DHFR
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S1135 | Pemetrexed | 94 mg/mL | <1 mg/mL | <1 mg/mL |
| S1210 | Methotrexate | <1 mg/mL | 90 mg/mL | <1 mg/mL |
| S1497 | Pralatrexate | <1 mg/mL | 28 mg/mL | <1 mg/mL |
| S2006 | Pyrimethamine | <1 mg/mL | 10 mg/mL | <1 mg/mL |
| S1618 | Sulfameter | <1 mg/mL | 56 mg/mL | <1 mg/mL |
| S5097 | Methotrexate disodium | 99 mg/mL | <1 mg/mL | -1 mg/mL |
| S5200 | Diaveridine | -1 mg/mL | 25 mg/mL | -1 mg/mL |
| S7785 | Pemetrexed Disodium Hydrate | 100 mg/mL | <1 mg/mL | <1 mg/mL |
- DHFR抑制剂（8）
- 新DHFR产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1135 |
PemetrexedPemetrexed是一种新型抗叶酸和抗代谢药物，作用于TS，DHFR和GARFT，无细胞试验中Ki分别为1.3 nM，7.2 nM，和65 nM。 |
Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
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| S1210 |
MethotrexateMethotrexate (MTX),一种叶酸类似物，是细菌、癌细胞和正常细胞中dihydrofolate reductase(DHFR)的非选择性抑制剂，与DHFR、NADPH形成无活性的三元复合物。 |
A. Viability comparison of REH vector control, BCL6 overexpression, or BCL6 overexpression cells pre-treated with 79-6 (125μM) following exposure to three chemotherapy drugs (Ara-C [1 μM], MTX [50 μM], VCR [25 μM]). (* = p < 0.05 BCL6 OX to vector control and # = p < 0.05 BCL6 OX to BCL6 + 79-6).
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| S1497 |
PralatrexatePralatrexate 是一种抗叶酸药，结构与叶酸类似，作用于一些细胞系，IC50低于300 nM。 |
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| S2006 |
PyrimethaminePyrimethamine是二氢叶酸还原酶(DHFR)抑制剂，用作抗疟药。 |
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| S1618 |
SulfameterSulfameter 是一种长效的磺胺类抗菌药。 |
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| S5097New |
Methotrexate disodiumMethotrexate sodium是tetrahydrofolate dehydrogenase的抑制剂，是一种抗肿瘤抗代谢药，具有免疫抑制活性。 |
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| S5200New |
DiaveridineDiaveridine是一种球虫抑制药，具有抗寄生虫活性，是dihydrofolate reductase (DHFR)抑制剂，在肺囊虫属中抑制叶酸合成。 |
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| S7785 |
Pemetrexed Disodium HydratePemetrexed Disodium Hydrate 培美曲塞是一种新型抗叶酸剂和抗代谢物质，作用于TS，DHFR 和 GARFT，Ki分别为1.3 nM，7.2 nM 和 65 nM。 |
Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
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