• PKM2
  • PMK2

PKM2 抑制剂 | 激活剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S7302 TEPP-46 (ML265) TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL. Pan
S8279 Shikonin Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB)< Pan PKM2, IC50: 0.3 μM; PKM2, IC50: 0.8 μM
S8616 PKM2 inhibitor(compound 3k) PKM2 inhibitor(Compound 3K, PKM2-IN-1) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2. Pan PKM2, IC50: 2.95 μM
S7928 DASA-58 DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator. Pan
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