Carbohydrate Metabolism

抑制剂选择性比较

Carbohydrate Metabolism产品

所有产品 Carbohydrate Metabolism调节剂(6) Carbohydrate Metabolism化学产品(2)

产品目录	产品描述	文献引用	实验数据
S2610	Lonidamine Lonidamine 是一种口服的小分子己糖激酶抑制剂，IC50为0.85 mM。	Arthritis Res Ther, 2019, 21(1):87
S2155	LY2608204 LY2608204 可以激活葡萄糖激酶(GK)， EC50 为 42 nM。Phase 2。	Sci Rep, 2017, 7:44681	ELISA measurements of secreted human insulin at 2 and 20 mM glucose for a subset of cell lines treated with the anti-diabetic drugs Tolbutamide (sulfonylurea), Liraglutide (GLP-1 R agonist) and LY2608204 (GCK activator). n = 4 measurements for each line. P<0.05 and *P<0.01 comparing drug treatment with no treatment at the same glucose concentration (two-sided unpaired t-test). Data shown as mean±s.e.m. Samples taken after 10-17 days in Stage 6. Act A, activin A; Alk5i, Alk5 receptor inhibitor II; CHIR, CHIR9901; KGF, keratinocyte growth factor; LDN, LDN193189; PdbU, phorbol 12,13-dibutyrate; RA, retinoic acid; T3, triiodothyronine; Y, Y27632.
S2035	Epalrestat Epalrestat是一种醛糖还原酶抑制剂，IC50为72 nM。
S3839	1-Deoxynojirimycin 1-Deoxynojirimycin is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.
S7447	ZLN005 ZLN005是一种作用于PGC-1α的强效组织特异性激活转录因子。	Peptides, 2019, 10.1016/j.peptides.2019.170120 Exp Cell Res, 2016, 345(1):25-36 Endocrine, 2016, 53(2):443-52	ZLN005 increased Sirt1 protein expression in cardiomyocytes.
S4701	2-Deoxy-D-glucose 2-Deoxy-D-glucose, 一种葡萄糖类似物，是具有抗病毒活性的糖酵解抑制剂。	FASEB J, 2018, 32(7):3924-3935 Int J Oncol, 2018, 52(6):1899-1911	(B) 2-DG activates AMPK and suppresses H3K27me3, PRC2 of ovarian cancer cells in normoglycemic condition.
S1950	Metformin HCl Metformin HCl 降低肝细胞中高血糖症，主要通过抑制肝糖原的产生（肝脏糖异生作用)发挥作用。	Biomed Pharmacother, 2019, 109:2548-2560 Biochem Biophys Res Commun, 2019, 515(2):332-338 Med Sci Monit, 2019, 25:5389-5400	Cropped immunoblot analyses for downstream effector proteins of the MAPK and PI3K/AKT/mTOR signaling pathways for NRASQ61 mutant lung carcinoma and neuroblastoma cell lines. Dual pathway inhibition can be achieved by combining metformin and trametinib, as evidenced by the abolishment of p-ERK and p-S6.
S1271	Acarbose Acarbose是一种肠道alpha-glucosidase抑制剂，用于治疗II型糖尿病。

产品目录	产品描述	文献引用	实验数据
S2610	Lonidamine Lonidamine 是一种口服的小分子己糖激酶抑制剂，IC50为0.85 mM。	Arthritis Res Ther, 2019, 21(1):87
S2155	LY2608204 LY2608204 可以激活葡萄糖激酶(GK)， EC50 为 42 nM。Phase 2。	Sci Rep, 2017, 7:44681	ELISA measurements of secreted human insulin at 2 and 20 mM glucose for a subset of cell lines treated with the anti-diabetic drugs Tolbutamide (sulfonylurea), Liraglutide (GLP-1 R agonist) and LY2608204 (GCK activator). n = 4 measurements for each line. P<0.05 and *P<0.01 comparing drug treatment with no treatment at the same glucose concentration (two-sided unpaired t-test). Data shown as mean±s.e.m. Samples taken after 10-17 days in Stage 6. Act A, activin A; Alk5i, Alk5 receptor inhibitor II; CHIR, CHIR9901; KGF, keratinocyte growth factor; LDN, LDN193189; PdbU, phorbol 12,13-dibutyrate; RA, retinoic acid; T3, triiodothyronine; Y, Y27632.
S2035	Epalrestat Epalrestat是一种醛糖还原酶抑制剂，IC50为72 nM。
S3839	1-Deoxynojirimycin 1-Deoxynojirimycin is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.
S7447	ZLN005 ZLN005是一种作用于PGC-1α的强效组织特异性激活转录因子。	Peptides, 2019, 10.1016/j.peptides.2019.170120 Exp Cell Res, 2016, 345(1):25-36 Endocrine, 2016, 53(2):443-52	ZLN005 increased Sirt1 protein expression in cardiomyocytes.
S4701	2-Deoxy-D-glucose 2-Deoxy-D-glucose, 一种葡萄糖类似物，是具有抗病毒活性的糖酵解抑制剂。	FASEB J, 2018, 32(7):3924-3935 Int J Oncol, 2018, 52(6):1899-1911	(B) 2-DG activates AMPK and suppresses H3K27me3, PRC2 of ovarian cancer cells in normoglycemic condition.

产品目录

产品描述

文献引用

实验数据

S1950

Metformin HCl

Metformin HCl 降低肝细胞中高血糖症，主要通过抑制肝糖原的产生（肝脏糖异生作用)发挥作用。

Biomed Pharmacother, 2019, 109:2548-2560

Biochem Biophys Res Commun, 2019, 515(2):332-338

Med Sci Monit, 2019, 25:5389-5400

S1271

Acarbose

Acarbose是一种肠道alpha-glucosidase抑制剂，用于治疗II型糖尿病。