PKM
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S8616 | PKM2 inhibitor(compound 3k) | <1 mg/mL | 6 mg/mL | <1 mg/mL |
| S7302 | TEPP-46 (ML265, CID-44246499, NCGC00186528) | <1 mg/mL | 74 mg/mL | <1 mg/mL |
| S7928 | DASA-58 | <1 mg/mL | 91 mg/mL | <1 mg/mL |
| S5545 | DL-Serine | 8 mg/mL | <1 mg/mL | -1 mg/mL |
- PKM抑制剂（4）
- 新PKM产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S8616 |
PKM2 inhibitor(compound 3k)PKM2 inhibitor (Compound 3K)是PKM2抑制剂，IC50为2.95 μM。对PKM1的IC50值比对PKM2的IC50值高4-5倍。 |
||
| S7302New |
TEPP-46 (ML265, CID-44246499, NCGC00186528)ML265是一种有效的PKM2激活剂，AC50为92 nM。相对于PKM1、PKR和PKL，对PKM2具有高选择性。 |
||
| S7928 |
DASA-58DASA-58是一种特异性且有效的Pyruvate kinase M2 (PKM2)激活剂。 |
Surface staining of total thymocytes from LckCre/Sin1fl/fl mice treated with vehicle or the PKM2 activator DASA-58. Upper panels are CD4 and CD8 staining. Lower panels are gated on the CD4 and CD8 DN subset for further CD44 and CD25 expression analyses. Numbers in the panels show the relative percentage of cells in that area.
|
|
| S5545New |
DL-SerineSerine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2. |
