LDHA 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S8590 GSK 2837808A

GSK2837808A is a selective LDHA (lactate dehydrogenase A) inhibitor with IC50 of 2.6 nM and 43 nM for hLDHA and hLDHB, respectively.

Selective hLDHA, IC50: 2.6 nM
S0108 AZ-33

AZ-33 (LDHA Inhibitor 33) is a Lactate dehydrogenase A (LDHA) inhibitor. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.

Selective LDHA, IC50: 0.5 μM
S6871 Sodium oxamate

Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.

Selective
S6675 (R)-GNE-140

(R)-GNE-140 is a selective inhibitor of the LDHA and LDHB with IC50s of 3 nM and 5 nM, respectively. The R enantiomer of GNE-140 is 18-fold more potent than S enantiomer.

Pan LDHA, IC50: 3 nM