IRE1

抑制剂选择性比较

IRE1产品

所有产品 IRE1抑制剂(5) 新IRE1产品

目录号	产品描述	文献引用	实验数据
S7272	4μ8C 4μ8C是高效的选择性IRE1 Rnase抑制剂，IC50为76 nM。	Cell Death Dis, 2019, 10(12):891 Free Radic Biol Med, 2018, 124:395-407 Sci Rep, 2018, 8(1):3496	H Representative immunofluorescence staining of TUNEL. Scale bars, 100 µm. I Representative images of DHE staining. Scale bars, 100 µm. Data are mean ± SEM, p < 0.05, p < 0.01, **p < 0.001 by unpaired Student's t-test.
S6623^New	APY29 APY29是一种I类IRE1α抑制剂，与IRE1α的ATP结合位点相结合，抑制其自我磷酸化(IC50 = 280 nM)、增强其RNase作用(EC50 = 460 nM)。
S7771	STF-083010 STF-083010是一种特异性IRE1α endonuclease抑制剂，而不影响其激酶活性。	Cell Death Dis, 2019, 10(9):651 Arch Toxicol, 2019, 93(4):965-986 Naunyn Schmiedebergs Arch Pharmacol, 2019, 10.1007/s00210-019-01739-7	The effect of TUDCA and STF-083010 on mouse decidualization.(B) The average weight of implantation sites on day 8 under TUDCA treatment.(D) The effect of TUDCA treatment on the weight of deciduoma. (F) The average weight of implantation sites on day 8 under STF-083010 treatment. (H) The effect of STF-083010 treatment on the weight of deciduoma. (I) The effect of TUDCA on the mRNA expression of Dtprp in vitro decidualization. (J) The effect of STF-083010 on the mRNA expression of Dtprp in vitro decidualization. Data are presented as the mean ± SD, *p < 0.05.
S8286	MKC-3946 MKC3946是IRE1α endoribonuclease domain的可溶性抑制剂，在多种骨髓瘤细胞株中引起适度的生长抑制作用，而不对正常单核细胞具有毒性作用。
S8658	kira6 Kira6是有效的II型IRE1α激酶抑制剂，IC50为0.6 μM。它能够浓度依赖性地抑制IRE1α(WT)激酶活性、XBP1 RNA剪接、Ins2 RNA剪接和寡聚化。	Cell Rep, 2016, 16(11):2914-2927

目录号	产品描述	文献引用	实验数据
S7272	4μ8C 4μ8C是高效的选择性IRE1 Rnase抑制剂，IC50为76 nM。	Cell Death Dis,2019, 10(12):891 Free Radic Biol Med,2018, 124:395-407 Sci Rep,2018, 8(1):3496	H Representative immunofluorescence staining of TUNEL. Scale bars, 100 µm. I Representative images of DHE staining. Scale bars, 100 µm. Data are mean ± SEM, p < 0.05, p < 0.01, **p < 0.001 by unpaired Student's t-test.
S6623^New	APY29 APY29是一种I类IRE1α抑制剂，与IRE1α的ATP结合位点相结合，抑制其自我磷酸化(IC50 = 280 nM)、增强其RNase作用(EC50 = 460 nM)。
S7771	STF-083010 STF-083010是一种特异性IRE1α endonuclease抑制剂，而不影响其激酶活性。	Cell Death Dis,2019, 10(9):651 Arch Toxicol,2019, 93(4):965-986 Naunyn Schmiedebergs Arch Pharmacol,2019, 10.1007/s00210-019-01739-7	The effect of TUDCA and STF-083010 on mouse decidualization.(B) The average weight of implantation sites on day 8 under TUDCA treatment.(D) The effect of TUDCA treatment on the weight of deciduoma. (F) The average weight of implantation sites on day 8 under STF-083010 treatment. (H) The effect of STF-083010 treatment on the weight of deciduoma. (I) The effect of TUDCA on the mRNA expression of Dtprp in vitro decidualization. (J) The effect of STF-083010 on the mRNA expression of Dtprp in vitro decidualization. Data are presented as the mean ± SD, *p < 0.05.
S8286	MKC-3946 MKC3946是IRE1α endoribonuclease domain的可溶性抑制剂，在多种骨髓瘤细胞株中引起适度的生长抑制作用，而不对正常单核细胞具有毒性作用。
S8658	kira6 Kira6是有效的II型IRE1α激酶抑制剂，IC50为0.6 μM。它能够浓度依赖性地抑制IRE1α(WT)激酶活性、XBP1 RNA剪接、Ins2 RNA剪接和寡聚化。	Cell Rep,2016, 16(11):2914-2927

Tags: IRE1 inhibitor | IRE1 modulator | IRE1 stress