HSP70 选择性抑制剂 | 激活剂 | 调节剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S8365 Apoptozole

Apoptozole是热激蛋白HSP70Hsc70的抑制剂,与HSP70和Hsc70的Kd值分别为0.14 μM和0.21 μM。它能够诱导caspase依赖性的凋亡反应。

Selective HSC70, Kd: 0.21 μM; HSP70, Kd: 0.14 μM
S7751 VER155008

VER-155008是一种有效的Hsp70家族抑制剂,无细胞试验中对HSP70,HSC70,和 GRP78的IC50分别为0.5 μM,2.6 μM,和 2.6 μM,比作用于HSP90选择性高100多倍。

Selective GRP78, IC50: 2.6 μM; HSC70, IC50: 2.6 μM; HSP70, IC50: 0.5 μM
S6193 YUM70

YUM70 is a potent inhibitor of glucose-regulated protein 78 (GRP78) inhibitor with an IC50 of 1.5 μM. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.

Selective GRP78, IC50: 1.5 μM
S8305 TRC051384

TRC051384是heat shock protein 70 (HSP70)的诱导物,同时也是有效的抗炎药。

Selective
S6568 ML346

ML346 is a Hsp70 activator and a novel modulator of proteostasis for protein conformational diseases.

Selective
S6721 JG98

JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.

Selective
S1052 Elesclomol (STA-4783)

Elesclomol (STA-4783)是一种新型有效的oxidative stress诱导剂,在肿瘤细胞中引起促凋亡作用。Phase 3。

Selective
S8299 HA15

HA15是特异靶向BiP/GRP78/HSPA5的小分子。在所检测的黑色素瘤细胞中具有抗肿瘤活性,包括从病人中分离得到的细胞和对BRAF抑制剂具有耐药性的细胞。

Selective
S7750 KNK437

KNK437 是一种泛-HSP 抑制剂,其抑制诱导型HSPs,包括 HSP105,HSP72,和 HSP40的合成。

Pan