MT Receptor
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S1259 | Ramelteon | <1 mg/mL | 52 mg/mL | 52 mg/mL |
| S1204 | Melatonin | <1 mg/mL | 47 mg/mL | 47 mg/mL |
| S4281 | Tasimelteon | -1 mg/mL | 49 mg/mL | -1 mg/mL |
特异性亚型抑制剂
- MT Receptor抑制剂（3）
- 新MT Receptor产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1259 |
RamelteonRamelteon是一种新型的的Melatonin受体激动剂，作用于人MT1和MT2受体及小鸡前脑Melatonin受体，Ki值分别为14 pM， 112 pM和23.1 pM。 |
(A) CLSM images of Porphyromonas gingivalis biofilm formed in the presence of melatonin and ramelteon at sub-MIC concentrations. Biofilm-forming cells were stained using the Live/Dead Bacterial Viability Kit. Dead cells were stained red, whereas live bacteria were stained green. In the presence of 50 μg/mL or 25 μg/mL ramelteon, the areas of biofilm formation were narrower than that of vehicle controls. Bars = 50 μm.
|
|
| S1204 |
MelatoninMelatonin是一种MT receptor激动剂激素, 用作膳食补充品。 |
C: EDU staining of adipocytes treated with MT for 24 h (n=3). D: Flow Cytometry analysis of cell cycle in adipocytes treated with MT for 24 h (n=3).
|
|
| S4281New |
TasimelteonTasimelteon is a selective dual melatonin receptor (MT1/MT2) agonist with 2.1-4.4 times greater affinity for the MT2 receptor believed to mediate circadian rhythm phase-shifting (Ki = 0.0692 nM and Ki = 0.17 nM in NIH-3T3 and CHOeK1 cells, respectively), than for the MT1 receptor (Ki = 0.304 nM and Ki = 0.35 nM, respectively). |
