DHFR

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研究领域

抑制剂选择性比较

DHFR产品

所有产品 DHFR抑制剂(7)

目录号	产品描述	文献引用	实验数据
S1135	Pemetrexed Pemetrexed 是一种新型抗叶酸和抗代谢药物，作用于TS，DHFR和GARFT，无细胞试验中K_i分别为1.3 nM，7.2 nM 和65 nM。Pemetrexed 可诱导自噬和细胞凋亡。	Nat Commun, 2020, 14;11(1):1825 J Hematol Oncol, 2020, 1;13(1):40 J Cell Mol Med, 2020, 24(10):5811-5816	Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
S1497	Pralatrexate Pralatrexate 是一种抗叶酸药，结构与叶酸类似，作用于一些细胞系，IC50低于300 nM。	Cancer Cell Int, 2020, 19;20:58 Oncotarget, 2020, 5;11(18):1576-1589 Blood, 2018, 131(4):397-407	PK parameters for pralatrexate in the study population. Concentration over time for each dose cohort of pralatrexate (A).
S2006	Pyrimethamine Pyrimethamine是二氢叶酸还原酶(DHFR)抑制剂，用作抗疟药。	PLoS Pathog, 2020, 16;16(3):e1008341 Cell, 2019, 178(1):160-175 Cell, 2019, 178(1):160-175
S1618	Sulfameter Sulfameter 是一种长效的磺胺类抗菌药。
S5097	Methotrexate disodium Methotrexate sodium是tetrahydrofolate dehydrogenase的抑制剂，是一种抗肿瘤抗代谢药，具有免疫抑制活性。
S7785	Pemetrexed Disodium Hydrate Pemetrexed Disodium Hydrate 培美曲塞是一种新型抗叶酸剂和抗代谢物质，作用于TS，DHFR 和 GARFT，K_i分别为1.3 nM，7.2 nM 和 65 nM。	J Cell Mol Med, 2020, 24(10):5811-5816 Cancer Cell Int, 2020, 19;20:58 BMC Cancer, 2019, 19(1):108	Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
S5200	Diaveridine Diaveridine是一种球虫抑制药，具有抗寄生虫活性，是dihydrofolate reductase (DHFR)抑制剂，在肺囊虫属中抑制叶酸合成。

目录号	产品描述	文献引用	实验数据
S1135	Pemetrexed Pemetrexed 是一种新型抗叶酸和抗代谢药物，作用于TS，DHFR和GARFT，无细胞试验中K_i分别为1.3 nM，7.2 nM 和65 nM。Pemetrexed 可诱导自噬和细胞凋亡。	Nat Commun,2020, 14;11(1):1825 J Hematol Oncol,2020, 1;13(1):40 J Cell Mol Med,2020, 24(10):5811-5816	Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
S1497	Pralatrexate Pralatrexate 是一种抗叶酸药，结构与叶酸类似，作用于一些细胞系，IC50低于300 nM。	Cancer Cell Int,2020, 19;20:58 Oncotarget,2020, 5;11(18):1576-1589 Blood,2018, 131(4):397-407	PK parameters for pralatrexate in the study population. Concentration over time for each dose cohort of pralatrexate (A).
S2006	Pyrimethamine Pyrimethamine是二氢叶酸还原酶(DHFR)抑制剂，用作抗疟药。	PLoS Pathog,2020, 16;16(3):e1008341 Cell,2019, 178(1):160-175 Cell,2019, 178(1):160-175
S1618	Sulfameter Sulfameter 是一种长效的磺胺类抗菌药。
S5097	Methotrexate disodium Methotrexate sodium是tetrahydrofolate dehydrogenase的抑制剂，是一种抗肿瘤抗代谢药，具有免疫抑制活性。
S7785	Pemetrexed Disodium Hydrate Pemetrexed Disodium Hydrate 培美曲塞是一种新型抗叶酸剂和抗代谢物质，作用于TS，DHFR 和 GARFT，K_i分别为1.3 nM，7.2 nM 和 65 nM。	J Cell Mol Med,2020, 24(10):5811-5816 Cancer Cell Int,2020, 19;20:58 BMC Cancer,2019, 19(1):108	Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
S5200	Diaveridine Diaveridine是一种球虫抑制药，具有抗寄生虫活性，是dihydrofolate reductase (DHFR)抑制剂，在肺囊虫属中抑制叶酸合成。