APC Anti-Human CD40 (5C3) mAb
别名: TNFRSF5; TNF receptor superfamily member 5; CD40L receptor; Bp50; p50
CD40 is a 45–48 kDa type I transmembrane glycoprotein primarily expressed on B lymphocytes, though it is absent on terminally differentiated B cells. It is also found on endothelial cells, basal epithelial cells, certain epithelial cell carcinomas, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, and CD34+ hematopoietic progenitor cells. CD40 plays a critical role in B-cell growth, proliferation, and differentiation, including immunoglobulin isotype switching. Engagement of CD40, particularly in the presence of IL-4 or costimulation with anti-µ or anti-CD20 antibodies, can promote B-cell proliferation.
CAS: null
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生物活性
| 产品描述 | CD40 is a 45–48 kDa type I transmembrane glycoprotein primarily expressed on B lymphocytes, though it is absent on terminally differentiated B cells. It is also found on endothelial cells, basal epithelial cells, certain epithelial cell carcinomas, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, and CD34+ hematopoietic progenitor cells. CD40 plays a critical role in B-cell growth, proliferation, and differentiation, including immunoglobulin isotype switching. Engagement of CD40, particularly in the presence of IL-4 or costimulation with anti-µ or anti-CD20 antibodies, can promote B-cell proliferation. |
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化学信息&溶解度
| 分子量 | 45-48 kDa | 分子式 | |
| CAS号 | SDF | -- | |
| 储存条件(自收到货起) | Store at 4°C in the dark to avoid freeze-thaw cycles | ||
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体内溶解配方 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | |||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
技术支持
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