|目录号||产品名||产品描述||Selective / Pan||IC50 / Ki|
TC-E 5003 (NSC 30176, Compound 2e) is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1) with IC50 of 1.5 μM. TC-E 5003 modulates the lipopolysaccharide (LPS)-induced AP-1 and NF-κB signaling pathways and can possibly be further developed as an anti-inflammatory compound.
|Selective||PRMT1, IC50: 1.5 μM|
AMI-1是一种有效的特异性Histone Methyltransferase (HMT)抑制剂，对酵母 Hmt1p 和人 PRMT1 的IC50分别为 3.0 μM 和 8.8 μM。
|Selective||human PRMT1, IC50: 8.8 μM|
C7280948 is a protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 12.8 μM in vitro.
|Selective||PRMT1, IC50: 12.8 μM|
|S5445||AMI-1 (free acid)||
AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.
MS023是一类高效选择性并且有细胞活性的I型PRMT抑制剂，其对PRMT1, PRMT3, PRMT4, PRMT6和PRMT8的IC50分别为30 nM, 119 nM, 83 nM, 4 nM, 和5 nM。
|Pan||PRMT1, IC50: 30 nM|
|S8858||GSK3368715 (EPZ019997) 3HCl||
GSK3368715 is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM.
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