PI4K

PI4K产品

目录号	产品描述	文献引用	实验数据
S1489	PIK-93 PIK-93是第一个有效的，人工合成的PI4K(PI4KIIIβ)抑制剂，IC50为19 nM；抑制PI3Kα，IC50为39 nM。	Sci Adv, 2019, 5(3):eaat4872 PLoS One, 2015, 10(3):e0122753 Clin Cancer Res, 2014, 20(16):4274-88	After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of PIK-93 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
S2728	AG-1478 (Tyrphostin AG-1478) AG-1478 (Tyrphostin AG-1478, NSC 693255) 是一种选择性EGFR抑制剂，在无细胞试验中IC50为3 nM，对HER2-Neu，PDGFR，Trk，Bcr-Abl和InsR几乎没有作用活性。AG-1478（Tyrphostin AG-1478）通过靶向 phosphatidylinositol 4-kinase IIIα (PI4KA) 抑制脑心肌炎病毒encephalomyocarditis virus (EMCV)和丙型肝炎病毒hepatitis c virus (HCV)。	Autophagy, 2020, 16(6):1061-1076 Mucosal Immunol, 2020, 4 Br J Pharmacol, 2020, 10.1111/bph.14998	A549 cells were treated with G15 (a specific antagonist of GPR30, 1 uM), AG1478 (a potent antagonist of EGFR, 10 uM), BPA (10-5 M) alone for 15 min or BPA after a 90-min pretreatment with G15 or AG1478 for 15 min. Then the expression of p-ERK1/2 and total ERK1/2 were measured by western blot analysis.
S6571	BQR695 BQR695是PI4KIIIβ抑制剂，对人源PI4KIIIβ的IC50值约为90 nM。
S6574	KDU691 KDU691是疟原虫PI4K特异性抑制剂，对其休眠子形式和肝内裂殖体的IC50值分别为0.18 μM和0.061 μM。

目录号	产品描述	文献引用	实验数据
S1489	PIK-93 PIK-93是第一个有效的，人工合成的PI4K(PI4KIIIβ)抑制剂，IC50为19 nM；抑制PI3Kα，IC50为39 nM。	Sci Adv,2019, 5(3):eaat4872 PLoS One,2015, 10(3):e0122753 Clin Cancer Res,2014, 20(16):4274-88	After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of PIK-93 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
S2728	AG-1478 (Tyrphostin AG-1478) AG-1478 (Tyrphostin AG-1478, NSC 693255) 是一种选择性EGFR抑制剂，在无细胞试验中IC50为3 nM，对HER2-Neu，PDGFR，Trk，Bcr-Abl和InsR几乎没有作用活性。AG-1478（Tyrphostin AG-1478）通过靶向 phosphatidylinositol 4-kinase IIIα (PI4KA) 抑制脑心肌炎病毒encephalomyocarditis virus (EMCV)和丙型肝炎病毒hepatitis c virus (HCV)。	Autophagy,2020, 16(6):1061-1076 Mucosal Immunol,2020, 4 Br J Pharmacol,2020, 10.1111/bph.14998	A549 cells were treated with G15 (a specific antagonist of GPR30, 1 uM), AG1478 (a potent antagonist of EGFR, 10 uM), BPA (10-5 M) alone for 15 min or BPA after a 90-min pretreatment with G15 or AG1478 for 15 min. Then the expression of p-ERK1/2 and total ERK1/2 were measured by western blot analysis.
S6571	BQR695 BQR695是PI4KIIIβ抑制剂，对人源PI4KIIIβ的IC50值约为90 nM。
S6574	KDU691 KDU691是疟原虫PI4K特异性抑制剂，对其休眠子形式和肝内裂殖体的IC50值分别为0.18 μM和0.061 μM。