DHFR
DHFR产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1135 |
PemetrexedPemetrexed (LY-231514) 是一种新型抗叶酸和抗代谢药物,作用于TS,DHFR和GARFT,无细胞试验中Ki分别为1.3 nM,7.2 nM 和65 nM。Pemetrexed 可诱导自噬和细胞凋亡。 |
![]() ![]() Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
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S1210 |
MethotrexateMethotrexate (MTX, NCI-C04671, Amethopterin, CL14377, WR19039),一种叶酸类似物,是细菌、癌细胞和正常细胞中dihydrofolate reductase(DHFR)的非选择性抑制剂,与DHFR、NADPH形成无活性的三元复合物。Methotrexate (MTX)可诱导凋亡。 |
![]() ![]() Toxicity of MTX (3) and toxic analogues 5 a-e on a) hY1R-expressing MDA-MB-468 and b) non-hYR-expressing HEK293 cells. Cell viability was determined by resazurin assay. Bars represent the mean±SEM of at least three independent experiments performed in triplicate. Measurements were normalized by using only HBSS, pH 7, treated cells (set at 100 %) and ethanol-treated cells (set at 0 %). Statistical significances refer to only HBSS, pH 7, treated cells indicated as a dashed line. |
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S1497 |
PralatrexatePralatrexate 是一种抗叶酸药,结构与叶酸类似,作用于一些细胞系,IC50低于300 nM。Pralatrexate 可诱导肿瘤细胞的凋亡。 |
![]() ![]() PK parameters for pralatrexate in the study population. Concentration over time for each dose cohort of pralatrexate (A).
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S2006 |
PyrimethaminePyrimethamine是二氢叶酸还原酶(DHFR)抑制剂,用作抗疟药。 |
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S2588New |
Calcium LevofolinateCalcium Levofolinate (Calcium Folinate, Levoleucovorin calcium) 是Folinic acid的钙盐,是用于癌症化疗的佐剂。 |
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S3129 |
TrimethoprimTrimethoprim (BW 56-72, NIH 204, NSC-106568) 是一种抑制细菌的抗生素,主要用于预防和治疗尿路感染。 |
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S5097 |
Methotrexate disodiumMethotrexate sodium是tetrahydrofolate dehydrogenase的抑制剂,是一种抗肿瘤抗代谢药,具有免疫抑制活性。 |
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S7785 |
Pemetrexed Disodium HydratePemetrexed Disodium Hydrate (LY-231514) 培美曲塞是一种新型抗叶酸剂和抗代谢物质,作用于TS,DHFR 和 GARFT,Ki分别为1.3 nM,7.2 nM 和 65 nM。Pemetrexed Disodium Hydrate 可刺激细胞自噬和凋亡。 |
![]() ![]() Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
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S5927 |
ProguanilProguanil (chlorguanide, chloroguanide) 是预防性抗疟药。它能抑制疟原虫的二氢叶酸还原酶,阻止嘌呤和嘧啶的合成。 |
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S5200 |
DiaveridineDiaveridine (AI3-23935, CCRIS-3784) 是一种球虫抑制药,具有抗寄生虫活性,是dihydrofolate reductase (DHFR)抑制剂,在肺囊虫属中抑制叶酸合成。 |
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S5136 |
Calcium folinateCalcium folinate (Leucovorin calcium, Folinic acid calcium salt, Wellcovorin) is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives. |
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S0320New |
Cycloguanil hydrochlorideCycloguanil hydrochloride is an active metabolite of Proguanil. Cycloguanil hydrochloride acts on malaria schizonts in erythrocytes and hepatocytes. |
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S1236 |
Leucovorin Calcium PentahydrateLeucovorin (Folinic acid) 是一种亚叶酸, 用于改善叶酸下降的状况。 |
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S0854New |
MetoprineMetoprine (BW 197U), a diaminopyrimidine derivative, is a potent inhibitor of histamine N-methyltransferase (HMT) that crosses the blood-brain barrier and increases brain histamine levels. Metoprine is an antifolate and antitumor agent. |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1135 |
PemetrexedPemetrexed (LY-231514) 是一种新型抗叶酸和抗代谢药物,作用于TS,DHFR和GARFT,无细胞试验中Ki分别为1.3 nM,7.2 nM 和65 nM。Pemetrexed 可诱导自噬和细胞凋亡。 |
![]() ![]() Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
|
|
S1210 |
MethotrexateMethotrexate (MTX, NCI-C04671, Amethopterin, CL14377, WR19039),一种叶酸类似物,是细菌、癌细胞和正常细胞中dihydrofolate reductase(DHFR)的非选择性抑制剂,与DHFR、NADPH形成无活性的三元复合物。Methotrexate (MTX)可诱导凋亡。 |
![]() ![]() Toxicity of MTX (3) and toxic analogues 5 a-e on a) hY1R-expressing MDA-MB-468 and b) non-hYR-expressing HEK293 cells. Cell viability was determined by resazurin assay. Bars represent the mean±SEM of at least three independent experiments performed in triplicate. Measurements were normalized by using only HBSS, pH 7, treated cells (set at 100 %) and ethanol-treated cells (set at 0 %). Statistical significances refer to only HBSS, pH 7, treated cells indicated as a dashed line. |
|
S1497 |
PralatrexatePralatrexate 是一种抗叶酸药,结构与叶酸类似,作用于一些细胞系,IC50低于300 nM。Pralatrexate 可诱导肿瘤细胞的凋亡。 |
![]() ![]() PK parameters for pralatrexate in the study population. Concentration over time for each dose cohort of pralatrexate (A).
|
|
S2006 |
PyrimethaminePyrimethamine是二氢叶酸还原酶(DHFR)抑制剂,用作抗疟药。 |
||
S2588New |
Calcium LevofolinateCalcium Levofolinate (Calcium Folinate, Levoleucovorin calcium) 是Folinic acid的钙盐,是用于癌症化疗的佐剂。 |
||
S3129 |
TrimethoprimTrimethoprim (BW 56-72, NIH 204, NSC-106568) 是一种抑制细菌的抗生素,主要用于预防和治疗尿路感染。 |
||
S5097 |
Methotrexate disodiumMethotrexate sodium是tetrahydrofolate dehydrogenase的抑制剂,是一种抗肿瘤抗代谢药,具有免疫抑制活性。 |
||
S7785 |
Pemetrexed Disodium HydratePemetrexed Disodium Hydrate (LY-231514) 培美曲塞是一种新型抗叶酸剂和抗代谢物质,作用于TS,DHFR 和 GARFT,Ki分别为1.3 nM,7.2 nM 和 65 nM。Pemetrexed Disodium Hydrate 可刺激细胞自噬和凋亡。 |
![]() ![]() Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
|
|
S5927 |
ProguanilProguanil (chlorguanide, chloroguanide) 是预防性抗疟药。它能抑制疟原虫的二氢叶酸还原酶,阻止嘌呤和嘧啶的合成。 |
||
S5200 |
DiaveridineDiaveridine (AI3-23935, CCRIS-3784) 是一种球虫抑制药,具有抗寄生虫活性,是dihydrofolate reductase (DHFR)抑制剂,在肺囊虫属中抑制叶酸合成。 |
||
S5136 |
Calcium folinateCalcium folinate (Leucovorin calcium, Folinic acid calcium salt, Wellcovorin) is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives. |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S0320New |
Cycloguanil hydrochlorideCycloguanil hydrochloride is an active metabolite of Proguanil. Cycloguanil hydrochloride acts on malaria schizonts in erythrocytes and hepatocytes. |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1236 |
Leucovorin Calcium PentahydrateLeucovorin (Folinic acid) 是一种亚叶酸, 用于改善叶酸下降的状况。 |
||
S0854New |
MetoprineMetoprine (BW 197U), a diaminopyrimidine derivative, is a potent inhibitor of histamine N-methyltransferase (HMT) that crosses the blood-brain barrier and increases brain histamine levels. Metoprine is an antifolate and antitumor agent. |