MT Receptor
信号通路图
研究领域
抑制剂选择性比较
特异性亚型抑制剂
MT Receptor产品
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S3584 |
LuzindoleLuzindole (N-0774, N-acetyl-2-benzyltryptamine) 是一种选择性 褪黑激素受体(melatonin receptor) 拮抗剂，对MT1的Ki值为179 nM，对MT2的Ki值为7.3 nM。 |
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| S1259 |
RamelteonRamelteon (TAK-375) 是一种新型的的Melatonin受体激动剂，作用于人MT1和MT2受体及小鸡前脑Melatonin受体，Ki值分别为14 pM， 112 pM和23.1 pM。 |
(M) (Left) Cresyl violet and Luxol fast blue staining of ipsilateral corpus striatum on day 3 post-TBI. Scale bar = 50 µm. (Right) Bar graph shows that ramelteon did not increase the percentage of area with normal myelin in the Nrf2 KO mouse brain compared with that in the vehicle group. n = 6 mice/group. *P < 0.05 vs. sham group (one-way ANOVA followed by Bonferroni post hoc test). (N) (Left) Fluoro-Jade C staining of the perilesional cerebral cortex on day 3 post-TBI. Scale bar = 30 µm. (Right) Bar graph shows that ramelteon did not decrease the number of degenerating neurons in the perilesional region of the Nrf2 KO mice. n = 6 mice/group. *P < 0.05 vs. sham group (one-way ANOVA followed by Bonferroni post hoc test).
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| S1204 |
Melatonin (NSC 113928)Melatonin (NSC 113928, NSC 56423, N-Acetyl-5-methoxytryptamine)是一种 MT receptor 激动剂激素, 用作膳食补充品。Melatonin 是一种选择性的 ATF-6 的抑制剂并可下调 COX-2。Melatonin 可增强线粒体自噬并调节凋亡和自噬的稳态。 |
TUNEL staining of treated adipocytes and flow cytometry analysis of positive TUNEL cells (n=3). |
|
| S4281 |
TasimelteonTasimelteon (BMS 214778, VEC 162) is a selective dual melatonin receptor (MT1/MT2) agonist with 2.1-4.4 times greater affinity for the MT2 receptor believed to mediate circadian rhythm phase-shifting (Ki = 0.0692 nM and Ki = 0.17 nM in NIH-3T3 and CHOeK1 cells, respectively), than for the MT1 receptor (Ki = 0.304 nM and Ki = 0.35 nM, respectively). |
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S3584 |
LuzindoleLuzindole (N-0774, N-acetyl-2-benzyltryptamine) 是一种选择性 褪黑激素受体(melatonin receptor) 拮抗剂，对MT1的Ki值为179 nM，对MT2的Ki值为7.3 nM。 |
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1259 |
RamelteonRamelteon (TAK-375) 是一种新型的的Melatonin受体激动剂，作用于人MT1和MT2受体及小鸡前脑Melatonin受体，Ki值分别为14 pM， 112 pM和23.1 pM。 |
(M) (Left) Cresyl violet and Luxol fast blue staining of ipsilateral corpus striatum on day 3 post-TBI. Scale bar = 50 µm. (Right) Bar graph shows that ramelteon did not increase the percentage of area with normal myelin in the Nrf2 KO mouse brain compared with that in the vehicle group. n = 6 mice/group. *P < 0.05 vs. sham group (one-way ANOVA followed by Bonferroni post hoc test). (N) (Left) Fluoro-Jade C staining of the perilesional cerebral cortex on day 3 post-TBI. Scale bar = 30 µm. (Right) Bar graph shows that ramelteon did not decrease the number of degenerating neurons in the perilesional region of the Nrf2 KO mice. n = 6 mice/group. *P < 0.05 vs. sham group (one-way ANOVA followed by Bonferroni post hoc test).
|
|
| S1204 |
Melatonin (NSC 113928)Melatonin (NSC 113928, NSC 56423, N-Acetyl-5-methoxytryptamine)是一种 MT receptor 激动剂激素, 用作膳食补充品。Melatonin 是一种选择性的 ATF-6 的抑制剂并可下调 COX-2。Melatonin 可增强线粒体自噬并调节凋亡和自噬的稳态。 |
TUNEL staining of treated adipocytes and flow cytometry analysis of positive TUNEL cells (n=3). |
|
| S4281 |
TasimelteonTasimelteon (BMS 214778, VEC 162) is a selective dual melatonin receptor (MT1/MT2) agonist with 2.1-4.4 times greater affinity for the MT2 receptor believed to mediate circadian rhythm phase-shifting (Ki = 0.0692 nM and Ki = 0.17 nM in NIH-3T3 and CHOeK1 cells, respectively), than for the MT1 receptor (Ki = 0.304 nM and Ki = 0.35 nM, respectively). |
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