Carbohydrate Metabolism

抑制剂选择性比较

Carbohydrate Metabolism产品

所有产品 Carbohydrate Metabolism抑制剂(10) Carbohydrate Metabolism激活剂(1) Carbohydrate Metabolism调节剂(6)

目录号	产品描述	文献引用	实验数据
S3245^New	Nodakenetin Nodakenetin (NANI) 是从Angelica decursiva中分离出的植物性香豆素，可抑制 α-glucosidase、PTP1B、rat lens aldose reductase (RLAR)、AChE、BChE 和 β-site amyloid precursor protein cleaving enzyme 1 (BACE1)。Nodakenetin 可改变 Bax 和 Bcl-2 的蛋白质表达，并促进线粒体凋亡。Nodakenetin 具有抗肿瘤活性。
S3300^New	Desoxyrhaponticin Desoxyrhaponticin (DC, DES) 是一种来自中国传统的营养食品 Rheum tanguticum Maxim. ex Balf. (rhubarb) 的对称二苯代乙烯配糖体，是 fatty acid synthase (FAS/FASN) 的抑制剂。Desoxyrhaponticin (DC, DES) 也是竞争性的 glucose 摄取的抑制剂，在兔肠膜囊泡和大鼠肠翻肠中的IC50值分别为148.3 μM和30.9 μM。Desoxyrhaponticin 对人癌细胞具有凋亡作用。
S0553^New	Butyl isobutyl phthalate Butyl isobutyl phthalate (BIP) 是一种从 Laminaria japonica 的根状茎中分离出来的，α-glucosidase 的非竞争性抑制剂，其IC50值为38 μM。Butyl isobutyl phthalate 具有显著的降血糖作用和治疗糖尿病的潜力。
S2589	Miglitol Miglitol (BAY-M-1099) 是一种口服抗糖尿病药物。
S3918	4',7-Dimethoxy-5-Hydroxyflavone 4',7-Dimethoxy-5-Hydroxyflavone (apigenin dimethylether) inhibits α-glucosidase and α-amylase enzymes and enhances 2-NBDG uptake in L6 cells.
S9378	4',5-Dihydroxyflavone 4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
S3796	Rebaudioside A Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste.
S4101	Voglibose Voglibose (AO 128) 是一种N取代的井岗霉醇胺衍生物，对α葡糖苷酶具有优异的抑制活性，也具有抗高血糖症和由高血糖症引起的各种疾病的作用。	G3 (Bethesda), 2020, 4;10(5):1585-1597
S4793	Cedryl acetate Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity.
S5426	Bromopyruvic acid Bromopyruvic acid (3-Bromopyruvic acid, 3-Bromopyruvate) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.	Nat Commun, 2019, 10(1):3981
S6921^New	Dorzagliatin Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) 是一种双效的 glucokinase (GK) 的激活剂，可改善2型糖尿病患者的血糖控制和胰腺β细胞功能。
S2610	Lonidamine Lonidamine (AF 1890, Diclondazolic Acid) 是一种口服的小分子己糖激酶抑制剂，IC50为0.85 mM。	Cancer Cell, 2020, 13;37(4):599-617 e7 Front Oncol, 2020, 10:52 Arthritis Res Ther, 2019, 21(1):87
S2155	LY2608204 LY2608204 可以激活葡萄糖激酶(GK)， EC50 为 42 nM。Phase 2。	Sci Rep, 2017, 7:44681 Nat Commun, 2016, 7:11463	ELISA measurements of secreted human insulin at 2 and 20 mM glucose for a subset of cell lines treated with the anti-diabetic drugs Tolbutamide (sulfonylurea), Liraglutide (GLP-1 R agonist) and LY2608204 (GCK activator). n = 4 measurements for each line. P<0.05 and *P<0.01 comparing drug treatment with no treatment at the same glucose concentration (two-sided unpaired t-test). Data shown as mean±s.e.m. Samples taken after 10-17 days in Stage 6. Act A, activin A; Alk5i, Alk5 receptor inhibitor II; CHIR, CHIR9901; KGF, keratinocyte growth factor; LDN, LDN193189; PdbU, phorbol 12,13-dibutyrate; RA, retinoic acid; T3, triiodothyronine; Y, Y27632.
S2035	Epalrestat Epalrestat (ONO-2235) 是一种醛糖还原酶 aldose reductase抑制剂，IC50为72 nM。	Int J Med Sci, 2020, 17(9):1246-1256 Mol Biol Rep, 2020, 10.1007/s11033-020-05685-z
S3278^New	Kaempferol-3-O-neohesperidoside Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) 是一种从Primula latifolia Lapeyr. 和 Primula vulgaris Hudson 的叶提取物中分离出的类黄酮，通过 PI3K - GSK-3 信号通路和 MAPK - PP1 通路来刺激大鼠比目鱼肌中的糖原合成 glycogen synthesis。
S3839	1-Deoxynojirimycin 1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.
S4701	2-Deoxy-D-glucose (2-DG) 2-Deoxy-D-glucose (2-DG, 2-deoxyglucose, NSC 15193), 一种葡萄糖类似物，是具有抗病毒活性的糖酵解抑制剂。2-Deoxy-D-glucose 可诱导凋亡并抑制 Herpes Simplex Virus type-1 (HSV-1) receptor 的表达。	Cancer Cell, 2020, 13;37(4):599-617 e7 Elife, 2020, 9e56749 PLoS Pathog, 2020, 9;16(6):e1008568	(B) 2-DG activates AMPK and suppresses H3K27me3, PRC2 of ovarian cancer cells in normoglycemic condition.
S1950	Metformin HCl Metformin HCl 降低肝细胞中高血糖症，主要通过抑制肝糖原的产生（肝脏糖异生作用)发挥作用。Metformin可促进单核细胞中的线粒体自噬。Metformin可通过激活JNK/p38 MAPK 信号通路和GAD153来诱导肺癌细胞系的凋亡。	Nat Commun, 2020, 11(1):3344 Cell Death Dis, 2020, 8;11(6):427 Int J Oncol, 2020, 56(5):1140-1151	Cropped immunoblot analyses for downstream effector proteins of the MAPK and PI3K/AKT/mTOR signaling pathways for NRASQ61 mutant lung carcinoma and neuroblastoma cell lines. Dual pathway inhibition can be achieved by combining metformin and trametinib, as evidenced by the abolishment of p-ERK and p-S6.
S1271	Acarbose Acarbose(BAY g 5421) 是一种肠道alpha-glucosidase抑制剂，用于治疗II型糖尿病。	Infect Genet Evol, 2020, 81:104210

目录号	产品描述	文献引用	实验数据
S3245^New	Nodakenetin Nodakenetin (NANI) 是从Angelica decursiva中分离出的植物性香豆素，可抑制 α-glucosidase、PTP1B、rat lens aldose reductase (RLAR)、AChE、BChE 和 β-site amyloid precursor protein cleaving enzyme 1 (BACE1)。Nodakenetin 可改变 Bax 和 Bcl-2 的蛋白质表达，并促进线粒体凋亡。Nodakenetin 具有抗肿瘤活性。
S3300^New	Desoxyrhaponticin Desoxyrhaponticin (DC, DES) 是一种来自中国传统的营养食品 Rheum tanguticum Maxim. ex Balf. (rhubarb) 的对称二苯代乙烯配糖体，是 fatty acid synthase (FAS/FASN) 的抑制剂。Desoxyrhaponticin (DC, DES) 也是竞争性的 glucose 摄取的抑制剂，在兔肠膜囊泡和大鼠肠翻肠中的IC50值分别为148.3 μM和30.9 μM。Desoxyrhaponticin 对人癌细胞具有凋亡作用。
S0553^New	Butyl isobutyl phthalate Butyl isobutyl phthalate (BIP) 是一种从 Laminaria japonica 的根状茎中分离出来的，α-glucosidase 的非竞争性抑制剂，其IC50值为38 μM。Butyl isobutyl phthalate 具有显著的降血糖作用和治疗糖尿病的潜力。
S2589	Miglitol Miglitol (BAY-M-1099) 是一种口服抗糖尿病药物。
S3918	4',7-Dimethoxy-5-Hydroxyflavone 4',7-Dimethoxy-5-Hydroxyflavone (apigenin dimethylether) inhibits α-glucosidase and α-amylase enzymes and enhances 2-NBDG uptake in L6 cells.
S9378	4',5-Dihydroxyflavone 4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
S3796	Rebaudioside A Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste.
S4101	Voglibose Voglibose (AO 128) 是一种N取代的井岗霉醇胺衍生物，对α葡糖苷酶具有优异的抑制活性，也具有抗高血糖症和由高血糖症引起的各种疾病的作用。	G3 (Bethesda),2020, 4;10(5):1585-1597
S4793	Cedryl acetate Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity.
S5426	Bromopyruvic acid Bromopyruvic acid (3-Bromopyruvic acid, 3-Bromopyruvate) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.	Nat Commun,2019, 10(1):3981

目录号

产品描述

文献引用

实验数据

S6921^New

Dorzagliatin

Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) 是一种双效的 glucokinase (GK) 的激活剂，可改善2型糖尿病患者的血糖控制和胰腺β细胞功能。

目录号	产品描述	文献引用	实验数据
S2610	Lonidamine Lonidamine (AF 1890, Diclondazolic Acid) 是一种口服的小分子己糖激酶抑制剂，IC50为0.85 mM。	Cancer Cell, 2020, 13;37(4):599-617 e7 Front Oncol, 2020, 10:52 Arthritis Res Ther, 2019, 21(1):87
S2155	LY2608204 LY2608204 可以激活葡萄糖激酶(GK)， EC50 为 42 nM。Phase 2。	Sci Rep, 2017, 7:44681 Nat Commun, 2016, 7:11463	ELISA measurements of secreted human insulin at 2 and 20 mM glucose for a subset of cell lines treated with the anti-diabetic drugs Tolbutamide (sulfonylurea), Liraglutide (GLP-1 R agonist) and LY2608204 (GCK activator). n = 4 measurements for each line. P<0.05 and *P<0.01 comparing drug treatment with no treatment at the same glucose concentration (two-sided unpaired t-test). Data shown as mean±s.e.m. Samples taken after 10-17 days in Stage 6. Act A, activin A; Alk5i, Alk5 receptor inhibitor II; CHIR, CHIR9901; KGF, keratinocyte growth factor; LDN, LDN193189; PdbU, phorbol 12,13-dibutyrate; RA, retinoic acid; T3, triiodothyronine; Y, Y27632.
S2035	Epalrestat Epalrestat (ONO-2235) 是一种醛糖还原酶 aldose reductase抑制剂，IC50为72 nM。	Int J Med Sci, 2020, 17(9):1246-1256 Mol Biol Rep, 2020, 10.1007/s11033-020-05685-z
S3278^New	Kaempferol-3-O-neohesperidoside Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) 是一种从Primula latifolia Lapeyr. 和 Primula vulgaris Hudson 的叶提取物中分离出的类黄酮，通过 PI3K - GSK-3 信号通路和 MAPK - PP1 通路来刺激大鼠比目鱼肌中的糖原合成 glycogen synthesis。
S3839	1-Deoxynojirimycin 1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.
S4701	2-Deoxy-D-glucose (2-DG) 2-Deoxy-D-glucose (2-DG, 2-deoxyglucose, NSC 15193), 一种葡萄糖类似物，是具有抗病毒活性的糖酵解抑制剂。2-Deoxy-D-glucose 可诱导凋亡并抑制 Herpes Simplex Virus type-1 (HSV-1) receptor 的表达。	Cancer Cell, 2020, 13;37(4):599-617 e7 Elife, 2020, 9e56749 PLoS Pathog, 2020, 9;16(6):e1008568	(B) 2-DG activates AMPK and suppresses H3K27me3, PRC2 of ovarian cancer cells in normoglycemic condition.

目录号

产品描述

文献引用

实验数据

S1950

Metformin HCl

Metformin HCl 降低肝细胞中高血糖症，主要通过抑制肝糖原的产生（肝脏糖异生作用)发挥作用。Metformin可促进单核细胞中的线粒体自噬。Metformin可通过激活JNK/p38 MAPK 信号通路和GAD153来诱导肺癌细胞系的凋亡。

Nat Commun, 2020, 11(1):3344

Cell Death Dis, 2020, 8;11(6):427

Int J Oncol, 2020, 56(5):1140-1151

S1271

Acarbose

Acarbose(BAY g 5421) 是一种肠道alpha-glucosidase抑制剂，用于治疗II型糖尿病。

Infect Genet Evol, 2020, 81:104210