- RIP1 kinase
- RIP2 kinase
- RIP3 kinase
RIP1-kinase 选择性抑制剂 | 激活剂
|目录号||产品名||产品描述||Selective / Pan||IC50 / Ki|
GSK3145095 is a potent and orally active RIP1 kinase inhibitor with IC50 of 6.3 nM with potential antineoplastic and immunomodulatory activities.
|Selective||RIP1 kinase, IC50: 6.3 nM|
GSK2982772是receptor-interacting protein-1 (RIP1) kinase的ATP竞争性抑制剂，IC50为1 nM。它能够抑制多种TNF依赖性的细胞反应，具有良好的激酶特异性和细胞活性。
|Selective||human RIP1, IC50: 16 nM|
GSK'963 is a chiral small-molecule inhibitor of RIP1 kinase (RIPK1) with an IC50 of 29 nM in FP binding assays. It is >10 000-fold selective for RIP1 over 339 other kinases.
|Selective||RIP1 kinase, IC50: 29 nM|
|S8641||Necrostatin 2 racemate (Nec-1s)||
Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) is a stable variant of Necrostatin-1. It is a more specific RIPK1 inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other kinase out of 485 human kinases.
GSK481是RIP1(Receptor Interacting Protein Kinase1)抑制剂，抑制RIP1以阻碍细胞坏死。
RIPA-56 is a highly-potent, selective, and metabolically stable RIP1 (RIPK1) inhibitor.
|Pan||RIP1, IC50: 13 nM|
|Pan||RIP1, EC50: 490 nM|
Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells.
GSK'547 is a highly selective and potent inhibitor of RIP1 (RIPK1) exhibiting a 400-fold improvement in mouse pharmacokinetic oral exposure compared with GSK'963
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