYYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9N|IvP87:TR?= NUm4VW44RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizOVE2QDhpPkK4N|UyPTh6PD;hQi=>
HepG2.2.15 MX;BcpRqfmm{YXygZZN{[Xl? MUS4JIRigXN? MWHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZBifGm2aYOgRkB3cXK3czDpcoZm[3SnZDDpckBpfW2jbjDI[ZBIOi5{LkG1JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhTE6DIILldIxq[2G2aX;uJIFnfGW{IEig[IF6eyCkeTDy[YFtKHSrbXWg[ox2d3Knc3PlcpQhWEOUIH3leIhw\CxiSVO1NF0xNjYQvF2= NXO4PIJGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0PVQzPTJpPkK4OFk1OjV{PD;hQi=>
MT4 Mm\TRY51cX[rcnHsJIF{e2G7 M2L0bFUh\GG7cx?= NVzsSGd6SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiLVkGgN2IhcW6oZXP0[YQhcW5iaIXtZY4hVVR2IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB3IHThfZMh[nliTWTUJIF{e2G7LDDFR|UxRTJwNUVOwG0> Mn7vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4NUmyOFYoRjJ6NkW5NlQ3RC:jPh?=
HepG2(2.2.15) NUXGbpAzSW62aY\pdoFtKGG|c3H5 M4C3dFYh\GG7cx?= M{[5dmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCjeYexJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{KEKuNk4yPSliY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqemGuIILldIxq[2G2aX;uJIJ6KG2nYYP1dolv\yCrboTyZYNmdGy3bHHyJJZqemGuIFTORUBkd3C7IH71cYJmeiCjZoTldkA3KGSjeYOgZplzKGK7IILlZYwufGmvZTDxVGNTKGG|c3H5MEBGSzVyPUCuNFA5QDgQvF2= NYXJb|J4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2PFIxPjdpPkK4OlgzODZ5PD;hQi=>
HepG2(2.2.15) MXzBcpRqfmm{YXygZZN{[Xl? NX3UOXRNPiCmYYnz M1\vS2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCjeYexJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{KEKuNk4yPSliY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqemGuIILldIxq[2G2aX;uJIJ6KG2nYYP1dolv\yCneITyZYNmdGy3bHHyJJZqemGuIFTORUBkd3C7IH71cYJmeiCjZoTldkA3KGSjeYOgZpkhemWjbD30bY1mKHGSQ2KgcYV1cG:mLDDFR|UxRTBwMENOwG0> Ml7HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEKwOlcoRjJ6NkiyNFY4RC:jPh?=
HepAD38 Mk\0RY51cX[rcnHsJIF{e2G7 M4LqemFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbn\lZ5Rm\CCrbjDoeY1idiCKZYDBSFM5KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDpcpRz[WOnbHz1cIFzKH[rcnHsJGRPSSCuZY\lcEBjgSCUVD3QR3IhdWW2aH;kMEBGSzVyPECuNFHPxE1? M4DVbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Nki4NlgxLz5{OE[4PFI5ODxxYU6=
HepAD38 NXzRPWdHSW62aY\pdoFtKGG|c3H5 M17IPGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbn\lZ5Rm\CCrbjDoeY1idiCKZYDBSFM5KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidCC{ZYDsbYNifGmxbjDifUBTXC2SQ2KgcYV1cG:mLDDFR|UxRTBwMEVOwG0> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ6OEK4NEc,Ojh4OEiyPFA9N2F-
HepAD38 NWLlSY9RSW62aY\pdoFtKGG|c3H5 NYfLcItXSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHnu[oVkfGWmIHnuJIh2dWGwIFjldGFFOzhiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJIV5fHKjY3XscJVt[XJidnnyZYwhTE6DIHzleoVtKGK7IGLUMXBEWiCvZYToc4QtKEWFNUC9NE4xPM7:TR?= M{DnSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Nki4NlgxLz5{OE[4PFI5ODxxYU6=
HepAD38 MX;BcpRqfmm{YXygZZN{[Xl? M{DqTWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbn\lZ5Rm\CCrbjDoeY1idiCKZYDBSFM5KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidCC{ZYDsbYNifGmxbjDifUBTXC2SQ2KgcYV1cG:mLDDFR|kxRTBwM988US=> M3LvOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Nki4NlgxLz5{OE[4PFI5ODxxYU6=
HepAD38 MUfBcpRqfmm{YXygZZN{[Xl? M4\Hc2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbn\lZ5Rm\CCrbjDoeY1idiCKZYDBSFM5KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDlfJRz[WOnbHz1cIFzKH[rcnHsJGRPSSCuZY\lcEBjgSCUVD3QR3IhdWW2aH;kMEBGSzlyPUCuN:69VQ>? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ6OEK4NEc,Ojh4OEiyPFA9N2F-
HepAD38 NGDiUYZCdnSrdnnyZYwh[XO|YYm= MkS4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFHEN|gh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHnueJJi[2WubIXsZZIhfmm{YXygSG5CKGyndnXsJIJ6KFKWLWDDVkBu\XSqb3SsJGVEQTB;MD63{txO NXjEe3FYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2PFgzQDBpPkK4Olg5OjhyPD;hQi=>
SupT1 MnHIRY51cX[rcnHsJIF{e2G7 NF;YfJo1QCCqcoO= M{\Bc2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHZUXi2JIIDz[ZVld3S7cHXkJGhKXjFiaX7m[YN1\WRiaX6gbJVu[W5iU4XwWFEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME2wMlHPxE1? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTBzNkGzNUc,OjlyMU[xN|E9N2F-
HepG2(2.2.15) NX\qRnRwSW62aY\pdoFtKGG|c3H5 M4LwNVYh\GG7cx?= MlzvRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFeyLFIvOi5zNTmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBFVkFicnXwcIlk[XSrb36gZYZ1\XJiNjDkZZl{KGK7IGLUMXBEWiCvZYToc4QtKEmFNUC8NE4y|ryP NEjGUZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUK4PFk1Oyd-MkmyPFg6PDN:L3G+
A549 NVrDXIt4SW62aY\pdoFtKGG|c3H5 M1TzUGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFidnnybY9veyCmZYLpeoVlKG[{b32gTGlXN1[VRz3HJI9zKEiLVj;IRUB3cXKrb37zJIlv\mWldHXkJFI6O1RiY3XscJMhfXOrbnegbJVu[W5iQUW0PUBk\WyuczDhd{B1[XKpZYSgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiC3c3nu[{Bkd22yb4Xu[EBxemVvbXn4[YQhfmm{aX;ud{Bnd2yub4fl[EBjgSCrbnP1ZoF1cW:wIIfpeIghfGG{Z3X0JINmdCxiSVO1NF0xNjVzzszN NFPMcHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[5PVkzPCd-Mkm2PVk6OjR:L3G+
HepG2.2.15 MmLQRY51cX[rcnHsJIF{e2G7 NVrxb2lqPiCmYYnz M2HKWGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmeGG2aYTpd{BDKH[rcoXzJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{LkKuNVUh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHX4eJJi[2WubIXsZZIhfmm{YXygSG5CKGyndnXsd{Bi\nSncjC2JIRigXNiYomgdXBEWi:WYYHNZY4h[XO|YYmsJGlEPTB;MD6wNlXPxE1? M3roPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMki2NlkzLz5|MEK4OlI6OjxxYU6=
MT4 NF\wVpVCdnSrdnnyZYwh[XO|YYm= M1PJRVUh\GG7cx?= NX3ieY9SSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDSSXMxPTZiY3;ueIFqdmmwZzDy[ZZmenOnIITyZY5{[3KrcIThd4UhUzFyM16gL{B[OThzQzDteZRidnRiaX7m[YN1\WRiaX6gbJVu[W5iTWS0JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBi\nSncjC1JIRigXNiYomgUXRVKGG|c3H5MEBGSzVyPUeuO|fPxE1? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODZyNk[3NEc,OzB4ME[2O|A9N2F-
MT4 NUPZb3NPSW62aY\pdoFtKGG|c3H5 M1nwclUh\GG7cx?= MmmwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\CC2eYDlJGhKXjFiM1KgbY5n\WO2ZXSgbY4hcHWvYX6gUXQ1KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA2KGSjeYOgZpkhVVSWIHHzd4F6NCCHQ{WwQVEzNjkQvF2= MnnlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB4ME[2O|AoRjNyNkC2OlcxRC:jPh?=
MT4 M4G1RWFvfGm4aYLhcEBie3OjeR?= NVzMdVdMPSCmYYnz MoTMRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSB|QjDpcoZm[3SnZDDpckBpfW2jbjDNWFQh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;0c5hq[2m2eTDh[pRmeiB3IHThfZMh[nliTWTUJIF{e2G7LDDFR|UxRTZwNEJOwG0> NI\yNoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEeyNVA3OCd-M{C3NlExPjB:L3G+
HepG2.2.15 NGnTV5VHfW6ldHnvckBie3OjeR?= MWW0JJVO NYn3O|J4PiCmYYnz MkfNTY5pcWKrdHnvckBw\iClYYDzbYQheHKxdHXpckBqdiCKZYDheIl1cXNiQjD2bZJ2eyCrbn\lZ5Rm\CCrbjDoeY1idiCKZYDHNk4zNjF3IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXKjbDDEUmEhdGW4ZXygZZQhPCC3TTDzeZBxdGWvZX70[YQhf2m2aDDmdoV{cCCvZXTpeY0h[2:wdHHpcolv\yClb33wc5Vv\CCndnXyfUAzKGSjeYOgZY5lKG2nYYP1doVlKGGodHXyJFYh\GG7czDifUBTXC2SQ2KgZY5idHm|aYOsJGlEPTB:MD6x{txO MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTB7MUS3PUc,OzFyOUG0O|k9N2F-
HepG2.2.15 MUHBcpRqfmm{YXygZZN{[Xl? NVr1ZWZNSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHnu[oVkfGWmIHnuJIh2dWGwIFjldGczNjJwMUWgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGO7dH;wcIF{dWmlIFTORUB{gW62aHXzbZMh[nlicnXl[EBidmRibYXuZ4ghdWW2aH;kMEBKSzVyPUKuNlLPxE1? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTJ{M{S2NEc,OzF{MkO0OlA9N2F-
C8166 MWjBcpRqfmm{YXygZZN{[Xl? NXvPW5FqPzJiaILz NGjFfndCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIEPCJIlv\mWldHXkJIlvKGi3bXHuJGM5OTZ4IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhe3mwY4n0bYFtKGOnbHyg[o9zdWG2aX;uJIlv[3WkYYTl[EBnd3JiN{KgbJJ{NCCHQ{WwQVAvO87:TR?= NWfC[GU4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GzNVAyOTVpPkOxN|ExOTF3PD;hQi=>
MT4 MXfBcpRqfmm{YXygZZN{[Xl? M{fHZVUh\GG7cx?= MX\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDkdpVoKHKnc3nzeIFvfCCKSW[tNUBp[XKkb4LpcochemW4ZYLz[UB1emGwc3PybZB1[XOnIF[yNldNN1ZzME\BJIRwfWKuZTDteZRidnRiaX7m[YN1\WRiaX6gbJVu[W5iTWS0JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIlv[3WkYYTl[EBnd3JiNTDkZZl{KGK7IF3UWEBie3OjeTygSWM2OD1zLkmy{txO M{jUclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNEO0NFM6Lz5|MUSzOFA{QTxxYU6=
MT4 MnPBRY51cX[rcnHsJIF{e2G7 NH33[HQ2KGSjeYO= NY\rRlg2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh\HK3ZzDy[ZNqe3SjboSgTGlXNTFiaHHyZo9zcW6pIILleoVze2VidILhcpNkemmydHHz[UBNOTBySTDteZRidnRiaX7m[YN1\WRiaX6gbJVu[W5iTWS0JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIlv[3WkYYTl[EBnd3JiNTDkZZl{KGK7IF3UWEBie3OjeTygSWM2OD1|LkG0{txO Mmf6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF2M{SwN|koRjNzNEO0NFM6RC:jPh?=
MT4 MkT2RY51cX[rcnHsJIF{e2G7 MmXxOUBl[Xm| MmTkRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\yC{ZYPpd5RidnRiSFnWMVEhcGG{Yn;ybY5oKHKndnXyd4UhfHKjboPjdolxfGG|ZTDFNVM5UyCvdYThcpQhcW6oZXP0[YQhcW5iaIXtZY4hVVR2IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHnuZ5Vj[XSnZDDmc5IhPSCmYYnzJIJ6KE2WVDDhd5NigSxiRVO1NF0{NjV6zszN MkDzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF2M{SwN|koRjNzNEO0NFM6RC:jPh?=
MT4 NVvFSYxJSW62aY\pdoFtKGG|c3H5 MYW1JIRigXN? M3TjbGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIRzfWdicnXzbZN1[W62IFjJWk0yKGijcnLvdolv\yC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgT|ExO05ibYX0ZY51KGmwZnXjeIVlKGmwIHj1cYFvKE2WNDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDpcoN2[mG2ZXSg[o9zKDViZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:Oy55zszN NY[wZ4ZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G0N|QxOzlpPkOxOFM1ODN7PD;hQi=>
MT4 MVvBcpRqfmm{YXygZZN{[Xl? NYHIfHRZPSCmYYnz Mn70RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXNTFiM1KgbY5n\WO2ZXSgbY4hcHWvYX6gUXQ1KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGmwY4XiZZRm\CCob4KgOUBl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME2zMlg5|ryP NWntUZUyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G0N|QxOzlpPkOxOFM1ODN7PD;hQi=>
MT4 M2ez[mFvfGm4aYLhcEBie3OjeR?= M{H1XFUh\GG7cx?= M3zobWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIRzfWdicnXzbZN1[W62IFjJWk0yKGijcnLvdolv\yC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgXVE5QExibYX0ZY51KGmwZnXjeIVlKGmwIHj1cYFvKE2WNDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDpcoN2[mG2ZXSg[o9zKDViZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:PC52Nd88US=> NHj0U|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUSzOFA{QSd-M{G0N|QxOzl:L3G+
MT4 MmfURY51cX[rcnHsJIF{e2G7 MkW2OUBl[Xm| NUnLV4h4SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh\HK3ZzDy[ZNqe3SjboSgTGlXNTFiaHHyZo9zcW6pIILleoVze2VidILhcpNkemmydHHz[UB[OThzQzDteZRidnRiaX7m[YN1\WRiaX6gbJVu[W5iTWS0JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIlv[3WkYYTl[EBnd3JiNTDkZZl{KGK7IF3UWEBie3OjeTygSWM2OD12LkW0{txO NIXSV209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUSzOFA{QSd-M{G0N|QxOzl:L3G+
MT4 MofCRY51cX[rcnHsJIF{e2G7 NHLUdFQ2KGSjeYO= NFT4WJdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBlenWpIILld4l{fGGwdDDITXYuOSCURWOwOVYhcGG{Yn;ybY5oKHKndnXyd4UhfHKjboPjdolxfGG|ZTDLNVA{Vi:\MUixR{Bld3WkbHWgcZV1[W62IHnu[oVkfGWmIHnuJIh2dWGwIF3UOEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBqdmO3YnH0[YQh\m:{IEWg[IF6eyCkeTDNWHQh[XO|YYmsJGVEPTB;NT61OO69VQ>? NVTjNnlGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G0N|QxOzlpPkOxOFM1ODN7PD;hQi=>
PBMC MkHJRY51cX[rcnHsJIF{e2G7 MkHnRY51cX[rcnHsJIFkfGm4aYT5JIlvKFCETTDj[YxteyCneIDy[ZN{\WRiYYOgTWM2OCxiSVO1NF0xNjByMt88US=> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFEwLz6FaFXNRmw9N2F-
HepG2.2.15 NHX5RW1CdnSrdnnyZYwh[XO|YYm= NIn4cWZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBp\XCjdHn0bZMhSiC4aYL1d{BqdiCqdX3hckBp\XCjdH;tZUBk\WyuIHzpcoUhMDJwMj6xOUBk\WyuczmsJGVEPTB;MD6wNe69VQ>? NGXEUXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDFxJ{7DbGVOSkx:L3G+
HepG2.2.15 MVXGeY5kfGmxbjDhd5NigQ>? M2G2fmVn\mWldHn2[UBkd26lZX70doF1cW:wIH7lZ4V{e2G{eTD0c{Bl\WO{ZXHz[UBmgHS{YXPlcIx2dGG{IFjldIF1cXSrczDCJJZqenW|IFTORUBt\X[nbIOgZpkhPTBnIHnuJIh2dWGwIHjldIF1d2KuYYP0c41iKGOnbHygcIlv\SBqMj6yMlE2KGOnbHzzLUBqdiC4aYTyc{whTUN3ME2wMlA{QM7:TR?= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFEwLz6FaFXNRmw9N2F-
PBMC NF\ETm5HfW6ldHnvckBie3OjeR?= NX;rXpJGS2:vcH;1coQhf2G|IITld5Rm\CCob4KgbZR{KGGwdHmtTGlXKGGldHn2bZR6KGGpYXnud5QhUEmYLUGgUGFKKGmwIHj1cYFvKHCncnnwbIVz[WxiYnzvc4QhdW:wb371Z4xm[XJiKGDCUUkh[2WubIOsJGVEPTB;MD6wOu69VQ>? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFEwLz6FaFXNRmw9N2F-
HepG2.2.15 MWPGeY5kfGmxbjDhd5NigQ>? MVLF[oZm[3SrdnWgZ49v[2WwdILheIlwdiCwZXPld5NienlidH:g[IVkemWjc3Wg[Zh1emGlZXzseYxieiCKZYDheIl1cXNiQjD2bZJ2eyCGTlGgcIV3\Wy|IHL5JFkxLSCrbjDoeY1idiCqZYDheI9jdGG|dH;tZUBk\WyuIHzpcoUhMDJwMj6xOUBk\WyuczmgbY4hfmm2cn:sJGVEQTB;MD6xOu69VQ>? MnXZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQyNyd-Q3jFUWJNRC:jPh?=
HepG2.2.15 MYXGeY5kfGmxbjDhd5NigQ>? MXjU[ZN1\WRiZn;yJJRp\SCnZn\lZ5RqfmViY3;uZ4VvfHKjdHnvckBz\XG3aYLl[EB1dyCrbnjpZol1KEiEVjDpckBJ\XCJMj6yMlE2KGi3bXHuJIxqfmW{IHPlcIx{NCCHQ{WwQVAvOs7:TR?= M33aWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1OS9pPlPoSW1DVDxxYU6=
PBMC NE[wfWNCdnSrdnnyZYwh[XO|YYm= NW\oe5FtSW62aY\pdoFtKGGldHn2bZR6KGmwIGDCUUBk\WyuczygTWM2OD1yLkKx{txO M3X3[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1OS9pPlPoSW1DVDxxYU6=
PBMC NEjqWVBCdnSrdnnyZYwh[XO|YYm= MlnxRY51cX[rcnHsJIFkfGm4aYT5JIlvKFCETTDj[YxteyCneIDy[ZN{\WRiYYOgTWM2OCxiSVO1NF0xNjJzzszN M3rJTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1OS9pPlPoSW1DVDxxYU6=
MT-4 NYe4UZR5SW62aY\pdoFtKGG|c3H5 MXjBcpRqfmm{YXygZYN1cX[rdImgbY4hVVRvNDDj[YxteyxiSVO1NF0xNjN5zszN NFzReY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDFxJ{7DbGVOSkx:L3G+
MT-4 NE\FXndCdnSrdnnyZYwh[XO|YYm= MlfvRY51cX[rcnHsJIFkfGm4aYT5JIlvKE2WLUSgZ4VtdHNiZYjwdoV{e2WmIHHzJGlEPTBuIFnDOVA:OC5|N988US=> NULNTnNXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTRzLze+R4hGVUKOPD;hQi=>
MT-4 M{PwS2FvfGm4aYLhcEBie3OjeR?= MkTwRY51cX[rcnHsJIFkfGm4aYT5JIlvKE2WLUSgZ4VtdHNiZYjwdoV{e2WmIHHzJGlEPTBuIFnDOVA:OC54Md88US=> NXLyO2V4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTRzLze+R4hGVUKOPD;hQi=>
MT-4 NUXvWWlxTnWwY4Tpc44h[XO|YYm= MUjDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCrdIOgZY51cS2KSW[gZYN1cX[rdImgbY4h[WO3dHXsfUBqdm[nY4Tl[EBOXC12IHPlcIx{NCCHQ{WwQVfPxE1? M2LSSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1OS9pPlPoSW1DVDxxYU6=

... Click to View More Cell Line Experimental Data

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 46 mg/mL (200.64 mM)
Water 46 mg/mL (200.64 mM)
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 229.26
化学式

C8H11N3O3S

CAS号 134678-17-4
储存条件 粉状
溶于溶剂
别名 GR109714X

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04133012 Recruiting Other: Samplings HIV-1 Infection ANRS Emerging Infectious Diseases|ViiV Healthcare February 10 2020 Not Applicable
NCT03869944 Recruiting Drug: Lamivudine Oral Solution HIV-1 ANRS Emerging Infectious Diseases|Institut National de la Santé Et de la Recherche Médicale France|Centre Muraz December 4 2019 Phase 2
NCT03870438 Recruiting Drug: Lamivudine Oral Solution HIV-1 ANRS Emerging Infectious Diseases|University Teaching Hospital Lusaka Zambia|Centre Muraz|Institut National de la Santé Et de la Recherche Médicale France|University of Bergen December 14 2019 Phase 3

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Reverse Transcriptase Signaling Pathway Map

相关Reverse Transcriptase产品

Tags: 购买Lamivudine (BCH-189) | Lamivudine (BCH-189)供应商 | 采购Lamivudine (BCH-189) | Lamivudine (BCH-189)价格 | Lamivudine (BCH-189)生产 | 订购Lamivudine (BCH-189) | Lamivudine (BCH-189)代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID