- RIP1 kinase
- RIP2 kinase
- RIP3 kinase
RIP2-kinase 选择性抑制剂 | 激活剂
|目录号||产品名||产品描述||Selective / Pan||IC50 / Ki|
BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. BDTX-189 exhibits anticancer activity.
|Selective||RIPK2, Kd: 1.2 nM|
|Selective||RIPK2, IC50: 0.11 μM|
|S8927||GSK2983559 (compound 3)||
GSK2983559 (compound 3, RIP2 kinase inhibitor 1, RIPK2-IN-1) is a potent inhibitor of receptor interacting protein 2 (RIP2) kinase with good kinase specificity.
GSK481是RIP1(Receptor Interacting Protein Kinase1)抑制剂，抑制RIP1以阻碍细胞坏死。
|Pan||RIP2, IC50: 5 nM|
RIPA-56 is a highly-potent, selective, and metabolically stable RIP1 (RIPK1) inhibitor.
|Pan||RIP1, IC50: 13 nM|
|Pan||RIP1, EC50: 490 nM|
GSK'547 is a highly selective and potent inhibitor of RIP1 (RIPK1) exhibiting a 400-fold improvement in mouse pharmacokinetic oral exposure compared with GSK'963
Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells.
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