Carbohydrate Metabolism
抑制剂选择性比较
Carbohydrate Metabolism产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S2610 |
LonidamineLonidamine 是一种口服的小分子己糖激酶抑制剂，IC50为0.85 mM。 |
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| S2155 |
LY2608204LY2608204 可以激活葡萄糖激酶(GK)， EC50 为 42 nM。Phase 2。 |
ELISA measurements of secreted human insulin at 2 and 20 mM glucose for a subset of cell lines treated with the anti-diabetic drugs Tolbutamide (sulfonylurea), Liraglutide (GLP-1 R agonist) and LY2608204 (GCK activator). n = 4 measurements for each line. *P<0.05 and **P<0.01 comparing drug treatment with no treatment at the same glucose concentration (two-sided unpaired t-test). Data shown as mean±s.e.m. Samples taken after 10-17 days in Stage 6. Act A, activin A; Alk5i, Alk5 receptor inhibitor II; CHIR, CHIR9901; KGF, keratinocyte growth factor; LDN, LDN193189; PdbU, phorbol 12,13-dibutyrate; RA, retinoic acid; T3, triiodothyronine; Y, Y27632.
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| S2035 |
EpalrestatEpalrestat是一种醛糖还原酶抑制剂，IC50为72 nM。 |
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| S3839 |
1-Deoxynojirimycin1-Deoxynojirimycin is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus. |
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| S7447 |
ZLN005ZLN005是一种作用于PGC-1α的强效组织特异性激活转录因子。 |
ZLN005 increased Sirt1 protein expression in cardiomyocytes.
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| S4701 |
2-Deoxy-D-glucose2-Deoxy-D-glucose, 一种葡萄糖类似物，是具有抗病毒活性的糖酵解抑制剂。 |
(B) 2-DG activates AMPK and suppresses H3K27me3, PRC2 of ovarian cancer cells in normoglycemic condition.
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| S1950 |
Metformin HClMetformin HCl 降低肝细胞中高血糖症，主要通过抑制肝糖原的产生（肝脏糖异生作用)发挥作用。 |
Cropped immunoblot analyses for downstream effector proteins of the MAPK and PI3K/AKT/mTOR signaling pathways for NRASQ61 mutant lung carcinoma and neuroblastoma cell lines. Dual pathway inhibition can be achieved by combining metformin and trametinib, as evidenced by the abolishment of p-ERK and p-S6.
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| S1271 |
AcarboseAcarbose是一种肠道alpha-glucosidase抑制剂，用于治疗II型糖尿病。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S2610 |
LonidamineLonidamine 是一种口服的小分子己糖激酶抑制剂，IC50为0.85 mM。 |
||
| S2155 |
LY2608204LY2608204 可以激活葡萄糖激酶(GK)， EC50 为 42 nM。Phase 2。 |
ELISA measurements of secreted human insulin at 2 and 20 mM glucose for a subset of cell lines treated with the anti-diabetic drugs Tolbutamide (sulfonylurea), Liraglutide (GLP-1 R agonist) and LY2608204 (GCK activator). n = 4 measurements for each line. *P<0.05 and **P<0.01 comparing drug treatment with no treatment at the same glucose concentration (two-sided unpaired t-test). Data shown as mean±s.e.m. Samples taken after 10-17 days in Stage 6. Act A, activin A; Alk5i, Alk5 receptor inhibitor II; CHIR, CHIR9901; KGF, keratinocyte growth factor; LDN, LDN193189; PdbU, phorbol 12,13-dibutyrate; RA, retinoic acid; T3, triiodothyronine; Y, Y27632.
|
|
| S2035 |
EpalrestatEpalrestat是一种醛糖还原酶抑制剂，IC50为72 nM。 |
||
| S3839 |
1-Deoxynojirimycin1-Deoxynojirimycin is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus. |
||
| S7447 |
ZLN005ZLN005是一种作用于PGC-1α的强效组织特异性激活转录因子。 |
ZLN005 increased Sirt1 protein expression in cardiomyocytes.
|
|
| S4701 |
2-Deoxy-D-glucose2-Deoxy-D-glucose, 一种葡萄糖类似物，是具有抗病毒活性的糖酵解抑制剂。 |
(B) 2-DG activates AMPK and suppresses H3K27me3, PRC2 of ovarian cancer cells in normoglycemic condition.
|
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1950 |
Metformin HClMetformin HCl 降低肝细胞中高血糖症，主要通过抑制肝糖原的产生（肝脏糖异生作用)发挥作用。 |
Cropped immunoblot analyses for downstream effector proteins of the MAPK and PI3K/AKT/mTOR signaling pathways for NRASQ61 mutant lung carcinoma and neuroblastoma cell lines. Dual pathway inhibition can be achieved by combining metformin and trametinib, as evidenced by the abolishment of p-ERK and p-S6.
|
|
| S1271 |
AcarboseAcarbose是一种肠道alpha-glucosidase抑制剂，用于治疗II型糖尿病。 |
