IRE1
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S7272 | 4μ8C | <1 mg/mL | 19 mg/mL | <1 mg/mL |
| S7771 | STF-083010 | <1 mg/mL | 63 mg/mL | <1 mg/mL |
| S8286 | MKC-3946 | <1 mg/mL | 38 mg/mL | 3 mg/mL |
| S8658 | kira6 | <1 mg/mL | 60 mg/mL | 60 mg/mL |
- IRE1抑制剂（4）
- 新IRE1产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7272 |
4μ8C4μ8C是高效的选择性IRE1 Rnase抑制剂，IC50为76 nM。 |
H Representative immunofluorescence staining of TUNEL. Scale bars, 100 µm. I Representative images of DHE staining. Scale bars, 100 µm. Data are mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001 by unpaired Student's t-test.
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| S7771 |
STF-083010STF-083010是一种特异性IRE1α endonuclease抑制剂，而不影响其激酶活性。 |
The effect of TUDCA and STF-083010 on mouse decidualization.(B) The average weight of implantation sites on day 8 under TUDCA treatment.(D) The effect of TUDCA treatment on the weight of deciduoma. (F) The average weight of implantation sites on day 8 under STF-083010 treatment. (H) The effect of STF-083010 treatment on the weight of deciduoma. (I) The effect of TUDCA on the mRNA expression of Dtprp in vitro decidualization. (J) The effect of STF-083010 on the mRNA expression of Dtprp in vitro decidualization. Data are presented as the mean ± SD, *p < 0.05. |
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| S8286 |
MKC-3946MKC3946是IRE1α endoribonuclease domain的可溶性抑制剂，在多种骨髓瘤细胞株中引起适度的生长抑制作用，而不对正常单核细胞具有毒性作用。 |
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| S8658New |
kira6Kira6是有效的II型IRE1α激酶抑制剂，IC50为0.6 μM。它能够浓度依赖性地抑制IRE1α(WT)激酶活性、XBP1 RNA剪接、Ins2 RNA剪接和寡聚化。 |
