MT2-receptor 激动剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S1259 Ramelteon

Ramelteon是一种新型的的Melatonin受体激动剂,作用于人MT1和MT2受体及小鸡前脑Melatonin受体,Ki值分别为14 pM, 112 pM和23.1 pM。

Pan MT2 receptor, Ki: 112 pM
S4281 Tasimelteon

Tasimelteon (BMS 214778, VEC 162) is a selective dual melatonin receptor (MT1/MT2) agonist with 2.1-4.4 times greater affinity for the MT2 receptor believed to mediate circadian rhythm phase-shifting (Ki = 0.0692 nM and Ki = 0.17 nM in NIH-3T3 and CHOeK1 cells, respectively), than for the MT1 receptor (Ki = 0.304 nM and Ki = 0.35 nM, respectively).

Pan MT2 receptor, pKi: 9.8