Carbohydrate Metabolism

抑制剂选择性比较

Carbohydrate Metabolism产品

所有产品 Carbohydrate Metabolism抑制剂(7) Carbohydrate Metabolism调节剂(5)

目录号	产品描述	文献引用	实验数据
S2589	Miglitol Miglitol 是一种口服抗糖尿病药物。
S3918	4',7-Dimethoxy-5-Hydroxyflavone 4',7-Dimethoxy-5-Hydroxyflavone (apigenin dimethylether) inhibits α-glucosidase and α-amylase enzymes and enhances 2-NBDG uptake in L6 cells.
S9378	4',5-Dihydroxyflavone 4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
S3796	Rebaudioside A Rebaudioside A (Stevia Extract), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste.
S4101	Voglibose Voglibose是一种N取代的井岗霉醇胺衍生物，对α葡糖苷酶具有优异的抑制活性，也具有抗高血糖症和由高血糖症引起的各种疾病的作用。	G3 (Bethesda), 2020, 4;10(5):1585-1597
S4793	Cedryl acetate N-Acetylneuraminic acid (Neu5Ac or NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes.
S5426	Bromopyruvic acid Bromopyruvic acid is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.	Nat Commun, 2019, 10(1):3981
S2610	Lonidamine Lonidamine 是一种口服的小分子己糖激酶抑制剂，IC50为0.85 mM。	Cancer Cell, 2020, 13;37(4):599-617 e7 Front Oncol, 2020, 10:52 Arthritis Res Ther, 2019, 21(1):87
S2155	LY2608204 LY2608204 可以激活葡萄糖激酶(GK)， EC50 为 42 nM。Phase 2。	Sci Rep, 2017, 7:44681 Nat Commun, 2016, 7:11463	ELISA measurements of secreted human insulin at 2 and 20 mM glucose for a subset of cell lines treated with the anti-diabetic drugs Tolbutamide (sulfonylurea), Liraglutide (GLP-1 R agonist) and LY2608204 (GCK activator). n = 4 measurements for each line. P<0.05 and *P<0.01 comparing drug treatment with no treatment at the same glucose concentration (two-sided unpaired t-test). Data shown as mean±s.e.m. Samples taken after 10-17 days in Stage 6. Act A, activin A; Alk5i, Alk5 receptor inhibitor II; CHIR, CHIR9901; KGF, keratinocyte growth factor; LDN, LDN193189; PdbU, phorbol 12,13-dibutyrate; RA, retinoic acid; T3, triiodothyronine; Y, Y27632.
S2035	Epalrestat Epalrestat是一种醛糖还原酶抑制剂，IC50为72 nM。	Int J Med Sci, 2020, 17(9):1246-1256
S3839	1-Deoxynojirimycin 1-Deoxynojirimycin is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.
S4701	2-Deoxy-D-glucose (2-DG) 2-Deoxy-D-glucose, 一种葡萄糖类似物，是具有抗病毒活性的糖酵解抑制剂。2-Deoxy-D-glucose 可诱导凋亡并抑制 Herpes Simplex Virus type-1 (HSV-1) receptor 的表达。	Cancer Cell, 2020, 13;37(4):599-617 e7 PLoS Pathog, 2020, 9;16(6):e1008568 Metabolism, 2020, 13;107:154231	(B) 2-DG activates AMPK and suppresses H3K27me3, PRC2 of ovarian cancer cells in normoglycemic condition.
S1950	Metformin HCl Metformin HCl 降低肝细胞中高血糖症，主要通过抑制肝糖原的产生（肝脏糖异生作用)发挥作用。Metformin可促进单核细胞中的线粒体自噬。Metformin可通过激活JNK/p38 MAPK 信号通路和GAD153来诱导肺癌细胞系的凋亡。	Nat Commun, 2020, 11(1):3344 Cell Death Dis, 2020, 8;11(6):427 Int J Oncol, 2020, 56(5):1140-1151	Cropped immunoblot analyses for downstream effector proteins of the MAPK and PI3K/AKT/mTOR signaling pathways for NRASQ61 mutant lung carcinoma and neuroblastoma cell lines. Dual pathway inhibition can be achieved by combining metformin and trametinib, as evidenced by the abolishment of p-ERK and p-S6.
S1271	Acarbose Acarbose是一种肠道alpha-glucosidase抑制剂，用于治疗II型糖尿病。	Infect Genet Evol, 2020, 81:104210

目录号	产品描述	文献引用	实验数据
S2589	Miglitol Miglitol 是一种口服抗糖尿病药物。
S3918	4',7-Dimethoxy-5-Hydroxyflavone 4',7-Dimethoxy-5-Hydroxyflavone (apigenin dimethylether) inhibits α-glucosidase and α-amylase enzymes and enhances 2-NBDG uptake in L6 cells.
S9378	4',5-Dihydroxyflavone 4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
S3796	Rebaudioside A Rebaudioside A (Stevia Extract), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste.
S4101	Voglibose Voglibose是一种N取代的井岗霉醇胺衍生物，对α葡糖苷酶具有优异的抑制活性，也具有抗高血糖症和由高血糖症引起的各种疾病的作用。	G3 (Bethesda),2020, 4;10(5):1585-1597
S4793	Cedryl acetate N-Acetylneuraminic acid (Neu5Ac or NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes.
S5426	Bromopyruvic acid Bromopyruvic acid is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.	Nat Commun,2019, 10(1):3981

目录号	产品描述	文献引用	实验数据
S2610	Lonidamine Lonidamine 是一种口服的小分子己糖激酶抑制剂，IC50为0.85 mM。	Cancer Cell, 2020, 13;37(4):599-617 e7 Front Oncol, 2020, 10:52 Arthritis Res Ther, 2019, 21(1):87
S2155	LY2608204 LY2608204 可以激活葡萄糖激酶(GK)， EC50 为 42 nM。Phase 2。	Sci Rep, 2017, 7:44681 Nat Commun, 2016, 7:11463	ELISA measurements of secreted human insulin at 2 and 20 mM glucose for a subset of cell lines treated with the anti-diabetic drugs Tolbutamide (sulfonylurea), Liraglutide (GLP-1 R agonist) and LY2608204 (GCK activator). n = 4 measurements for each line. P<0.05 and *P<0.01 comparing drug treatment with no treatment at the same glucose concentration (two-sided unpaired t-test). Data shown as mean±s.e.m. Samples taken after 10-17 days in Stage 6. Act A, activin A; Alk5i, Alk5 receptor inhibitor II; CHIR, CHIR9901; KGF, keratinocyte growth factor; LDN, LDN193189; PdbU, phorbol 12,13-dibutyrate; RA, retinoic acid; T3, triiodothyronine; Y, Y27632.
S2035	Epalrestat Epalrestat是一种醛糖还原酶抑制剂，IC50为72 nM。	Int J Med Sci, 2020, 17(9):1246-1256
S3839	1-Deoxynojirimycin 1-Deoxynojirimycin is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.
S4701	2-Deoxy-D-glucose (2-DG) 2-Deoxy-D-glucose, 一种葡萄糖类似物，是具有抗病毒活性的糖酵解抑制剂。2-Deoxy-D-glucose 可诱导凋亡并抑制 Herpes Simplex Virus type-1 (HSV-1) receptor 的表达。	Cancer Cell, 2020, 13;37(4):599-617 e7 PLoS Pathog, 2020, 9;16(6):e1008568 Metabolism, 2020, 13;107:154231	(B) 2-DG activates AMPK and suppresses H3K27me3, PRC2 of ovarian cancer cells in normoglycemic condition.

目录号

产品描述

文献引用

实验数据

S1950

Metformin HCl

Metformin HCl 降低肝细胞中高血糖症，主要通过抑制肝糖原的产生（肝脏糖异生作用)发挥作用。Metformin可促进单核细胞中的线粒体自噬。Metformin可通过激活JNK/p38 MAPK 信号通路和GAD153来诱导肺癌细胞系的凋亡。

Nat Commun, 2020, 11(1):3344

Cell Death Dis, 2020, 8;11(6):427

Int J Oncol, 2020, 56(5):1140-1151

S1271

Acarbose

Acarbose是一种肠道alpha-glucosidase抑制剂，用于治疗II型糖尿病。

Infect Genet Evol, 2020, 81:104210