Dexamethasone Acetate

For research use only. Not for use in humans.

目录号:S3124 别名: NSC 39471 中文名称:醋酸地塞米松

Dexamethasone Acetate Chemical Structure

CAS No. 1177-87-3

Dexamethasone (NSC 39471) 是一种有效的糖皮质激素类合成物,属于类固醇药物。Dexamethasone用于很多炎症和自身免疫病的治疗,例如风湿性关节炎和支气管痉挛。接受化疗的癌症病人服用dexamethasone去抵消部分化疗带来的副作用。Dexamethasone 也用在诊断方面,利用它能抑制垂体一肾上腺轴特性。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1061.82 现货
RMB 791.97 现货
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产品安全说明书

IL Receptor抑制剂选择性比较

生物活性

产品描述 Dexamethasone (NSC 39471) 是一种有效的糖皮质激素类合成物,属于类固醇药物。Dexamethasone用于很多炎症和自身免疫病的治疗,例如风湿性关节炎和支气管痉挛。接受化疗的癌症病人服用dexamethasone去抵消部分化疗带来的副作用。Dexamethasone 也用在诊断方面,利用它能抑制垂体一肾上腺轴特性。
靶点
interleukin receptor [1]
体外研究

Dexamethasone用于很多炎症和自身免疫病的治疗,例如风湿性关节炎和支气管痉挛。接受化疗的癌症病人服用dexamethasone去抵消部分化疗带来的副作用。Dexamethasone 也用在诊断方面,利用它能抑制垂体一肾上腺轴特性。

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT ; 

PubMed: 29436611     


Dexamethasone (C) promoted Akt phosphorylation in PC3 cells and inhibited Akt phosphorylation in PC3-AR9.

GRP78 / GRP94 / pIREα / IREα / peIF2α / eIF2α CHOP ; 

PubMed: 24691439     


Dexamethasone induced ER stress and activated the UPR in human TM cells. Primary human TM cells obtained from normal human donors were treated with dexamethasone for 48 hours. GRP78, GRP94, CHOP, and phosphorylation of IRE1 and eIF2α were examined by Western blot analysis (n = 3).

BCRP / P-gp / Mrp2 ; 

PubMed: 18524938     


Dexamethasone induced bcrp, p-glycoprotein (p-gp), and mrp2 protein expression in brain endothelial cells. A: representative Western blots demonstrating the concentration-dependent increase in protein expression of bcrp, p-gp, and mrp2 in primary endothelial cells when cultured with dexamethasone for 24 h. Quantitative analysis by densitometry of three different experiments is also shown. B: dexamethasone-induced increase in bcrp, p-gp, and mrp2 expression after incubation of endothelial cells with 250 nM dexamethasone was dependent on the time of exposure. Quantitative analysis by densitometry of three different experiments is also shown. *P < 0.05 vs. untreated cells, **P < 0.01 vs. untreated cells.

29436611 24691439 18524938
Immunofluorescence
GRP78; 

PubMed: 24691439     


Human TM cells were treated with vehicle or dexamethasone for 48 hours and stained with GRP78 and phalloidin (which stains F-actin) (n = 3). Dexamethasone treatment increased actin and GRP78 levels. Scale bars: 50 μm.

24691439
Growth inhibition assay
Cell viability; 

PubMed: 22719835     


(A) Proliferation of MC3T3-E1 cells was measured by CCK8 (colorimetric cell counting kit-8) after cells were treated with 0, 0.001,0.01,0.1, 1.0 and 10.0 µmol/L dexamethasone for 24 hours. treatment with 1 and 10 µmol/L DEX remarkably reduced cell proliferation. B) Cell death was measured by typan blue incorporation after cells were treated with 0, 0.001,0.01,0.1, 1.0 and 10.0 µmol/L dexamethasone for 24 hours. treatment with 1 and 10 µmol/L dexamethasone remarkably increased dead cell population Values are means+SEM (n = 3). *P< 0.05 vs corresponding untreated controls.

22719835
体内研究 Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. [4] Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats. [5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验:[5]
- 合并
  • Animal Models: Sprague-Dawley rats
  • Dosages: 100 μg/kg
  • Administration: Intraperitoneal injection
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 87 mg/mL (200.23 mM)
Water Insoluble
Ethanol '20 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 434.5
化学式

C24H31FO6

CAS号 1177-87-3
储存条件 粉状
溶于溶剂
别名 NSC 39471

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04911361 Not yet recruiting Drug: Dexamethasone Dry Eye Research Insight LLC July 26 2021 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID