PKM

特异性亚型抑制剂

• PKM2 Selective

PKM产品

目录号	产品描述	文献引用	实验数据
S8279	Shikonin (C.I. 75535) Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844)是一种 Pyruvate kinase M2 (PKM2) 有效的、特异的抑制剂。它是紫草的主要成分，紫草是一种中草药，具有多种生物活性。在细胞荧光淬灭试验中，Shikonin也是TMEM16A氯离子通道的抑制剂。Shikonin 通过抑制 tumor necrosis factor-α (TNF-α) 发挥抗炎作用，并可通过抑制 proteasome 来阻止 nuclear factor-κB (NF-κB) 信号途径的激活。	Adv Sci (Weinh), 2022, 10.1002/advs.202104055 Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Bioengineered, 2022, 13(3):5928-5941
S8616	PKM2 inhibitor(compound 3k) PKM2 inhibitor (Compound 3K)是PKM2抑制剂，IC50为2.95 μM。对PKM1的IC50值比对PKM2的IC50值高4-5倍。	Exp Cell Res, 2022, S0014-4827(22)00045-3 Eur J Pharmacol, 2022, S0014-2999(22)00105-4 Cell Biol Int, 2022, 10.1002/cbin.11780
S6508	Mitapivat Mitapivat (AG-348)是丙酮酸激酶PKM2的激活剂。PKM2参与糖酵解。
S7302	TEPP-46 (ML265) TEPP-46 (ML265, CID-44246499, NCGC00186528)是一种有效的PKM2激活剂，AC50为92 nM。相对于PKM1、PKR和PKL，对PKM2具有高选择性。	Fitoterapia, 2021, 152:104922
S7928	DASA-58 DASA-58是一种特异性且有效的Pyruvate kinase M2 (PKM2)激活剂。	Int J Mol Sci, 2022, 23(2)775 Cell Biol Int, 2022, 10.1002/cbin.11780 PLoS Pathog, 2021, 17(3):e1008866	Surface staining of total thymocytes from LckCre/Sin1fl/fl mice treated with vehicle or the PKM2 activator DASA-58. Upper panels are CD4 and CD8 staining. Lower panels are gated on the CD4 and CD8 DN subset for further CD44 and CD25 expression analyses. Numbers in the panels show the relative percentage of cells in that area.
S5545	DL-Serine Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.

目录号	产品描述	文献引用	实验数据
S8279	Shikonin (C.I. 75535) Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844)是一种 Pyruvate kinase M2 (PKM2) 有效的、特异的抑制剂。它是紫草的主要成分，紫草是一种中草药，具有多种生物活性。在细胞荧光淬灭试验中，Shikonin也是TMEM16A氯离子通道的抑制剂。Shikonin 通过抑制 tumor necrosis factor-α (TNF-α) 发挥抗炎作用，并可通过抑制 proteasome 来阻止 nuclear factor-κB (NF-κB) 信号途径的激活。	Adv Sci (Weinh),2022, 10.1002/advs.202104055 Nat Chem Biol,2022, 10.1038/s41589-022-00996-7 Bioengineered,2022, 13(3):5928-5941
S8616	PKM2 inhibitor(compound 3k) PKM2 inhibitor (Compound 3K)是PKM2抑制剂，IC50为2.95 μM。对PKM1的IC50值比对PKM2的IC50值高4-5倍。	Exp Cell Res,2022, S0014-4827(22)00045-3 Eur J Pharmacol,2022, S0014-2999(22)00105-4 Cell Biol Int,2022, 10.1002/cbin.11780

目录号	产品描述	文献引用	实验数据
S6508	Mitapivat Mitapivat (AG-348)是丙酮酸激酶PKM2的激活剂。PKM2参与糖酵解。
S7302	TEPP-46 (ML265) TEPP-46 (ML265, CID-44246499, NCGC00186528)是一种有效的PKM2激活剂，AC50为92 nM。相对于PKM1、PKR和PKL，对PKM2具有高选择性。	Fitoterapia, 2021, 152:104922
S7928	DASA-58 DASA-58是一种特异性且有效的Pyruvate kinase M2 (PKM2)激活剂。	Int J Mol Sci, 2022, 23(2)775 Cell Biol Int, 2022, 10.1002/cbin.11780 PLoS Pathog, 2021, 17(3):e1008866	Surface staining of total thymocytes from LckCre/Sin1fl/fl mice treated with vehicle or the PKM2 activator DASA-58. Upper panels are CD4 and CD8 staining. Lower panels are gated on the CD4 and CD8 DN subset for further CD44 and CD25 expression analyses. Numbers in the panels show the relative percentage of cells in that area.
S5545	DL-Serine Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.