DHFR
信号通路图
研究领域
抑制剂选择性比较
DHFR产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1135 |
PemetrexedPemetrexed是一种新型抗叶酸和抗代谢药物，作用于TS，DHFR和GARFT，无细胞试验中Ki分别为1.3 nM，7.2 nM，和65 nM。 |
Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
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| S1210 |
MethotrexateMethotrexate (MTX),一种叶酸类似物，是细菌、癌细胞和正常细胞中dihydrofolate reductase(DHFR)的非选择性抑制剂，与DHFR、NADPH形成无活性的三元复合物。 |
Toxicity of MTX (3) and toxic analogues 5 a-e on a) hY1R-expressing MDA-MB-468 and b) non-hYR-expressing HEK293 cells. Cell viability was determined by resazurin assay. Bars represent the mean±SEM of at least three independent experiments performed in triplicate. Measurements were normalized by using only HBSS, pH 7, treated cells (set at 100 %) and ethanol-treated cells (set at 0 %). Statistical significances refer to only HBSS, pH 7, treated cells indicated as a dashed line. |
|
| S1497 |
PralatrexatePralatrexate 是一种抗叶酸药，结构与叶酸类似，作用于一些细胞系，IC50低于300 nM。 |
PK parameters for pralatrexate in the study population. Concentration over time for each dose cohort of pralatrexate (A).
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| S2006 |
PyrimethaminePyrimethamine是二氢叶酸还原酶(DHFR)抑制剂，用作抗疟药。 |
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| S1618 |
SulfameterSulfameter 是一种长效的磺胺类抗菌药。 |
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| S5097 |
Methotrexate disodiumMethotrexate sodium是tetrahydrofolate dehydrogenase的抑制剂，是一种抗肿瘤抗代谢药，具有免疫抑制活性。 |
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| S7785 |
Pemetrexed Disodium HydratePemetrexed Disodium Hydrate 培美曲塞是一种新型抗叶酸剂和抗代谢物质，作用于TS，DHFR 和 GARFT，Ki分别为1.3 nM，7.2 nM 和 65 nM。 |
Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
|
|
| S5200 |
DiaveridineDiaveridine是一种球虫抑制药，具有抗寄生虫活性，是dihydrofolate reductase (DHFR)抑制剂，在肺囊虫属中抑制叶酸合成。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1135 |
PemetrexedPemetrexed是一种新型抗叶酸和抗代谢药物，作用于TS，DHFR和GARFT，无细胞试验中Ki分别为1.3 nM，7.2 nM，和65 nM。 |
Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
|
|
| S1210 |
MethotrexateMethotrexate (MTX),一种叶酸类似物，是细菌、癌细胞和正常细胞中dihydrofolate reductase(DHFR)的非选择性抑制剂，与DHFR、NADPH形成无活性的三元复合物。 |
Toxicity of MTX (3) and toxic analogues 5 a-e on a) hY1R-expressing MDA-MB-468 and b) non-hYR-expressing HEK293 cells. Cell viability was determined by resazurin assay. Bars represent the mean±SEM of at least three independent experiments performed in triplicate. Measurements were normalized by using only HBSS, pH 7, treated cells (set at 100 %) and ethanol-treated cells (set at 0 %). Statistical significances refer to only HBSS, pH 7, treated cells indicated as a dashed line. |
|
| S1497 |
PralatrexatePralatrexate 是一种抗叶酸药，结构与叶酸类似，作用于一些细胞系，IC50低于300 nM。 |
PK parameters for pralatrexate in the study population. Concentration over time for each dose cohort of pralatrexate (A).
|
|
| S2006 |
PyrimethaminePyrimethamine是二氢叶酸还原酶(DHFR)抑制剂，用作抗疟药。 |
||
| S1618 |
SulfameterSulfameter 是一种长效的磺胺类抗菌药。 |
||
| S5097 |
Methotrexate disodiumMethotrexate sodium是tetrahydrofolate dehydrogenase的抑制剂，是一种抗肿瘤抗代谢药，具有免疫抑制活性。 |
||
| S7785 |
Pemetrexed Disodium HydratePemetrexed Disodium Hydrate 培美曲塞是一种新型抗叶酸剂和抗代谢物质，作用于TS，DHFR 和 GARFT，Ki分别为1.3 nM，7.2 nM 和 65 nM。 |
Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
|
|
| S5200 |
DiaveridineDiaveridine是一种球虫抑制药，具有抗寄生虫活性，是dihydrofolate reductase (DHFR)抑制剂，在肺囊虫属中抑制叶酸合成。 |
