AF647 Anti-Human CD314/NKG2D (1D11) mAb
别名: CD314; KLRK1; KLR; NKG2D; NKG2-D; NK cell receptor D
CD314, also known as NKG2D or KLRK1, is a 42 kDa type II transmembrane glycoprotein and a member of the C-type lectin family. It is expressed on human NK cells, as well as on virtually all TCR γ/δ+ and CD8+ TCR α/β+ T cells. NKG2D functions as an activating receptor that binds strongly to several ligands, including MICA, MICB, and ULBP-1, -2, and -3, which are expressed by different target cell types. Unlike other natural cytotoxicity receptors (NCR), NKG2D is not restricted to NK cells. It plays a critical role in natural cytotoxicity, aiding normal NK cells in attacking a variety of tumor or normal target cells. NKG2D can complement the role of NCR in tumor cell lysis, and combined masking of both NCR and NKG2D can lead to a complete inhi
CAS: null
AF647 Anti-Human CD314/NKG2D (1D11) mAb相关产品
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| 相关化合物库 | 激酶抑制剂库 FDA药物库 天然产物库 已知活性药物库-I 高选择性抑制剂库 | 点击展开 |
生物活性
| 产品描述 | CD314, also known as NKG2D or KLRK1, is a 42 kDa type II transmembrane glycoprotein and a member of the C-type lectin family. It is expressed on human NK cells, as well as on virtually all TCR γ/δ+ and CD8+ TCR α/β+ T cells. NKG2D functions as an activating receptor that binds strongly to several ligands, including MICA, MICB, and ULBP-1, -2, and -3, which are expressed by different target cell types. Unlike other natural cytotoxicity receptors (NCR), NKG2D is not restricted to NK cells. It plays a critical role in natural cytotoxicity, aiding normal NK cells in attacking a variety of tumor or normal target cells. NKG2D can complement the role of NCR in tumor cell lysis, and combined masking of both NCR and NKG2D can lead to a complete inhi |
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化学信息&溶解度
| 分子量 | 42 kDa | 分子式 | |
| CAS号 | SDF | -- | |
| 储存条件(自收到货起) | Store at 4°C in the dark to avoid freeze-thaw cycles | ||
|
体内溶解配方 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | |||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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