Calpain 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S7424 PD 151746

PD 151746是一种选择性,细胞渗透性的calpain抑制剂,对μ-Calpain 的Ki为2.6M,比m-Calpain约高出20倍的选择性。

Selective m-calpain, IC50: 5.33 μM; μ-Calpain, IC50: 260 nM
S7394 MDL-28170

MDL-28170 blocks γ-secretase. MDL-28170 is also a potent, selective and membrane-permeable cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration.

Selective
S7396 Calpeptin

Calpeptin是一种有效的,细胞渗透性 calpain 抑制剂,对钙蛋白酶 I (猪红细胞),钙蛋白酶 II (猪肾脏),木瓜蛋白酶,和钙蛋白酶 I (人血小板)的ID50分别为52 nM,34 nM,138 nM,和40 nM 。

Pan Calpain I (human platelets), ID50: 40 nM; Calpain II (porcine kidney), ID50: 34 nM; Calpain I (porcine erythrocytes), ID50: 52 nM