DDR
抑制剂选择性比较
特异性亚型抑制剂
DDR产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S7014 |
Merestinib (LY2801653)Merestinib (LY2801653) 是一种2型ATP竞争型的慢抑制剂,抑制Met (c-Met)酪氨酸激酶,Ki值为2 nM。药效的停留时间为0.00132 min(-1),t1/2为525 min。Merestinib (LY2801653) 还可抑制MST1R、AXL、ROS1、MKNK1/2、FLT3、MERTK、DDR1和DDR2,其对应的IC50值分别为11 nM、2 nM、23 nM、7 nM、7 nM、10 nM、0.1 nM 和 7 nM。 |
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S7498 |
DDR1-IN-1DDR1-IN-1是一种有效的选择性discoidin domain receptor 1 (DDR1)受体酪氨酸激酶抑制剂,IC50 为 105 nM,选择性大约是作用于DDR2的3倍。 |
![]() ![]() j,k, Gene expression ofMYOCD (j) and ACTA2 ( SMA, k) after applying inhibitors of key components involved in the DDR2 downstream signalling pathway to HSCs cultured within 3D collagen matrix subjected to stretching (ST) (n=3, one-way ANOVA, **P=0.0036, ****P<0.0001). l,m, Expression of SMA was significantly reduced after treatment with related inhibitors in early-stage FμNs. (n=4, one-way ANOVA, ***P=0.001, ****P<0.0001). DDR2i: DDR1-IN-1
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S6817 |
VU6015929VU6015929 是一种选择性的 Discoidin Domain Receptor 1/2 (DDR1/2) 的抑制剂,对DDR1和DDR2的IC50值分别为4.67 nM和7.39 nM。VU6015929 可有效地抑制IV型胶原蛋白的产生。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S7014 |
Merestinib (LY2801653)Merestinib (LY2801653) 是一种2型ATP竞争型的慢抑制剂,抑制Met (c-Met)酪氨酸激酶,Ki值为2 nM。药效的停留时间为0.00132 min(-1),t1/2为525 min。Merestinib (LY2801653) 还可抑制MST1R、AXL、ROS1、MKNK1/2、FLT3、MERTK、DDR1和DDR2,其对应的IC50值分别为11 nM、2 nM、23 nM、7 nM、7 nM、10 nM、0.1 nM 和 7 nM。 |
||
S7498 |
DDR1-IN-1DDR1-IN-1是一种有效的选择性discoidin domain receptor 1 (DDR1)受体酪氨酸激酶抑制剂,IC50 为 105 nM,选择性大约是作用于DDR2的3倍。 |
![]() ![]() j,k, Gene expression ofMYOCD (j) and ACTA2 ( SMA, k) after applying inhibitors of key components involved in the DDR2 downstream signalling pathway to HSCs cultured within 3D collagen matrix subjected to stretching (ST) (n=3, one-way ANOVA, **P=0.0036, ****P<0.0001). l,m, Expression of SMA was significantly reduced after treatment with related inhibitors in early-stage FμNs. (n=4, one-way ANOVA, ***P=0.001, ****P<0.0001). DDR2i: DDR1-IN-1
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S6817 |
VU6015929VU6015929 是一种选择性的 Discoidin Domain Receptor 1/2 (DDR1/2) 的抑制剂,对DDR1和DDR2的IC50值分别为4.67 nM和7.39 nM。VU6015929 可有效地抑制IV型胶原蛋白的产生。 |