Carbohydrate Metabolism

抑制剂选择性比较

Carbohydrate Metabolism产品

目录号 产品描述 文献引用 实验数据
S3245New

Nodakenetin

Nodakenetin (NANI) 是从Angelica decursiva中分离出的植物性香豆素,可抑制 α-glucosidasePTP1Brat lens aldose reductase (RLAR)AChEBChEβ-site amyloid precursor protein cleaving enzyme 1 (BACE1)。Nodakenetin 可改变 BaxBcl-2 的蛋白质表达,并促进线粒体凋亡。Nodakenetin 具有抗肿瘤活性。

S3300New

Desoxyrhaponticin

Desoxyrhaponticin (DC, DES) 是一种来自中国传统的营养食品 Rheum tanguticum Maxim. ex Balf. (rhubarb) 的对称二苯代乙烯配糖体,是 fatty acid synthase (FAS/FASN) 的抑制剂。Desoxyrhaponticin (DC, DES) 也是竞争性的 glucose 摄取的抑制剂,在兔肠膜囊泡和大鼠肠翻肠中的IC50值分别为148.3 μM和30.9 μM。Desoxyrhaponticin 对人癌细胞具有凋亡作用。

S0553New

Butyl isobutyl phthalate 

Butyl isobutyl phthalate (BIP) 是一种从 Laminaria japonica 的根状茎中分离出来的,α-glucosidase 的非竞争性抑制剂,其IC50值为38 μM。Butyl isobutyl phthalate 具有显著的降血糖作用和治疗糖尿病的潜力。

S2589

Miglitol

Miglitol (BAY-M-1099) 是一种口服抗糖尿病药物。

S3918

4',7-Dimethoxy-5-Hydroxyflavone

4',7-Dimethoxy-5-Hydroxyflavone (apigenin dimethylether) inhibits α-glucosidase and α-amylase enzymes and enhances 2-NBDG uptake in L6 cells.

S9378

4',5-Dihydroxyflavone

4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.

S3796

Rebaudioside A

Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste.

S4101

Voglibose

Voglibose (AO 128) 是一种N取代的井岗霉醇胺衍生物,对α葡糖苷酶具有优异的抑制活性,也具有抗高血糖症和由高血糖症引起的各种疾病的作用。

S4793

Cedryl acetate

Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity.

S5426

Bromopyruvic acid

Bromopyruvic acid (3-Bromopyruvic acid, 3-Bromopyruvate) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.

S6921New

Dorzagliatin

Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) 是一种双效的 glucokinase (GK) 的激活剂,可改善2型糖尿病患者的血糖控制和胰腺β细胞功能。

S2610

Lonidamine

Lonidamine (AF 1890, Diclondazolic Acid) 是一种口服的小分子己糖激酶抑制剂,IC50为0.85 mM。

S2155

LY2608204

LY2608204 可以激活葡萄糖激酶(GK), EC50 为 42 nM。Phase 2。

S2035

Epalrestat

Epalrestat (ONO-2235) 是一种醛糖还原酶 aldose reductase抑制剂,IC50为72 nM。

S3278New

Kaempferol-3-O-neohesperidoside

Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) 是一种从Primula latifolia Lapeyr. 和 Primula vulgaris Hudson 的叶提取物中分离出的类黄酮,通过 PI3K - GSK-3 信号通路和 MAPK - PP1 通路来刺激大鼠比目鱼肌中的糖原合成 glycogen synthesis

S3839

1-Deoxynojirimycin

1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.

S4701

2-Deoxy-D-glucose (2-DG)

2-Deoxy-D-glucose (2-DG, 2-deoxyglucose, NSC 15193), 一种葡萄糖类似物,是具有抗病毒活性的糖酵解抑制剂。2-Deoxy-D-glucose 可诱导凋亡并抑制 Herpes Simplex Virus type-1 (HSV-1) receptor 的表达。

S1950

Metformin HCl

Metformin HCl 降低肝细胞中高血糖症,主要通过抑制肝糖原的产生(肝脏糖异生作用)发挥作用。Metformin可促进单核细胞中的线粒体自噬。Metformin可通过激活JNK/p38 MAPK 信号通路和GAD153来诱导肺癌细胞系的凋亡。

S1271

Acarbose

Acarbose(BAY g 5421) 是一种肠道alpha-glucosidase抑制剂,用于治疗II型糖尿病。

目录号 产品描述 文献引用 实验数据
S3245New

Nodakenetin

Nodakenetin (NANI) 是从Angelica decursiva中分离出的植物性香豆素,可抑制 α-glucosidasePTP1Brat lens aldose reductase (RLAR)AChEBChEβ-site amyloid precursor protein cleaving enzyme 1 (BACE1)。Nodakenetin 可改变 BaxBcl-2 的蛋白质表达,并促进线粒体凋亡。Nodakenetin 具有抗肿瘤活性。

S3300New

Desoxyrhaponticin

Desoxyrhaponticin (DC, DES) 是一种来自中国传统的营养食品 Rheum tanguticum Maxim. ex Balf. (rhubarb) 的对称二苯代乙烯配糖体,是 fatty acid synthase (FAS/FASN) 的抑制剂。Desoxyrhaponticin (DC, DES) 也是竞争性的 glucose 摄取的抑制剂,在兔肠膜囊泡和大鼠肠翻肠中的IC50值分别为148.3 μM和30.9 μM。Desoxyrhaponticin 对人癌细胞具有凋亡作用。

S0553New

Butyl isobutyl phthalate 

Butyl isobutyl phthalate (BIP) 是一种从 Laminaria japonica 的根状茎中分离出来的,α-glucosidase 的非竞争性抑制剂,其IC50值为38 μM。Butyl isobutyl phthalate 具有显著的降血糖作用和治疗糖尿病的潜力。

S2589

Miglitol

Miglitol (BAY-M-1099) 是一种口服抗糖尿病药物。

S3918

4',7-Dimethoxy-5-Hydroxyflavone

4',7-Dimethoxy-5-Hydroxyflavone (apigenin dimethylether) inhibits α-glucosidase and α-amylase enzymes and enhances 2-NBDG uptake in L6 cells.

S9378

4',5-Dihydroxyflavone

4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.

S3796

Rebaudioside A

Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste.

S4101

Voglibose

Voglibose (AO 128) 是一种N取代的井岗霉醇胺衍生物,对α葡糖苷酶具有优异的抑制活性,也具有抗高血糖症和由高血糖症引起的各种疾病的作用。

S4793

Cedryl acetate

Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity.

S5426

Bromopyruvic acid

Bromopyruvic acid (3-Bromopyruvic acid, 3-Bromopyruvate) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.

目录号 产品描述 文献引用 实验数据
S6921New

Dorzagliatin

Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) 是一种双效的 glucokinase (GK) 的激活剂,可改善2型糖尿病患者的血糖控制和胰腺β细胞功能。

目录号 产品描述 文献引用 实验数据
S2610

Lonidamine

Lonidamine (AF 1890, Diclondazolic Acid) 是一种口服的小分子己糖激酶抑制剂,IC50为0.85 mM。

S2155

LY2608204

LY2608204 可以激活葡萄糖激酶(GK), EC50 为 42 nM。Phase 2。

S2035

Epalrestat

Epalrestat (ONO-2235) 是一种醛糖还原酶 aldose reductase抑制剂,IC50为72 nM。

S3278New

Kaempferol-3-O-neohesperidoside

Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) 是一种从Primula latifolia Lapeyr. 和 Primula vulgaris Hudson 的叶提取物中分离出的类黄酮,通过 PI3K - GSK-3 信号通路和 MAPK - PP1 通路来刺激大鼠比目鱼肌中的糖原合成 glycogen synthesis

S3839

1-Deoxynojirimycin

1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.

S4701

2-Deoxy-D-glucose (2-DG)

2-Deoxy-D-glucose (2-DG, 2-deoxyglucose, NSC 15193), 一种葡萄糖类似物,是具有抗病毒活性的糖酵解抑制剂。2-Deoxy-D-glucose 可诱导凋亡并抑制 Herpes Simplex Virus type-1 (HSV-1) receptor 的表达。

目录号 产品描述 文献引用 实验数据
S1950

Metformin HCl

Metformin HCl 降低肝细胞中高血糖症,主要通过抑制肝糖原的产生(肝脏糖异生作用)发挥作用。Metformin可促进单核细胞中的线粒体自噬。Metformin可通过激活JNK/p38 MAPK 信号通路和GAD153来诱导肺癌细胞系的凋亡。

S1271

Acarbose

Acarbose(BAY g 5421) 是一种肠道alpha-glucosidase抑制剂,用于治疗II型糖尿病。