Thrombin
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S2196 | Dabigatran (BIBR 953) | <1 mg/mL | 0.5 mg/mL | 0.01 mg/mL |
| S2154 | Dabigatran Etexilate | <1 mg/mL | 126 mg/mL | 12 mg/mL |
| S2069 | Argatroban | <1 mg/mL | 9 mg/mL | 6 mg/mL |
| S5252 | Ozagrel sodium | 50 mg/mL | 1 mg/mL | <1 mg/mL |
| S5074 | Argatroban Monohydrate | <1 mg/mL | 100 mg/mL | 40 mg/mL |
| S3200 | Triflusal | <1 mg/mL | 50 mg/mL | 50 mg/mL |
| S4740 | Sodium ferulate | 43 mg/mL | 2 mg/mL | <1 mg/mL |
| S4502 | Eltrombopag | <1 mg/mL | 26 mg/mL | <1 mg/mL |
| S5286 | Ramatroban | <1 mg/mL | 83 mg/mL | 83 mg/mL |
| S2229 | Eltrombopag Olamine | <1 mg/mL | 89 mg/mL | <1 mg/mL |
| S1346 | Heparin sodium | 100 mg/mL | <1 mg/mL | <1 mg/mL |
Thrombin产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S2196 |
Dabigatran (BIBR 953)Dabigatran (BIBR 953)是一种有效的非肽类凝血酶抑制剂，无细胞试验中IC50为9.3 nM。 |
The peak fluorescence of each time course at the specified drug concentration are plotted as a function of concentration of (C) dabigatran. Each dose-response curve was fitted to the Hill equation, and these curves are shown in red for thrombin inhibitors (B,C).
|
|
| S2154 |
Dabigatran EtexilateDabigatran Etexilate是dabigatran的前体药物，dabigatran是一种有效的、非肽类小分子化合物，可特异地、可逆性地抑制游离的和结合了血凝块的凝血酶。 |
|
|
| S2069 |
ArgatrobanArgatroban是一种有效的、选择性的thrombin 合成抑制剂，Ki值范围为5 nM-39 nM，被用作抗凝剂。 |
||
| S5252New |
Ozagrel sodiumSodium ozagrel (ozagrel) is a thromboxane A2 synthase inhibitor with neuroprotective properties. |
||
| S5074New |
Argatroban MonohydrateArgatroban是一种直接的、选择性的thrombin抑制剂，具有抗凝活性。 |
||
| S3200 |
TriflusalTriflusal是一种抗血栓药剂，通过乙酰化环氧化酶-1来不可逆的抑制血小板中血栓素-B2的产生。 |
||
| S4740 |
Sodium ferulateSodium ferulate (SF), 是ferulic acid的钠盐形式，是一种用于治疗心血管和脑血管疾病、防止血栓形成的传统中药。 |
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| S4502 |
EltrombopagEltrombopag,属于biarylhydrazone小分子，是一种thrombopoietin receptor (TpoR)的非肽类激动剂，用于治疗慢性丙型肝炎相关的血小板减少和慢性免疫性(自发的)血小板减少(ITP)。 |
Effect of eltrombopag on cell cycle progression in Huh7 cells. (A) Cells were treated with EP (0 and 10 μg/ml) for 72 h. DNA was stained with propidium iodide, and flow cytometric analysis of cell phase distribution was performed using a Muse™ cell analyzer. (B) Cells were treated with EP (0, 1 and 10 μg/ml) for 72 h. Protein expression was determined by western blot analysis using anti-cyclin D1, anti-p21 and anti-GAPDH antibodies. SDS-PAGE was performed on acrylamide gels.
|
|
| S5286New |
RamatrobanRamatroban (BAY u 3405) is a thromboxane A2(TxA2) receptor antagonist with Ki value of 10 to 13 nM. It also antagonizes a newly identified PGD2 receptor, CRTh2 expressed on the inflammatory cells. |
||
| S2229 |
Eltrombopag OlamineEltrombopag Olamine 是小分子，c-mpl (TpoR)受体激动剂，抑制 hERG K+通道尾电流，IC50为0.69 μM。 |
||
| S1346 |
Heparin sodiumHeparin sodium属于一类葡聚糖，可以和多种蛋白相互作用产生多种生物活性，临床上用作抗凝剂。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S2196 |
Dabigatran (BIBR 953)Dabigatran (BIBR 953)是一种有效的非肽类凝血酶抑制剂，无细胞试验中IC50为9.3 nM。 |
The peak fluorescence of each time course at the specified drug concentration are plotted as a function of concentration of (C) dabigatran. Each dose-response curve was fitted to the Hill equation, and these curves are shown in red for thrombin inhibitors (B,C).
|
|
| S2154 |
Dabigatran EtexilateDabigatran Etexilate是dabigatran的前体药物，dabigatran是一种有效的、非肽类小分子化合物，可特异地、可逆性地抑制游离的和结合了血凝块的凝血酶。 |
|
|
| S2069 |
ArgatrobanArgatroban是一种有效的、选择性的thrombin 合成抑制剂，Ki值范围为5 nM-39 nM，被用作抗凝剂。 |
||
| S5252New |
Ozagrel sodiumSodium ozagrel (ozagrel) is a thromboxane A2 synthase inhibitor with neuroprotective properties. |
||
| S5074New |
Argatroban MonohydrateArgatroban是一种直接的、选择性的thrombin抑制剂，具有抗凝活性。 |
||
| S3200 |
TriflusalTriflusal是一种抗血栓药剂，通过乙酰化环氧化酶-1来不可逆的抑制血小板中血栓素-B2的产生。 |
||
| S4740 |
Sodium ferulateSodium ferulate (SF), 是ferulic acid的钠盐形式，是一种用于治疗心血管和脑血管疾病、防止血栓形成的传统中药。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S4502 |
EltrombopagEltrombopag,属于biarylhydrazone小分子，是一种thrombopoietin receptor (TpoR)的非肽类激动剂，用于治疗慢性丙型肝炎相关的血小板减少和慢性免疫性(自发的)血小板减少(ITP)。 |
2015, 44(3):398-408 2018, 22(11):5367-5377 2016, 44(3):398-408 |
Effect of eltrombopag on cell cycle progression in Huh7 cells. (A) Cells were treated with EP (0 and 10 μg/ml) for 72 h. DNA was stained with propidium iodide, and flow cytometric analysis of cell phase distribution was performed using a Muse™ cell analyzer. (B) Cells were treated with EP (0, 1 and 10 μg/ml) for 72 h. Protein expression was determined by western blot analysis using anti-cyclin D1, anti-p21 and anti-GAPDH antibodies. SDS-PAGE was performed on acrylamide gels.
|
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S5286New |
RamatrobanRamatroban (BAY u 3405) is a thromboxane A2(TxA2) receptor antagonist with Ki value of 10 to 13 nM. It also antagonizes a newly identified PGD2 receptor, CRTh2 expressed on the inflammatory cells. |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S2229 |
Eltrombopag OlamineEltrombopag Olamine 是小分子，c-mpl (TpoR)受体激动剂，抑制 hERG K+通道尾电流，IC50为0.69 μM。 |
2018, 22(11):5367-5377 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1346 |
Heparin sodiumHeparin sodium属于一类葡聚糖，可以和多种蛋白相互作用产生多种生物活性，临床上用作抗凝剂。 |
