• EGFR/ErbB1
  • HER2/ErbB2
  • ErbB3
  • ErbB4
  • mutant EGFR

ErbB3 抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S2192 Sapitinib (AZD8931) Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2. Pan ErbB3, IC50: 4 nM
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