ACAT 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S0820 RP-64477

RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). RP-64477 inhibits ACAT activity with IC50 of 113 nM, 503 nM, and 180 nM in human intestinal (CaCo-2), hepatic (HepG2) and monocytic (THP-1) cell assays, respectively.

Selective ACAT, IC50: 180 nM; ACAT, IC50: 503 nM; ACAT, IC50: 113 nM
S2187 Avasimibe (CI-1011)

Avasimibe抑制ACATIC50为3.3 μM,也抑制人P450同工酶CYP2C9, CYP1A2和CYP2C19,IC50分别为2.9 μM, 13.9 μM和26.5 μM,

Selective ACAT, IC50: 3.3 μM
S4189 Cyclandelate

Cyclandelate是大鼠肝脏acycloenzymeA:胆固醇酰基转移酶(ACAT)的有效抑制剂,IC50为80μM。

Selective ACAT, IC50: 80 μM