Reverse Transcriptase

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抑制剂选择性比较
溶解性比较

目录号	产品目录	溶解度(25°C)
目录号	产品目录	水	DMSO	酒精
S1401	Tenofovir	2 mg/mL	4 mg/mL	<1 mg/mL
S1400	Tenofovir Disoproxil Fumarate	<1 mg/mL	100 mg/mL	44 mg/mL
S1704	Emtricitabine	49 mg/mL	49 mg/mL	9 mg/mL
S1252	Entecavir Hydrate	<1 mg/mL	59 mg/mL	<1 mg/mL
S1718	Adefovir Dipivoxil	<1 mg/mL	100 mg/mL	100 mg/mL
S5068	Adefovir	0.1 mg/mL	<1 mg/mL	<1 mg/mL
S5423	4-Chloro-2-(trifluoroacetyl)aniline hydrochloride	-1 mg/mL	52 mg/mL	-1 mg/mL
S5246	Entecavir	<1 mg/mL	55 mg/mL	<1 mg/mL
S5215	Abacavir	-1 mg/mL	57 mg/mL	-1 mg/mL
S4890	Bifendate	-1 mg/mL	83 mg/mL	-1 mg/mL
S3606	Fangchinoline	<1 mg/mL	100 mg/mL	4 mg/mL
S1742	Nevirapine	<1 mg/mL	53 mg/mL	<1 mg/mL
S1702	Didanosine	<1 mg/mL	47 mg/mL	<1 mg/mL
S1706	Lamivudine	46 mg/mL	46 mg/mL	<1 mg/mL
S1398	Stavudine (d4T)	<1 mg/mL	45 mg/mL	15 mg/mL
S1651	Telbivudine	48 mg/mL	48 mg/mL	2 mg/mL
S3080	Etravirine (TMC125)	<1 mg/mL	42 mg/mL	<1 mg/mL
S2579	Zidovudine	53 mg/mL	53 mg/mL	18 mg/mL
S1719	Zalcitabine	42 mg/mL	7 mg/mL	<1 mg/mL
S3165	Abacavir sulfate	36 mg/mL	<1 mg/mL	<1 mg/mL
S2914	Dapivirine (TMC120)	<1 mg/mL	34 mg/mL	<1 mg/mL
S3076	Foscarnet Sodium	3 mg/mL	7 mg/mL	<1 mg/mL
S7303	Rilpivirine	<1 mg/mL	73 mg/mL	<1 mg/mL
S4187	Salicylanilide	<1 mg/mL	43 mg/mL	18 mg/mL
S4685	Efavirenz	<1 mg/mL	63 mg/mL	63 mg/mL
S7856	Tenofovir Alafenamide (GS-7340)	<1 mg/mL	95 mg/mL	95 mg/mL

Reverse Transcriptase抑制剂（26）
新Reverse Transcriptase产品

产品目录	产品描述	文献引用	实验数据
S1401	Tenofovir Tenofovir 对reverse transcriptase（逆转录酶）和B型肝炎病毒感染具有抑制作用。	Sci Transl Med, 2014, 6(262):262ra157 Sci Signal, 2015, 8(399):ra104 Retrovirology, 2015, 10.1186/s12977-015-0139-7	The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; ** p<0.0001; * p<0.001 (unpaired t-test).
S1400	Tenofovir Disoproxil Fumarate Tenofovir Disoproxil Fumarate 属于一类抗逆转录病毒药物，其通过与天然底物脱氧腺苷5’-三磷酸盐竞争以及整合到DNA后终止DNA链抑制HIV reverse transcriptase活性。	Sci Transl Med, 2014, 6(262):262ra157 Retrovirology, 2015, 10.1186/s12977-015-0139-7 Stem Cells Dev, 2015, 24(7):814-23	Human PBMCs containing indicated concentrations of Tenofovir disoproxil fumarate were inoculated with 5 ng mock-exposed or semen-exposed R5-HIV-luciferase, or 50 ng R5-HIV-luciferase as infectivity matched control. Infection rates were determined 3 days post inoculation.
S1704	Emtricitabine Emtricitabine (FTC)是一种新型的核苷剂，对人类免疫缺陷病毒HIV和HBV具有抑制活性。是逆转录酶抑制剂，在细胞中的半衰期为39 h。	J Immunol, 2014, 193(7):3577-89
S1252	Entecavir Hydrate Entecavir，一个新的脱氧鸟嘌呤核苷类似物，是乙肝病毒复制的选择性抑制剂。	J Hepatol, 2015, 10.1016/j.jhep.2015.02.048
S1718	Adefovir Dipivoxil Adefovir Dipivoxil 抑制逆转录酶（丙型肝炎病毒（HBV）在体内复制的关键酶）。
S5068^New	Adefovir Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
S5423^New	4-Chloro-2-(trifluoroacetyl)aniline hydrochloride 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor.
S5246^New	Entecavir Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).
S5215^New	Abacavir Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.
S4890^New	Bifendate Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.
S3606^New	Fangchinoline Fangchinoline是双苄基异喹啉类生物碱，是HIV-1的新型抑制剂，具有缓解疼痛、降低血压和抗菌活性。
S1742	Nevirapine Nevirapine 是一种非核苷逆转录酶抑制剂(NNRTI)，用于治疗HIV-1感染和AIDS。	Sci Transl Med, 2014, 6(262):262ra157	Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 d post infection by measuring β-galactosidase. Left: the mean enzyme activities. Middle: normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of nevirapine were set at 100%. Right: IC50 values.
S1702	Didanosine Didanosine是一种逆转录酶抑制剂，IC50为0.49 μM。
S1706	Lamivudine Lamivudine是一种有效的核苷类似物逆转录酶抑制剂，用于治疗慢性乙肝和艾滋病。它主要是通过阻滞HIV逆转录酶和乙肝病毒聚合酶发挥其作用。		The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.
S1398	Stavudine (d4T) Stavudine (d4T)是一种核苷类似物逆转录酶抑制剂（NARTI），有效作用于HIV。
S1651	Telbivudine Telbivudine是一种HBV逆转录酶抑制剂，用于治疗乙型肝炎感染。	Sci Rep, 2013, 3:2105
S3080	Etravirine (TMC125) Etravirine (TMC125)是一种非核苷类逆转录酶抑制剂(NNRTI)，用于治疗HIV。
S2579	Zidovudine Zidovudine是一种逆转录酶抑制剂。它能够降低同源重组效率。Zidovudine降低了CRISPR介导的特定序列基因组敲入效率，但增强了其敲除效率。
S1719	Zalcitabine Zalcitabine是一种核苷类HIV逆转录酶抑制剂(NARTI)。
S3165	Abacavir sulfate Abacavir sulfate是一种常用的核苷类似物，具有抗HIV-1病毒活性。Abacavir是一种鸟嘌呤类似物，它的靶点是病毒的反转录酶。
S2914	Dapivirine (TMC120) Dapivirine (TMC120)是一种非核苷类抑制剂，作用于HIV逆转录酶，IC50为24 nM，抑制多种不同类型的HIV-1分离株，包括多种耐NNRTI的分离株。Phase 3。
S3076	Foscarnet Sodium Foscarnet Sodium通过非竞争性抑制dNTPs而抑制病毒RNA聚合酶，逆转录酶，DNA聚合酶。
S7303	Rilpivirine Rilpivirine是非核苷逆转录抑制剂(NNRTI)，被用于治疗HIV-1感染。
S4187	Salicylanilide Salicylanilides是一组具有广泛的生物活性的化合物，具有抗病毒效力，抗菌（包括抗分枝杆菌），和抗真菌活性。
S4685	Efavirenz Efavirenz是一种合成的、非核苷类逆转录酶抑制剂，具有抗病毒活性。
S7856	Tenofovir Alafenamide (GS-7340) Tenofovir Alafenamide (GS-7340)是tenofovir的前药，tenofovir是一种reverse transcriptase抑制剂，用于治疗HIV和乙型肝炎。

研究领域

产品类型

Reverse Transcriptase

信号通路图

研究领域