|目录号||产品名||产品描述||Selective / Pan||IC50 / Ki|
GSK2837808A is a selective LDHA (lactate dehydrogenase A) inhibitor with IC50 of 2.6 nM and 43 nM for hLDHA and hLDHB, respectively.
|Selective||hLDHA, IC50: 2.6 nM|
AZ-33 (LDHA Inhibitor 33) is a Lactate dehydrogenase A (LDHA) inhibitor. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.
|Selective||LDHA, IC50: 0.5 μM|
Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.
(R)-GNE-140 is a selective inhibitor of the LDHA and LDHB with IC50s of 3 nM and 5 nM, respectively. The R enantiomer of GNE-140 is 18-fold more potent than S enantiomer.
|Pan||LDHA, IC50: 3 nM|
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