PRMT1 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S0855 TC-E 5003

TC-E 5003 (NSC 30176, Compound 2e) is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1) with IC50 of 1.5 μM. TC-E 5003 modulates the lipopolysaccharide (LPS)-induced AP-1 and NF-κB signaling pathways and can possibly be further developed as an anti-inflammatory compound.

Selective PRMT1, IC50: 1.5 μM
S7884 AMI-1

AMI-1是一种有效的特异性Histone Methyltransferase (HMT)抑制剂,对酵母 Hmt1p 和人 PRMT1 的IC50分别为 3.0 μM 和 8.8 μM。

Selective human PRMT1, IC50: 8.8 μM
S6737 C7280948

C7280948 is a protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 12.8 μM in vitro.

Selective PRMT1, IC50: 12.8 μM
S5445 AMI-1 (free acid)

AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.

S8112 MS023

MS023是一类高效选择性并且有细胞活性的I型PRMT抑制剂,其对PRMT1, PRMT3, PRMT4, PRMT6和PRMT8的IC50分别为30 nM, 119 nM, 83 nM, 4 nM, 和5 nM。

Pan PRMT1, IC50: 30 nM
S8858 GSK3368715 (EPZ019997) 3HCl

GSK3368715 is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM.