PI4K
抑制剂选择性比较
PI4K产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S1489 |
PIK-93PIK-93是第一个有效的,人工合成的PI4K(PI4KIIIβ)抑制剂,IC50为19 nM;抑制PI3Kα,IC50为39 nM。 |
![]() ![]() After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of PIK-93 for 3h,followed by 20-minute stimolation of 100ng/ml EGF. |
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S2728 |
AG-1478 (Tyrphostin AG-1478)AG-1478 (Tyrphostin AG-1478, NSC 693255) 是一种选择性EGFR抑制剂,在无细胞试验中IC50为3 nM,对HER2-Neu,PDGFR,Trk,Bcr-Abl和InsR几乎没有作用活性。AG-1478(Tyrphostin AG-1478)通过靶向 phosphatidylinositol 4-kinase IIIα (PI4KA) 抑制脑心肌炎病毒encephalomyocarditis virus (EMCV)和丙型肝炎病毒hepatitis c virus (HCV)。 |
![]() ![]() A549 cells were treated with G15 (a specific antagonist of GPR30, 1 uM), AG1478 (a potent antagonist of EGFR, 10 uM), BPA (10-5 M) alone for 15 min or BPA after a 90-min pretreatment with G15 or AG1478 for 15 min. Then the expression of p-ERK1/2 and total ERK1/2 were measured by western blot analysis.
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S0041New |
UCB9608UCB9608 (compound 44) 是一种有效的、选择性的 PI4KIIIβ 的口服生物利用的抑制剂,其IC50值为 11 nM。UCB9608 是一种有效的免疫抑制剂,可改善代谢稳定性并表现出出色的药代动力学特性。 |
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S6571 |
BQR695BQR695 (NVP-BQR695)是PI4KIIIβ抑制剂,对人源PI4KIIIβ的IC50值约为90 nM。 |
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S6574 |
KDU691KDU691是疟原虫PI4K特异性抑制剂,对其休眠子形式和肝内裂殖体的IC50值分别为0.18 μM和0.061 μM。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1489 |
PIK-93PIK-93是第一个有效的,人工合成的PI4K(PI4KIIIβ)抑制剂,IC50为19 nM;抑制PI3Kα,IC50为39 nM。 |
![]() ![]() After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of PIK-93 for 3h,followed by 20-minute stimolation of 100ng/ml EGF. |
|
S2728 |
AG-1478 (Tyrphostin AG-1478)AG-1478 (Tyrphostin AG-1478, NSC 693255) 是一种选择性EGFR抑制剂,在无细胞试验中IC50为3 nM,对HER2-Neu,PDGFR,Trk,Bcr-Abl和InsR几乎没有作用活性。AG-1478(Tyrphostin AG-1478)通过靶向 phosphatidylinositol 4-kinase IIIα (PI4KA) 抑制脑心肌炎病毒encephalomyocarditis virus (EMCV)和丙型肝炎病毒hepatitis c virus (HCV)。 |
![]() ![]() A549 cells were treated with G15 (a specific antagonist of GPR30, 1 uM), AG1478 (a potent antagonist of EGFR, 10 uM), BPA (10-5 M) alone for 15 min or BPA after a 90-min pretreatment with G15 or AG1478 for 15 min. Then the expression of p-ERK1/2 and total ERK1/2 were measured by western blot analysis.
|
|
S0041New |
UCB9608UCB9608 (compound 44) 是一种有效的、选择性的 PI4KIIIβ 的口服生物利用的抑制剂,其IC50值为 11 nM。UCB9608 是一种有效的免疫抑制剂,可改善代谢稳定性并表现出出色的药代动力学特性。 |
||
S6571 |
BQR695BQR695 (NVP-BQR695)是PI4KIIIβ抑制剂,对人源PI4KIIIβ的IC50值约为90 nM。 |
||
S6574 |
KDU691KDU691是疟原虫PI4K特异性抑制剂,对其休眠子形式和肝内裂殖体的IC50值分别为0.18 μM和0.061 μM。 |