ERK5 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S1531 BIX 02189

BIX02189是一种选择性的MEK5抑制剂,无细胞试验中IC50为1.5 nM,也抑制ERK5催化活性,IC50为59 nM,且不抑制密切相关的激酶MEK1,MEK2,ERK2,和JNK2。

Selective ERK5, IC50: 59 nM
S7525 XMD8-92

XMD8-92 是强效的选择性的BMK1/ERK5抑制剂,其Kd为80 nM。

Selective BMK1, Kd: 80 nM
S7334 ERK5-IN-1

ERK5-IN-1 是一种有效的选择性 ERK5 抑制剂,IC50 为 162 nM。

Selective ERK5, IC50: 162 nM
S6786 ERK5-IN-2

ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50 of 0.82 μM and 3 μM for ERK5 and ERK5 MEF2D, respectively.

Selective ERK5 MEF2D, IC50: 3 μM; ERK5, IC50: 0.82 μM
S8896 BAY-885

BAY885 is a novel inhibitor of ERK5.

Selective
S0726 XMD8-85 (ERK5-IN-1)

XMD8-85 (ERK5-IN-1) is a potent dual inhibitor of ERK5 and LRRK2 with IC50 of 87 nM and 26 nM, respectively.

Selective